“Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation”. Br J Dermatol139 Suppl 52: 8–11. (October 1998). doi:10.1046/j.1365-2133.1998.1390s2008.x. PMID9990414.
Dee Anna Glaser (2004-8). “Anti-aging products and cosmeceuticals”. Facial plastic surgery clinics of North America12 (3): 363–372. doi:10.1016/j.fsc.2004.03.004. PMID15261173. "The greatest obstacle in using topical retinoids is the high incidence of irritation. A retinoid dermatitis can develop, manifesting as redness and flakiness or as an increase in skin sensitivity. ... however, patients often stop the therapy if not prepared for this possible reaction. ... Adapalene gel, a naphthoic acid derivative, is a third generation retinoid approved for the treatment of acne. It is reported to have a much lower irritation potential, no phototoxicity, and fewer problems with sensitization."
Kolli, Sree S.; Pecone, Danielle; Pona, Adrian; et al (2019). “Topical Retinoids in Acne Vulgaris: A Systematic Review”. American Journal of Clinical Dermatology20 (3): 345–365. doi:10.1007/s40257-019-00423-z. PMID30674002.
Bagatin E, Gonçalves HS, Sato M; et al (2018-6). “Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging”. European journal of dermatology : EJD28 (3): 343–350. doi:10.1684/ejd.2018.3320. PMID30105991.
Herane, María Isabel; Orlandi, Cecilia; Zegpi, Emilia; et al (2011). “Clinical efficacy of adapalene (Differin®) 0.3% gel in Chilean women with cutaneous photoaging”. Journal of Dermatological Treatment23 (1): 57–64. doi:10.3109/09546634.2011.631981. PMID22007702.
Kang S, Goldfarb MT, Weiss JS; et al (2003-7). “Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial”. Journal of the American Academy of Dermatology49 (1): 83–90. doi:10.1067/mjd.2003.451. PMID12833014.
Dogra, Sunil; Kanwar, Amrinder J.; Parsad, Devinder (2002). “Adapalene in the Treatment of Melasma: A Preliminary Report”. The Journal of Dermatology29 (8): 539–540. doi:10.1111/j.1346-8138.2002.tb00324.x. PMID12227492.
“Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study”. J Am Acad Dermatol49 (3 Suppl): S211–7. (2003). doi:10.1067/S0190-9622(03)01152-6. PMID12963897.
“Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies”. Indian J Dermatol Venereol Leprol73 (5): 326–9. (2007). doi:10.4103/0378-6323.34010. PMID17921613.
“Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation”. Br J Dermatol139 Suppl 52: 8–11. (October 1998). doi:10.1046/j.1365-2133.1998.1390s2008.x. PMID9990414.
Dee Anna Glaser (2004-8). “Anti-aging products and cosmeceuticals”. Facial plastic surgery clinics of North America12 (3): 363–372. doi:10.1016/j.fsc.2004.03.004. PMID15261173. "The greatest obstacle in using topical retinoids is the high incidence of irritation. A retinoid dermatitis can develop, manifesting as redness and flakiness or as an increase in skin sensitivity. ... however, patients often stop the therapy if not prepared for this possible reaction. ... Adapalene gel, a naphthoic acid derivative, is a third generation retinoid approved for the treatment of acne. It is reported to have a much lower irritation potential, no phototoxicity, and fewer problems with sensitization."
Kolli, Sree S.; Pecone, Danielle; Pona, Adrian; et al (2019). “Topical Retinoids in Acne Vulgaris: A Systematic Review”. American Journal of Clinical Dermatology20 (3): 345–365. doi:10.1007/s40257-019-00423-z. PMID30674002.
Bagatin E, Gonçalves HS, Sato M; et al (2018-6). “Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging”. European journal of dermatology : EJD28 (3): 343–350. doi:10.1684/ejd.2018.3320. PMID30105991.
Herane, María Isabel; Orlandi, Cecilia; Zegpi, Emilia; et al (2011). “Clinical efficacy of adapalene (Differin®) 0.3% gel in Chilean women with cutaneous photoaging”. Journal of Dermatological Treatment23 (1): 57–64. doi:10.3109/09546634.2011.631981. PMID22007702.
Kang S, Goldfarb MT, Weiss JS; et al (2003-7). “Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial”. Journal of the American Academy of Dermatology49 (1): 83–90. doi:10.1067/mjd.2003.451. PMID12833014.
Dogra, Sunil; Kanwar, Amrinder J.; Parsad, Devinder (2002). “Adapalene in the Treatment of Melasma: A Preliminary Report”. The Journal of Dermatology29 (8): 539–540. doi:10.1111/j.1346-8138.2002.tb00324.x. PMID12227492.
“Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study”. J Am Acad Dermatol49 (3 Suppl): S211–7. (2003). doi:10.1067/S0190-9622(03)01152-6. PMID12963897.
“Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies”. Indian J Dermatol Venereol Leprol73 (5): 326–9. (2007). doi:10.4103/0378-6323.34010. PMID17921613.
