TSC2 (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "TSC2" in Japanese language version.

Last modified: 17:28:28, 21 November 2025 (UTC)

Ref.Un. Ref.Website

Global rank Japanese rank

6446nih.gov

5^th place

11^th place

3426doi.org

2^nd place

3^rd place

62ensembl.org

630^th place

1,132^nd place

11worldcat.org

4^th place

12^th place

11uzh.ch

1,380^th place

9,870^th place

doi.org (Global: 2^nd place; Japanese: 3^rd place)

“Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients”. The EMBO Journal 36 (24): 3650–3665. (December 2017). doi:10.15252/embj.201796700. PMC 5730846. PMID 29127155.
“Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways.”. Proc Natl Acad Sci U S A 116 (8): 2977–2986. (February 2019). doi:10.1073/pnas.1812943116. PMC 6386676. PMID 30728291.
“Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis”. Scientific Reports 7 (1): 4174. (June 2017). doi:10.1038/s41598-017-04528-5. PMC 5482840. PMID 28646232.
“The tuberous sclerosis complex”. Annals of the New York Academy of Sciences 1184: 87–105. (January 2010). doi:10.1111/j.1749-6632.2009.05117.x. PMC 2892799. PMID 20146692.
“Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity”. Molecular and Cellular Biology 24 (18): 7965–75. (September 2004). doi:10.1128/MCB.24.18.7965-7975.2004. PMC 515062. PMID 15340059.
Dibble, Christian C.; Elis, Winfried; Menon, Suchithra; Qin, Wei; Klekota, Justin; Asara, John M.; Finan, Peter M.; Kwiatkowski, David J. et al. (2012-08-24). “TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1”. Molecular Cell 47 (4): 535–546. doi:10.1016/j.molcel.2012.06.009. ISSN 1097-4164. PMC 3693578. PMID 22795129.
“Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin”. The Journal of Biological Chemistry 277 (38): 35364–70. (September 2002). doi:10.1074/jbc.M205838200. PMID 12167664.
“Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase”. Proceedings of the National Academy of Sciences of the United States of America 101 (37): 13489–94. (September 2004). doi:10.1073/pnas.0405659101. PMC 518784. PMID 15342917.
“The tuberin-hamartin complex negatively regulates beta-catenin signaling activity”. The Journal of Biological Chemistry 278 (8): 5947–51. (February 2003). doi:10.1074/jbc.C200473200. PMID 12511557.
“Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway”. The Journal of Biological Chemistry 281 (52): 40242–51. (December 2006). doi:10.1074/jbc.M608116200. PMID 17077083.
“TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth”. Cell 126 (5): 955–68. (September 2006). doi:10.1016/j.cell.2006.06.055. PMID 16959574.
“Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis”. Cell 121 (2): 179–93. (April 2005). doi:10.1016/j.cell.2005.02.031. PMID 15851026.
“Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth”. The Journal of Biological Chemistry 281 (49): 37321–9. (December 2006). doi:10.1074/jbc.M605241200. PMID 17043358.
“Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex”. The Journal of Biological Chemistry 279 (2): 1351–8. (January 2004). doi:10.1074/jbc.M310208200. PMID 14559897.
“TSC2 mediates cellular energy response to control cell growth and survival”. Cell 115 (5): 577–90. (November 2003). doi:10.1016/S0092-8674(03)00929-2. PMID 14651849.
“The LKB1 tumor suppressor negatively regulates mTOR signaling”. Cancer Cell 6 (1): 91–9. (July 2004). doi:10.1016/j.ccr.2004.06.007. PMID 15261145.
“Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner”. The Journal of Biological Chemistry 278 (35): 32493–6. (August 2003). doi:10.1074/jbc.C300226200. PMID 12842888.
“Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin”. Archives of Biochemistry and Biophysics 404 (2): 210–7. (August 2002). doi:10.1016/S0003-9861(02)00300-4. PMID 12147258.
“Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling”. Genes & Development 17 (15): 1829–34. (August 2003). doi:10.1101/gad.1110003. PMC 196227. PMID 12869586.
“Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2”. Molecular Cell 11 (6): 1457–66. (June 2003). doi:10.1016/S1097-2765(03)00220-X. PMID 12820960.
“Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins”. Nature Cell Biology 5 (6): 578–81. (June 2003). doi:10.1038/ncb999. PMID 12771962.
“Rheb binds and regulates the mTOR kinase”. Current Biology 15 (8): 702–13. (April 2005). doi:10.1016/j.cub.2005.02.053. PMID 15854902.
“Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)”. The Biochemical Journal 388 (Pt 3): 973–84. (June 2005). doi:10.1042/BJ20041888. PMC 1183479. PMID 15757502.
“Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin”. The Journal of Biological Chemistry 279 (34): 35664–70. (August 2004). doi:10.1074/jbc.M403385200. PMID 15175323.
“E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6”. Genes to Cells 13 (3): 285–94. (March 2008). doi:10.1111/j.1365-2443.2008.01162.x. PMID 18298802.
“Identification and characterization of the interaction between tuberin and 14-3-3zeta”. The Journal of Biological Chemistry 277 (42): 39417–24. (October 2002). doi:10.1074/jbc.M204802200. PMID 12176984.

ensembl.org (Global: 630^th place; Japanese: 1,132^nd place)

may2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000103197 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002496 - Ensembl, May 2017

nih.gov (Global: 5^th place; Japanese: 11^th place)

pubmed.ncbi.nlm.nih.gov

“Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients”. The EMBO Journal 36 (24): 3650–3665. (December 2017). doi:10.15252/embj.201796700. PMC 5730846. PMID 29127155.
“Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways.”. Proc Natl Acad Sci U S A 116 (8): 2977–2986. (February 2019). doi:10.1073/pnas.1812943116. PMC 6386676. PMID 30728291.
“Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis”. Scientific Reports 7 (1): 4174. (June 2017). doi:10.1038/s41598-017-04528-5. PMC 5482840. PMID 28646232.
“The tuberous sclerosis complex”. Annals of the New York Academy of Sciences 1184: 87–105. (January 2010). doi:10.1111/j.1749-6632.2009.05117.x. PMC 2892799. PMID 20146692.
“Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity”. Molecular and Cellular Biology 24 (18): 7965–75. (September 2004). doi:10.1128/MCB.24.18.7965-7975.2004. PMC 515062. PMID 15340059.
Dibble, Christian C.; Elis, Winfried; Menon, Suchithra; Qin, Wei; Klekota, Justin; Asara, John M.; Finan, Peter M.; Kwiatkowski, David J. et al. (2012-08-24). “TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1”. Molecular Cell 47 (4): 535–546. doi:10.1016/j.molcel.2012.06.009. ISSN 1097-4164. PMC 3693578. PMID 22795129.
“Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin”. The Journal of Biological Chemistry 277 (38): 35364–70. (September 2002). doi:10.1074/jbc.M205838200. PMID 12167664.
“Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase”. Proceedings of the National Academy of Sciences of the United States of America 101 (37): 13489–94. (September 2004). doi:10.1073/pnas.0405659101. PMC 518784. PMID 15342917.
“The tuberin-hamartin complex negatively regulates beta-catenin signaling activity”. The Journal of Biological Chemistry 278 (8): 5947–51. (February 2003). doi:10.1074/jbc.C200473200. PMID 12511557.
“Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway”. The Journal of Biological Chemistry 281 (52): 40242–51. (December 2006). doi:10.1074/jbc.M608116200. PMID 17077083.
“TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth”. Cell 126 (5): 955–68. (September 2006). doi:10.1016/j.cell.2006.06.055. PMID 16959574.
“Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis”. Cell 121 (2): 179–93. (April 2005). doi:10.1016/j.cell.2005.02.031. PMID 15851026.
“Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth”. The Journal of Biological Chemistry 281 (49): 37321–9. (December 2006). doi:10.1074/jbc.M605241200. PMID 17043358.
“Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex”. The Journal of Biological Chemistry 279 (2): 1351–8. (January 2004). doi:10.1074/jbc.M310208200. PMID 14559897.
“TSC2 mediates cellular energy response to control cell growth and survival”. Cell 115 (5): 577–90. (November 2003). doi:10.1016/S0092-8674(03)00929-2. PMID 14651849.
“The LKB1 tumor suppressor negatively regulates mTOR signaling”. Cancer Cell 6 (1): 91–9. (July 2004). doi:10.1016/j.ccr.2004.06.007. PMID 15261145.
“Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner”. The Journal of Biological Chemistry 278 (35): 32493–6. (August 2003). doi:10.1074/jbc.C300226200. PMID 12842888.
“Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin”. Archives of Biochemistry and Biophysics 404 (2): 210–7. (August 2002). doi:10.1016/S0003-9861(02)00300-4. PMID 12147258.
“Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling”. Genes & Development 17 (15): 1829–34. (August 2003). doi:10.1101/gad.1110003. PMC 196227. PMID 12869586.
“Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2”. Molecular Cell 11 (6): 1457–66. (June 2003). doi:10.1016/S1097-2765(03)00220-X. PMID 12820960.
“Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins”. Nature Cell Biology 5 (6): 578–81. (June 2003). doi:10.1038/ncb999. PMID 12771962.
“Rheb binds and regulates the mTOR kinase”. Current Biology 15 (8): 702–13. (April 2005). doi:10.1016/j.cub.2005.02.053. PMID 15854902.
“Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)”. The Biochemical Journal 388 (Pt 3): 973–84. (June 2005). doi:10.1042/BJ20041888. PMC 1183479. PMID 15757502.
“Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin”. The Journal of Biological Chemistry 279 (34): 35664–70. (August 2004). doi:10.1074/jbc.M403385200. PMID 15175323.
“E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6”. Genes to Cells 13 (3): 285–94. (March 2008). doi:10.1111/j.1365-2443.2008.01162.x. PMID 18298802.
“Identification and characterization of the interaction between tuberin and 14-3-3zeta”. The Journal of Biological Chemistry 277 (42): 39417–24. (October 2002). doi:10.1074/jbc.M204802200. PMID 12176984.

ncbi.nlm.nih.gov

Human PubMed Reference:
Mouse PubMed Reference:
“Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients”. The EMBO Journal 36 (24): 3650–3665. (December 2017). doi:10.15252/embj.201796700. PMC 5730846. PMID 29127155.
“Entrez Gene: TSC2 tuberous sclerosis 2”. 2022年1月9日閲覧。
“Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways.”. Proc Natl Acad Sci U S A 116 (8): 2977–2986. (February 2019). doi:10.1073/pnas.1812943116. PMC 6386676. PMID 30728291.
“Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis”. Scientific Reports 7 (1): 4174. (June 2017). doi:10.1038/s41598-017-04528-5. PMC 5482840. PMID 28646232.
“The tuberous sclerosis complex”. Annals of the New York Academy of Sciences 1184: 87–105. (January 2010). doi:10.1111/j.1749-6632.2009.05117.x. PMC 2892799. PMID 20146692.
“Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity”. Molecular and Cellular Biology 24 (18): 7965–75. (September 2004). doi:10.1128/MCB.24.18.7965-7975.2004. PMC 515062. PMID 15340059.
Dibble, Christian C.; Elis, Winfried; Menon, Suchithra; Qin, Wei; Klekota, Justin; Asara, John M.; Finan, Peter M.; Kwiatkowski, David J. et al. (2012-08-24). “TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1”. Molecular Cell 47 (4): 535–546. doi:10.1016/j.molcel.2012.06.009. ISSN 1097-4164. PMC 3693578. PMID 22795129.
“Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase”. Proceedings of the National Academy of Sciences of the United States of America 101 (37): 13489–94. (September 2004). doi:10.1073/pnas.0405659101. PMC 518784. PMID 15342917.
“Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling”. Genes & Development 17 (15): 1829–34. (August 2003). doi:10.1101/gad.1110003. PMC 196227. PMID 12869586.
“Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)”. The Biochemical Journal 388 (Pt 3): 973–84. (June 2005). doi:10.1042/BJ20041888. PMC 1183479. PMID 15757502.

pmc.ncbi.nlm.nih.gov

uzh.ch (Global: 1,380^th place; Japanese: 9,870^th place)

zora.uzh.ch

“Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2”. Molecular Cell 11 (6): 1457–66. (June 2003). doi:10.1016/S1097-2765(03)00220-X. PMID 12820960.

worldcat.org (Global: 4^th place; Japanese: 12^th place)

search.worldcat.org

Dibble, Christian C.; Elis, Winfried; Menon, Suchithra; Qin, Wei; Klekota, Justin; Asara, John M.; Finan, Peter M.; Kwiatkowski, David J. et al. (2012-08-24). “TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1”. Molecular Cell 47 (4): 535–546. doi:10.1016/j.molcel.2012.06.009. ISSN 1097-4164. PMC 3693578. PMID 22795129.