Metadone (Italian Wikipedia)

Analysis of information sources in references of the Wikipedia article "Metadone" in Italian language version.

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Romach MK, Piafsky KM, Abel JG, Khouw V, Sellers EM, Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma, in Clin. Pharmacol. Ther., vol. 29, n. 2, febbraio 1981, pp. 211–7, PMID 7193106.
Watson CP, Methadone for neuropathic pain: a new use for an old drug?, in Can J Neurol Sci, vol. 32, n. 3, agosto 2005, pp. 271–2, PMID 16225164.
Fitzgibbon DR, Ready LB, Intravenous high-dose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine, in Pain, vol. 73, n. 2, novembre 1997, pp. 259–61, PMID 9415514.
Sabatowski R, Kasper SM, Radbruch L, Patient-controlled analgesia with intravenous L-methadone in a child with cancer pain refractory to high-dose morphine, in J Pain Symptom Manage, vol. 23, n. 1, gennaio 2002, pp. 3–5, PMID 11779660.
Nilsson MI, Grönbladh L, Widerlöv E, Anggård E, Pharmacokinetics of methadone in methadone maintenance treatment: characterization of therapeutic failures, in Eur. J. Clin. Pharmacol., vol. 25, n. 4, 1983, pp. 497–501, PMID 6653644.
Nair MK, Patel K, Starer PJ, Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient, in Addiction, vol. 103, n. 12, dicembre 2008, pp. 2062–4, DOI:10.1111/j.1360-0443.2008.02390.x, PMID 19469750.
McBay AJ, Toxicological findings in fatal poisonings, in Clin. Chem., vol. 19, n. 4, aprile 1973, pp. 361–5, PMID 4574410.
Tong TG, Pond SM, Kreek MJ, Jaffery NF, Benowitz NL, Phenytoin-induced methadone withdrawal, in Ann. Intern. Med., vol. 94, n. 3, marzo 1981, pp. 349–51, PMID 7224382.
Cobb MN, Desai J, Brown LS, Zannikos PN, Rainey PM, The effect of fluconazole on the clinical pharmacokinetics of methadone, in Clin. Pharmacol. Ther., vol. 63, n. 6, giugno 1998, pp. 655–62, DOI:10.1016/S0009-9236(98)90089-3, PMID 9663180.
Trapnell CB, Klecker RW, Jamis-Dow C, Collins JM, Glucuronidation of 3'-azido-3'-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid, in Antimicrob. Agents Chemother., vol. 42, n. 7, luglio 1998, pp. 1592–6, PMC 105651, PMID 9660989.
Kharasch ED, Hoffer C, Whittington D, Walker A, Bedynek PS, Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir, in Anesthesiology, vol. 110, n. 3, marzo 2009, pp. 660–72, DOI:10.1097/ALN.0b013e3181986a9a, PMID 19225389.
Mellon RD, Simone AF, Rappaport BA, Use of anesthetic agents in neonates and young children, in Anesth. Analg., vol. 104, n. 3, marzo 2007, pp. 509–20, DOI:10.1213/01.ane.0000255729.96438.b0, PMID 17312200.
Mercadante S, Villari P, Ferrera P, Arcuri E, David F, Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases, in Clin J Pain, vol. 25, n. 7, settembre 2009, pp. 648–9, DOI:10.1097/AJP.0b013e3181a68a85, PMID 19692808.
Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs, in J. Pharmacol. Exp. Ther., vol. 316, n. 3, marzo 2006, pp. 1098–106, DOI:10.1124/jpet.105.093393, PMID 16278312.
Chen PP, Chui PT, Gin T, Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery, in Eur J Anaesthesiol, vol. 13, n. 5, settembre 1996, pp. 485–91, PMID 8889424.
Reid MC, Engles-Horton LL, Weber MB, Kerns RD, Rogers EL, O'Connor PG, Use of opioid medications for chronic noncancer pain syndromes in primary care, in J Gen Intern Med, vol. 17, n. 3, marzo 2002, pp. 173–9, PMC 1495018, PMID 11929502.
N. Moryl, J. Santiago-Palma; C. Kornick; S. Derby; D. Fischberg; R. Payne; PL. Manfredi, Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain., in Pain, vol. 96, n. 3, aprile 2002, pp. 325-8, PMID 11973005.
(EN) Peter Staats; Wallace, Mark, Pain medicine and management: just the facts, New York, McGraw-Hill, Medical Pub. Division, 2005, p. 228, ISBN 0-07-141182-8.

books.google.com

(EN) Glen R. Hanson, Peter J. Venturelli e Annette E. Fleckenstein, Drugs and society, Jones & Bartlett Learning, p. 269, ISBN 978-0-7637-3732-0.
Nicola Garzotto, Psichiatria pratica, Piccin, 1985, p. 197, ISBN 978-88-299-0184-5.
Q. Alan Xu e Timothy L. Madden, Analytical Methods for Therapeutic Drug Monitoring and Toxicology, John Wiley and Sons, 15 febbraio 2011, p. 309, ISBN 978-0-470-45561-6.
Brunton, Goodman e Blumenthal, p. 361. (EN) Laurence L. Brunton, Louis Sanford Goodman, Donald Blumenthal, Iain Buxton, Goodman and Gilman's manual of pharmacology and therapeutics, McGraw-Hill Professional, 28 settembre 2007, ISBN 978-0-07-144343-2.
(EN) Richard Finkel, Michelle Alexia Clark, Pamela C. Champe, Luigi X. Cubeddu, Pharmacology, Lippincott Williams & Wilkins, 1º luglio 2008, p. 165, ISBN 978-0-7817-7155-9.
S. Mercadante, La gestione del dolore postoperatorio. Linee guida di trattamento. Con CD-ROM, Elsevier, 2007, p. 67, ISBN 978-88-214-2992-7.
Aldo Zangara, Terapia medica ragionata, Piccin, 2002, p. 92, ISBN 978-88-299-1649-8. URL consultato il 24 febbraio 2011.
Yarbro, Goodman e Frogge, p. 676. (EN) Connie Henke Yarbro, Michelle Goodman e Margaret Hansen Frogge, Cancer Nursing: Principles and Practice, Jones & Bartlett Learning, 21 aprile 2010, ISBN 978-0-7637-6357-2.
(EN) V. Tim Malhotra e Natalie Moryl, Dx/Rx: palliative cancer care, Jones & Bartlett Learning, 27 gennaio 2006, p. 30, ISBN 978-0-7637-2639-3.
Chabner, Lynch e Longo, p. 183. (EN) Bruce Chabner, Thomas J. Lynch e Dan L. Longo, Harrison's Manual of Oncology, McGraw Hill Professional, 11 novembre 2007, ISBN 978-0-07-141189-9.
Barbera e De Carlo, p. 786. Carlo Barbera, Giuseppe De Carlo e Luca De Carlo, Testo unico di pubblica sicurezza, Maggioli Editore, 2008, ISBN 978-88-387-4029-9.

doi.org

dx.doi.org

MA. Benítez-Rosario, A. Salinas-Martín; A. Aguirre-Jaime; L. Pérez-Méndez; M. Feria, Morphine-methadone opioid rotation in cancer patients: analysis of dose ratio predicting factors., in J Pain Symptom Manage, vol. 37, n. 6, giugno 2009, pp. 1061-8, DOI:10.1016/j.jpainsymman.2008.05.016, PMID 19171458.
PW. Walker, S. Palla; BL. Pei; G. Kaur; K. Zhang; J. Hanohano; M. Munsell; E. Bruera, Switching from methadone to a different opioid: what is the equianalgesic dose ratio?, in J Palliat Med, vol. 11, n. 8, ottobre 2008, pp. 1103-8, DOI:10.1089/jpm.2007.0285, PMID 18980450.
Larson ME, Richards TM, Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance, in Clin Med Res, vol. 7, n. 4, dicembre 2009, pp. 134–41, DOI:10.3121/cmr.2009.859, PMC 2801695, PMID 19920164.
Shiran MR, Lennard MS, Iqbal MZ, et al., Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment, in Br J Clin Pharmacol, vol. 67, n. 1, gennaio 2009, pp. 29–37, DOI:10.1111/j.1365-2125.2008.03312.x, PMC 2668081, PMID 19133059.
Matsui A, Williams JT, Activation of μ-opioid receptors and block of KIR 3 potassium channels and NMDA receptor conductance by l- and d-methadone in rat locus coeruleus, in Br. J. Pharmacol., vol. 161, n. 6, novembre 2010, pp. 1403–13, DOI:10.1111/j.1476-5381.2010.00967.x, PMID 20659105.
Pollock AB, Tegeler ML, Morgan V, Baumrucker SJ, Morphine to Methadone Conversion: An Interpretation of Published Data, in Am J Hosp Palliat Care, giugno 2010, DOI:10.1177/1049909110373508, PMID 20555039.
Leppert W, The role of methadone in cancer pain treatment--a review, in Int. J. Clin. Pract., vol. 63, n. 7, luglio 2009, pp. 1095–109, DOI:10.1111/j.1742-1241.2008.01990.x, PMID 19570126.
Benítez-Rosario MA, Feria M, Salinas-Martín A, Martínez-Castillo LP, Martín-Ortega JJ, Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain, in Cancer, vol. 101, n. 12, dicembre 2004, pp. 2866–73, DOI:10.1002/cncr.20712, PMID 15529307.
Yennurajalingam S, Peuckmann V, Bruera E, Recent developments in cancer pain assessment and management, in Support Cancer Ther, vol. 1, n. 2, gennaio 2004, pp. 97–110, DOI:10.3816/SCT.2004.n.003, PMID 18628186.
Shaiova L, The role of methadone in the treatment of moderate to severe cancer pain, in Support Cancer Ther, vol. 2, n. 3, aprile 2005, pp. 176–80, DOI:10.3816/SCT.2005.n.010, PMID 18628169.
Prieto-Alvarez P, Tello-Galindo I, Cuenca-Peña J, Rull-Bartomeu M, Gomar-Sancho C, Continuous epidural infusion of racemic methadone results in effective postoperative analgesia and low plasma concentrations, in Can J Anaesth, vol. 49, n. 1, gennaio 2002, pp. 25–31, DOI:10.1007/BF03020415, PMID 11782325.
Deiss RG, Rodwell TC, Garfein RS, Tuberculosis and illicit drug use: review and update, in Clin. Infect. Dis., vol. 48, n. 1, gennaio 2009, pp. 72–82, DOI:10.1086/594126, PMID 19046064.
Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED, Enantiomeric metabolic interactions and stereoselective human methadone metabolism, in J. Pharmacol. Exp. Ther., vol. 321, n. 1, aprile 2007, pp. 389–99, DOI:10.1124/jpet.106.117580, PMID 17259447.
Herrlin K, Segerdahl M, Gustafsson LL, Kalso E, Methadone, ciprofloxacin, and adverse drug reactions, in Lancet, vol. 356, n. 9247, dicembre 2000, pp. 2069–70, DOI:10.1016/S0140-6736(00)03409-7, PMID 11145498.
Nair MK, Patel K, Starer PJ, Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient, in Addiction, vol. 103, n. 12, dicembre 2008, pp. 2062–4, DOI:10.1111/j.1360-0443.2008.02390.x, PMID 19469750.
Bush E, Miller C, Friedman I, A case of serotonin syndrome and mutism associated with methadone, in J Palliat Med, vol. 9, n. 6, dicembre 2006, pp. 1257–9, DOI:10.1089/jpm.2006.9.1257, PMID 17187532.
Greenwald MK, Behavioral economic analysis of drug preference using multiple choice procedure data, in Drug Alcohol Depend, vol. 93, n. 1-2, gennaio 2008, pp. 103–10, DOI:10.1016/j.drugalcdep.2007.09.002, PMC 2248460, PMID 17949924.
Alleyne S, Alao A, Batki SL, Lamotrigine-associated rash and blood dyscrasias in a methadone-treatment patient with hepatitis C, in Psychosomatics, vol. 47, n. 3, 2006, pp. 257–8, DOI:10.1176/appi.psy.47.3.257, PMID 16684944.
Jackson L, Ting A, McKay S, Galea P, Skeoch C, A randomised controlled trial of morphine versus phenobarbitone for neonatal abstinence syndrome, in Arch. Dis. Child. Fetal Neonatal Ed., vol. 89, n. 4, luglio 2004, pp. F300–4, DOI:10.1136/adc.2003.033555, PMC 1721707, PMID 15210660.
Cobb MN, Desai J, Brown LS, Zannikos PN, Rainey PM, The effect of fluconazole on the clinical pharmacokinetics of methadone, in Clin. Pharmacol. Ther., vol. 63, n. 6, giugno 1998, pp. 655–62, DOI:10.1016/S0009-9236(98)90089-3, PMID 9663180.
Moody DE, Fang WB, Lin SN, Weyant DM, Strom SC, Omiecinski CJ, Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes, in Drug Metab. Dispos., vol. 37, n. 12, dicembre 2009, pp. 2323–9, DOI:10.1124/dmd.109.028605, PMC 2784702, PMID 19773542.
Kharasch ED, Hoffer C, Whittington D, Walker A, Bedynek PS, Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir, in Anesthesiology, vol. 110, n. 3, marzo 2009, pp. 660–72, DOI:10.1097/ALN.0b013e3181986a9a, PMID 19225389.
Coles LD, Lee IJ, Hassan HE, Eddington ND, Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice, in J Pharm Sci, vol. 98, n. 8, agosto 2009, pp. 2832–46, DOI:10.1002/jps.21644, PMID 19116954.
Lüthi B, Huttner A, Speck RF, Mueller NJ, Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir, in Eur. J. Clin. Microbiol. Infect. Dis., vol. 26, n. 5, maggio 2007, pp. 367–9, DOI:10.1007/s10096-007-0293-5, PMID 17440756.
Haney M, Hart CL, Foltin RW, Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers, in Neuropsychopharmacology, vol. 31, n. 8, agosto 2006, pp. 1814–21, DOI:10.1038/sj.npp.1300999, PMID 16407903.
Mellon RD, Simone AF, Rappaport BA, Use of anesthetic agents in neonates and young children, in Anesth. Analg., vol. 104, n. 3, marzo 2007, pp. 509–20, DOI:10.1213/01.ane.0000255729.96438.b0, PMID 17312200.
Vorspan F, Ksouda K, Bloch V, et al., A case report of transient but clinically relevant interaction between methadone and duloxetine: a reply to McCance-Katz et al, in Am J Addict, vol. 19, n. 5, settembre 2010, pp. 458–9, DOI:10.1111/j.1521-0391.2010.00062.x, PMID 20716309.
Bosmans T, Schauvliege S, Gasthuys F, et al., Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs, in Vet Anaesth Analg, vol. 38, n. 2, marzo 2011, pp. 146–57, DOI:10.1111/j.1467-2995.2011.00595.x, PMID 21303446.
Meyer MR, Maurer HH, Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse, in Pharmacogenomics, vol. 12, n. 2, febbraio 2011, pp. 215–33, DOI:10.2217/pgs.10.171, PMID 21332315.
Mercadante S, Villari P, Ferrera P, Arcuri E, David F, Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases, in Clin J Pain, vol. 25, n. 7, settembre 2009, pp. 648–9, DOI:10.1097/AJP.0b013e3181a68a85, PMID 19692808.
Steinberg M, Morin AK, Mild serotonin syndrome associated with concurrent linezolid and fluoxetine, in Am J Health Syst Pharm, vol. 64, n. 1, gennaio 2007, pp. 59–62, DOI:10.2146/ajhp060227, PMID 17189581.
Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs, in J. Pharmacol. Exp. Ther., vol. 316, n. 3, marzo 2006, pp. 1098–106, DOI:10.1124/jpet.105.093393, PMID 16278312.
Junttila MJ, Gonzalez M, Lizotte E, et al., Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias, in Circulation, vol. 117, n. 14, aprile 2008, pp. 1890–3, DOI:10.1161/CIRCULATIONAHA.107.746495, PMID 18391123.
Auer U, Mosing M, Moens YP, The effect of low dose rocuronium on globe position, muscle relaxation and ventilation in dogs: a clinical study, in Vet Ophthalmol, vol. 10, n. 5, 2007, pp. 295–8, DOI:10.1111/j.1463-5224.2007.00553.x, PMID 17760708.
Prosser JM, Mills A, Rhim ES, Perrone J, Torsade de pointes caused by polypharmacy and substance abuse in a patient with human immunodeficiency virus, in Int J Emerg Med, vol. 1, n. 3, settembre 2008, pp. 217–20, DOI:10.1007/s12245-008-0052-0, PMC 2657284, PMID 19384521.
Poluzzi E, Raschi E, Moretti U, De Ponti F, Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS), in Pharmacoepidemiol Drug Saf, vol. 18, n. 6, giugno 2009, pp. 512–8, DOI:10.1002/pds.1746, PMID 19358226.
Silva de Lima M, Farrell M, Lima Reisser AA, Soares B, WITHDRAWN: Antidepressants for cocaine dependence, in Cochrane Database Syst Rev, n. 2, 2010, pp. CD002950, DOI:10.1002/14651858.CD002950.pub2, PMID 20166064.
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA, Commonly prescribed medications and potential false-positive urine drug screens, in Am J Health Syst Pharm, vol. 67, n. 16, agosto 2010, pp. 1344–50, DOI:10.2146/ajhp090477, PMID 20689123.
Gerber JG, Rhodes RJ, Gal J, Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19, in Chirality, vol. 16, n. 1, gennaio 2004, pp. 36–44, DOI:10.1002/chir.10303, PMID 14628297.
Molassiotis A, Smith JA, Bennett MI, et al., Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough, in Cough, vol. 6, 2010, p. 9, DOI:10.1186/1745-9974-6-9, PMC 2978117, PMID 20925935.
Bolser DC, Pharmacologic management of cough, in Otolaryngol. Clin. North Am., vol. 43, n. 1, febbraio 2010, pp. 147–55, xi, DOI:10.1016/j.otc.2009.11.008, PMC 2827356, PMID 20172264.
Dicpinigaitis PV, Currently available antitussives, in Pulm Pharmacol Ther, vol. 22, n. 2, aprile 2009, pp. 148–51, DOI:10.1016/j.pupt.2008.08.002, PMID 18771744.
Claudia Friesen, Mareike Roscher, Andreas Alt and Erich Miltner, Methadone, Commonly Used as Maintenance Medication for Outpatient Treatment of Opioid Dependence, Kills Leukemia Cells and Overcomes Chemoresistance, in Cancer Research, vol. 68, n. 15, 2008, pp. 6059–6064, DOI:10.1158/0008-5472.CAN-08-1227, PMID 18676827.
Perez-Alvarez S, Cuenca-Lopez MD, de Mera RM, et al., Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis, in Biochim. Biophys. Acta, vol. 1802, n. 11, novembre 2010, pp. 1036–47, DOI:10.1016/j.bbadis.2010.07.024, PMID 20691259.
Perez-Alvarez S, Iglesias-Guimarais V, Solesio ME, et al., Methadone induces CAD degradation and AIF-mediated necrotic-like cell death in neuroblastoma cells, in Pharmacol. Res., vol. 63, n. 4, aprile 2011, pp. 352–60, DOI:10.1016/j.phrs.2010.12.001, PMID 21145398.
Mannelli P, Patkar AA, Peindl K, Gorelick DA, Wu LT, Gottheil E, Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial, in Addict Biol, vol. 14, n. 2, aprile 2009, pp. 204–13, DOI:10.1111/j.1369-1600.2008.00119.x, PMC 2657183, PMID 18715283.

medicinadelledipendenze.it

Alessandro Zotto, Guido Mannaioni, Farmacologia e tossicologia del L-metadone, in Italian Journal of the Addictions, vol. 7, n. 26, giugno 2017, pp. 7-9.

nih.gov

ncbi.nlm.nih.gov

S. Mercadante, Opioid rotation for cancer pain: rationale and clinical aspects., in Cancer, vol. 86, n. 9, novembre 1999, pp. 1856-66, PMID 10547561.
Mercadante S, Ferrera P, Villari P, Adile C, Casuccio A., Switching from oxycodone to methadone in advanced cancer patients, in Supportive Care in Cancer, vol. 20, n. 1, luglio 2011, pp. 191-194, PMID 21901297.
MA. Benítez-Rosario, A. Salinas-Martín; A. Aguirre-Jaime; L. Pérez-Méndez; M. Feria, Morphine-methadone opioid rotation in cancer patients: analysis of dose ratio predicting factors., in J Pain Symptom Manage, vol. 37, n. 6, giugno 2009, pp. 1061-8, DOI:10.1016/j.jpainsymman.2008.05.016, PMID 19171458.
Gensini GF., New disposition for pain therapy in Italy, center for headache should be integrated in the network, in Neurological Sciences, vol. 32, maggio 2011, p. 67-70, PMID 21533716.
PW. Walker, S. Palla; BL. Pei; G. Kaur; K. Zhang; J. Hanohano; M. Munsell; E. Bruera, Switching from methadone to a different opioid: what is the equianalgesic dose ratio?, in J Palliat Med, vol. 11, n. 8, ottobre 2008, pp. 1103-8, DOI:10.1089/jpm.2007.0285, PMID 18980450.
de Castro A, Jones HE, Johnson RE, Gray TR, Shakleya DM, Huestis MA, Maternal methadone dose, placental methadone concentrations, and neonatal outcomes, in Clinical Chemistry 2011, vol. 57, gennaio 2011, pp. 449-458, PMID 21245372.
Glatstein MM, Garcia-Bournissen F, Finkelstein Y, Koren G, Methadone exposure during lactation, in College of Family Physicians of Canada, dicembre 2008, PMID 19074706.
Kell MJ, Utilization of plasma and urine methadone concentrations to optimize treatment in maintenance clinics: I. Measurement techniques for a clinical setting, in Journal of addictive diseases: the official journal of the ASAM, American Society of Addiction Medicine, vol. 13, n. 1, 1994, pp. 5–26, PMID 8018740.
Eap CB, Buclin T, Baumann P, Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence, in Clinical pharmacokinetics, vol. 41, n. 14, 2002, pp. 1153–93, PMID 12405865.
Lynn RK, Olsen GD, Leger RM, Gordon WP, Smith RG, Gerber N, The secretion of methadone and its major metabolite in the gastric juice of humans: comparison with blood and salivary concentrations, in Drug Metab. Dispos., vol. 4, n. 5, 1976, pp. 504–9, PMID 10151.
Larson ME, Richards TM, Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance, in Clin Med Res, vol. 7, n. 4, dicembre 2009, pp. 134–41, DOI:10.3121/cmr.2009.859, PMC 2801695, PMID 19920164.
Shiran MR, Lennard MS, Iqbal MZ, et al., Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment, in Br J Clin Pharmacol, vol. 67, n. 1, gennaio 2009, pp. 29–37, DOI:10.1111/j.1365-2125.2008.03312.x, PMC 2668081, PMID 19133059.
Armstrong SC, Cozza KL, Med-psych drug-drug interactions update, in Psychosomatics, vol. 43, n. 2, 2002, pp. 169–70, PMID 11998586.
(LT) Reingardiene D, Jodziūniene L, Lazauskas R, [Methadone treatment and its dangers], in Medicina (Kaunas), vol. 45, n. 5, 2009, pp. 419–25, PMID 19535889.
Matsui A, Williams JT, Activation of μ-opioid receptors and block of KIR 3 potassium channels and NMDA receptor conductance by l- and d-methadone in rat locus coeruleus, in Br. J. Pharmacol., vol. 161, n. 6, novembre 2010, pp. 1403–13, DOI:10.1111/j.1476-5381.2010.00967.x, PMID 20659105.
Pollock AB, Tegeler ML, Morgan V, Baumrucker SJ, Morphine to Methadone Conversion: An Interpretation of Published Data, in Am J Hosp Palliat Care, giugno 2010, DOI:10.1177/1049909110373508, PMID 20555039.
Leppert W, The role of methadone in cancer pain treatment--a review, in Int. J. Clin. Pract., vol. 63, n. 7, luglio 2009, pp. 1095–109, DOI:10.1111/j.1742-1241.2008.01990.x, PMID 19570126.
Romach MK, Piafsky KM, Abel JG, Khouw V, Sellers EM, Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma, in Clin. Pharmacol. Ther., vol. 29, n. 2, febbraio 1981, pp. 211–7, PMID 7193106.
Vetulani J, Drug addiction. Part III. Pharmacotherapy of addiction, in Pol J Pharmacol, vol. 53, n. 5, 2001, pp. 415–34, PMID 11990060.
Davis AM, Inturrisi CE, d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia, in J. Pharmacol. Exp. Ther., vol. 289, n. 2, maggio 1999, pp. 1048–53, PMID 10215686.
Benítez-Rosario MA, Feria M, Salinas-Martín A, Martínez-Castillo LP, Martín-Ortega JJ, Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain, in Cancer, vol. 101, n. 12, dicembre 2004, pp. 2866–73, DOI:10.1002/cncr.20712, PMID 15529307.
Inturrisi CE, Pharmacology of methadone and its isomers, in Minerva Anestesiol, vol. 71, n. 7-8, 2005, pp. 435–7, PMID 16012416.
Shah S, Diwan S, Methadone: does stigma play a role as a barrier to treatment of chronic pain?, in Pain Physician, vol. 13, n. 3, 2010, pp. 289–93, PMID 20495594.
Yennurajalingam S, Peuckmann V, Bruera E, Recent developments in cancer pain assessment and management, in Support Cancer Ther, vol. 1, n. 2, gennaio 2004, pp. 97–110, DOI:10.3816/SCT.2004.n.003, PMID 18628186.
Shaiova L, The role of methadone in the treatment of moderate to severe cancer pain, in Support Cancer Ther, vol. 2, n. 3, aprile 2005, pp. 176–80, DOI:10.3816/SCT.2005.n.010, PMID 18628169.
Moulin DE, Clark AJ, Gilron I, et al., Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society, in Pain Res Manag, vol. 12, n. 1, 2007, pp. 13–21, PMC 2670721, PMID 17372630.
Watson CP, Methadone for neuropathic pain: a new use for an old drug?, in Can J Neurol Sci, vol. 32, n. 3, agosto 2005, pp. 271–2, PMID 16225164.
Fitzgibbon DR, Ready LB, Intravenous high-dose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine, in Pain, vol. 73, n. 2, novembre 1997, pp. 259–61, PMID 9415514.
Santiago-Palma J, Khojainova N, Kornick C, et al., Intravenous methadone in the management of chronic cancer pain: safe and effective starting doses when substituting methadone for fentanyl, in Cancer, vol. 92, n. 7, ottobre 2001, pp. 1919–25, PMID 11745266.
Sabatowski R, Kasper SM, Radbruch L, Patient-controlled analgesia with intravenous L-methadone in a child with cancer pain refractory to high-dose morphine, in J Pain Symptom Manage, vol. 23, n. 1, gennaio 2002, pp. 3–5, PMID 11779660.
Prieto-Alvarez P, Tello-Galindo I, Cuenca-Peña J, Rull-Bartomeu M, Gomar-Sancho C, Continuous epidural infusion of racemic methadone results in effective postoperative analgesia and low plasma concentrations, in Can J Anaesth, vol. 49, n. 1, gennaio 2002, pp. 25–31, DOI:10.1007/BF03020415, PMID 11782325.
(ES) Prieto-Alvarez MP, Fuentes-Bellido JG, López-Cebollada J, Lorenzo-Foz JP, [Comparative study of postoperative analgesia with methadone and fentanyl in continuous peridural perfusion], in Rev Esp Anestesiol Reanim, vol. 44, n. 8, ottobre 1997, pp. 305–9, PMID 9424683.
Nilsson MI, Grönbladh L, Widerlöv E, Anggård E, Pharmacokinetics of methadone in methadone maintenance treatment: characterization of therapeutic failures, in Eur. J. Clin. Pharmacol., vol. 25, n. 4, 1983, pp. 497–501, PMID 6653644.
Deiss RG, Rodwell TC, Garfein RS, Tuberculosis and illicit drug use: review and update, in Clin. Infect. Dis., vol. 48, n. 1, gennaio 2009, pp. 72–82, DOI:10.1086/594126, PMID 19046064.
Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED, Enantiomeric metabolic interactions and stereoselective human methadone metabolism, in J. Pharmacol. Exp. Ther., vol. 321, n. 1, aprile 2007, pp. 389–99, DOI:10.1124/jpet.106.117580, PMID 17259447.
Raistrick D, Hay A, Wolff K, Methadone maintenance and tuberculosis treatment, in BMJ, vol. 313, n. 7062, ottobre 1996, pp. 925–6, PMC 2352264, PMID 8876100.
Herrlin K, Segerdahl M, Gustafsson LL, Kalso E, Methadone, ciprofloxacin, and adverse drug reactions, in Lancet, vol. 356, n. 9247, dicembre 2000, pp. 2069–70, DOI:10.1016/S0140-6736(00)03409-7, PMID 11145498.
Nair MK, Patel K, Starer PJ, Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient, in Addiction, vol. 103, n. 12, dicembre 2008, pp. 2062–4, DOI:10.1111/j.1360-0443.2008.02390.x, PMID 19469750.
Eap CB, Bertschy G, Powell K, Baumann P, Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone, in J Clin Psychopharmacol, vol. 17, n. 2, aprile 1997, pp. 113–7, PMID 10950475.
Iribarne C, Picart D, Dréano Y, Berthou F, In vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine, in Fundam Clin Pharmacol, vol. 12, n. 2, 1998, pp. 194–9, PMID 9565774.
Bush E, Miller C, Friedman I, A case of serotonin syndrome and mutism associated with methadone, in J Palliat Med, vol. 9, n. 6, dicembre 2006, pp. 1257–9, DOI:10.1089/jpm.2006.9.1257, PMID 17187532.
Baumann P, Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors, in Clin Pharmacokinet, vol. 31, n. 6, dicembre 1996, pp. 444–69, PMID 8968657.
(ES) Moreno Brea MR, Rojas Corrales O, Gibert-Rahola J, Micó JA, [Drug interactions of methadone with CNS-active agents], in Actas Esp Psiquiatr, vol. 27, n. 2, 1999, pp. 103–10, PMID 10380152.
Greenwald MK, Behavioral economic analysis of drug preference using multiple choice procedure data, in Drug Alcohol Depend, vol. 93, n. 1-2, gennaio 2008, pp. 103–10, DOI:10.1016/j.drugalcdep.2007.09.002, PMC 2248460, PMID 17949924.
Alleyne S, Alao A, Batki SL, Lamotrigine-associated rash and blood dyscrasias in a methadone-treatment patient with hepatitis C, in Psychosomatics, vol. 47, n. 3, 2006, pp. 257–8, DOI:10.1176/appi.psy.47.3.257, PMID 16684944.
Jackson L, Ting A, McKay S, Galea P, Skeoch C, A randomised controlled trial of morphine versus phenobarbitone for neonatal abstinence syndrome, in Arch. Dis. Child. Fetal Neonatal Ed., vol. 89, n. 4, luglio 2004, pp. F300–4, DOI:10.1136/adc.2003.033555, PMC 1721707, PMID 15210660.
McBay AJ, Toxicological findings in fatal poisonings, in Clin. Chem., vol. 19, n. 4, aprile 1973, pp. 361–5, PMID 4574410.
Tong TG, Pond SM, Kreek MJ, Jaffery NF, Benowitz NL, Phenytoin-induced methadone withdrawal, in Ann. Intern. Med., vol. 94, n. 3, marzo 1981, pp. 349–51, PMID 7224382.
Cobb MN, Desai J, Brown LS, Zannikos PN, Rainey PM, The effect of fluconazole on the clinical pharmacokinetics of methadone, in Clin. Pharmacol. Ther., vol. 63, n. 6, giugno 1998, pp. 655–62, DOI:10.1016/S0009-9236(98)90089-3, PMID 9663180.
Trapnell CB, Klecker RW, Jamis-Dow C, Collins JM, Glucuronidation of 3'-azido-3'-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid, in Antimicrob. Agents Chemother., vol. 42, n. 7, luglio 1998, pp. 1592–6, PMC 105651, PMID 9660989.
Moody DE, Fang WB, Lin SN, Weyant DM, Strom SC, Omiecinski CJ, Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes, in Drug Metab. Dispos., vol. 37, n. 12, dicembre 2009, pp. 2323–9, DOI:10.1124/dmd.109.028605, PMC 2784702, PMID 19773542.
Kharasch ED, Hoffer C, Whittington D, Walker A, Bedynek PS, Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir, in Anesthesiology, vol. 110, n. 3, marzo 2009, pp. 660–72, DOI:10.1097/ALN.0b013e3181986a9a, PMID 19225389.
Coles LD, Lee IJ, Hassan HE, Eddington ND, Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice, in J Pharm Sci, vol. 98, n. 8, agosto 2009, pp. 2832–46, DOI:10.1002/jps.21644, PMID 19116954.
Lüthi B, Huttner A, Speck RF, Mueller NJ, Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir, in Eur. J. Clin. Microbiol. Infect. Dis., vol. 26, n. 5, maggio 2007, pp. 367–9, DOI:10.1007/s10096-007-0293-5, PMID 17440756.
Esteban J, Pellín Mde L, Gimeno C, et al., Increase of R-/S-methadone enantiomer concentration ratio in serum of patients treated with either nevirapine or efavirenz, in Drug Metab Lett, vol. 2, n. 4, dicembre 2008, pp. 269–79, PMID 19356104.
Manfredi R, Calza L, Chiodo F, Efavirenz versus nevirapine in current clinical practice: a prospective, open-label observational study, in J. Acquir. Immune Defic. Syndr., vol. 35, n. 5, aprile 2004, pp. 492–502, PMID 15021314.
Keller GA, Ponte ML, Di Girolamo G, Other drugs acting on nervous system associated with QT-interval prolongation, in Curr Drug Saf, vol. 5, n. 1, gennaio 2010, pp. 105–11, PMID 20210727.
Haney M, Hart CL, Foltin RW, Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers, in Neuropsychopharmacology, vol. 31, n. 8, agosto 2006, pp. 1814–21, DOI:10.1038/sj.npp.1300999, PMID 16407903.
Nicholls L, Bragaw L, Ruetsch C, Opioid dependence treatment and guidelines, in J Manag Care Pharm, vol. 16, 1 Suppl B, febbraio 2010, pp. S14–21, PMID 20146550.
Mellon RD, Simone AF, Rappaport BA, Use of anesthetic agents in neonates and young children, in Anesth. Analg., vol. 104, n. 3, marzo 2007, pp. 509–20, DOI:10.1213/01.ane.0000255729.96438.b0, PMID 17312200.
Vorspan F, Ksouda K, Bloch V, et al., A case report of transient but clinically relevant interaction between methadone and duloxetine: a reply to McCance-Katz et al, in Am J Addict, vol. 19, n. 5, settembre 2010, pp. 458–9, DOI:10.1111/j.1521-0391.2010.00062.x, PMID 20716309.
(FR) Gaudreau J, [Aurore, child martyr. Essay on violence done to children], in Sante Ment Que, vol. 17, n. 1, 1992, pp. 55–72, PMID 1515533.
Bosmans T, Schauvliege S, Gasthuys F, et al., Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs, in Vet Anaesth Analg, vol. 38, n. 2, marzo 2011, pp. 146–57, DOI:10.1111/j.1467-2995.2011.00595.x, PMID 21303446.
Meyer MR, Maurer HH, Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse, in Pharmacogenomics, vol. 12, n. 2, febbraio 2011, pp. 215–33, DOI:10.2217/pgs.10.171, PMID 21332315.
Mercadante S, Villari P, Ferrera P, Arcuri E, David F, Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases, in Clin J Pain, vol. 25, n. 7, settembre 2009, pp. 648–9, DOI:10.1097/AJP.0b013e3181a68a85, PMID 19692808.
Steinberg M, Morin AK, Mild serotonin syndrome associated with concurrent linezolid and fluoxetine, in Am J Health Syst Pharm, vol. 64, n. 1, gennaio 2007, pp. 59–62, DOI:10.2146/ajhp060227, PMID 17189581.
Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs, in J. Pharmacol. Exp. Ther., vol. 316, n. 3, marzo 2006, pp. 1098–106, DOI:10.1124/jpet.105.093393, PMID 16278312.
Chen PP, Chui PT, Gin T, Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery, in Eur J Anaesthesiol, vol. 13, n. 5, settembre 1996, pp. 485–91, PMID 8889424.
Junttila MJ, Gonzalez M, Lizotte E, et al., Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias, in Circulation, vol. 117, n. 14, aprile 2008, pp. 1890–3, DOI:10.1161/CIRCULATIONAHA.107.746495, PMID 18391123.
Auer U, Mosing M, Moens YP, The effect of low dose rocuronium on globe position, muscle relaxation and ventilation in dogs: a clinical study, in Vet Ophthalmol, vol. 10, n. 5, 2007, pp. 295–8, DOI:10.1111/j.1463-5224.2007.00553.x, PMID 17760708.
Hofling CK, Winslow WW, Kellner R, Drug therapy, in Prog Neurol Psychiatry, vol. 27, 1972, pp. 339–54, PMID 4575598.
Prosser JM, Mills A, Rhim ES, Perrone J, Torsade de pointes caused by polypharmacy and substance abuse in a patient with human immunodeficiency virus, in Int J Emerg Med, vol. 1, n. 3, settembre 2008, pp. 217–20, DOI:10.1007/s12245-008-0052-0, PMC 2657284, PMID 19384521.
Poluzzi E, Raschi E, Moretti U, De Ponti F, Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS), in Pharmacoepidemiol Drug Saf, vol. 18, n. 6, giugno 2009, pp. 512–8, DOI:10.1002/pds.1746, PMID 19358226.
(FR) Furlan V, Taburet AM, [Drug interactions with antiretroviral agents], in Therapie, vol. 56, n. 3, 2001, pp. 267–71, PMID 11475806.
Silva de Lima M, Farrell M, Lima Reisser AA, Soares B, WITHDRAWN: Antidepressants for cocaine dependence, in Cochrane Database Syst Rev, n. 2, 2010, pp. CD002950, DOI:10.1002/14651858.CD002950.pub2, PMID 20166064.
Gongadze N, Kezeli T, Antelava N, Prolong QT interval and "torsades de pointes" associated with different group of drugs, in Georgian Med News, n. 153, dicembre 2007, pp. 45–9, PMID 18250496.
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA, Commonly prescribed medications and potential false-positive urine drug screens, in Am J Health Syst Pharm, vol. 67, n. 16, agosto 2010, pp. 1344–50, DOI:10.2146/ajhp090477, PMID 20689123.
Gerber JG, Rhodes RJ, Gal J, Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19, in Chirality, vol. 16, n. 1, gennaio 2004, pp. 36–44, DOI:10.1002/chir.10303, PMID 14628297.
Reid MC, Engles-Horton LL, Weber MB, Kerns RD, Rogers EL, O'Connor PG, Use of opioid medications for chronic noncancer pain syndromes in primary care, in J Gen Intern Med, vol. 17, n. 3, marzo 2002, pp. 173–9, PMC 1495018, PMID 11929502.
Molassiotis A, Smith JA, Bennett MI, et al., Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough, in Cough, vol. 6, 2010, p. 9, DOI:10.1186/1745-9974-6-9, PMC 2978117, PMID 20925935.
Bolser DC, Pharmacologic management of cough, in Otolaryngol. Clin. North Am., vol. 43, n. 1, febbraio 2010, pp. 147–55, xi, DOI:10.1016/j.otc.2009.11.008, PMC 2827356, PMID 20172264.
Dicpinigaitis PV, Currently available antitussives, in Pulm Pharmacol Ther, vol. 22, n. 2, aprile 2009, pp. 148–51, DOI:10.1016/j.pupt.2008.08.002, PMID 18771744.
Claudia Friesen, Mareike Roscher, Andreas Alt and Erich Miltner, Methadone, Commonly Used as Maintenance Medication for Outpatient Treatment of Opioid Dependence, Kills Leukemia Cells and Overcomes Chemoresistance, in Cancer Research, vol. 68, n. 15, 2008, pp. 6059–6064, DOI:10.1158/0008-5472.CAN-08-1227, PMID 18676827.
Perez-Alvarez S, Cuenca-Lopez MD, de Mera RM, et al., Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis, in Biochim. Biophys. Acta, vol. 1802, n. 11, novembre 2010, pp. 1036–47, DOI:10.1016/j.bbadis.2010.07.024, PMID 20691259.
Perez-Alvarez S, Iglesias-Guimarais V, Solesio ME, et al., Methadone induces CAD degradation and AIF-mediated necrotic-like cell death in neuroblastoma cells, in Pharmacol. Res., vol. 63, n. 4, aprile 2011, pp. 352–60, DOI:10.1016/j.phrs.2010.12.001, PMID 21145398.
N. Moryl, J. Santiago-Palma; C. Kornick; S. Derby; D. Fischberg; R. Payne; PL. Manfredi, Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain., in Pain, vol. 96, n. 3, aprile 2002, pp. 325-8, PMID 11973005.
L. Nicholls, L. Bragaw; C. Ruetsch, Opioid dependence treatment and guidelines., in J Manag Care Pharm, vol. 16, 1 Suppl B, febbraio 2010, pp. S14-21, PMID 20146550.
Nicholls L, Bragaw L, Ruetsch C, Opioid dependence treatment and guidelines, in J Manag Care Pharm, vol. 16, 1 Suppl B, febbraio 2010, pp. S14–21, PMID 20146550.
Mannelli P, Patkar AA, Peindl K, Gorelick DA, Wu LT, Gottheil E, Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial, in Addict Biol, vol. 14, n. 2, aprile 2009, pp. 204–13, DOI:10.1111/j.1369-1600.2008.00119.x, PMC 2657183, PMID 18715283.
M. Connock, A. Juarez-Garcia; S. Jowett; E. Frew; Z. Liu; RJ. Taylor; A. Fry-Smith; E. Day; N. Lintzeris; T. Roberts; A. Burls, Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation., in Health Technol Assess, vol. 11, n. 9, marzo 2007, pp. 1-171, iii-iv, PMID 17313907.
H. Joseph, S. Stancliff; J. Langrod, Methadone maintenance treatment (MMT): a review of historical and clinical issues., in Mt Sinai J Med, vol. 67, n. 5-6, pp. 347-64, PMID 11064485.

pubchem.ncbi.nlm.nih.gov

(EN) pubchem.ncbi.nlm.nih.gov.

oadoi.org

MA. Benítez-Rosario, A. Salinas-Martín; A. Aguirre-Jaime; L. Pérez-Méndez; M. Feria, Morphine-methadone opioid rotation in cancer patients: analysis of dose ratio predicting factors., in J Pain Symptom Manage, vol. 37, n. 6, giugno 2009, pp. 1061-8, DOI:10.1016/j.jpainsymman.2008.05.016, PMID 19171458.
PW. Walker, S. Palla; BL. Pei; G. Kaur; K. Zhang; J. Hanohano; M. Munsell; E. Bruera, Switching from methadone to a different opioid: what is the equianalgesic dose ratio?, in J Palliat Med, vol. 11, n. 8, ottobre 2008, pp. 1103-8, DOI:10.1089/jpm.2007.0285, PMID 18980450.
Matsui A, Williams JT, Activation of μ-opioid receptors and block of KIR 3 potassium channels and NMDA receptor conductance by l- and d-methadone in rat locus coeruleus, in Br. J. Pharmacol., vol. 161, n. 6, novembre 2010, pp. 1403–13, DOI:10.1111/j.1476-5381.2010.00967.x, PMID 20659105.
Pollock AB, Tegeler ML, Morgan V, Baumrucker SJ, Morphine to Methadone Conversion: An Interpretation of Published Data, in Am J Hosp Palliat Care, giugno 2010, DOI:10.1177/1049909110373508, PMID 20555039.
Leppert W, The role of methadone in cancer pain treatment--a review, in Int. J. Clin. Pract., vol. 63, n. 7, luglio 2009, pp. 1095–109, DOI:10.1111/j.1742-1241.2008.01990.x, PMID 19570126.
Benítez-Rosario MA, Feria M, Salinas-Martín A, Martínez-Castillo LP, Martín-Ortega JJ, Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain, in Cancer, vol. 101, n. 12, dicembre 2004, pp. 2866–73, DOI:10.1002/cncr.20712, PMID 15529307.
Yennurajalingam S, Peuckmann V, Bruera E, Recent developments in cancer pain assessment and management, in Support Cancer Ther, vol. 1, n. 2, gennaio 2004, pp. 97–110, DOI:10.3816/SCT.2004.n.003, PMID 18628186.
Shaiova L, The role of methadone in the treatment of moderate to severe cancer pain, in Support Cancer Ther, vol. 2, n. 3, aprile 2005, pp. 176–80, DOI:10.3816/SCT.2005.n.010, PMID 18628169.
Prieto-Alvarez P, Tello-Galindo I, Cuenca-Peña J, Rull-Bartomeu M, Gomar-Sancho C, Continuous epidural infusion of racemic methadone results in effective postoperative analgesia and low plasma concentrations, in Can J Anaesth, vol. 49, n. 1, gennaio 2002, pp. 25–31, DOI:10.1007/BF03020415, PMID 11782325.
Deiss RG, Rodwell TC, Garfein RS, Tuberculosis and illicit drug use: review and update, in Clin. Infect. Dis., vol. 48, n. 1, gennaio 2009, pp. 72–82, DOI:10.1086/594126, PMID 19046064.
Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED, Enantiomeric metabolic interactions and stereoselective human methadone metabolism, in J. Pharmacol. Exp. Ther., vol. 321, n. 1, aprile 2007, pp. 389–99, DOI:10.1124/jpet.106.117580, PMID 17259447.
Herrlin K, Segerdahl M, Gustafsson LL, Kalso E, Methadone, ciprofloxacin, and adverse drug reactions, in Lancet, vol. 356, n. 9247, dicembre 2000, pp. 2069–70, DOI:10.1016/S0140-6736(00)03409-7, PMID 11145498.
Bush E, Miller C, Friedman I, A case of serotonin syndrome and mutism associated with methadone, in J Palliat Med, vol. 9, n. 6, dicembre 2006, pp. 1257–9, DOI:10.1089/jpm.2006.9.1257, PMID 17187532.
Alleyne S, Alao A, Batki SL, Lamotrigine-associated rash and blood dyscrasias in a methadone-treatment patient with hepatitis C, in Psychosomatics, vol. 47, n. 3, 2006, pp. 257–8, DOI:10.1176/appi.psy.47.3.257, PMID 16684944.
Coles LD, Lee IJ, Hassan HE, Eddington ND, Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice, in J Pharm Sci, vol. 98, n. 8, agosto 2009, pp. 2832–46, DOI:10.1002/jps.21644, PMID 19116954.
Lüthi B, Huttner A, Speck RF, Mueller NJ, Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir, in Eur. J. Clin. Microbiol. Infect. Dis., vol. 26, n. 5, maggio 2007, pp. 367–9, DOI:10.1007/s10096-007-0293-5, PMID 17440756.
Haney M, Hart CL, Foltin RW, Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers, in Neuropsychopharmacology, vol. 31, n. 8, agosto 2006, pp. 1814–21, DOI:10.1038/sj.npp.1300999, PMID 16407903.
Vorspan F, Ksouda K, Bloch V, et al., A case report of transient but clinically relevant interaction between methadone and duloxetine: a reply to McCance-Katz et al, in Am J Addict, vol. 19, n. 5, settembre 2010, pp. 458–9, DOI:10.1111/j.1521-0391.2010.00062.x, PMID 20716309.
Bosmans T, Schauvliege S, Gasthuys F, et al., Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs, in Vet Anaesth Analg, vol. 38, n. 2, marzo 2011, pp. 146–57, DOI:10.1111/j.1467-2995.2011.00595.x, PMID 21303446.
Meyer MR, Maurer HH, Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse, in Pharmacogenomics, vol. 12, n. 2, febbraio 2011, pp. 215–33, DOI:10.2217/pgs.10.171, PMID 21332315.
Steinberg M, Morin AK, Mild serotonin syndrome associated with concurrent linezolid and fluoxetine, in Am J Health Syst Pharm, vol. 64, n. 1, gennaio 2007, pp. 59–62, DOI:10.2146/ajhp060227, PMID 17189581.
Junttila MJ, Gonzalez M, Lizotte E, et al., Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias, in Circulation, vol. 117, n. 14, aprile 2008, pp. 1890–3, DOI:10.1161/CIRCULATIONAHA.107.746495, PMID 18391123.
Auer U, Mosing M, Moens YP, The effect of low dose rocuronium on globe position, muscle relaxation and ventilation in dogs: a clinical study, in Vet Ophthalmol, vol. 10, n. 5, 2007, pp. 295–8, DOI:10.1111/j.1463-5224.2007.00553.x, PMID 17760708.
Poluzzi E, Raschi E, Moretti U, De Ponti F, Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS), in Pharmacoepidemiol Drug Saf, vol. 18, n. 6, giugno 2009, pp. 512–8, DOI:10.1002/pds.1746, PMID 19358226.
Silva de Lima M, Farrell M, Lima Reisser AA, Soares B, WITHDRAWN: Antidepressants for cocaine dependence, in Cochrane Database Syst Rev, n. 2, 2010, pp. CD002950, DOI:10.1002/14651858.CD002950.pub2, PMID 20166064.
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA, Commonly prescribed medications and potential false-positive urine drug screens, in Am J Health Syst Pharm, vol. 67, n. 16, agosto 2010, pp. 1344–50, DOI:10.2146/ajhp090477, PMID 20689123.
Gerber JG, Rhodes RJ, Gal J, Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19, in Chirality, vol. 16, n. 1, gennaio 2004, pp. 36–44, DOI:10.1002/chir.10303, PMID 14628297.
Dicpinigaitis PV, Currently available antitussives, in Pulm Pharmacol Ther, vol. 22, n. 2, aprile 2009, pp. 148–51, DOI:10.1016/j.pupt.2008.08.002, PMID 18771744.
Claudia Friesen, Mareike Roscher, Andreas Alt and Erich Miltner, Methadone, Commonly Used as Maintenance Medication for Outpatient Treatment of Opioid Dependence, Kills Leukemia Cells and Overcomes Chemoresistance, in Cancer Research, vol. 68, n. 15, 2008, pp. 6059–6064, DOI:10.1158/0008-5472.CAN-08-1227, PMID 18676827.
Perez-Alvarez S, Cuenca-Lopez MD, de Mera RM, et al., Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis, in Biochim. Biophys. Acta, vol. 1802, n. 11, novembre 2010, pp. 1036–47, DOI:10.1016/j.bbadis.2010.07.024, PMID 20691259.
Perez-Alvarez S, Iglesias-Guimarais V, Solesio ME, et al., Methadone induces CAD degradation and AIF-mediated necrotic-like cell death in neuroblastoma cells, in Pharmacol. Res., vol. 63, n. 4, aprile 2011, pp. 352–60, DOI:10.1016/j.phrs.2010.12.001, PMID 21145398.

unodc.org

(EN) UNODC - Bulletin on Narcotics - 1956 Issue 1 - 002, su unodc.org.
(EN) UNODC - Bulletin on Narcotics - 1951 Issue 2 - 005, su unodc.org.

web.archive.org

Methadone WHO Model Lists of Essential Medicines Archiviato il 27 febbraio 2011 in Internet Archive.
RP Mattick, C Breen, J Kimber, Marina Davoli: "Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence" Cochrane Drugs and Alcohol Group, 2009, su www2.cochrane.org. URL consultato il 25 febbraio 2011 (archiviato dall'url originale il 17 marzo 2011).
(EN) disinformation | m is for methadone, su old.disinfo.com (archiviato dall'url originale l'11 gennaio 2012).
(DE) Methadone patent application, su drugtext.org (archiviato dall'url originale il 9 gennaio 2012).
(EN) web.archive.org, su exchangesupplies.org (archiviato dall'url originale il 20 novembre 2003).
Methadone Briefing, su exchangesupplies.org. URL consultato il 9 luglio 2007 (archiviato dall'url originale il 20 novembre 2003).
John Manfredonia, Prescribing Methadone for Pain Management in End-of-Life Care, su jaoa.org, JAOA The Journal of the American Osteopathic Association, 18 marzo 2005 (archiviato dall'url originale il 20 maggio 2007).
Metadone Cl Molteni 1Mg, su torrinomedica.it (archiviato dall'url originale il 23 luglio 2011).
Individualized use of methadone and opioid rotation in the comprehensive management of cancer pain associated with poor prognostic indicators, su pain, Elsevier, Amsterdam, PAYS-BAS, 1996, vol. 67, no1, pp. 115-119 (30 ref.). URL consultato il 25 febbraio 2011 (archiviato dall'url originale il 30 dicembre 2011).
Methadone, su nlm.nih.gov, MedlinePlus (archiviato dall'url originale il 27 febbraio 2008).

who.int

apps.who.int

Methadone WHO Model Lists of Essential Medicines Archiviato il 27 febbraio 2011 in Internet Archive.