MDMA (Italian Wikipedia)

Analysis of information sources in references of the Wikipedia article "MDMA" in Italian language version.

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clinicaltrials.gov (Global: 4,259th place; Italian: 3,825th place)

  • CTG Labs - NCBI, su www.clinicaltrials.gov. URL consultato il 23 novembre 2023.
  • CTG Labs - NCBI, su www.clinicaltrials.gov. URL consultato il 23 novembre 2023.

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eurekaselect.com (Global: low place; Italian: 7,821st place)

  • (EN) Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review, su eurekaselect.com. URL consultato il 9 maggio 2017.
    «• Chronic MDMA use results in serotonergic toxicity, thereby altering the regional cerebral blood flow that can be studied using fMRI. • The effects of chronic MDMA use have been analysed in various neurocognitive domains such as working memory, episodic memory, semantic memory, visual stimulation, motor function and impulsivity. Structural neuroimaging in MDMA users has shown reduction in brain 5-HT transporter (5-HTT) and 5-HT2a receptor levels using positron emission tomography (PET) or single photon emission computed tomography (SPECT) and reduced grey matter density in various brain regions using voxel based morphometry method (VBM). Chemical Neuroimaging, assaying the levels of myoinositol (MI) and N-acetylaspartate (NAA) in the brains of MDMA users using proton magnetic resonance spectroscopy (MRS), has not revealed any consistent results. Functional magnetic resonance imaging (fMRI) studies have shown task evoked differences in regional brain activation, measured as blood oxygen level dependent (BOLD) signal intensity and/or spatial extent of activation, in MDMA users and controls. Neurocognitive studies, in MDMA users, have consistently revealed dose related memory and learning problems. Serotonergic innervation is known to regulate the cerebral microvasculature. Chronic MDMA use results in serotonin toxicity, therefore MDMA users are expected to have altered regional blood flow detectable in fMRI. Animal data has suggested that MDMA is selectively more toxic to the axons more distal to the brainstem cell bodies, that is, those present mainly in the occipital cortesemente. Also, human PET and SPECT studies have revealed significant reductions in serotonin transporter binding, most evident in the occipital cortex. The effects of poly-drug exposure may result in additive neurotoxicity or mutual neuro-protection. MDMA is known to induce hyperthermia which is a prooxidant neurotoxic condition. Hyperthermia is known to accentuate the neurotoxic potential of MDMA as well as methamphetamine. On the other hand, lowering of the core body temperature has been shown to have a neuroprotective effect."»

europa.eu (Global: 62nd place; Italian: 64th place)

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toxnet.nlm.nih.gov

  • (EN) TOXNET, su toxnet.nlm.nih.gov. URL consultato il 9 maggio 2017.

pubmed.ncbi.nlm.nih.gov

  • R. Baker e M. Bowers, Ritonavir and ecstasy, in BETA: bulletin of experimental treatments for AIDS: a publication of the San Francisco AIDS Foundation, 1997-03, p. 5. URL consultato il 22 maggio 2023.

nytimes.com (Global: 7th place; Italian: 15th place)

  • (EN) Drake Bennett, Dr. Ecstasy, in The New York Times, 30 gennaio 2005. URL consultato il 14 novembre 2023.

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academic.oup.com

  • De Win, Maartje M. L e Gerry Jager, Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users, in Brain, vol. 131, n. 11, 1º novembre 2008, pp. 2936-2945, DOI:10.1093/brain/awn255. URL consultato il 25 giugno 2017.
    «[...]This first prospective imaging study in novel ecstasy users suggests that even a low to moderate ecstasy dose of 1–80 tablets (mean 6, median 2 tablets) has some sustained effects on the brain. [...]Decreased FA and increased ADC in the thalamus may reflect ecstasy-induced axonal damage, because axonal cell membranes are known to be responsible for most of the restriction of water diffusion and axonal damage lead to decreased FA and increased ADC. This finding of ecstasy-induced brain pathology in the thalamus corroborates findings from previous studies showing decreased thalamic SERT densities in (heavy) ecstasy users, most probably reflecting damage to terminals of serotonergic axons [...]These findings suggest sustained effects of ecstasy on brain microvasculature, white matter maturation and possibly axonal damage due to low dosages of ecstasy. Although we do not know yet whether these effects are reversible or not, we cannot exclude that ecstasy even in low doses is neurotoxic to the brain.»

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