アポリポプロテインE (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "アポリポプロテインE" in Japanese language version.

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Mahley RW, Weisgraber KH, Huang Y (April 8, 2009). “Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS”. Journal of Lipid Research 50 (Suppl): S183–S188. doi:10.1194/jlr.R800069-JLR200. PMC 2674716. PMID 19106071.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (February 2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy”. Nature Reviews. Neurology 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Puglielli L, Tanzi RE, Kovacs DM (April 2003). “Alzheimer's disease: the cholesterol connection” (英語). Nature Neuroscience 6 (4): 345–51. doi:10.1038/nn0403-345. PMID 12658281.
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, ((Megens RTA)), Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, ((Habenicht AJR)) (January 2019). “ApoE attenuates unresolvable inflammation by complex formation with activated C1q” (英語). Nature Medicine 25 (3): 496–506. doi:10.1038/s41591-018-0336-8. PMC 6420126. PMID 30692699.
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P (January 2001). “A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis”. Molecular Cell 7 (1): 161–71. doi:10.1016/S1097-2765(01)00164-2. PMID 11172721.
Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). “Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell & Melanoma Research 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Phillips MC (September 2014). “Apolipoprotein E isoforms and lipoprotein metabolism”. IUBMB Life 66 (9): 616–23. doi:10.1002/iub.1314. PMID 25328986.
Singh PP, Singh M, Mastana SS (2006). “APOE distribution in world populations with new data from India and the UK”. Annals of Human Biology 33 (3): 279–308. doi:10.1080/03014460600594513. PMID 17092867.
Eisenberg DT, Kuzawa CW, Hayes MG (September 2010). “Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history”. American Journal of Physical Anthropology 143 (1): 100–11. doi:10.1002/ajpa.21298. PMID 20734437.
Zuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J (2006). “Variation at APOE and STH loci and Alzheimer's disease”. Behavioral and Brain Functions 2 (1): 13. doi:10.1186/1744-9081-2-13. PMC 1526745. PMID 16603077.
Ghebranious N, Ivacic L, Mallum J, Dokken C (2005). “Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technology”. Nucleic Acids Research 33 (17): e149. doi:10.1093/nar/gni155. PMC 1243648. PMID 16204452.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.”. Nat Rev Neurol 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Feussner G, Feussner V, Hoffmann MM, Lohrmann J, Wieland H, März W (1998). “Molecular basis of type III hyperlipoproteinemia in Germany”. Human Mutation 11 (6): 417–23. doi:10.1002/(SICI)1098-1004(1998)11:6<417::AID-HUMU1>3.0.CO;2-5. PMID 9603433.
Civeira F, Pocoví M, Cenarro A, Casao E, Vilella E, Joven J, González J, Garcia-Otín AL, Ordovás JM (December 1996). “Apo E variants in patients with type III hyperlipoproteinemia”. Atherosclerosis 127 (2): 273–82. doi:10.1016/S0021-9150(96)05969-2. PMID 9125318.
Huang X, Chen PC, Poole C (June 2004). “APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease”. Neurology 62 (12): 2198–202. doi:10.1212/01.wnl.0000130159.28215.6a. PMID 15210882.
Federoff M, Jimenez-Rolando B, Nalls MA, Singleton AB (May 2012). “A large study reveals no association between APOE and Parkinson's disease”. Neurobiology of Disease 46 (2): 389–92. doi:10.1016/j.nbd.2012.02.002. PMC 3323723. PMID 22349451.
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (August 1993). “Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families”. Science 261 (5123): 921–23. Bibcode: 1993Sci...261..921C. doi:10.1126/science.8346443. PMID 8346443.
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (March 1993). “Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease”. Proceedings of the National Academy of Sciences of the United States of America 90 (5): 1977–81. Bibcode: 1993PNAS...90.1977S. doi:10.1073/pnas.90.5.1977. PMC 46003. PMID 8446617.
Deary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ (August 2002). “Cognitive change and the APOE epsilon 4 allele”. Nature 418 (6901): 932. doi:10.1038/418932a. hdl:1842/702. PMID 12198535.
Farlow MR, He Y, Tekin S, Xu J, Lane R, Charles HC (November 2004). “Impact of APOE in mild cognitive impairment”. Neurology 63 (10): 1898–901. doi:10.1212/01.wnl.0000144279.21502.b7. PMID 15557508.
Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK (June 2008). “Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression”. Proceedings of the National Academy of Sciences of the United States of America 105 (25): 8718–23. doi:10.1073/pnas.0803526105. PMC 2438419. PMID 18562290.
Chapman J, Vinokurov S, Achiron A, Karussis DM, Mitosek-Szewczyk K, Birnbaum M, Michaelson DM, Korczyn AD (February 2001). “APOE genotype is a major predictor of long-term progression of disability in MS”. Neurology 56 (3): 312–16. doi:10.1212/wnl.56.3.312. PMID 11171894.
Schmidt S, Barcellos LF, DeSombre K, Rimmler JB, Lincoln RR, Bucher P, Saunders AM, Lai E, Martin ER, Vance JM, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines JL (March 2002). “Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis”. American Journal of Human Genetics 70 (3): 708–17. doi:10.1086/339269. PMC 384947. PMID 11836653.
Friedman G, Froom P, Sazbon L, Grinblatt I, Shochina M, Tsenter J, Babaey S, Yehuda B, Groswasser Z (January 1999). “Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury”. Neurology 52 (2): 244–48. doi:10.1212/wnl.52.2.244. PMID 9932938.
McCarron MO, Delong D, Alberts MJ (October 1999). “APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis”. Neurology 53 (6): 1308–11. doi:10.1212/wnl.53.6.1308. PMID 10522889.
Kadotani H, Kadotani T, Young T, Peppard PE, Finn L, Colrain IM, Murphy GM, Mignot E (June 2001). “Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults”. JAMA 285 (22): 2888–90. doi:10.1001/jama.285.22.2888. PMID 11401610.
Gottlieb DJ, DeStefano AL, Foley DJ, Mignot E, Redline S, Givelber RJ, Young T (August 2004). “APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study”. Neurology 63 (4): 664–68. doi:10.1212/01.wnl.0000134671.99649.32. PMID 15326239.
Jacobs EG, Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL (February 2013). “Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use”. PLOS ONE 8 (2): e54713. doi:10.1371/journal.pone.0054713. PMC 3572118. PMID 23418430.
Raber J (May 2008). “AR, apoE, and cognitive function”. Hormones and Behavior 53 (5): 706–15. doi:10.1016/j.yhbeh.2008.02.012. PMC 2409114. PMID 18395206.
Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (October 2020). “APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort” (英語). The Journals of Gerontology: Series A 75 (11): 2231–2232. doi:10.1093/gerona/glaa131. ISSN 1079-5006. PMC 7314139. PMID 32451547.
Huebbe P, Nebel A, Siegert S, Moehring J, Boesch-Saadatmandi C, Most E, Pallauf J, Egert S, Müller MJ, Schreiber S, Nöthlings U, Rimbach G (September 2011). “APOE ε4 is associated with higher vitamin D levels in targeted replacement mice and humans”. FASEB Journal 25 (9): 3262–70. doi:10.1096/fj.11-180935. PMID 21659554.
Mondadori CR, de Quervain DJ, Buchmann A, Mustovic H, Wollmer MA, Schmidt CF, Boesiger P, Hock C, Nitsch RM, Papassotiropoulos A, Henke K (August 2007). “Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers”. Cerebral Cortex 17 (8): 1934–47. doi:10.1093/cercor/bhl103. PMID 17077159.
Zhang Z, Mu J, Li J, Li W, Song J (January 2013). “Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression”. Genetic Testing and Molecular Biomarkers 17 (1): 47–51. doi:10.1089/gtmb.2012.0253. PMC 3525887. PMID 23171142.
Rogers JT, Weeber EJ (August 2008). “Reelin and apoE actions on signal transduction, synaptic function and memory formation”. Neuron Glia Biology 4 (3): 259–70. doi:10.1017/S1740925X09990184. PMID 19674510.
Sacks FM (February 2015). “The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia”. Current Opinion in Lipidology 26 (1): 56–63. doi:10.1097/MOL.0000000000000146. PMC 4371603. PMID 25551803.
Jiang L, Zhong J, Dou X, Cheng C, Huang Z, Sun X (Aug 2015). “Effects of ApoE on intracellular calcium levels and apoptosis of neurons after mechanical injury”. Neuroscience 301: 375–83. doi:10.1016/j.neuroscience.2015.06.005. PMID 26073697.
van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB (October 2005). “Apolipoprotein-mediated pathways of lipid antigen presentation”. Nature 437 (7060): 906–10. Bibcode: 2005Natur.437..906E. doi:10.1038/nature04001. PMID 16208376.
Zhang HL, Wu J, Zhu J (2010). “The role of apolipoprotein E in Guillain–Barré syndrome and experimental autoimmune neuritis”. Journal of Biomedicine & Biotechnology 2010 ( ): 357412. doi:10.1155/2010/357412. PMC 2825561. PMID 20182542.
Braesch-Andersen S, Paulie S, Smedman C, Mia S, Kumagai-Braesch M (2013). “ApoE production in human monocytes and its regulation by inflammatory cytokines”. PLOS ONE 8 (11): e79908. Bibcode: 2013PLoSO...879908B. doi:10.1371/journal.pone.0079908. PMC 3828220. PMID 24244577.
Notkola IL, Sulkava R, Pekkanen J, Erkinjuntti T, Ehnholm C, Kivinen P, Tuomilehto J, Nissinen A (1998-01-01). “Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease”. Neuroepidemiology 17 (1): 14–20. doi:10.1159/000026149. PMID 9549720.
Petanceska SS, DeRosa S, Sharma A, Diaz N, Duff K, Tint SG, Refolo LM, Pappolla M (2003-01-01). “Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol”. Journal of Molecular Neuroscience 20 (3): 395–406. doi:10.1385/JMN:20:3:395. PMID 14501024.
Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H (August 2002). “Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease”. Annals of Internal Medicine 137 (3): 149–55. doi:10.7326/0003-4819-137-3-200208060-00006. PMID 12160362.
Wisniewski T, Frangione B (February 1992). “Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid”. Neuroscience Letters 135 (2): 235–38. doi:10.1016/0304-3940(92)90444-C. PMID 1625800.
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE (June 2008). “ApoE promotes the proteolytic degradation of Abeta”. Neuron (Cell Press) 58 (5): 681–93. doi:10.1016/j.neuron.2008.04.010. PMC 2493297. PMID 18549781 (2008-06-13).
Hauser PS, Ryan RO (October 2013). “Impact of apolipoprotein E on Alzheimer's disease”. Current Alzheimer Research 10 (8): 809–17. doi:10.2174/15672050113109990156. PMC 3995977. PMID 23919769.
Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE (June 1994). “Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease”. Nature Genetics 7 (2): 180–84. doi:10.1038/ng0694-180. PMID 7920638.
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM (1997). “Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium”. JAMA 278 (16): 1349–56. doi:10.1001/jama.1997.03550160069041. PMID 9343467.
Damoiseaux, Jessica S.; Seeley, William W.; Zhou, Juan; Shirer, William R.; Coppola, Giovanni; Karydas, Anna; Rosen, Howard J.; Miller, Bruce L. et al. (2012-06-13). “Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels” (英語). Journal of Neuroscience 32 (24): 8254–62. doi:10.1523/JNEUROSCI.0305-12.2012. ISSN 0270-6474. PMC 3394933. PMID 22699906.
Hunter LE, Freudenberg-Hua Yun, Davies P, Kim M, Lipton RB, Stewart WF, Srinivasan P, Hu S, Lipton ML (2020-04-01). “Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players” (英語). JAMA Neurology 77 (4): 419. doi:10.1001/jamaneurol.2019.4828. ISSN 2168-6149. PMC 6990972. PMID 31985774.
McNeill E, Channon KM, Greaves DR (June 2010). “Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications”. Clinical Science 118 (11): 641–55. doi:10.1042/CS20090488. PMID 20210786.
Kassa FA, Van Den Ham K, Rainone A, Fournier S, Boilard E, Olivier M (September 2016). “Absence of apolipoprotein E protects mice from cerebral malaria”. Scientific Reports 6 ( ): 33615. Bibcode: 2016NatSR...633615K. doi:10.1038/srep33615. PMC 5028887. PMID 27647324.
Wozniak MA, Riley EM, Itzhaki RF (March 2004). "Apolipoprotein E polymorphisms and risk of malaria". Journal of Medical Genetics. 41 (3): 145–46. doi:10.1136/jmg.2003.014613. PMC 1735716. PMID 14985370。
Babin PJ, Thisse C, Durliat M, Andre M, Akimenko MA, Thisse B (1997). “Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development”. PNAS 94 (16): 8622–27. Bibcode: 1997PNAS...94.8622B. doi:10.1073/pnas.94.16.8622. PMC 23048. PMID 9238027.
Huebbe P, Rimbach G (2017). “Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors”. Ageing Research Reviews 37: 146–61. doi:10.1016/j.arr.2017.06.002. PMID 28647612.
McIntosh AM, Bennett C, Dickson D, Anestis SF, Watts DP, Webster TH, Fontenot MB, Bradley BJ (2012). “The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes)”. PLOS ONE 7 (10): e47760. Bibcode: 2012PLoSO...747760M. doi:10.1371/journal.pone.0047760. PMC 3480407. PMID 23112842.
Finch CE, Stanford CB (2004). “Meat-adaptive genes and the evolution of slower aging in humans”. The Quarterly Review of Biology 79 (1): 3–50. doi:10.1086/381662. PMID 15101252.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000130203 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002985 - Ensembl, May 2017

handle.net

hdl.handle.net

Deary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ (August 2002). “Cognitive change and the APOE epsilon 4 allele”. Nature 418 (6901): 932. doi:10.1038/418932a. hdl:1842/702. PMID 12198535.

harvard.edu

ui.adsabs.harvard.edu

Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (August 1993). “Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families”. Science 261 (5123): 921–23. Bibcode: 1993Sci...261..921C. doi:10.1126/science.8346443. PMID 8346443.
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (March 1993). “Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease”. Proceedings of the National Academy of Sciences of the United States of America 90 (5): 1977–81. Bibcode: 1993PNAS...90.1977S. doi:10.1073/pnas.90.5.1977. PMC 46003. PMID 8446617.
van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB (October 2005). “Apolipoprotein-mediated pathways of lipid antigen presentation”. Nature 437 (7060): 906–10. Bibcode: 2005Natur.437..906E. doi:10.1038/nature04001. PMID 16208376.
Braesch-Andersen S, Paulie S, Smedman C, Mia S, Kumagai-Braesch M (2013). “ApoE production in human monocytes and its regulation by inflammatory cytokines”. PLOS ONE 8 (11): e79908. Bibcode: 2013PLoSO...879908B. doi:10.1371/journal.pone.0079908. PMC 3828220. PMID 24244577.
Kassa FA, Van Den Ham K, Rainone A, Fournier S, Boilard E, Olivier M (September 2016). “Absence of apolipoprotein E protects mice from cerebral malaria”. Scientific Reports 6 ( ): 33615. Bibcode: 2016NatSR...633615K. doi:10.1038/srep33615. PMC 5028887. PMID 27647324.
Babin PJ, Thisse C, Durliat M, Andre M, Akimenko MA, Thisse B (1997). “Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development”. PNAS 94 (16): 8622–27. Bibcode: 1997PNAS...94.8622B. doi:10.1073/pnas.94.16.8622. PMC 23048. PMID 9238027.
McIntosh AM, Bennett C, Dickson D, Anestis SF, Watts DP, Webster TH, Fontenot MB, Bradley BJ (2012). “The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes)”. PLOS ONE 7 (10): e47760. Bibcode: 2012PLoSO...747760M. doi:10.1371/journal.pone.0047760. PMC 3480407. PMID 23112842.

jamanetwork.com

Hunter LE, Freudenberg-Hua Yun, Davies P, Kim M, Lipton RB, Stewart WF, Srinivasan P, Hu S, Lipton ML (2020-04-01). “Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players” (英語). JAMA Neurology 77 (4): 419. doi:10.1001/jamaneurol.2019.4828. ISSN 2168-6149. PMC 6990972. PMID 31985774.

nih.gov

pubmed.ncbi.nlm.nih.gov

Mahley RW, Weisgraber KH, Huang Y (April 8, 2009). “Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS”. Journal of Lipid Research 50 (Suppl): S183–S188. doi:10.1194/jlr.R800069-JLR200. PMC 2674716. PMID 19106071.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (February 2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy”. Nature Reviews. Neurology 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Puglielli L, Tanzi RE, Kovacs DM (April 2003). “Alzheimer's disease: the cholesterol connection” (英語). Nature Neuroscience 6 (4): 345–51. doi:10.1038/nn0403-345. PMID 12658281.
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, ((Megens RTA)), Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, ((Habenicht AJR)) (January 2019). “ApoE attenuates unresolvable inflammation by complex formation with activated C1q” (英語). Nature Medicine 25 (3): 496–506. doi:10.1038/s41591-018-0336-8. PMC 6420126. PMID 30692699.
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P (January 2001). “A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis”. Molecular Cell 7 (1): 161–71. doi:10.1016/S1097-2765(01)00164-2. PMID 11172721.
Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). “Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell & Melanoma Research 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Phillips MC (September 2014). “Apolipoprotein E isoforms and lipoprotein metabolism”. IUBMB Life 66 (9): 616–23. doi:10.1002/iub.1314. PMID 25328986.
Singh PP, Singh M, Mastana SS (2006). “APOE distribution in world populations with new data from India and the UK”. Annals of Human Biology 33 (3): 279–308. doi:10.1080/03014460600594513. PMID 17092867.
Eisenberg DT, Kuzawa CW, Hayes MG (September 2010). “Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history”. American Journal of Physical Anthropology 143 (1): 100–11. doi:10.1002/ajpa.21298. PMID 20734437.
Zuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J (2006). “Variation at APOE and STH loci and Alzheimer's disease”. Behavioral and Brain Functions 2 (1): 13. doi:10.1186/1744-9081-2-13. PMC 1526745. PMID 16603077.
Ghebranious N, Ivacic L, Mallum J, Dokken C (2005). “Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technology”. Nucleic Acids Research 33 (17): e149. doi:10.1093/nar/gni155. PMC 1243648. PMID 16204452.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.”. Nat Rev Neurol 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Weisgraber KH, Innerarity TL, Mahley RW (March 1982). “Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site”. The Journal of Biological Chemistry 257 (5): 2518–21. PMID 6277903.
Breslow JL, Zannis VI, SanGiacomo TR, Third JL, Tracy T, Glueck CJ (November 1982). “Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2”. Journal of Lipid Research 23 (8): 1224–35. PMID 7175379.
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Hauser PS, Ryan RO (October 2013). “Impact of apolipoprotein E on Alzheimer's disease”. Current Alzheimer Research 10 (8): 809–17. doi:10.2174/15672050113109990156. PMC 3995977. PMID 23919769.
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Wozniak MA, Riley EM, Itzhaki RF (March 2004). "Apolipoprotein E polymorphisms and risk of malaria". Journal of Medical Genetics. 41 (3): 145–46. doi:10.1136/jmg.2003.014613. PMC 1735716. PMID 14985370。
Babin PJ, Thisse C, Durliat M, Andre M, Akimenko MA, Thisse B (1997). “Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development”. PNAS 94 (16): 8622–27. Bibcode: 1997PNAS...94.8622B. doi:10.1073/pnas.94.16.8622. PMC 23048. PMID 9238027.
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ncbi.nlm.nih.gov

Human PubMed Reference:
Mouse PubMed Reference:
Mahley RW, Weisgraber KH, Huang Y (April 8, 2009). “Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS”. Journal of Lipid Research 50 (Suppl): S183–S188. doi:10.1194/jlr.R800069-JLR200. PMC 2674716. PMID 19106071.
“Entrez Gene: APOE apolipoprotein E”. 2020年11月2日閲覧。
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (February 2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy”. Nature Reviews. Neurology 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, ((Megens RTA)), Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, ((Habenicht AJR)) (January 2019). “ApoE attenuates unresolvable inflammation by complex formation with activated C1q” (英語). Nature Medicine 25 (3): 496–506. doi:10.1038/s41591-018-0336-8. PMC 6420126. PMID 30692699.
Zuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J (2006). “Variation at APOE and STH loci and Alzheimer's disease”. Behavioral and Brain Functions 2 (1): 13. doi:10.1186/1744-9081-2-13. PMC 1526745. PMID 16603077.
Ghebranious N, Ivacic L, Mallum J, Dokken C (2005). “Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technology”. Nucleic Acids Research 33 (17): e149. doi:10.1093/nar/gni155. PMC 1243648. PMID 16204452.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.”. Nat Rev Neurol 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Federoff M, Jimenez-Rolando B, Nalls MA, Singleton AB (May 2012). “A large study reveals no association between APOE and Parkinson's disease”. Neurobiology of Disease 46 (2): 389–92. doi:10.1016/j.nbd.2012.02.002. PMC 3323723. PMID 22349451.
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (March 1993). “Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease”. Proceedings of the National Academy of Sciences of the United States of America 90 (5): 1977–81. Bibcode: 1993PNAS...90.1977S. doi:10.1073/pnas.90.5.1977. PMC 46003. PMID 8446617.
Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK (June 2008). “Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression”. Proceedings of the National Academy of Sciences of the United States of America 105 (25): 8718–23. doi:10.1073/pnas.0803526105. PMC 2438419. PMID 18562290.
Schmidt S, Barcellos LF, DeSombre K, Rimmler JB, Lincoln RR, Bucher P, Saunders AM, Lai E, Martin ER, Vance JM, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines JL (March 2002). “Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis”. American Journal of Human Genetics 70 (3): 708–17. doi:10.1086/339269. PMC 384947. PMID 11836653.
Jacobs EG, Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL (February 2013). “Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use”. PLOS ONE 8 (2): e54713. doi:10.1371/journal.pone.0054713. PMC 3572118. PMID 23418430.
Raber J (May 2008). “AR, apoE, and cognitive function”. Hormones and Behavior 53 (5): 706–15. doi:10.1016/j.yhbeh.2008.02.012. PMC 2409114. PMID 18395206.
Zhang Z, Mu J, Li J, Li W, Song J (January 2013). “Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression”. Genetic Testing and Molecular Biomarkers 17 (1): 47–51. doi:10.1089/gtmb.2012.0253. PMC 3525887. PMID 23171142.
Sacks FM (February 2015). “The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia”. Current Opinion in Lipidology 26 (1): 56–63. doi:10.1097/MOL.0000000000000146. PMC 4371603. PMID 25551803.
Zhang HL, Wu J, Zhu J (2010). “The role of apolipoprotein E in Guillain–Barré syndrome and experimental autoimmune neuritis”. Journal of Biomedicine & Biotechnology 2010 ( ): 357412. doi:10.1155/2010/357412. PMC 2825561. PMID 20182542.
Braesch-Andersen S, Paulie S, Smedman C, Mia S, Kumagai-Braesch M (2013). “ApoE production in human monocytes and its regulation by inflammatory cytokines”. PLOS ONE 8 (11): e79908. Bibcode: 2013PLoSO...879908B. doi:10.1371/journal.pone.0079908. PMC 3828220. PMID 24244577.
Sepehrnia B, Kamboh MI, Adams-Campbell LL, Bunker CH, Nwankwo M, Majumder PP, Ferrell RE (October 1989). “Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in Nigerian blacks”. American Journal of Human Genetics 45 (4): 586–91. PMC 1683508. PMID 2491016.
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE (June 2008). “ApoE promotes the proteolytic degradation of Abeta”. Neuron (Cell Press) 58 (5): 681–93. doi:10.1016/j.neuron.2008.04.010. PMC 2493297. PMID 18549781 (2008-06-13).
Hauser PS, Ryan RO (October 2013). “Impact of apolipoprotein E on Alzheimer's disease”. Current Alzheimer Research 10 (8): 809–17. doi:10.2174/15672050113109990156. PMC 3995977. PMID 23919769.
Damoiseaux, Jessica S.; Seeley, William W.; Zhou, Juan; Shirer, William R.; Coppola, Giovanni; Karydas, Anna; Rosen, Howard J.; Miller, Bruce L. et al. (2012-06-13). “Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels” (英語). Journal of Neuroscience 32 (24): 8254–62. doi:10.1523/JNEUROSCI.0305-12.2012. ISSN 0270-6474. PMC 3394933. PMID 22699906.
Kassa FA, Van Den Ham K, Rainone A, Fournier S, Boilard E, Olivier M (September 2016). “Absence of apolipoprotein E protects mice from cerebral malaria”. Scientific Reports 6 ( ): 33615. Bibcode: 2016NatSR...633615K. doi:10.1038/srep33615. PMC 5028887. PMID 27647324.
Wozniak MA, Riley EM, Itzhaki RF (March 2004). "Apolipoprotein E polymorphisms and risk of malaria". Journal of Medical Genetics. 41 (3): 145–46. doi:10.1136/jmg.2003.014613. PMC 1735716. PMID 14985370。
Babin PJ, Thisse C, Durliat M, Andre M, Akimenko MA, Thisse B (1997). “Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development”. PNAS 94 (16): 8622–27. Bibcode: 1997PNAS...94.8622B. doi:10.1073/pnas.94.16.8622. PMC 23048. PMID 9238027.
McIntosh AM, Bennett C, Dickson D, Anestis SF, Watts DP, Webster TH, Fontenot MB, Bradley BJ (2012). “The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes)”. PLOS ONE 7 (10): e47760. Bibcode: 2012PLoSO...747760M. doi:10.1371/journal.pone.0047760. PMC 3480407. PMID 23112842.

pmc.ncbi.nlm.nih.gov

Mahley RW, Weisgraber KH, Huang Y (April 8, 2009). “Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS”. Journal of Lipid Research 50 (Suppl): S183–S188. doi:10.1194/jlr.R800069-JLR200. PMC 2674716. PMID 19106071.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (February 2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy”. Nature Reviews. Neurology 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, ((Megens RTA)), Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, ((Habenicht AJR)) (January 2019). “ApoE attenuates unresolvable inflammation by complex formation with activated C1q” (英語). Nature Medicine 25 (3): 496–506. doi:10.1038/s41591-018-0336-8. PMC 6420126. PMID 30692699.
Zuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J (2006). “Variation at APOE and STH loci and Alzheimer's disease”. Behavioral and Brain Functions 2 (1): 13. doi:10.1186/1744-9081-2-13. PMC 1526745. PMID 16603077.
Ghebranious N, Ivacic L, Mallum J, Dokken C (2005). “Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technology”. Nucleic Acids Research 33 (17): e149. doi:10.1093/nar/gni155. PMC 1243648. PMID 16204452.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (2013). “Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.”. Nat Rev Neurol 9 (2): 106–18. doi:10.1038/nrneurol.2012.263. PMC 3726719. PMID 23296339.
Federoff M, Jimenez-Rolando B, Nalls MA, Singleton AB (May 2012). “A large study reveals no association between APOE and Parkinson's disease”. Neurobiology of Disease 46 (2): 389–92. doi:10.1016/j.nbd.2012.02.002. PMC 3323723. PMID 22349451.
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (March 1993). “Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease”. Proceedings of the National Academy of Sciences of the United States of America 90 (5): 1977–81. Bibcode: 1993PNAS...90.1977S. doi:10.1073/pnas.90.5.1977. PMC 46003. PMID 8446617.
Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK (June 2008). “Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression”. Proceedings of the National Academy of Sciences of the United States of America 105 (25): 8718–23. doi:10.1073/pnas.0803526105. PMC 2438419. PMID 18562290.
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Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (October 2020). “APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort” (英語). The Journals of Gerontology: Series A 75 (11): 2231–2232. doi:10.1093/gerona/glaa131. ISSN 1079-5006. PMC 7314139. PMID 32451547.

wikipathways.org

この双方向伝達経路地図はWikiPathwaysで編集できる: “Statin_Pathway_WP430”. 2014年5月7日閲覧。

wikipedia.org

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GRCh38: Ensembl release 89: ENSG00000130203 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002985 - Ensembl, May 2017

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Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (October 2020). “APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort” (英語). The Journals of Gerontology: Series A 75 (11): 2231–2232. doi:10.1093/gerona/glaa131. ISSN 1079-5006. PMC 7314139. PMID 32451547.
Damoiseaux, Jessica S.; Seeley, William W.; Zhou, Juan; Shirer, William R.; Coppola, Giovanni; Karydas, Anna; Rosen, Howard J.; Miller, Bruce L. et al. (2012-06-13). “Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels” (英語). Journal of Neuroscience 32 (24): 8254–62. doi:10.1523/JNEUROSCI.0305-12.2012. ISSN 0270-6474. PMC 3394933. PMID 22699906.
Hunter LE, Freudenberg-Hua Yun, Davies P, Kim M, Lipton RB, Stewart WF, Srinivasan P, Hu S, Lipton ML (2020-04-01). “Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players” (英語). JAMA Neurology 77 (4): 419. doi:10.1001/jamaneurol.2019.4828. ISSN 2168-6149. PMC 6990972. PMID 31985774.