PAK1 (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "PAK1" in Japanese language version.

refsWebsite

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doi.org (Global: 2^nd place; Japanese: 6^th place)

“Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway”. Current Biology 6 (5): 598–605. (May 1996). doi:10.1016/S0960-9822(02)00546-8. PMID 8805275.
“Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma”. Cytogenetics and Cell Genetics 79 (1–2): 125–31. (Apr 1998). doi:10.1159/000134699. PMID 9533029.
“PAK thread from amoeba to mammals”. Journal of Cellular Biochemistry 107 (4): 579–85. (July 2009). doi:10.1002/jcb.22159. PMC 2718766. PMID 19350548.
“A brain serine/threonine protein kinase activated by Cdc42 and Rac1”. Nature 367 (6458): 40–6. (January 1994). Bibcode: 1994Natur.367...40M. doi:10.1038/367040a0. PMID 8107774.
“A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20”. The EMBO Journal 14 (9): 1970–8. (May 1995). doi:10.1002/j.1460-2075.1995.tb07189.x. PMC 398296. PMID 7744004.
“P21-activated kinases in human cancer”. Cancer and Metastasis Reviews 22 (4): 385–93. (December 2003). doi:10.1023/a:1023729130497. PMID 12884913.
“p21-activated kinases in cancer”. Nature Reviews. Cancer 6 (6): 459–71. (June 2006). doi:10.1038/nrc1892. PMID 16723992.
“PAK signalling during the development and progression of cancer”. Nature Reviews. Cancer 14 (1): 13–25. (January 2014). doi:10.1038/nrc3645. PMC 4115244. PMID 24505617.
PAKs in Human Cancer Progression: From Inception to Cancer Therapeutic to Future Oncobiology. 130. (2016). 137–209. doi:10.1016/bs.acr.2016.01.002. ISBN 9780128047897. PMID 27037753
“HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases”. Molecular Cell 49 (4): 668–79. (February 2013). doi:10.1016/j.molcel.2012.12.004. PMID 23317503.
“An emerging role for p21-activated kinases (Paks) in viral infections”. Trends in Cell Biology 20 (3): 160–9. (March 2010). doi:10.1016/j.tcb.2009.12.005. PMC 6489496. PMID 20071173.
“PAK1 is a novel cardiac protective signaling molecule”. Frontiers of Medicine 8 (4): 399–403. (December 2014). doi:10.1007/s11684-014-0380-9. PMID 25416031.
“PAK in Alzheimer disease, Huntington disease and X-linked mental retardation”. Cellular Logistics 2 (2): 117–125. (April 2012). doi:10.4161/cl.21602. PMC 3490962. PMID 23162743.
Kumar, Rakesh; Sanawar, Rahul; Li, Xiaodong; Li, Feng (2017-03-20). “Structure, biochemistry, and biology of PAK kinases”. Gene 605: 20–31. doi:10.1016/j.gene.2016.12.014. ISSN 1879-0038. PMC 5250584. PMID 28007610.
“An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase”. Chemistry & Biology 15 (4): 322–31. (April 2008). doi:10.1016/j.chembiol.2008.03.005. PMC 4353635. PMID 18420139.
“P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion” (英語). The Journal of Biological Chemistry 288 (5): 3025–35. (February 2013). doi:10.1074/jbc.M112.424770. PMC 3561527. PMID 23258534.
“The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1”. The Journal of Biological Chemistry 271 (35): 20997–1000. (August 1996). doi:10.1074/jbc.271.35.20997. PMID 8798379.
“Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase”. The Journal of Biological Chemistry 273 (43): 28238–46. (October 1998). doi:10.1074/jbc.273.43.28238. PMID 9774445.
“Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis”. The Journal of Biological Chemistry 275 (50): 39451–7. (December 2000). doi:10.1074/jbc.M006150200. PMID 10967114.
“Basic fibroblast growth factor-induced translocation of p21-activated kinase to the membrane is independent of phospholipase C-gamma1 in the differentiation of PC12 cells”. Experimental & Molecular Medicine 34 (2): 172–6. (May 2002). doi:10.1038/emm.2002.25. PMID 12085993.
“Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases”. The Journal of Biological Chemistry 276 (29): 26741–4. (July 2001). doi:10.1074/jbc.C100229200. PMID 11356824.
“Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells”. FEBS Letters 535 (1–3): 6–10. (January 2003). doi:10.1016/s0014-5793(02)03846-2. PMID 12560069.
“Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells”. European Journal of Biochemistry 271 (8): 1557–65. (April 2004). doi:10.1111/j.1432-1033.2004.04066.x. PMID 15066181.
“Phosphoinositides are essential coactivators for p21-activated kinase 1”. Molecular Cell 40 (3): 493–500. (November 2010). doi:10.1016/j.molcel.2010.10.015. PMC 3026281. PMID 21070974.
Bagheri-Yarmand, R.; Mandal, M.; Taludker, A. H.; Wang, R. A.; Vadlamudi, R. K.; Kung, H. J.; Kumar, R. (2001-08-03). “Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells”. The Journal of Biological Chemistry 276 (31): 29403–29409. doi:10.1074/jbc.M103129200. ISSN 0021-9258. PMID 11382770.
“Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration”. Molecular and Cellular Biology 23 (22): 8058–69. (November 2003). doi:10.1128/mcb.23.22.8058-8069.2003. PMC 262366. PMID 14585966.
“JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions”. The Journal of Biological Chemistry 282 (42): 30985–96. (October 2007). doi:10.1074/jbc.M701794200. PMID 17726028.
“ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration”. Clinical & Experimental Metastasis 27 (7): 481–91. (October 2010). doi:10.1007/s10585-010-9337-9. PMC 2954413. PMID 20526801.
“Protein kinase CK2 phosphorylates and activates p21-activated kinase 1”. Molecular Biology of the Cell 24 (18): 2990–9. (September 2013). doi:10.1091/mbc.E13-04-0204. PMC 3771959. PMID 23885116.
“Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway”. Proceedings of the National Academy of Sciences of the United States of America 97 (1): 185–9. (January 2000). Bibcode: 2000PNAS...97..185M. doi:10.1073/pnas.97.1.185. PMC 26637. PMID 10618392.
“Cell surface heparan sulfate participates in CXCL1-induced signaling”. Biochemistry 42 (4): 1071–7. (February 2003). doi:10.1021/bi026425a. PMC 2667446. PMID 12549928.
“ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival”. The Journal of Biological Chemistry 280 (22): 21483–90. (June 2005). doi:10.1074/jbc.M500097200. PMID 15784622.
“Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1”. Gastroenterology 143 (1): 199–212.e4. (July 2012). doi:10.1053/j.gastro.2012.03.053. PMID 22484303.
“STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells”. The Journal of Biological Chemistry 287 (22): 18758–68. (May 2012). doi:10.1074/jbc.M111.316422. PMC 3365778. PMID 22493453.
“RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage”. Cancer Research 72 (21): 5516–28. (November 2012). doi:10.1158/0008-5472.CAN-12-0775. PMC 3548429. PMID 22971344.
“Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma”. PLOS ONE 8 (3): e58413. (2013). Bibcode: 2013PLoSO...858413C. doi:10.1371/journal.pone.0058413. PMC 3596390. PMID 23516476.
“N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation”. Glycobiology 23 (9): 1097–109. (September 2013). doi:10.1093/glycob/cwt049. PMID 23811795.
“BRAF activates and physically interacts with PAK to regulate cell motility”. Endocrine-Related Cancer 21 (6): 865–77. (2014). doi:10.1530/ERC-14-0424. PMC 4487662. PMID 25228413.
“The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)”. The Journal of Biological Chemistry 290 (34): 21076–85. (August 2015). doi:10.1074/jbc.M115.675124. PMC 4543665. PMID 26160174.
“Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1”. Nature Cell Biology 4 (9): 681–90. (September 2002). doi:10.1038/ncb838. PMID 12198493.
“Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16”. The Journal of Biological Chemistry 276 (3): 1677–80. (January 2001). doi:10.1074/jbc.C000635200. PMID 11058583.
“p21-activated kinase links Rac/Cdc42 signaling to merlin”. The Journal of Biological Chemistry 277 (2): 883–6. (January 2002). doi:10.1074/jbc.C100553200. PMID 11719502.
“Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK)”. Genes to Cells 7 (2): 91–7. (February 2002). doi:10.1046/j.1356-9597.2001.00504.x. PMID 11895474.
“p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells”. EMBO Reports 3 (8): 767–73. (August 2002). doi:10.1093/embo-reports/kvf157. PMC 1084211. PMID 12151336.
“P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium”. The EMBO Journal 21 (20): 5437–47. (October 2002). doi:10.1093/emboj/cdf543. PMC 129075. PMID 12374744.
“Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands”. The Journal of Cell Biology 161 (3): 583–92. (May 2003). doi:10.1083/jcb.200212066. PMC 2172951. PMID 12732616.
“Functional inactivation of a transcriptional corepressor by a signaling kinase”. Nature Structural Biology 10 (8): 622–8. (August 2003). doi:10.1038/nsb957. PMID 12872159.
“The generation of diversity and pattern in animal development”. Cell 68 (2): 185–99. (January 1992). doi:10.1016/0092-8674(92)90465-o. PMID 1733498.
“p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate”. EMBO Reports 5 (2): 154–60. (February 2004). doi:10.1038/sj.embor.7400079. PMC 1298990. PMID 14749719.
Vadlamudi, Ratna K.; Bagheri-Yarmand, Rozita; Yang, Zhibo; Balasenthil, Seetharaman; Nguyen, Diep; Sahin, Aysegul A.; den Hollander, Petra; Kumar, Rakesh (2004-06). “Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes”. Cancer Cell 5 (6): 575–585. doi:10.1016/j.ccr.2004.05.022. ISSN 1535-6108. PMID 15193260.
“Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase”. Oncogene 23 (49): 8118–27. (October 2004). doi:10.1038/sj.onc.1207969. PMID 15378030.
“An essential role of Pak1 phosphorylation of SHARP in Notch signaling”. Oncogene 24 (28): 4591–6. (June 2005). doi:10.1038/sj.onc.1208672. PMID 15824732.
“p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B”. Molecular and Cellular Biology 25 (9): 3726–36. (May 2005). doi:10.1128/MCB.25.9.3726-3736.2005. PMC 1084301. PMID 15831477.
“Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions”. Cancer Research 65 (8): 3179–84. (April 2005). doi:10.1158/0008-5472.CAN-04-3480. PMID 15833848.
“VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin”. Nature Cell Biology 8 (11): 1223–34. (November 2006). doi:10.1038/ncb1486. PMID 17060906.
“Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1”. Proceedings of the National Academy of Sciences of the United States of America 104 (14): 5866–71. (April 2007). Bibcode: 2007PNAS..104.5866M. doi:10.1073/pnas.0701065104. PMC 1851583. PMID 17389360.
“Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase”. Proceedings of the National Academy of Sciences of the United States of America 104 (16): 6782–7. (April 2007). Bibcode: 2007PNAS..104.6782A. doi:10.1073/pnas.0701999104. PMC 1871862. PMID 17420447.
“Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1”. The Journal of Biological Chemistry 282 (27): 19820–30. (July 2007). doi:10.1074/jbc.M702309200. PMID 17491012.
“Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells”. British Journal of Cancer 98 (6): 1132–40. (March 2008). doi:10.1038/sj.bjc.6604261. PMC 2275482. PMID 18283314.
“Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation”. Oncogene 27 (39): 5233–42. (September 2008). doi:10.1038/onc.2008.151. PMC 3621709. PMID 18521086.
“SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration”. Molecular Cell 37 (3): 321–32. (February 2010). doi:10.1016/j.molcel.2010.01.004. PMC 2824333. PMID 20159552.
“A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells”. Oncogene 31 (8): 1001–12. (February 2012). doi:10.1038/onc.2011.294. PMID 21822311.
“p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112”. PLOS ONE 6 (11): e27637. (2011). Bibcode: 2011PLoSO...627637Y. doi:10.1371/journal.pone.0027637. PMC 3214075. PMID 22096607.
“p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis”. Molecular and Cellular Biology 20 (2): 453–61. (January 2000). doi:10.1128/mcb.20.2.453-461.2000. PMC 85099. PMID 10611223.
“PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling”. Oncogene 31 (29): 3397–408. (July 2012). doi:10.1038/onc.2011.515. PMC 3291810. PMID 22105362.
“PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation”. The Journal of Cell Biology 162 (2): 281–91. (July 2003). doi:10.1083/jcb.200212141. PMC 2172784. PMID 12876277.
“PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells”. PLOS ONE 7 (7): e42012. (2012). Bibcode: 2012PLoSO...742012R. doi:10.1371/journal.pone.0042012. PMC 3407072. PMID 22848689.
“MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response”. Cell Reports 2 (6): 1657–69. (December 2012). doi:10.1016/j.celrep.2012.11.018. PMC 3554793. PMID 23260667.
“PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis”. Oncotarget 6 (12): 9877–86. (2015). doi:10.18632/oncotarget.3185. PMC 4496403. PMID 25888627.
“Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics”. The Journal of Cell Biology 173 (4): 587–9. (May 2006). doi:10.1083/jcb.200509075. PMC 2063867. PMID 16717130.
“p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells”. The Journal of Biological Chemistry 279 (2): 1422–8. (January 2004). doi:10.1074/jbc.M309937200. PMID 14530270.
“Nuclear localization and chromatin targets of p21-activated kinase 1”. The Journal of Biological Chemistry 280 (18): 18130–7. (May 2005). doi:10.1074/jbc.M412607200. PMID 15749698.
“Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1”. International Journal of Cancer 125 (11): 2511–9. (December 2009). doi:10.1002/ijc.24588. PMID 19610058.
“p21-activated kinase-1 signaling regulates transcription of tissue factor and tissue factor pathway inhibitor”. The Journal of Biological Chemistry 287 (47): 39291–302. (November 2012). doi:10.1074/jbc.M112.404061. PMC 3501013. PMID 23038262.
“P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion”. The Journal of Biological Chemistry 288 (5): 3025–35. (February 2013). doi:10.1074/jbc.M112.424770. PMC 3561527. PMID 23258534.
“Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis”. Oncogene 34 (4): 455–64. (January 2015). doi:10.1038/onc.2013.576. PMID 24561527.
“p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor”. The Journal of Biological Chemistry 279 (18): 18392–400. (April 2004). doi:10.1074/jbc.M400084200. PMID 14970201.
“p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate”. EMBO Reports 5 (2): 154–60. (February 2004). doi:10.1038/sj.embor.7400079. PMC 1298990. PMID 14749719.
“Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells”. The Journal of Biological Chemistry 276 (31): 29403–9. (August 2001). doi:10.1074/jbc.M103129200. PMID 11382770.
“Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1”. The Journal of Biological Chemistry 277 (6): 4395–405. (February 2002). doi:10.1074/jbc.M110000200. PMID 11733498.
“ArhGAP15, a novel human RacGAP protein with GTPase binding property”. FEBS Letters 539 (1–3): 131–7. (March 2003). doi:10.1016/s0014-5793(03)00213-8. PMID 12650940.
“Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA”. The Journal of Biological Chemistry 273 (15): 8776–82. (April 1998). doi:10.1074/jbc.273.15.8776. PMID 9535855.
“Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology”. The Journal of Biological Chemistry 276 (52): 49043–52. (December 2001). doi:10.1074/jbc.M105599200. PMID 11604394.
“Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes”. Cancer Cell 5 (6): 575–85. (June 2004). doi:10.1016/j.ccr.2004.05.022. PMID 15193260.
“Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics”. Nature Cell Biology 1 (5): 253–9. (September 1999). doi:10.1038/12963. PMID 10559936.
“A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT”. The EMBO Journal 20 (3): 457–65. (February 2001). doi:10.1093/emboj/20.3.457. PMC 133476. PMID 11157752.
“Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck”. The Journal of Biological Chemistry 274 (9): 5542–9. (February 1999). doi:10.1074/jbc.274.9.5542. PMID 10026169.
“Interaction of the Nck adapter protein with p21-activated kinase (PAK1)”. The Journal of Biological Chemistry 271 (42): 25746–9. (October 1996). doi:10.1074/jbc.271.42.25746. PMID 8824201.
“Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1”. Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6174–9. (May 2001). Bibcode: 2001PNAS...98.6174X. doi:10.1073/pnas.101137298. PMC 33441. PMID 11371639.
“RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo”. Nature 424 (6947): 461–4. (July 2003). Bibcode: 2003Natur.424..461K. doi:10.1038/nature01817. PMID 12879077.

ensembl.org (Global: 1,626^th place; Japanese: 2,625^th place)

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000149269 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030774 - Ensembl, May 2017

harvard.edu (Global: 18^th place; Japanese: 107^th place)

ui.adsabs.harvard.edu

“A brain serine/threonine protein kinase activated by Cdc42 and Rac1”. Nature 367 (6458): 40–6. (January 1994). Bibcode: 1994Natur.367...40M. doi:10.1038/367040a0. PMID 8107774.
“Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway”. Proceedings of the National Academy of Sciences of the United States of America 97 (1): 185–9. (January 2000). Bibcode: 2000PNAS...97..185M. doi:10.1073/pnas.97.1.185. PMC 26637. PMID 10618392.
“Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma”. PLOS ONE 8 (3): e58413. (2013). Bibcode: 2013PLoSO...858413C. doi:10.1371/journal.pone.0058413. PMC 3596390. PMID 23516476.
“Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1”. Proceedings of the National Academy of Sciences of the United States of America 104 (14): 5866–71. (April 2007). Bibcode: 2007PNAS..104.5866M. doi:10.1073/pnas.0701065104. PMC 1851583. PMID 17389360.
“Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase”. Proceedings of the National Academy of Sciences of the United States of America 104 (16): 6782–7. (April 2007). Bibcode: 2007PNAS..104.6782A. doi:10.1073/pnas.0701999104. PMC 1871862. PMID 17420447.
“p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112”. PLOS ONE 6 (11): e27637. (2011). Bibcode: 2011PLoSO...627637Y. doi:10.1371/journal.pone.0027637. PMC 3214075. PMID 22096607.
“PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells”. PLOS ONE 7 (7): e42012. (2012). Bibcode: 2012PLoSO...742012R. doi:10.1371/journal.pone.0042012. PMC 3407072. PMID 22848689.
“Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1”. Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6174–9. (May 2001). Bibcode: 2001PNAS...98.6174X. doi:10.1073/pnas.101137298. PMC 33441. PMID 11371639.
“RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo”. Nature 424 (6947): 461–4. (July 2003). Bibcode: 2003Natur.424..461K. doi:10.1038/nature01817. PMID 12879077.

dash.harvard.edu

“PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling”. Oncogene 31 (29): 3397–408. (July 2012). doi:10.1038/onc.2011.515. PMC 3291810. PMID 22105362.

nih.gov (Global: 4^th place; Japanese: 24^th place)

pubmed.ncbi.nlm.nih.gov

“Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway”. Current Biology 6 (5): 598–605. (May 1996). doi:10.1016/S0960-9822(02)00546-8. PMID 8805275.
“Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma”. Cytogenetics and Cell Genetics 79 (1–2): 125–31. (Apr 1998). doi:10.1159/000134699. PMID 9533029.
“PAK thread from amoeba to mammals”. Journal of Cellular Biochemistry 107 (4): 579–85. (July 2009). doi:10.1002/jcb.22159. PMC 2718766. PMID 19350548.
“A brain serine/threonine protein kinase activated by Cdc42 and Rac1”. Nature 367 (6458): 40–6. (January 1994). Bibcode: 1994Natur.367...40M. doi:10.1038/367040a0. PMID 8107774.
“A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20”. The EMBO Journal 14 (9): 1970–8. (May 1995). doi:10.1002/j.1460-2075.1995.tb07189.x. PMC 398296. PMID 7744004.
“P21-activated kinases in human cancer”. Cancer and Metastasis Reviews 22 (4): 385–93. (December 2003). doi:10.1023/a:1023729130497. PMID 12884913.
“p21-activated kinases in cancer”. Nature Reviews. Cancer 6 (6): 459–71. (June 2006). doi:10.1038/nrc1892. PMID 16723992.
“PAK signalling during the development and progression of cancer”. Nature Reviews. Cancer 14 (1): 13–25. (January 2014). doi:10.1038/nrc3645. PMC 4115244. PMID 24505617.
PAKs in Human Cancer Progression: From Inception to Cancer Therapeutic to Future Oncobiology. 130. (2016). 137–209. doi:10.1016/bs.acr.2016.01.002. ISBN 9780128047897. PMID 27037753
“HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases”. Molecular Cell 49 (4): 668–79. (February 2013). doi:10.1016/j.molcel.2012.12.004. PMID 23317503.
“An emerging role for p21-activated kinases (Paks) in viral infections”. Trends in Cell Biology 20 (3): 160–9. (March 2010). doi:10.1016/j.tcb.2009.12.005. PMC 6489496. PMID 20071173.
“PAK1 is a novel cardiac protective signaling molecule”. Frontiers of Medicine 8 (4): 399–403. (December 2014). doi:10.1007/s11684-014-0380-9. PMID 25416031.
“PAK in Alzheimer disease, Huntington disease and X-linked mental retardation”. Cellular Logistics 2 (2): 117–125. (April 2012). doi:10.4161/cl.21602. PMC 3490962. PMID 23162743.
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“Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases”. The Journal of Biological Chemistry 276 (29): 26741–4. (July 2001). doi:10.1074/jbc.C100229200. PMID 11356824.
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“Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation”. Cancer Research 63 (24): 8837–47. (December 2003). PMID 14695200.
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“STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells”. The Journal of Biological Chemistry 287 (22): 18758–68. (May 2012). doi:10.1074/jbc.M111.316422. PMC 3365778. PMID 22493453.
“RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage”. Cancer Research 72 (21): 5516–28. (November 2012). doi:10.1158/0008-5472.CAN-12-0775. PMC 3548429. PMID 22971344.
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“BRAF activates and physically interacts with PAK to regulate cell motility”. Endocrine-Related Cancer 21 (6): 865–77. (2014). doi:10.1530/ERC-14-0424. PMC 4487662. PMID 25228413.
“The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)”. The Journal of Biological Chemistry 290 (34): 21076–85. (August 2015). doi:10.1074/jbc.M115.675124. PMC 4543665. PMID 26160174.
“Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1”. Nature Cell Biology 4 (9): 681–90. (September 2002). doi:10.1038/ncb838. PMID 12198493.
“Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16”. The Journal of Biological Chemistry 276 (3): 1677–80. (January 2001). doi:10.1074/jbc.C000635200. PMID 11058583.
“p21-activated kinase links Rac/Cdc42 signaling to merlin”. The Journal of Biological Chemistry 277 (2): 883–6. (January 2002). doi:10.1074/jbc.C100553200. PMID 11719502.
“Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK)”. Genes to Cells 7 (2): 91–7. (February 2002). doi:10.1046/j.1356-9597.2001.00504.x. PMID 11895474.
“p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells”. EMBO Reports 3 (8): 767–73. (August 2002). doi:10.1093/embo-reports/kvf157. PMC 1084211. PMID 12151336.
“P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium”. The EMBO Journal 21 (20): 5437–47. (October 2002). doi:10.1093/emboj/cdf543. PMC 129075. PMID 12374744.
“Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands”. The Journal of Cell Biology 161 (3): 583–92. (May 2003). doi:10.1083/jcb.200212066. PMC 2172951. PMID 12732616.
“Functional inactivation of a transcriptional corepressor by a signaling kinase”. Nature Structural Biology 10 (8): 622–8. (August 2003). doi:10.1038/nsb957. PMID 12872159.
“The generation of diversity and pattern in animal development”. Cell 68 (2): 185–99. (January 1992). doi:10.1016/0092-8674(92)90465-o. PMID 1733498.
“p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate”. EMBO Reports 5 (2): 154–60. (February 2004). doi:10.1038/sj.embor.7400079. PMC 1298990. PMID 14749719.
Vadlamudi, Ratna K.; Bagheri-Yarmand, Rozita; Yang, Zhibo; Balasenthil, Seetharaman; Nguyen, Diep; Sahin, Aysegul A.; den Hollander, Petra; Kumar, Rakesh (2004-06). “Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes”. Cancer Cell 5 (6): 575–585. doi:10.1016/j.ccr.2004.05.022. ISSN 1535-6108. PMID 15193260.
“Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase”. Oncogene 23 (49): 8118–27. (October 2004). doi:10.1038/sj.onc.1207969. PMID 15378030.
“An essential role of Pak1 phosphorylation of SHARP in Notch signaling”. Oncogene 24 (28): 4591–6. (June 2005). doi:10.1038/sj.onc.1208672. PMID 15824732.
“p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B”. Molecular and Cellular Biology 25 (9): 3726–36. (May 2005). doi:10.1128/MCB.25.9.3726-3736.2005. PMC 1084301. PMID 15831477.
“Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions”. Cancer Research 65 (8): 3179–84. (April 2005). doi:10.1158/0008-5472.CAN-04-3480. PMID 15833848.
“VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin”. Nature Cell Biology 8 (11): 1223–34. (November 2006). doi:10.1038/ncb1486. PMID 17060906.
“Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1”. Proceedings of the National Academy of Sciences of the United States of America 104 (14): 5866–71. (April 2007). Bibcode: 2007PNAS..104.5866M. doi:10.1073/pnas.0701065104. PMC 1851583. PMID 17389360.
“Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase”. Proceedings of the National Academy of Sciences of the United States of America 104 (16): 6782–7. (April 2007). Bibcode: 2007PNAS..104.6782A. doi:10.1073/pnas.0701999104. PMC 1871862. PMID 17420447.
“Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1”. The Journal of Biological Chemistry 282 (27): 19820–30. (July 2007). doi:10.1074/jbc.M702309200. PMID 17491012.
“Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells”. British Journal of Cancer 98 (6): 1132–40. (March 2008). doi:10.1038/sj.bjc.6604261. PMC 2275482. PMID 18283314.
“Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation”. Oncogene 27 (39): 5233–42. (September 2008). doi:10.1038/onc.2008.151. PMC 3621709. PMID 18521086.
“SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration”. Molecular Cell 37 (3): 321–32. (February 2010). doi:10.1016/j.molcel.2010.01.004. PMC 2824333. PMID 20159552.
“A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells”. Oncogene 31 (8): 1001–12. (February 2012). doi:10.1038/onc.2011.294. PMID 21822311.
“p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112”. PLOS ONE 6 (11): e27637. (2011). Bibcode: 2011PLoSO...627637Y. doi:10.1371/journal.pone.0027637. PMC 3214075. PMID 22096607.
“p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis”. Molecular and Cellular Biology 20 (2): 453–61. (January 2000). doi:10.1128/mcb.20.2.453-461.2000. PMC 85099. PMID 10611223.
“PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling”. Oncogene 31 (29): 3397–408. (July 2012). doi:10.1038/onc.2011.515. PMC 3291810. PMID 22105362.
“PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation”. The Journal of Cell Biology 162 (2): 281–91. (July 2003). doi:10.1083/jcb.200212141. PMC 2172784. PMID 12876277.
“PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells”. PLOS ONE 7 (7): e42012. (2012). Bibcode: 2012PLoSO...742012R. doi:10.1371/journal.pone.0042012. PMC 3407072. PMID 22848689.
“MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response”. Cell Reports 2 (6): 1657–69. (December 2012). doi:10.1016/j.celrep.2012.11.018. PMC 3554793. PMID 23260667.
“PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis”. Oncotarget 6 (12): 9877–86. (2015). doi:10.18632/oncotarget.3185. PMC 4496403. PMID 25888627.
“Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics”. The Journal of Cell Biology 173 (4): 587–9. (May 2006). doi:10.1083/jcb.200509075. PMC 2063867. PMID 16717130.
“p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells”. The Journal of Biological Chemistry 279 (2): 1422–8. (January 2004). doi:10.1074/jbc.M309937200. PMID 14530270.
“Nuclear localization and chromatin targets of p21-activated kinase 1”. The Journal of Biological Chemistry 280 (18): 18130–7. (May 2005). doi:10.1074/jbc.M412607200. PMID 15749698.
“Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1”. International Journal of Cancer 125 (11): 2511–9. (December 2009). doi:10.1002/ijc.24588. PMID 19610058.
“p21-activated kinase-1 signaling regulates transcription of tissue factor and tissue factor pathway inhibitor”. The Journal of Biological Chemistry 287 (47): 39291–302. (November 2012). doi:10.1074/jbc.M112.404061. PMC 3501013. PMID 23038262.
“P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion”. The Journal of Biological Chemistry 288 (5): 3025–35. (February 2013). doi:10.1074/jbc.M112.424770. PMC 3561527. PMID 23258534.
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“Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1”. The Journal of Biological Chemistry 277 (6): 4395–405. (February 2002). doi:10.1074/jbc.M110000200. PMID 11733498.
“ArhGAP15, a novel human RacGAP protein with GTPase binding property”. FEBS Letters 539 (1–3): 131–7. (March 2003). doi:10.1016/s0014-5793(03)00213-8. PMID 12650940.
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“Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology”. The Journal of Biological Chemistry 276 (52): 49043–52. (December 2001). doi:10.1074/jbc.M105599200. PMID 11604394.
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“Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics”. Nature Cell Biology 1 (5): 253–9. (September 1999). doi:10.1038/12963. PMID 10559936.
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“Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)”. 2022年11月26日閲覧。

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GRCh38: Ensembl release 89: ENSG00000149269 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030774 - Ensembl, May 2017

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Kumar, Rakesh; Sanawar, Rahul; Li, Xiaodong; Li, Feng (2017-03-20). “Structure, biochemistry, and biology of PAK kinases”. Gene 605: 20–31. doi:10.1016/j.gene.2016.12.014. ISSN 1879-0038. PMC 5250584. PMID 28007610.
Bagheri-Yarmand, R.; Mandal, M.; Taludker, A. H.; Wang, R. A.; Vadlamudi, R. K.; Kung, H. J.; Kumar, R. (2001-08-03). “Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells”. The Journal of Biological Chemistry 276 (31): 29403–29409. doi:10.1074/jbc.M103129200. ISSN 0021-9258. PMID 11382770.
Vadlamudi, Ratna K.; Bagheri-Yarmand, Rozita; Yang, Zhibo; Balasenthil, Seetharaman; Nguyen, Diep; Sahin, Aysegul A.; den Hollander, Petra; Kumar, Rakesh (2004-06). “Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes”. Cancer Cell 5 (6): 575–585. doi:10.1016/j.ccr.2004.05.022. ISSN 1535-6108. PMID 15193260.