トポイソメラーゼ阻害薬 (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "トポイソメラーゼ阻害薬" in Japanese language version.

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Cushman, Mark; Jayaraman, Muthusamy; Vroman, Jeffrey A.; Fukunaga, Anna K.; Fox, Brian M.; Kohlhagen, Glenda; Strumberg, Dirk; Pommier, Yves (October 2000). “Synthesis of New Indeno[1,2- c isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors”] (英語). Journal of Medicinal Chemistry 43 (20): 3688–3698. doi:10.1021/jm000029d. ISSN 0022-2623. PMID 11020283.
Staker, Bart L.; Feese, Michael D.; Cushman, Mark; Pommier, Yves; Zembower, David; Stewart, Lance; Burgin, Alex B. (April 2005). “Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex” (英語). Journal of Medicinal Chemistry 48 (7): 2336–2345. doi:10.1021/jm049146p. ISSN 0022-2623. PMID 15801827.
Yamashita, Yoshinori; Fujii, Noboru; Murakata, Chikara; Ashizawa, Tadashi; Okabe, Masami; Nakano, Hirofumi (1992-12-08). “Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives” (英語). Biochemistry 31 (48): 12069–12075. doi:10.1021/bi00163a015. ISSN 0006-2960. PMID 1333791.
Cushman, Mark; Cheng, Leung (September 1978). “Stereoselective oxidation by thionyl chloride leading to the indeno[1,2-cisoquinoline system”] (英語). The Journal of Organic Chemistry 43 (19): 3781–3783. doi:10.1021/jo00413a036. ISSN 0022-3263.
Shen, Linus L.; Mitscher, Lester A.; Sharma, Padam N.; O'Donnell, T. J.; Chu, Daniel W. T.; Cooper, Curt S.; Rosen, Terry; Pernet, Andre G. (1989-05-02). “Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model” (英語). Biochemistry 28 (9): 3886–3894. doi:10.1021/bi00435a039. ISSN 0006-2960. PMID 2546585.

ascopubs.org

Lynch, T (1996-12-01). “Topotecan today.”. Journal of Clinical Oncology 14 (12): 3053–3055. doi:10.1200/JCO.1996.14.12.3053. ISSN 0732-183X. PMID 8955649.

aspetjournals.org

molpharm.aspetjournals.org

Ganapathi, R.; Constantinou, A.; Kamath, N.; Dubyak, G.; Grabowski, D.; Krivacic, K. (1996-08-01). “Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.” (英語). Molecular Pharmacology 50 (2): 243–248. ISSN 0026-895X. PMID 8700130.

clinicaltrials.gov

“A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults with Relapsed Solid Tumors and Lymphomas”. 2023年9月20日閲覧。

doi.org

Delgado, Justine L.; Hsieh, Chao-Ming; Chan, Nei-Li; Hiasa, Hiroshi (2018-01-31). “Topoisomerases as anticancer targets” (英語). Biochemical Journal 475 (2): 373–398. doi:10.1042/BCJ20160583. ISSN 0264-6021. PMC 6110615. PMID 29363591.
Waksman, Selman A.; Woodruff, H. Boyd (1940). “The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria*1”. Journal of Bacteriology 40 (4): 581–600. doi:10.1128/jb.40.4.581-600.1940. ISSN 0021-9193. PMC 374661. PMID 16560371.
Bush, Karen (December 2010). “The coming of age of antibiotics: discovery and therapeutic value: Origins of antibiotic drug discovery” (英語). Annals of the New York Academy of Sciences 1213 (1): 1–4. doi:10.1111/j.1749-6632.2010.05872.x. PMID 21175674.
Chevrette, Marc G.; Currie, Cameron R. (March 2019). “Emerging evolutionary paradigms in antibiotic discovery” (英語). Journal of Industrial Microbiology & Biotechnology 46 (3–4): 257–271. doi:10.1007/s10295-018-2085-6. ISSN 1367-5435. PMID 30269177.
Marinello, Jessica; Delcuratolo, Maria; Capranico, Giovanni (2018-11-06). “Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives”. International Journal of Molecular Sciences 19 (11): 3480. doi:10.3390/ijms19113480. ISSN 1422-0067. PMC 6275052. PMID 30404148.
Buzun, Kamila; Bielawska, Anna; Bielawski, Krzysztof; Gornowicz, Agnieszka (2020-01-01). “DNA topoisomerases as molecular targets for anticancer drugs” (英語). Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1): 1781–1799. doi:10.1080/14756366.2020.1821676. ISSN 1475-6366. PMC 7534307. PMID 32975138.
Wall, Monroe E. (1998). “Camptothecin and taxol: Discovery to clinic” (英語). Medicinal Research Reviews 18 (5): 299–314. doi:10.1002/(SICI)1098-1128(199809)18:5<299::AID-MED2>3.0.CO;2-O. ISSN 1098-1128. PMID 9735871.
Mitscher, Lester A. (2005-06-14). “Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents”. ChemInform 36 (24): 559–92. doi:10.1002/chin.200524274. ISSN 0931-7597. PMID 15700957.
Gellert, M.; Mizuuchi, K.; O'Dea, M. H.; Nash, H. A. (1976-11-01). “DNA gyrase: an enzyme that introduces superhelical turns into DNA.” (英語). Proceedings of the National Academy of Sciences 73 (11): 3872–3876. Bibcode: 1976PNAS...73.3872G. doi:10.1073/pnas.73.11.3872. ISSN 0027-8424. PMC 431247. PMID 186775.
Sinkule, J. A. (March 1984). “Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent”. Pharmacotherapy 4 (2): 61–73. doi:10.1002/j.1875-9114.1984.tb03318.x. ISSN 0277-0008. PMID 6326063.
Benjanuwattra, Juthipong; Siri-Angkul, Natthaphat; Chattipakorn, Siriporn C.; Chattipakorn, Nipon (January 2020). “Doxorubicin and its proarrhythmic effects: A comprehensive review of the evidence from experimental and clinical studies” (英語). Pharmacological Research 151: 104542. doi:10.1016/j.phrs.2019.104542. PMID 31730804.
Kojiri, Katsuhisa; Kondo, Hisao; Yoshinari, Tomoko; Arakawa, Hiroharu; Nakajima, Shigeru; Satoh, Fumio; Kawamura, Kenji; Okura, Akira et al. (1991). “A new antitumor substance, BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.” (英語). The Journal of Antibiotics 44 (7): 723–728. doi:10.7164/antibiotics.44.723. ISSN 0021-8820. PMID 1652582.
Cushman, Mark; Jayaraman, Muthusamy; Vroman, Jeffrey A.; Fukunaga, Anna K.; Fox, Brian M.; Kohlhagen, Glenda; Strumberg, Dirk; Pommier, Yves (October 2000). “Synthesis of New Indeno[1,2- c isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors”] (英語). Journal of Medicinal Chemistry 43 (20): 3688–3698. doi:10.1021/jm000029d. ISSN 0022-2623. PMID 11020283.
Sinha, Birandra K. (1995-01-01). “Topoisomerase Inhibitors” (英語). Drugs 49 (1): 11–19. doi:10.2165/00003495-199549010-00002. ISSN 1179-1950. PMID 7705211.
Pommier, Yves (2009-07-08). “DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition”. Chemical Reviews 109 (7): 2894–2902. doi:10.1021/cr900097c. ISSN 0009-2665. PMC 2707511. PMID 19476377.
Pommier, Yves; Leo, Elisabetta; Zhang, Hongliang; Marchand, Christophe (2010-05-28). “DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs” (英語). Chemistry & Biology 17 (5): 421–433. doi:10.1016/j.chembiol.2010.04.012. ISSN 1074-5521. PMC 7316379. PMID 20534341.
Pommier, Yves (October 2006). “Topoisomerase I inhibitors: camptothecins and beyond” (英語). Nature Reviews Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-1768. PMID 16990856.
Perdue, Robert E.; Smith, Robert L.; Wall, Monroe E.; Hartwell, Jonathan L.; Abbott, Betty J.; Perdue, Robert E.; Smith, Robert L.; Wall, Monroe E. et al. (1970) (英語). Camptotheca acuminata Decaisne (Nyssaceae) Source of Camptothecin, an Antileukemic Alkaloid. Technical Bulletin. doi:10.22004/AG.ECON.171841.
D'yakonov, Vladimir A.; Dzhemileva, Lilya U.; Dzhemilev, Usein M. (2017), “Advances in the Chemistry of Natural and Semisynthetic Topoisomerase I/II Inhibitors” (英語), Studies in Natural Products Chemistry (Elsevier) 54: pp. 21–86, doi:10.1016/b978-0-444-63929-5.00002-4, ISBN 978-0-444-63929-5 2020年12月20日閲覧。
Liu, Ying-Qian; Li, Wen-Qun; Morris‐Natschke, Susan L.; Qian, Keduo; Yang, Liu; Zhu, Gao-Xiang; Wu, Xiao-Bing; Chen, An-Liang et al. (2015). “Perspectives on Biologically Active Camptothecin Derivatives” (英語). Medicinal Research Reviews 35 (4): 753–789. doi:10.1002/med.21342. ISSN 1098-1128. PMC 4465867. PMID 25808858.
Cunha, Kênya Silva; Reguly, Maria Luíza; Graf, Ulrich; Rodrigues de Andrade, Heloisa Helena (2002-03-01). “Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination” (英語). Mutagenesis 17 (2): 141–147. doi:10.1093/mutage/17.2.141. ISSN 0267-8357. PMID 11880543.
Hsiang, Y. H.; Hertzberg, R.; Hecht, S.; Liu, L. F. (1985-11-25). “Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I”. The Journal of Biological Chemistry 260 (27): 14873–14878. doi:10.1016/S0021-9258(17)38654-4. ISSN 0021-9258. PMID 2997227.
Staker, Bart L.; Feese, Michael D.; Cushman, Mark; Pommier, Yves; Zembower, David; Stewart, Lance; Burgin, Alex B. (April 2005). “Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex” (英語). Journal of Medicinal Chemistry 48 (7): 2336–2345. doi:10.1021/jm049146p. ISSN 0022-2623. PMID 15801827.
Lu, Ai-jun; Zhang, Zhen-shan; Zheng, Ming-yue; Zou, Han-jun; Luo, Xiao-min; Jiang, Hua-liang (February 2007). “3D-QSAR study of 20 ( S )-camptothecin analogs” (英語). Acta Pharmacologica Sinica 28 (2): 307–314. doi:10.1111/j.1745-7254.2007.00477.x. ISSN 1745-7254. PMID 17241535.
Ulukan, Hulya; Swaan, Peter W. (2002-10-01). “Camptothecins” (英語). Drugs 62 (14): 2039–2057. doi:10.2165/00003495-200262140-00004. ISSN 1179-1950. PMID 12269849.
HOPKINS, R. P. (1983-12-01). “Principles of Biochemistry, Seventh Edition (two volumes): General Aspects, Mammalian Biochemistry”. Biochemical Society Transactions 11 (6): 829–830. doi:10.1042/bst0110829a. ISSN 0300-5127. https://doi.org/10.1042/bst0110829a.
Lynch, T (1996-12-01). “Topotecan today.”. Journal of Clinical Oncology 14 (12): 3053–3055. doi:10.1200/JCO.1996.14.12.3053. ISSN 0732-183X. PMID 8955649.
Hu, Guohua; Zekria, David; Cai, Xun; Ni, Xiaoling (June 2015). “Current status of CPT and its analogues in the treatment of malignancies” (英語). Phytochemistry Reviews 14 (3): 429–441. doi:10.1007/s11101-015-9397-1. ISSN 1568-7767.
Pommier, Yves; Pourquier, Philippe; Urasaki, Yoshimasa; Wu, Jiaxi; Laco, Gary S. (October 1999). “Topoisomerase I inhibitors: selectivity and cellular resistance”. Drug Resistance Updates 2 (5): 307–318. doi:10.1054/drup.1999.0102. ISSN 1368-7646. PMID 11504505.
Pommier, Yves (2006-10). “Topoisomerase I inhibitors: camptothecins and beyond”. Nature Reviews. Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-175X. PMID 16990856.
Long, Byron H.; Rose, William C.; Vyas, Dolatrai M.; Matson, James A.; Forenza, Salvatore (March 2002). “Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles”. Current Medicinal Chemistry. Anti-Cancer Agents 2 (2): 255–266. doi:10.2174/1568011023354218. ISSN 1568-0118. PMID 12678746.
Yamashita, Yoshinori; Fujii, Noboru; Murakata, Chikara; Ashizawa, Tadashi; Okabe, Masami; Nakano, Hirofumi (1992-12-08). “Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives” (英語). Biochemistry 31 (48): 12069–12075. doi:10.1021/bi00163a015. ISSN 0006-2960. PMID 1333791.
Cushman, Mark; Cheng, Leung (September 1978). “Stereoselective oxidation by thionyl chloride leading to the indeno[1,2-cisoquinoline system”] (英語). The Journal of Organic Chemistry 43 (19): 3781–3783. doi:10.1021/jo00413a036. ISSN 0022-3263.
Cui, Yue; Wu, Linhui; Cao, Ruoxue; Xu, Hui; Xia, Jun; Wang, Z Peter; Ma, Jia (2020). “Antitumor functions and mechanisms of nitidine chloride in human cancers” (英語). Journal of Cancer 11 (5): 1250–1256. doi:10.7150/jca.37890. ISSN 1837-9664. PMC 6959075. PMID 31956371. http://www.jcancer.org/v11p1250.htm.
Xu, Yang; Her, Chengtao (2015-07-22). “Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy” (英語). Biomolecules 5 (3): 1652–1670. doi:10.3390/biom5031652. ISSN 2218-273X. PMC 4598769. PMID 26287259.
Aldred, Katie J.; Kerns, Robert J.; Osheroff, Neil (2014-03-18). “Mechanism of Quinolone Action and Resistance”. Biochemistry 53 (10): 1565–1574. doi:10.1021/bi5000564. ISSN 0006-2960. PMC 3985860. PMID 24576155.
Hevener, KirkE.; Verstak, Tatsiana A.; Lutat, Katie E.; Riggsbee, Daniel L.; Mooney, Jeremiah W. (October 2018). “Recent developments in topoisomerase-targeted cancer chemotherapy”. Acta Pharmaceutica Sinica B 8 (6): 844–861. doi:10.1016/j.apsb.2018.07.008. ISSN 2211-3835. PMC 6251812. PMID 30505655.
Kampranis, S. C.; Gormley, N. A.; Tranter, R.; Orphanides, G.; Maxwell, A. (1999-02-16). “Probing the binding of coumarins and cyclothialidines to DNA gyrase”. Biochemistry 38 (7): 1967–1976. doi:10.1021/bi982320p. ISSN 0006-2960. PMID 10026280.
Classen, Scott; Olland, Stephane; Berger, James M. (2003-09-16). “Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187” (英語). Proceedings of the National Academy of Sciences 100 (19): 10629–10634. Bibcode: 2003PNAS..10010629C. doi:10.1073/pnas.1832879100. ISSN 0027-8424. PMC 196855. PMID 12963818.
Thorn, Caroline F.; Oshiro, Connie; Marsh, Sharon; Hernandez-Boussard, Tina; McLeod, Howard; Klein, Teri E.; Altman, Russ B. (July 2011). “Doxorubicin pathways: pharmacodynamics and adverse effects” (英語). Pharmacogenetics and Genomics 21 (7): 440–446. doi:10.1097/FPC.0b013e32833ffb56. ISSN 1744-6872. PMC 3116111. PMID 21048526.
Montecucco, Alessandra; Zanetta, Francesca; Biamonti, Giuseppe (2015-01-19). “Molecular mechanisms of etoposide”. EXCLI Journal 14: 95–108. doi:10.17179/excli2014-561. ISSN 1611-2156. PMC 4652635. PMID 26600742.
Lewis, R J; Singh, O M; Smith, C V; Skarzynski, T; Maxwell, A; Wonacott, A J; Wigley, D B (1996-03-15). “The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.”. The EMBO Journal 15 (6): 1412–1420. doi:10.1002/j.1460-2075.1996.tb00483.x. ISSN 0261-4189. PMC 450046. PMID 8635474.
Anderson, V. E.; Osheroff, N. (March 2001). “Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde”. Current Pharmaceutical Design 7 (5): 337–353. doi:10.2174/1381612013398013. ISSN 1381-6128. PMID 11254893.
Collin, Frédéric; Karkare, Shantanu; Maxwell, Anthony (2011-11). “Exploiting bacterial DNA gyrase as a drug target: current state and perspectives”. Applied Microbiology and Biotechnology 92 (3): 479–497. doi:10.1007/s00253-011-3557-z. ISSN 1432-0614. PMC 3189412. PMID 21904817.
Waksman, S. A.; Woodruff, H. B. (1941-08). “Actinomyces antibioticus, a New Soil Organism Antagonistic to Pathogenic and Non-pathogenic Bacteria”. Journal of Bacteriology 42 (2): 231–249. doi:10.1128/jb.42.2.231-249.1941. ISSN 0021-9193. PMC PMC374755. PMID 16560451.
Li, Qun; Mitscher, Lester A.; Shen, Linus L. (2000). “The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors” (英語). Medicinal Research Reviews 20 (4): 231–293. doi:10.1002/1098-1128(200007)20:4<231::AID-MED1>3.0.CO;2-N. ISSN 1098-1128. PMID 10861727.
Bisacchi, Gregory S. (2015-06-25). “Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story"”. Journal of Medicinal Chemistry 58 (12): 4874–4882. doi:10.1021/jm501881c. ISSN 1520-4804. PMID 25738967.
Laponogov, Ivan; Sohi, Maninder K; Veselkov, Dennis A; Pan, Xiao-Su; Sawhney, Ritica; Thompson, Andrew W; McAuley, Katherine E; Fisher, L Mark et al. (June 2009). “Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases” (英語). Nature Structural & Molecular Biology 16 (6): 667–669. doi:10.1038/nsmb.1604. ISSN 1545-9993. PMID 19448616.
Wolfson, John S.; Hooper, David C. (1991-12-30). “Overview of fluoroquinolone safety” (英語). The American Journal of Medicine. Fluoroquinolones in the Treatment of Human Infection: The Role of Temafloxacin 91 (6, Supplement 1): S153–S161. doi:10.1016/0002-9343(91)90330-Z. ISSN 0002-9343. PMID 1767803.
Drlica, Karl; Hiasa, Hiroshi; Kerns, Robert; Malik, Muhammad; Mustaev, Arkady; Zhao, Xilin (August 2009). “Quinolones: Action and Resistance Updated”. Current Topics in Medicinal Chemistry 9 (11): 981–998. doi:10.2174/156802609789630947. ISSN 1568-0266. PMC 3182077. PMID 19747119.
Yoshida, H.; Bogaki, M.; Nakamura, M.; Yamanaka, L. M.; Nakamura, S. (1991-08-01). “Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.” (英語). Antimicrobial Agents and Chemotherapy 35 (8): 1647–1650. doi:10.1128/AAC.35.8.1647. ISSN 0066-4804. PMC 245234. PMID 1656869.
Shen, Linus L.; Mitscher, Lester A.; Sharma, Padam N.; O'Donnell, T. J.; Chu, Daniel W. T.; Cooper, Curt S.; Rosen, Terry; Pernet, Andre G. (1989-05-02). “Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model” (英語). Biochemistry 28 (9): 3886–3894. doi:10.1021/bi00435a039. ISSN 0006-2960. PMID 2546585.
Nitiss, John L. (May 2009). “Targeting DNA topoisomerase II in cancer chemotherapy”. Nature Reviews. Cancer 9 (5): 338–350. doi:10.1038/nrc2607. ISSN 1474-175X. PMC 2748742. PMID 19377506.
Wohlkonig, Alexandre; Chan, Pan F; Fosberry, Andrew P; Homes, Paul; Huang, Jianzhong; Kranz, Michael; Leydon, Vaughan R; Miles, Timothy J et al. (2010-08-29). “Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance”. Nature Structural & Molecular Biology 17 (9): 1152–1153. doi:10.1038/nsmb.1892. ISSN 1545-9993. PMID 20802486. https://doi.org/10.1038/nsmb.1892.
Leo, Elisabetta; Gould, Katherine A.; Pan, Xiao-Su; Capranico, Giovanni; Sanderson, Mark R.; Palumbo, Manlio; Fisher, L. Mark (2005-01-18). “Novel Symmetric and Asymmetric DNA Scission Determinants forStreptococcus pneumoniaeTopoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site”. Journal of Biological Chemistry 280 (14): 14252–14263. doi:10.1074/jbc.m500156200. ISSN 0021-9258. PMID 15659402.
Atwal, Mandeep; Swan, Rebecca L.; Rowe, Chloe; Lee, Ka C.; Lee, David C.; Armstrong, Lyle; Cowell, Ian G.; Austin, Caroline A. (October 2019). “Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations”. Molecular Pharmacology 96 (4): 475–484. doi:10.1124/mol.119.117259. ISSN 0026-895X. PMC 6744389. PMID 31399497.
McGowan, John V; Chung, Robin; Maulik, Angshuman; Piotrowska, Izabela; Walker, J Malcolm; Yellon, Derek M (February 2017). “Anthracycline Chemotherapy and Cardiotoxicity” (英語). Cardiovascular Drugs and Therapy 31 (1): 63–75. doi:10.1007/s10557-016-6711-0. ISSN 0920-3206. PMC 5346598. PMID 28185035.
Matyszewska, Dorota; Nazaruk, Ewa; Campbell, Richard A. (January 2021). “Interactions of anticancer drugs doxorubicin and idarubicin with lipid monolayers: New insight into the composition, structure and morphology” (英語). Journal of Colloid and Interface Science 581 (Pt A): 403–416. Bibcode: 2021JCIS..581..403M. doi:10.1016/j.jcis.2020.07.092. PMID 32771749.
Imbert, T. F. (March 1998). “Discovery of podophyllotoxins”. Biochimie 80 (3): 207–222. doi:10.1016/s0300-9084(98)80004-7. ISSN 0300-9084. PMID 9615861.
Clark, Peter I.; Slevin, Maurice L. (1987-04-01). “The Clinical Pharmacology of Etoposide and Teniposide” (英語). Clinical Pharmacokinetics 12 (4): 223–252. doi:10.2165/00003088-198712040-00001. ISSN 1179-1926. PMID 3297462.
“Food and Drug Administration (FDA)”, SpringerReference (Berlin/Heidelberg: Springer-Verlag), (2011), doi:10.1007/springerreference_32222 2020年12月13日閲覧。
Vogelzang, N. J.; Raghavan, D.; Kennedy, B. J. (January 1982). “VP-16-213 (etoposide): the mandrake root from Issyk-Kul”. The American Journal of Medicine 72 (1): 136–144. doi:10.1016/0002-9343(82)90600-3. ISSN 0002-9343. PMID 6277188.
Postmus, Haaxma-Reiche, Smit, Groen, Karnicka, Lewinski, Meerbeeck, Clerico, Gregor, Curran, Sahmoud, Kirkpatrick, and Giaccone, Pieter E., Hanny, Egbert, Groen, Hanna, Tadeusz, Jan van, Mario, Anna, Desmond, Tarek, Anne, and Giuseppe (2000). “Treatment of Brain Metastases of Small-Cell Lung Cancer: Comparing Teniposide and Teniposide With Whole-Brain Radiotherapy—A Phase III Study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group”. Journal of Clinical Oncology 18 (19 (October 1)): 3400–3408. doi:10.1200/JCO.2000.18.19.3400. PMID 11013281.
Manfait, M.; Chourpa, I.; Sokolov, K.; Morjani, H.; Riou, J.-F.; Lavelle, F.; Nabiev, I. (1993), Theophanides, Theophile; Anastassopoulou, Jane; Fotopoulos, Nikolaos, eds., “Intercalating and Non-Intercalating Antitumor Drugs: Structure-Function Correlations as Probed by Surface-Enhanced Raman Spectroscopy” (英語), Fifth International Conference on the Spectroscopy of Biological Molecules (Dordrecht: Springer Netherlands): pp. 59–64, doi:10.1007/978-94-011-1934-4_18, ISBN 978-94-011-1934-4 2020年12月15日閲覧。
Guryanova, Olga A.; Shank, Kaitlyn; Spitzer, Barbara; Luciani, Luisa; Koche, Richard P.; Garrett-Bakelman, Francine E.; Ganzel, Chezi; Durham, Benjamin H. et al. (December 2016). “DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling”. Nature Medicine 22 (12): 1488–1495. doi:10.1038/nm.4210. ISSN 1546-170X. PMC 5359771. PMID 27841873.
Ganapathi, Ram N.; Ganapathi, Mahrukh K. (2013-08-01). “Mechanisms regulating resistance to inhibitors of topoisomerase II”. Frontiers in Pharmacology 4: 89. doi:10.3389/fphar.2013.00089. ISSN 1663-9812. PMC 3729981. PMID 23914174.
Matsumoto, Yoshihito; Takano, Hiroshi; Kunishio, Katsuzo; Nagao, Seigo; Fojo, Tito (2001). “Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines” (英語). Japanese Journal of Cancer Research 92 (10): 1133–1137. doi:10.1111/j.1349-7006.2001.tb01069.x. ISSN 1349-7006. PMC 5926608. PMID 11676865.
Andoh, Toshiwo; Ishida, Ryoji (1998-10-01). “Catalytic inhibitors of DNA topoisomerase II” (英語). Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1400 (1): 155–171. doi:10.1016/S0167-4781(98)00133-X. ISSN 0167-4781. PMID 9748552.
Andoh, T. (March 1998). “Bis(2,6-dioxopiperazines), catalytic inhibitors of DNA topoisomerase II, as molecular probes, cardioprotectors and antitumor drugs”. Biochimie 80 (3): 235–246. doi:10.1016/s0300-9084(98)80006-0. ISSN 0300-9084. PMID 9615863.
Langer, Seppo W (2014-09-15). “Dexrazoxane for the treatment of chemotherapy-related side effects”. Cancer Management and Research 6: 357–363. doi:10.2147/CMAR.S47238. ISSN 1179-1322. PMC 4168851. PMID 25246808.
Weiss, G.; Loyevsky, M.; Gordeuk, V. R. (January 1999). “Dexrazoxane (ICRF-187)”. General Pharmacology 32 (1): 155–158. doi:10.1016/s0306-3623(98)00100-1. ISSN 0306-3623. PMID 9888268.
“Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer”. Proc. Natl. Acad. Sci. U.S.A. 103 (23): 8822–7. (2006). Bibcode: 2006PNAS..103.8822A. doi:10.1073/pnas.0600645103. PMC 1466544. PMID 16723399.
“Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology”. Semin. Cancer Biol. 20 (5): 329–39. (2010). doi:10.1016/j.semcancer.2010.10.002. PMC 3040982. PMID 20934517.
“Correlation between the methylation of SULF2 and WRN promoter and the irinotecan chemosensitivity in gastric cancer”. BMC Gastroenterol. 13: 173. (2013). doi:10.1186/1471-230X-13-173. PMC 3877991. PMID 24359226.
“Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease”. Biogerontology 13 (1): 49–62. (2012). doi:10.1007/s10522-011-9341-8. PMID 21786128.
“Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells”. Oncol. Rep. 28 (4): 1146–52. (2012). doi:10.3892/or.2012.1912. PMC 3583574. PMID 22797812.
“Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase”. Biol. Pharm. Bull. 30 (10): 1958–61. (2007). doi:10.1248/bpb.30.1958. PMID 17917271.
“Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells”. Cancer Sci. 99 (5): 843–8. (2008). doi:10.1111/j.1349-7006.2008.00778.x. PMID 18312465.

drugbank.com

go.drugbank.com

“Novobiocin”. go.drugbank.com. 2020年12月10日閲覧。

elsevier.com

linkinghub.elsevier.com

Benjanuwattra, Juthipong; Siri-Angkul, Natthaphat; Chattipakorn, Siriporn C.; Chattipakorn, Nipon (January 2020). “Doxorubicin and its proarrhythmic effects: A comprehensive review of the evidence from experimental and clinical studies” (英語). Pharmacological Research 151: 104542. doi:10.1016/j.phrs.2019.104542. PMID 31730804.
D'yakonov, Vladimir A.; Dzhemileva, Lilya U.; Dzhemilev, Usein M. (2017), “Advances in the Chemistry of Natural and Semisynthetic Topoisomerase I/II Inhibitors” (英語), Studies in Natural Products Chemistry (Elsevier) 54: pp. 21–86, doi:10.1016/b978-0-444-63929-5.00002-4, ISBN 978-0-444-63929-5 2020年12月20日閲覧。

fda.gov

Research, Center for Drug Evaluation and (2019-04-15). “FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes” (英語). FDA.

harvard.edu

ui.adsabs.harvard.edu

Gellert, M.; Mizuuchi, K.; O'Dea, M. H.; Nash, H. A. (1976-11-01). “DNA gyrase: an enzyme that introduces superhelical turns into DNA.” (英語). Proceedings of the National Academy of Sciences 73 (11): 3872–3876. Bibcode: 1976PNAS...73.3872G. doi:10.1073/pnas.73.11.3872. ISSN 0027-8424. PMC 431247. PMID 186775.
Classen, Scott; Olland, Stephane; Berger, James M. (2003-09-16). “Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187” (英語). Proceedings of the National Academy of Sciences 100 (19): 10629–10634. Bibcode: 2003PNAS..10010629C. doi:10.1073/pnas.1832879100. ISSN 0027-8424. PMC 196855. PMID 12963818.
Matyszewska, Dorota; Nazaruk, Ewa; Campbell, Richard A. (January 2021). “Interactions of anticancer drugs doxorubicin and idarubicin with lipid monolayers: New insight into the composition, structure and morphology” (英語). Journal of Colloid and Interface Science 581 (Pt A): 403–416. Bibcode: 2021JCIS..581..403M. doi:10.1016/j.jcis.2020.07.092. PMID 32771749.
“Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer”. Proc. Natl. Acad. Sci. U.S.A. 103 (23): 8822–7. (2006). Bibcode: 2006PNAS..103.8822A. doi:10.1073/pnas.0600645103. PMC 1466544. PMID 16723399.

jcancer.org

Cui, Yue; Wu, Linhui; Cao, Ruoxue; Xu, Hui; Xia, Jun; Wang, Z Peter; Ma, Jia (2020). “Antitumor functions and mechanisms of nitidine chloride in human cancers” (英語). Journal of Cancer 11 (5): 1250–1256. doi:10.7150/jca.37890. ISSN 1837-9664. PMC 6959075. PMID 31956371. http://www.jcancer.org/v11p1250.htm.

jst.go.jp

joi.jlc.jst.go.jp

Kojiri, Katsuhisa; Kondo, Hisao; Yoshinari, Tomoko; Arakawa, Hiroharu; Nakajima, Shigeru; Satoh, Fumio; Kawamura, Kenji; Okura, Akira et al. (1991). “A new antitumor substance, BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.” (英語). The Journal of Antibiotics 44 (7): 723–728. doi:10.7164/antibiotics.44.723. ISSN 0021-8820. PMID 1652582.

nature.com

Pommier, Yves (October 2006). “Topoisomerase I inhibitors: camptothecins and beyond” (英語). Nature Reviews Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-1768. PMID 16990856.
Laponogov, Ivan; Sohi, Maninder K; Veselkov, Dennis A; Pan, Xiao-Su; Sawhney, Ritica; Thompson, Andrew W; McAuley, Katherine E; Fisher, L Mark et al. (June 2009). “Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases” (英語). Nature Structural & Molecular Biology 16 (6): 667–669. doi:10.1038/nsmb.1604. ISSN 1545-9993. PMID 19448616.

ncats.io

drugs.ncats.io

“NCATS Inxight: Drugs — NOVOBIOCIN” (英語). drugs.ncats.io. 2020年12月10日閲覧。

nih.gov

pubmed.ncbi.nlm.nih.gov

Delgado, Justine L.; Hsieh, Chao-Ming; Chan, Nei-Li; Hiasa, Hiroshi (2018-01-31). “Topoisomerases as anticancer targets” (英語). Biochemical Journal 475 (2): 373–398. doi:10.1042/BCJ20160583. ISSN 0264-6021. PMC 6110615. PMID 29363591.
Waksman, Selman A.; Woodruff, H. Boyd (1940). “The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria*1”. Journal of Bacteriology 40 (4): 581–600. doi:10.1128/jb.40.4.581-600.1940. ISSN 0021-9193. PMC 374661. PMID 16560371.
Bush, Karen (December 2010). “The coming of age of antibiotics: discovery and therapeutic value: Origins of antibiotic drug discovery” (英語). Annals of the New York Academy of Sciences 1213 (1): 1–4. doi:10.1111/j.1749-6632.2010.05872.x. PMID 21175674.
Chevrette, Marc G.; Currie, Cameron R. (March 2019). “Emerging evolutionary paradigms in antibiotic discovery” (英語). Journal of Industrial Microbiology & Biotechnology 46 (3–4): 257–271. doi:10.1007/s10295-018-2085-6. ISSN 1367-5435. PMID 30269177.
Di Marco, A.; Cassinelli, G.; Arcamone, F. (1981). “The discovery of daunorubicin”. Cancer Treatment Reports 65 Suppl 4: 3–8. ISSN 0361-5960. PMID 7049379.
Marinello, Jessica; Delcuratolo, Maria; Capranico, Giovanni (2018-11-06). “Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives”. International Journal of Molecular Sciences 19 (11): 3480. doi:10.3390/ijms19113480. ISSN 1422-0067. PMC 6275052. PMID 30404148.
Buzun, Kamila; Bielawska, Anna; Bielawski, Krzysztof; Gornowicz, Agnieszka (2020-01-01). “DNA topoisomerases as molecular targets for anticancer drugs” (英語). Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1): 1781–1799. doi:10.1080/14756366.2020.1821676. ISSN 1475-6366. PMC 7534307. PMID 32975138.
Wall, Monroe E. (1998). “Camptothecin and taxol: Discovery to clinic” (英語). Medicinal Research Reviews 18 (5): 299–314. doi:10.1002/(SICI)1098-1128(199809)18:5<299::AID-MED2>3.0.CO;2-O. ISSN 1098-1128. PMID 9735871.
Mitscher, Lester A. (2005-06-14). “Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents”. ChemInform 36 (24): 559–92. doi:10.1002/chin.200524274. ISSN 0931-7597. PMID 15700957.
Gellert, M.; Mizuuchi, K.; O'Dea, M. H.; Nash, H. A. (1976-11-01). “DNA gyrase: an enzyme that introduces superhelical turns into DNA.” (英語). Proceedings of the National Academy of Sciences 73 (11): 3872–3876. Bibcode: 1976PNAS...73.3872G. doi:10.1073/pnas.73.11.3872. ISSN 0027-8424. PMC 431247. PMID 186775.
Sinkule, J. A. (March 1984). “Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent”. Pharmacotherapy 4 (2): 61–73. doi:10.1002/j.1875-9114.1984.tb03318.x. ISSN 0277-0008. PMID 6326063.
Benjanuwattra, Juthipong; Siri-Angkul, Natthaphat; Chattipakorn, Siriporn C.; Chattipakorn, Nipon (January 2020). “Doxorubicin and its proarrhythmic effects: A comprehensive review of the evidence from experimental and clinical studies” (英語). Pharmacological Research 151: 104542. doi:10.1016/j.phrs.2019.104542. PMID 31730804.
Kojiri, Katsuhisa; Kondo, Hisao; Yoshinari, Tomoko; Arakawa, Hiroharu; Nakajima, Shigeru; Satoh, Fumio; Kawamura, Kenji; Okura, Akira et al. (1991). “A new antitumor substance, BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.” (英語). The Journal of Antibiotics 44 (7): 723–728. doi:10.7164/antibiotics.44.723. ISSN 0021-8820. PMID 1652582.
Cushman, Mark; Jayaraman, Muthusamy; Vroman, Jeffrey A.; Fukunaga, Anna K.; Fox, Brian M.; Kohlhagen, Glenda; Strumberg, Dirk; Pommier, Yves (October 2000). “Synthesis of New Indeno[1,2- c isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors”] (英語). Journal of Medicinal Chemistry 43 (20): 3688–3698. doi:10.1021/jm000029d. ISSN 0022-2623. PMID 11020283.
Li, Fengzhi; Jiang, Tao; Li, Qingyong; Ling, Xiang (2017-12-01). “Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?”. American Journal of Cancer Research 7 (12): 2350–2394. ISSN 2156-6976. PMC 5752681. PMID 29312794.
Sinha, Birandra K. (1995-01-01). “Topoisomerase Inhibitors” (英語). Drugs 49 (1): 11–19. doi:10.2165/00003495-199549010-00002. ISSN 1179-1950. PMID 7705211.
Pommier, Yves (2009-07-08). “DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition”. Chemical Reviews 109 (7): 2894–2902. doi:10.1021/cr900097c. ISSN 0009-2665. PMC 2707511. PMID 19476377.
Pommier, Yves; Leo, Elisabetta; Zhang, Hongliang; Marchand, Christophe (2010-05-28). “DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs” (英語). Chemistry & Biology 17 (5): 421–433. doi:10.1016/j.chembiol.2010.04.012. ISSN 1074-5521. PMC 7316379. PMID 20534341.
Pommier, Yves (October 2006). “Topoisomerase I inhibitors: camptothecins and beyond” (英語). Nature Reviews Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-1768. PMID 16990856.
Liu, Ying-Qian; Li, Wen-Qun; Morris‐Natschke, Susan L.; Qian, Keduo; Yang, Liu; Zhu, Gao-Xiang; Wu, Xiao-Bing; Chen, An-Liang et al. (2015). “Perspectives on Biologically Active Camptothecin Derivatives” (英語). Medicinal Research Reviews 35 (4): 753–789. doi:10.1002/med.21342. ISSN 1098-1128. PMC 4465867. PMID 25808858.
Cunha, Kênya Silva; Reguly, Maria Luíza; Graf, Ulrich; Rodrigues de Andrade, Heloisa Helena (2002-03-01). “Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination” (英語). Mutagenesis 17 (2): 141–147. doi:10.1093/mutage/17.2.141. ISSN 0267-8357. PMID 11880543.
Hsiang, Y. H.; Hertzberg, R.; Hecht, S.; Liu, L. F. (1985-11-25). “Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I”. The Journal of Biological Chemistry 260 (27): 14873–14878. doi:10.1016/S0021-9258(17)38654-4. ISSN 0021-9258. PMID 2997227.
Staker, Bart L.; Feese, Michael D.; Cushman, Mark; Pommier, Yves; Zembower, David; Stewart, Lance; Burgin, Alex B. (April 2005). “Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex” (英語). Journal of Medicinal Chemistry 48 (7): 2336–2345. doi:10.1021/jm049146p. ISSN 0022-2623. PMID 15801827.
Lu, Ai-jun; Zhang, Zhen-shan; Zheng, Ming-yue; Zou, Han-jun; Luo, Xiao-min; Jiang, Hua-liang (February 2007). “3D-QSAR study of 20 ( S )-camptothecin analogs” (英語). Acta Pharmacologica Sinica 28 (2): 307–314. doi:10.1111/j.1745-7254.2007.00477.x. ISSN 1745-7254. PMID 17241535.
Ulukan, Hulya; Swaan, Peter W. (2002-10-01). “Camptothecins” (英語). Drugs 62 (14): 2039–2057. doi:10.2165/00003495-200262140-00004. ISSN 1179-1950. PMID 12269849.
Lynch, T (1996-12-01). “Topotecan today.”. Journal of Clinical Oncology 14 (12): 3053–3055. doi:10.1200/JCO.1996.14.12.3053. ISSN 0732-183X. PMID 8955649.
Pommier, Yves; Pourquier, Philippe; Urasaki, Yoshimasa; Wu, Jiaxi; Laco, Gary S. (October 1999). “Topoisomerase I inhibitors: selectivity and cellular resistance”. Drug Resistance Updates 2 (5): 307–318. doi:10.1054/drup.1999.0102. ISSN 1368-7646. PMID 11504505.
Pommier, Yves (2006-10). “Topoisomerase I inhibitors: camptothecins and beyond”. Nature Reviews. Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-175X. PMID 16990856.
Long, Byron H.; Rose, William C.; Vyas, Dolatrai M.; Matson, James A.; Forenza, Salvatore (March 2002). “Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles”. Current Medicinal Chemistry. Anti-Cancer Agents 2 (2): 255–266. doi:10.2174/1568011023354218. ISSN 1568-0118. PMID 12678746.
Li, Tsai-Kun; Houghton, Peter J.; Desai, Shyamal D.; Daroui, Parima; Liu, Angela A.; Hars, Eszter S.; Ruchelman, Alexander L.; LaVoie, Edmond J. et al. (2003-12-01). “Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug”. Cancer Research 63 (23): 8400–8407. ISSN 0008-5472. PMID 14679002.
Yamashita, Yoshinori; Fujii, Noboru; Murakata, Chikara; Ashizawa, Tadashi; Okabe, Masami; Nakano, Hirofumi (1992-12-08). “Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives” (英語). Biochemistry 31 (48): 12069–12075. doi:10.1021/bi00163a015. ISSN 0006-2960. PMID 1333791.
Cui, Yue; Wu, Linhui; Cao, Ruoxue; Xu, Hui; Xia, Jun; Wang, Z Peter; Ma, Jia (2020). “Antitumor functions and mechanisms of nitidine chloride in human cancers” (英語). Journal of Cancer 11 (5): 1250–1256. doi:10.7150/jca.37890. ISSN 1837-9664. PMC 6959075. PMID 31956371. http://www.jcancer.org/v11p1250.htm.
Xu, Yang; Her, Chengtao (2015-07-22). “Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy” (英語). Biomolecules 5 (3): 1652–1670. doi:10.3390/biom5031652. ISSN 2218-273X. PMC 4598769. PMID 26287259.
Aldred, Katie J.; Kerns, Robert J.; Osheroff, Neil (2014-03-18). “Mechanism of Quinolone Action and Resistance”. Biochemistry 53 (10): 1565–1574. doi:10.1021/bi5000564. ISSN 0006-2960. PMC 3985860. PMID 24576155.
Hevener, KirkE.; Verstak, Tatsiana A.; Lutat, Katie E.; Riggsbee, Daniel L.; Mooney, Jeremiah W. (October 2018). “Recent developments in topoisomerase-targeted cancer chemotherapy”. Acta Pharmaceutica Sinica B 8 (6): 844–861. doi:10.1016/j.apsb.2018.07.008. ISSN 2211-3835. PMC 6251812. PMID 30505655.
Kampranis, S. C.; Gormley, N. A.; Tranter, R.; Orphanides, G.; Maxwell, A. (1999-02-16). “Probing the binding of coumarins and cyclothialidines to DNA gyrase”. Biochemistry 38 (7): 1967–1976. doi:10.1021/bi982320p. ISSN 0006-2960. PMID 10026280.
Classen, Scott; Olland, Stephane; Berger, James M. (2003-09-16). “Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187” (英語). Proceedings of the National Academy of Sciences 100 (19): 10629–10634. Bibcode: 2003PNAS..10010629C. doi:10.1073/pnas.1832879100. ISSN 0027-8424. PMC 196855. PMID 12963818.
Thorn, Caroline F.; Oshiro, Connie; Marsh, Sharon; Hernandez-Boussard, Tina; McLeod, Howard; Klein, Teri E.; Altman, Russ B. (July 2011). “Doxorubicin pathways: pharmacodynamics and adverse effects” (英語). Pharmacogenetics and Genomics 21 (7): 440–446. doi:10.1097/FPC.0b013e32833ffb56. ISSN 1744-6872. PMC 3116111. PMID 21048526.
Montecucco, Alessandra; Zanetta, Francesca; Biamonti, Giuseppe (2015-01-19). “Molecular mechanisms of etoposide”. EXCLI Journal 14: 95–108. doi:10.17179/excli2014-561. ISSN 1611-2156. PMC 4652635. PMID 26600742.
Lewis, R J; Singh, O M; Smith, C V; Skarzynski, T; Maxwell, A; Wonacott, A J; Wigley, D B (1996-03-15). “The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.”. The EMBO Journal 15 (6): 1412–1420. doi:10.1002/j.1460-2075.1996.tb00483.x. ISSN 0261-4189. PMC 450046. PMID 8635474.
Anderson, V. E.; Osheroff, N. (March 2001). “Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde”. Current Pharmaceutical Design 7 (5): 337–353. doi:10.2174/1381612013398013. ISSN 1381-6128. PMID 11254893.
Collin, Frédéric; Karkare, Shantanu; Maxwell, Anthony (2011-11). “Exploiting bacterial DNA gyrase as a drug target: current state and perspectives”. Applied Microbiology and Biotechnology 92 (3): 479–497. doi:10.1007/s00253-011-3557-z. ISSN 1432-0614. PMC 3189412. PMID 21904817.
Waksman, S. A.; Woodruff, H. B. (1941-08). “Actinomyces antibioticus, a New Soil Organism Antagonistic to Pathogenic and Non-pathogenic Bacteria”. Journal of Bacteriology 42 (2): 231–249. doi:10.1128/jb.42.2.231-249.1941. ISSN 0021-9193. PMC PMC374755. PMID 16560451.
Li, Qun; Mitscher, Lester A.; Shen, Linus L. (2000). “The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors” (英語). Medicinal Research Reviews 20 (4): 231–293. doi:10.1002/1098-1128(200007)20:4<231::AID-MED1>3.0.CO;2-N. ISSN 1098-1128. PMID 10861727.
Bisacchi, Gregory S. (2015-06-25). “Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story"”. Journal of Medicinal Chemistry 58 (12): 4874–4882. doi:10.1021/jm501881c. ISSN 1520-4804. PMID 25738967.
Laponogov, Ivan; Sohi, Maninder K; Veselkov, Dennis A; Pan, Xiao-Su; Sawhney, Ritica; Thompson, Andrew W; McAuley, Katherine E; Fisher, L Mark et al. (June 2009). “Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases” (英語). Nature Structural & Molecular Biology 16 (6): 667–669. doi:10.1038/nsmb.1604. ISSN 1545-9993. PMID 19448616.
Wolfson, John S.; Hooper, David C. (1991-12-30). “Overview of fluoroquinolone safety” (英語). The American Journal of Medicine. Fluoroquinolones in the Treatment of Human Infection: The Role of Temafloxacin 91 (6, Supplement 1): S153–S161. doi:10.1016/0002-9343(91)90330-Z. ISSN 0002-9343. PMID 1767803.
Drlica, Karl; Hiasa, Hiroshi; Kerns, Robert; Malik, Muhammad; Mustaev, Arkady; Zhao, Xilin (August 2009). “Quinolones: Action and Resistance Updated”. Current Topics in Medicinal Chemistry 9 (11): 981–998. doi:10.2174/156802609789630947. ISSN 1568-0266. PMC 3182077. PMID 19747119.
Yoshida, H.; Bogaki, M.; Nakamura, M.; Yamanaka, L. M.; Nakamura, S. (1991-08-01). “Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.” (英語). Antimicrobial Agents and Chemotherapy 35 (8): 1647–1650. doi:10.1128/AAC.35.8.1647. ISSN 0066-4804. PMC 245234. PMID 1656869.
Shen, Linus L.; Mitscher, Lester A.; Sharma, Padam N.; O'Donnell, T. J.; Chu, Daniel W. T.; Cooper, Curt S.; Rosen, Terry; Pernet, Andre G. (1989-05-02). “Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model” (英語). Biochemistry 28 (9): 3886–3894. doi:10.1021/bi00435a039. ISSN 0006-2960. PMID 2546585.
Nitiss, John L. (May 2009). “Targeting DNA topoisomerase II in cancer chemotherapy”. Nature Reviews. Cancer 9 (5): 338–350. doi:10.1038/nrc2607. ISSN 1474-175X. PMC 2748742. PMID 19377506.
Wohlkonig, Alexandre; Chan, Pan F; Fosberry, Andrew P; Homes, Paul; Huang, Jianzhong; Kranz, Michael; Leydon, Vaughan R; Miles, Timothy J et al. (2010-08-29). “Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance”. Nature Structural & Molecular Biology 17 (9): 1152–1153. doi:10.1038/nsmb.1892. ISSN 1545-9993. PMID 20802486. https://doi.org/10.1038/nsmb.1892.
Leo, Elisabetta; Gould, Katherine A.; Pan, Xiao-Su; Capranico, Giovanni; Sanderson, Mark R.; Palumbo, Manlio; Fisher, L. Mark (2005-01-18). “Novel Symmetric and Asymmetric DNA Scission Determinants forStreptococcus pneumoniaeTopoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site”. Journal of Biological Chemistry 280 (14): 14252–14263. doi:10.1074/jbc.m500156200. ISSN 0021-9258. PMID 15659402.
Atwal, Mandeep; Swan, Rebecca L.; Rowe, Chloe; Lee, Ka C.; Lee, David C.; Armstrong, Lyle; Cowell, Ian G.; Austin, Caroline A. (October 2019). “Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations”. Molecular Pharmacology 96 (4): 475–484. doi:10.1124/mol.119.117259. ISSN 0026-895X. PMC 6744389. PMID 31399497.
McGowan, John V; Chung, Robin; Maulik, Angshuman; Piotrowska, Izabela; Walker, J Malcolm; Yellon, Derek M (February 2017). “Anthracycline Chemotherapy and Cardiotoxicity” (英語). Cardiovascular Drugs and Therapy 31 (1): 63–75. doi:10.1007/s10557-016-6711-0. ISSN 0920-3206. PMC 5346598. PMID 28185035.
Matyszewska, Dorota; Nazaruk, Ewa; Campbell, Richard A. (January 2021). “Interactions of anticancer drugs doxorubicin and idarubicin with lipid monolayers: New insight into the composition, structure and morphology” (英語). Journal of Colloid and Interface Science 581 (Pt A): 403–416. Bibcode: 2021JCIS..581..403M. doi:10.1016/j.jcis.2020.07.092. PMID 32771749.
Imbert, T. F. (March 1998). “Discovery of podophyllotoxins”. Biochimie 80 (3): 207–222. doi:10.1016/s0300-9084(98)80004-7. ISSN 0300-9084. PMID 9615861.
Clark, Peter I.; Slevin, Maurice L. (1987-04-01). “The Clinical Pharmacology of Etoposide and Teniposide” (英語). Clinical Pharmacokinetics 12 (4): 223–252. doi:10.2165/00003088-198712040-00001. ISSN 1179-1926. PMID 3297462.
Vogelzang, N. J.; Raghavan, D.; Kennedy, B. J. (January 1982). “VP-16-213 (etoposide): the mandrake root from Issyk-Kul”. The American Journal of Medicine 72 (1): 136–144. doi:10.1016/0002-9343(82)90600-3. ISSN 0002-9343. PMID 6277188.
Postmus, Haaxma-Reiche, Smit, Groen, Karnicka, Lewinski, Meerbeeck, Clerico, Gregor, Curran, Sahmoud, Kirkpatrick, and Giaccone, Pieter E., Hanny, Egbert, Groen, Hanna, Tadeusz, Jan van, Mario, Anna, Desmond, Tarek, Anne, and Giuseppe (2000). “Treatment of Brain Metastases of Small-Cell Lung Cancer: Comparing Teniposide and Teniposide With Whole-Brain Radiotherapy—A Phase III Study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group”. Journal of Clinical Oncology 18 (19 (October 1)): 3400–3408. doi:10.1200/JCO.2000.18.19.3400. PMID 11013281.
Guryanova, Olga A.; Shank, Kaitlyn; Spitzer, Barbara; Luciani, Luisa; Koche, Richard P.; Garrett-Bakelman, Francine E.; Ganzel, Chezi; Durham, Benjamin H. et al. (December 2016). “DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling”. Nature Medicine 22 (12): 1488–1495. doi:10.1038/nm.4210. ISSN 1546-170X. PMC 5359771. PMID 27841873.
Ganapathi, R.; Constantinou, A.; Kamath, N.; Dubyak, G.; Grabowski, D.; Krivacic, K. (1996-08-01). “Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.” (英語). Molecular Pharmacology 50 (2): 243–248. ISSN 0026-895X. PMID 8700130.
Ganapathi, Ram N.; Ganapathi, Mahrukh K. (2013-08-01). “Mechanisms regulating resistance to inhibitors of topoisomerase II”. Frontiers in Pharmacology 4: 89. doi:10.3389/fphar.2013.00089. ISSN 1663-9812. PMC 3729981. PMID 23914174.
Matsumoto, Yoshihito; Takano, Hiroshi; Kunishio, Katsuzo; Nagao, Seigo; Fojo, Tito (2001). “Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines” (英語). Japanese Journal of Cancer Research 92 (10): 1133–1137. doi:10.1111/j.1349-7006.2001.tb01069.x. ISSN 1349-7006. PMC 5926608. PMID 11676865.
Andoh, Toshiwo; Ishida, Ryoji (1998-10-01). “Catalytic inhibitors of DNA topoisomerase II” (英語). Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1400 (1): 155–171. doi:10.1016/S0167-4781(98)00133-X. ISSN 0167-4781. PMID 9748552.
Kerrigan, D.; Pommier, Y.; Kohn, K. W. (1987). “Protein-linked DNA strand breaks produced by etoposide and teniposide in mouse L1210 and human VA-13 and HT-29 cell lines: relationship to cytotoxicity”. NCI Monographs (4): 117–121. ISSN 0893-2751. PMID 3041238.
Andoh, T. (March 1998). “Bis(2,6-dioxopiperazines), catalytic inhibitors of DNA topoisomerase II, as molecular probes, cardioprotectors and antitumor drugs”. Biochimie 80 (3): 235–246. doi:10.1016/s0300-9084(98)80006-0. ISSN 0300-9084. PMID 9615863.
Langer, Seppo W (2014-09-15). “Dexrazoxane for the treatment of chemotherapy-related side effects”. Cancer Management and Research 6: 357–363. doi:10.2147/CMAR.S47238. ISSN 1179-1322. PMC 4168851. PMID 25246808.
Weiss, G.; Loyevsky, M.; Gordeuk, V. R. (January 1999). “Dexrazoxane (ICRF-187)”. General Pharmacology 32 (1): 155–158. doi:10.1016/s0306-3623(98)00100-1. ISSN 0306-3623. PMID 9888268.
“Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer”. Proc. Natl. Acad. Sci. U.S.A. 103 (23): 8822–7. (2006). Bibcode: 2006PNAS..103.8822A. doi:10.1073/pnas.0600645103. PMC 1466544. PMID 16723399.
“Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology”. Semin. Cancer Biol. 20 (5): 329–39. (2010). doi:10.1016/j.semcancer.2010.10.002. PMC 3040982. PMID 20934517.
“Correlation between the methylation of SULF2 and WRN promoter and the irinotecan chemosensitivity in gastric cancer”. BMC Gastroenterol. 13: 173. (2013). doi:10.1186/1471-230X-13-173. PMC 3877991. PMID 24359226.
“Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease”. Biogerontology 13 (1): 49–62. (2012). doi:10.1007/s10522-011-9341-8. PMID 21786128.
“Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells”. Oncol. Rep. 28 (4): 1146–52. (2012). doi:10.3892/or.2012.1912. PMC 3583574. PMID 22797812.
“Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase”. Biol. Pharm. Bull. 30 (10): 1958–61. (2007). doi:10.1248/bpb.30.1958. PMID 17917271.
“Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells”. Cancer Sci. 99 (5): 843–8. (2008). doi:10.1111/j.1349-7006.2008.00778.x. PMID 18312465.

pmc.ncbi.nlm.nih.gov

Delgado, Justine L.; Hsieh, Chao-Ming; Chan, Nei-Li; Hiasa, Hiroshi (2018-01-31). “Topoisomerases as anticancer targets” (英語). Biochemical Journal 475 (2): 373–398. doi:10.1042/BCJ20160583. ISSN 0264-6021. PMC 6110615. PMID 29363591.
Waksman, Selman A.; Woodruff, H. Boyd (1940). “The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria*1”. Journal of Bacteriology 40 (4): 581–600. doi:10.1128/jb.40.4.581-600.1940. ISSN 0021-9193. PMC 374661. PMID 16560371.
Marinello, Jessica; Delcuratolo, Maria; Capranico, Giovanni (2018-11-06). “Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives”. International Journal of Molecular Sciences 19 (11): 3480. doi:10.3390/ijms19113480. ISSN 1422-0067. PMC 6275052. PMID 30404148.
Buzun, Kamila; Bielawska, Anna; Bielawski, Krzysztof; Gornowicz, Agnieszka (2020-01-01). “DNA topoisomerases as molecular targets for anticancer drugs” (英語). Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1): 1781–1799. doi:10.1080/14756366.2020.1821676. ISSN 1475-6366. PMC 7534307. PMID 32975138.
Gellert, M.; Mizuuchi, K.; O'Dea, M. H.; Nash, H. A. (1976-11-01). “DNA gyrase: an enzyme that introduces superhelical turns into DNA.” (英語). Proceedings of the National Academy of Sciences 73 (11): 3872–3876. Bibcode: 1976PNAS...73.3872G. doi:10.1073/pnas.73.11.3872. ISSN 0027-8424. PMC 431247. PMID 186775.
Li, Fengzhi; Jiang, Tao; Li, Qingyong; Ling, Xiang (2017-12-01). “Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?”. American Journal of Cancer Research 7 (12): 2350–2394. ISSN 2156-6976. PMC 5752681. PMID 29312794.
Pommier, Yves (2009-07-08). “DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition”. Chemical Reviews 109 (7): 2894–2902. doi:10.1021/cr900097c. ISSN 0009-2665. PMC 2707511. PMID 19476377.
Pommier, Yves; Leo, Elisabetta; Zhang, Hongliang; Marchand, Christophe (2010-05-28). “DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs” (英語). Chemistry & Biology 17 (5): 421–433. doi:10.1016/j.chembiol.2010.04.012. ISSN 1074-5521. PMC 7316379. PMID 20534341.
Liu, Ying-Qian; Li, Wen-Qun; Morris‐Natschke, Susan L.; Qian, Keduo; Yang, Liu; Zhu, Gao-Xiang; Wu, Xiao-Bing; Chen, An-Liang et al. (2015). “Perspectives on Biologically Active Camptothecin Derivatives” (英語). Medicinal Research Reviews 35 (4): 753–789. doi:10.1002/med.21342. ISSN 1098-1128. PMC 4465867. PMID 25808858.
Cui, Yue; Wu, Linhui; Cao, Ruoxue; Xu, Hui; Xia, Jun; Wang, Z Peter; Ma, Jia (2020). “Antitumor functions and mechanisms of nitidine chloride in human cancers” (英語). Journal of Cancer 11 (5): 1250–1256. doi:10.7150/jca.37890. ISSN 1837-9664. PMC 6959075. PMID 31956371. http://www.jcancer.org/v11p1250.htm.
Xu, Yang; Her, Chengtao (2015-07-22). “Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy” (英語). Biomolecules 5 (3): 1652–1670. doi:10.3390/biom5031652. ISSN 2218-273X. PMC 4598769. PMID 26287259.
Aldred, Katie J.; Kerns, Robert J.; Osheroff, Neil (2014-03-18). “Mechanism of Quinolone Action and Resistance”. Biochemistry 53 (10): 1565–1574. doi:10.1021/bi5000564. ISSN 0006-2960. PMC 3985860. PMID 24576155.
Hevener, KirkE.; Verstak, Tatsiana A.; Lutat, Katie E.; Riggsbee, Daniel L.; Mooney, Jeremiah W. (October 2018). “Recent developments in topoisomerase-targeted cancer chemotherapy”. Acta Pharmaceutica Sinica B 8 (6): 844–861. doi:10.1016/j.apsb.2018.07.008. ISSN 2211-3835. PMC 6251812. PMID 30505655.
Classen, Scott; Olland, Stephane; Berger, James M. (2003-09-16). “Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187” (英語). Proceedings of the National Academy of Sciences 100 (19): 10629–10634. Bibcode: 2003PNAS..10010629C. doi:10.1073/pnas.1832879100. ISSN 0027-8424. PMC 196855. PMID 12963818.
Thorn, Caroline F.; Oshiro, Connie; Marsh, Sharon; Hernandez-Boussard, Tina; McLeod, Howard; Klein, Teri E.; Altman, Russ B. (July 2011). “Doxorubicin pathways: pharmacodynamics and adverse effects” (英語). Pharmacogenetics and Genomics 21 (7): 440–446. doi:10.1097/FPC.0b013e32833ffb56. ISSN 1744-6872. PMC 3116111. PMID 21048526.
Montecucco, Alessandra; Zanetta, Francesca; Biamonti, Giuseppe (2015-01-19). “Molecular mechanisms of etoposide”. EXCLI Journal 14: 95–108. doi:10.17179/excli2014-561. ISSN 1611-2156. PMC 4652635. PMID 26600742.
Lewis, R J; Singh, O M; Smith, C V; Skarzynski, T; Maxwell, A; Wonacott, A J; Wigley, D B (1996-03-15). “The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.”. The EMBO Journal 15 (6): 1412–1420. doi:10.1002/j.1460-2075.1996.tb00483.x. ISSN 0261-4189. PMC 450046. PMID 8635474.
Collin, Frédéric; Karkare, Shantanu; Maxwell, Anthony (2011-11). “Exploiting bacterial DNA gyrase as a drug target: current state and perspectives”. Applied Microbiology and Biotechnology 92 (3): 479–497. doi:10.1007/s00253-011-3557-z. ISSN 1432-0614. PMC 3189412. PMID 21904817.
Waksman, S. A.; Woodruff, H. B. (1941-08). “Actinomyces antibioticus, a New Soil Organism Antagonistic to Pathogenic and Non-pathogenic Bacteria”. Journal of Bacteriology 42 (2): 231–249. doi:10.1128/jb.42.2.231-249.1941. ISSN 0021-9193. PMC PMC374755. PMID 16560451.
Drlica, Karl; Hiasa, Hiroshi; Kerns, Robert; Malik, Muhammad; Mustaev, Arkady; Zhao, Xilin (August 2009). “Quinolones: Action and Resistance Updated”. Current Topics in Medicinal Chemistry 9 (11): 981–998. doi:10.2174/156802609789630947. ISSN 1568-0266. PMC 3182077. PMID 19747119.
Yoshida, H.; Bogaki, M.; Nakamura, M.; Yamanaka, L. M.; Nakamura, S. (1991-08-01). “Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.” (英語). Antimicrobial Agents and Chemotherapy 35 (8): 1647–1650. doi:10.1128/AAC.35.8.1647. ISSN 0066-4804. PMC 245234. PMID 1656869.
Nitiss, John L. (May 2009). “Targeting DNA topoisomerase II in cancer chemotherapy”. Nature Reviews. Cancer 9 (5): 338–350. doi:10.1038/nrc2607. ISSN 1474-175X. PMC 2748742. PMID 19377506.
Atwal, Mandeep; Swan, Rebecca L.; Rowe, Chloe; Lee, Ka C.; Lee, David C.; Armstrong, Lyle; Cowell, Ian G.; Austin, Caroline A. (October 2019). “Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations”. Molecular Pharmacology 96 (4): 475–484. doi:10.1124/mol.119.117259. ISSN 0026-895X. PMC 6744389. PMID 31399497.
McGowan, John V; Chung, Robin; Maulik, Angshuman; Piotrowska, Izabela; Walker, J Malcolm; Yellon, Derek M (February 2017). “Anthracycline Chemotherapy and Cardiotoxicity” (英語). Cardiovascular Drugs and Therapy 31 (1): 63–75. doi:10.1007/s10557-016-6711-0. ISSN 0920-3206. PMC 5346598. PMID 28185035.
Guryanova, Olga A.; Shank, Kaitlyn; Spitzer, Barbara; Luciani, Luisa; Koche, Richard P.; Garrett-Bakelman, Francine E.; Ganzel, Chezi; Durham, Benjamin H. et al. (December 2016). “DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling”. Nature Medicine 22 (12): 1488–1495. doi:10.1038/nm.4210. ISSN 1546-170X. PMC 5359771. PMID 27841873.
Ganapathi, Ram N.; Ganapathi, Mahrukh K. (2013-08-01). “Mechanisms regulating resistance to inhibitors of topoisomerase II”. Frontiers in Pharmacology 4: 89. doi:10.3389/fphar.2013.00089. ISSN 1663-9812. PMC 3729981. PMID 23914174.
Matsumoto, Yoshihito; Takano, Hiroshi; Kunishio, Katsuzo; Nagao, Seigo; Fojo, Tito (2001). “Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines” (英語). Japanese Journal of Cancer Research 92 (10): 1133–1137. doi:10.1111/j.1349-7006.2001.tb01069.x. ISSN 1349-7006. PMC 5926608. PMID 11676865.
Langer, Seppo W (2014-09-15). “Dexrazoxane for the treatment of chemotherapy-related side effects”. Cancer Management and Research 6: 357–363. doi:10.2147/CMAR.S47238. ISSN 1179-1322. PMC 4168851. PMID 25246808.
“Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer”. Proc. Natl. Acad. Sci. U.S.A. 103 (23): 8822–7. (2006). Bibcode: 2006PNAS..103.8822A. doi:10.1073/pnas.0600645103. PMC 1466544. PMID 16723399.
“Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology”. Semin. Cancer Biol. 20 (5): 329–39. (2010). doi:10.1016/j.semcancer.2010.10.002. PMC 3040982. PMID 20934517.
“Correlation between the methylation of SULF2 and WRN promoter and the irinotecan chemosensitivity in gastric cancer”. BMC Gastroenterol. 13: 173. (2013). doi:10.1186/1471-230X-13-173. PMC 3877991. PMID 24359226.
“Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells”. Oncol. Rep. 28 (4): 1146–52. (2012). doi:10.3892/or.2012.1912. PMC 3583574. PMID 22797812.

ncbi.nlm.nih.gov

Waksman, Selman A.; Woodruff, H. Boyd (1940). “The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria*1”. Journal of Bacteriology 40 (4): 581–600. doi:10.1128/jb.40.4.581-600.1940. ISSN 0021-9193. PMC 374661. PMID 16560371.
Marinello, Jessica; Delcuratolo, Maria; Capranico, Giovanni (2018-11-06). “Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives”. International Journal of Molecular Sciences 19 (11): 3480. doi:10.3390/ijms19113480. ISSN 1422-0067. PMC 6275052. PMID 30404148.
Buzun, Kamila; Bielawska, Anna; Bielawski, Krzysztof; Gornowicz, Agnieszka (2020-01-01). “DNA topoisomerases as molecular targets for anticancer drugs” (英語). Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1): 1781–1799. doi:10.1080/14756366.2020.1821676. ISSN 1475-6366. PMC 7534307. PMID 32975138.
Gellert, M.; Mizuuchi, K.; O'Dea, M. H.; Nash, H. A. (1976-11-01). “DNA gyrase: an enzyme that introduces superhelical turns into DNA.” (英語). Proceedings of the National Academy of Sciences 73 (11): 3872–3876. Bibcode: 1976PNAS...73.3872G. doi:10.1073/pnas.73.11.3872. ISSN 0027-8424. PMC 431247. PMID 186775.
Li, Fengzhi; Jiang, Tao; Li, Qingyong; Ling, Xiang (2017-12-01). “Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?”. American Journal of Cancer Research 7 (12): 2350–2394. ISSN 2156-6976. PMC 5752681. PMID 29312794.
Pommier, Yves (2009-07-08). “DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition”. Chemical Reviews 109 (7): 2894–2902. doi:10.1021/cr900097c. ISSN 0009-2665. PMC 2707511. PMID 19476377.
Pommier, Yves; Leo, Elisabetta; Zhang, Hongliang; Marchand, Christophe (2010-05-28). “DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs” (英語). Chemistry & Biology 17 (5): 421–433. doi:10.1016/j.chembiol.2010.04.012. ISSN 1074-5521. PMC 7316379. PMID 20534341.
Liu, Ying-Qian; Li, Wen-Qun; Morris‐Natschke, Susan L.; Qian, Keduo; Yang, Liu; Zhu, Gao-Xiang; Wu, Xiao-Bing; Chen, An-Liang et al. (2015). “Perspectives on Biologically Active Camptothecin Derivatives” (英語). Medicinal Research Reviews 35 (4): 753–789. doi:10.1002/med.21342. ISSN 1098-1128. PMC 4465867. PMID 25808858.
Xu, Yang; Her, Chengtao (2015-07-22). “Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy” (英語). Biomolecules 5 (3): 1652–1670. doi:10.3390/biom5031652. ISSN 2218-273X. PMC 4598769. PMID 26287259.
Aldred, Katie J.; Kerns, Robert J.; Osheroff, Neil (2014-03-18). “Mechanism of Quinolone Action and Resistance”. Biochemistry 53 (10): 1565–1574. doi:10.1021/bi5000564. ISSN 0006-2960. PMC 3985860. PMID 24576155.
Hevener, KirkE.; Verstak, Tatsiana A.; Lutat, Katie E.; Riggsbee, Daniel L.; Mooney, Jeremiah W. (October 2018). “Recent developments in topoisomerase-targeted cancer chemotherapy”. Acta Pharmaceutica Sinica B 8 (6): 844–861. doi:10.1016/j.apsb.2018.07.008. ISSN 2211-3835. PMC 6251812. PMID 30505655.
Classen, Scott; Olland, Stephane; Berger, James M. (2003-09-16). “Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187” (英語). Proceedings of the National Academy of Sciences 100 (19): 10629–10634. Bibcode: 2003PNAS..10010629C. doi:10.1073/pnas.1832879100. ISSN 0027-8424. PMC 196855. PMID 12963818.
Thorn, Caroline F.; Oshiro, Connie; Marsh, Sharon; Hernandez-Boussard, Tina; McLeod, Howard; Klein, Teri E.; Altman, Russ B. (July 2011). “Doxorubicin pathways: pharmacodynamics and adverse effects” (英語). Pharmacogenetics and Genomics 21 (7): 440–446. doi:10.1097/FPC.0b013e32833ffb56. ISSN 1744-6872. PMC 3116111. PMID 21048526.
Montecucco, Alessandra; Zanetta, Francesca; Biamonti, Giuseppe (2015-01-19). “Molecular mechanisms of etoposide”. EXCLI Journal 14: 95–108. doi:10.17179/excli2014-561. ISSN 1611-2156. PMC 4652635. PMID 26600742.
Lewis, R J; Singh, O M; Smith, C V; Skarzynski, T; Maxwell, A; Wonacott, A J; Wigley, D B (1996-03-15). “The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.”. The EMBO Journal 15 (6): 1412–1420. doi:10.1002/j.1460-2075.1996.tb00483.x. ISSN 0261-4189. PMC 450046. PMID 8635474.
Drlica, Karl; Hiasa, Hiroshi; Kerns, Robert; Malik, Muhammad; Mustaev, Arkady; Zhao, Xilin (August 2009). “Quinolones: Action and Resistance Updated”. Current Topics in Medicinal Chemistry 9 (11): 981–998. doi:10.2174/156802609789630947. ISSN 1568-0266. PMC 3182077. PMID 19747119.
Yoshida, H.; Bogaki, M.; Nakamura, M.; Yamanaka, L. M.; Nakamura, S. (1991-08-01). “Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.” (英語). Antimicrobial Agents and Chemotherapy 35 (8): 1647–1650. doi:10.1128/AAC.35.8.1647. ISSN 0066-4804. PMC 245234. PMID 1656869.
Nitiss, John L. (May 2009). “Targeting DNA topoisomerase II in cancer chemotherapy”. Nature Reviews. Cancer 9 (5): 338–350. doi:10.1038/nrc2607. ISSN 1474-175X. PMC 2748742. PMID 19377506.
Atwal, Mandeep; Swan, Rebecca L.; Rowe, Chloe; Lee, Ka C.; Lee, David C.; Armstrong, Lyle; Cowell, Ian G.; Austin, Caroline A. (October 2019). “Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations”. Molecular Pharmacology 96 (4): 475–484. doi:10.1124/mol.119.117259. ISSN 0026-895X. PMC 6744389. PMID 31399497.
McGowan, John V; Chung, Robin; Maulik, Angshuman; Piotrowska, Izabela; Walker, J Malcolm; Yellon, Derek M (February 2017). “Anthracycline Chemotherapy and Cardiotoxicity” (英語). Cardiovascular Drugs and Therapy 31 (1): 63–75. doi:10.1007/s10557-016-6711-0. ISSN 0920-3206. PMC 5346598. PMID 28185035.
Guryanova, Olga A.; Shank, Kaitlyn; Spitzer, Barbara; Luciani, Luisa; Koche, Richard P.; Garrett-Bakelman, Francine E.; Ganzel, Chezi; Durham, Benjamin H. et al. (December 2016). “DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling”. Nature Medicine 22 (12): 1488–1495. doi:10.1038/nm.4210. ISSN 1546-170X. PMC 5359771. PMID 27841873.
Ganapathi, Ram N.; Ganapathi, Mahrukh K. (2013-08-01). “Mechanisms regulating resistance to inhibitors of topoisomerase II”. Frontiers in Pharmacology 4: 89. doi:10.3389/fphar.2013.00089. ISSN 1663-9812. PMC 3729981. PMID 23914174.
Matsumoto, Yoshihito; Takano, Hiroshi; Kunishio, Katsuzo; Nagao, Seigo; Fojo, Tito (2001). “Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines” (英語). Japanese Journal of Cancer Research 92 (10): 1133–1137. doi:10.1111/j.1349-7006.2001.tb01069.x. ISSN 1349-7006. PMC 5926608. PMID 11676865.
Langer, Seppo W (2014-09-15). “Dexrazoxane for the treatment of chemotherapy-related side effects”. Cancer Management and Research 6: 357–363. doi:10.2147/CMAR.S47238. ISSN 1179-1322. PMC 4168851. PMID 25246808.
“Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer”. Proc. Natl. Acad. Sci. U.S.A. 103 (23): 8822–7. (2006). Bibcode: 2006PNAS..103.8822A. doi:10.1073/pnas.0600645103. PMC 1466544. PMID 16723399.
“Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology”. Semin. Cancer Biol. 20 (5): 329–39. (2010). doi:10.1016/j.semcancer.2010.10.002. PMC 3040982. PMID 20934517.
“Correlation between the methylation of SULF2 and WRN promoter and the irinotecan chemosensitivity in gastric cancer”. BMC Gastroenterol. 13: 173. (2013). doi:10.1186/1471-230X-13-173. PMC 3877991. PMID 24359226.
“Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells”. Oncol. Rep. 28 (4): 1146–52. (2012). doi:10.3892/or.2012.1912. PMC 3583574. PMID 22797812.

pubchem.ncbi.nlm.nih.gov

PubChem. “Dexrazoxane” (英語). pubchem.ncbi.nlm.nih.gov. 2020年12月10日閲覧。
PubChem. “Novobiocin” (英語). pubchem.ncbi.nlm.nih.gov. 2020年12月10日閲覧。

oup.com

academic.oup.com

Cunha, Kênya Silva; Reguly, Maria Luíza; Graf, Ulrich; Rodrigues de Andrade, Heloisa Helena (2002-03-01). “Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination” (英語). Mutagenesis 17 (2): 141–147. doi:10.1093/mutage/17.2.141. ISSN 0267-8357. PMID 11880543.

portlandpress.com

Delgado, Justine L.; Hsieh, Chao-Ming; Chan, Nei-Li; Hiasa, Hiroshi (2018-01-31). “Topoisomerases as anticancer targets” (英語). Biochemical Journal 475 (2): 373–398. doi:10.1042/BCJ20160583. ISSN 0264-6021. PMC 6110615. PMID 29363591.

sciencedirect.com

Andoh, Toshiwo; Ishida, Ryoji (1998-10-01). “Catalytic inhibitors of DNA topoisomerase II” (英語). Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1400 (1): 155–171. doi:10.1016/S0167-4781(98)00133-X. ISSN 0167-4781. PMID 9748552.

springer.com

link.springer.com

Chevrette, Marc G.; Currie, Cameron R. (March 2019). “Emerging evolutionary paradigms in antibiotic discovery” (英語). Journal of Industrial Microbiology & Biotechnology 46 (3–4): 257–271. doi:10.1007/s10295-018-2085-6. ISSN 1367-5435. PMID 30269177.
Hu, Guohua; Zekria, David; Cai, Xun; Ni, Xiaoling (June 2015). “Current status of CPT and its analogues in the treatment of malignancies” (英語). Phytochemistry Reviews 14 (3): 429–441. doi:10.1007/s11101-015-9397-1. ISSN 1568-7767.

umn.edu

ageconsearch.umn.edu

Perdue, Robert E.; Smith, Robert L.; Wall, Monroe E.; Hartwell, Jonathan L.; Abbott, Betty J.; Perdue, Robert E.; Smith, Robert L.; Wall, Monroe E. et al. (1970) (英語). Camptotheca acuminata Decaisne (Nyssaceae) Source of Camptothecin, an Antileukemic Alkaloid. Technical Bulletin. doi:10.22004/AG.ECON.171841.

who.int

apps.who.int

World Health Organization (2019) (英語). World Health Organization model list of essential medicines: 21st list 2019.

wiley.com

onlinelibrary.wiley.com

doi.wiley.com

Bush, Karen (December 2010). “The coming of age of antibiotics: discovery and therapeutic value: Origins of antibiotic drug discovery” (英語). Annals of the New York Academy of Sciences 1213 (1): 1–4. doi:10.1111/j.1749-6632.2010.05872.x. PMID 21175674.

worldcat.org

search.worldcat.org

Delgado, Justine L.; Hsieh, Chao-Ming; Chan, Nei-Li; Hiasa, Hiroshi (2018-01-31). “Topoisomerases as anticancer targets” (英語). Biochemical Journal 475 (2): 373–398. doi:10.1042/BCJ20160583. ISSN 0264-6021. PMC 6110615. PMID 29363591.
Waksman, Selman A.; Woodruff, H. Boyd (1940). “The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria*1”. Journal of Bacteriology 40 (4): 581–600. doi:10.1128/jb.40.4.581-600.1940. ISSN 0021-9193. PMC 374661. PMID 16560371.
Chevrette, Marc G.; Currie, Cameron R. (March 2019). “Emerging evolutionary paradigms in antibiotic discovery” (英語). Journal of Industrial Microbiology & Biotechnology 46 (3–4): 257–271. doi:10.1007/s10295-018-2085-6. ISSN 1367-5435. PMID 30269177.
Di Marco, A.; Cassinelli, G.; Arcamone, F. (1981). “The discovery of daunorubicin”. Cancer Treatment Reports 65 Suppl 4: 3–8. ISSN 0361-5960. PMID 7049379.
Marinello, Jessica; Delcuratolo, Maria; Capranico, Giovanni (2018-11-06). “Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives”. International Journal of Molecular Sciences 19 (11): 3480. doi:10.3390/ijms19113480. ISSN 1422-0067. PMC 6275052. PMID 30404148.
Buzun, Kamila; Bielawska, Anna; Bielawski, Krzysztof; Gornowicz, Agnieszka (2020-01-01). “DNA topoisomerases as molecular targets for anticancer drugs” (英語). Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1): 1781–1799. doi:10.1080/14756366.2020.1821676. ISSN 1475-6366. PMC 7534307. PMID 32975138.
Wall, Monroe E. (1998). “Camptothecin and taxol: Discovery to clinic” (英語). Medicinal Research Reviews 18 (5): 299–314. doi:10.1002/(SICI)1098-1128(199809)18:5<299::AID-MED2>3.0.CO;2-O. ISSN 1098-1128. PMID 9735871.
Mitscher, Lester A. (2005-06-14). “Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents”. ChemInform 36 (24): 559–92. doi:10.1002/chin.200524274. ISSN 0931-7597. PMID 15700957.
Gellert, M.; Mizuuchi, K.; O'Dea, M. H.; Nash, H. A. (1976-11-01). “DNA gyrase: an enzyme that introduces superhelical turns into DNA.” (英語). Proceedings of the National Academy of Sciences 73 (11): 3872–3876. Bibcode: 1976PNAS...73.3872G. doi:10.1073/pnas.73.11.3872. ISSN 0027-8424. PMC 431247. PMID 186775.
Sinkule, J. A. (March 1984). “Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent”. Pharmacotherapy 4 (2): 61–73. doi:10.1002/j.1875-9114.1984.tb03318.x. ISSN 0277-0008. PMID 6326063.
Kojiri, Katsuhisa; Kondo, Hisao; Yoshinari, Tomoko; Arakawa, Hiroharu; Nakajima, Shigeru; Satoh, Fumio; Kawamura, Kenji; Okura, Akira et al. (1991). “A new antitumor substance, BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.” (英語). The Journal of Antibiotics 44 (7): 723–728. doi:10.7164/antibiotics.44.723. ISSN 0021-8820. PMID 1652582.
Cushman, Mark; Jayaraman, Muthusamy; Vroman, Jeffrey A.; Fukunaga, Anna K.; Fox, Brian M.; Kohlhagen, Glenda; Strumberg, Dirk; Pommier, Yves (October 2000). “Synthesis of New Indeno[1,2- c isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors”] (英語). Journal of Medicinal Chemistry 43 (20): 3688–3698. doi:10.1021/jm000029d. ISSN 0022-2623. PMID 11020283.
Li, Fengzhi; Jiang, Tao; Li, Qingyong; Ling, Xiang (2017-12-01). “Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?”. American Journal of Cancer Research 7 (12): 2350–2394. ISSN 2156-6976. PMC 5752681. PMID 29312794.
Sinha, Birandra K. (1995-01-01). “Topoisomerase Inhibitors” (英語). Drugs 49 (1): 11–19. doi:10.2165/00003495-199549010-00002. ISSN 1179-1950. PMID 7705211.
Pommier, Yves (2009-07-08). “DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition”. Chemical Reviews 109 (7): 2894–2902. doi:10.1021/cr900097c. ISSN 0009-2665. PMC 2707511. PMID 19476377.
Pommier, Yves; Leo, Elisabetta; Zhang, Hongliang; Marchand, Christophe (2010-05-28). “DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs” (英語). Chemistry & Biology 17 (5): 421–433. doi:10.1016/j.chembiol.2010.04.012. ISSN 1074-5521. PMC 7316379. PMID 20534341.
Pommier, Yves (October 2006). “Topoisomerase I inhibitors: camptothecins and beyond” (英語). Nature Reviews Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-1768. PMID 16990856.
Liu, Ying-Qian; Li, Wen-Qun; Morris‐Natschke, Susan L.; Qian, Keduo; Yang, Liu; Zhu, Gao-Xiang; Wu, Xiao-Bing; Chen, An-Liang et al. (2015). “Perspectives on Biologically Active Camptothecin Derivatives” (英語). Medicinal Research Reviews 35 (4): 753–789. doi:10.1002/med.21342. ISSN 1098-1128. PMC 4465867. PMID 25808858.
Cunha, Kênya Silva; Reguly, Maria Luíza; Graf, Ulrich; Rodrigues de Andrade, Heloisa Helena (2002-03-01). “Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination” (英語). Mutagenesis 17 (2): 141–147. doi:10.1093/mutage/17.2.141. ISSN 0267-8357. PMID 11880543.
Hsiang, Y. H.; Hertzberg, R.; Hecht, S.; Liu, L. F. (1985-11-25). “Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I”. The Journal of Biological Chemistry 260 (27): 14873–14878. doi:10.1016/S0021-9258(17)38654-4. ISSN 0021-9258. PMID 2997227.
Staker, Bart L.; Feese, Michael D.; Cushman, Mark; Pommier, Yves; Zembower, David; Stewart, Lance; Burgin, Alex B. (April 2005). “Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex” (英語). Journal of Medicinal Chemistry 48 (7): 2336–2345. doi:10.1021/jm049146p. ISSN 0022-2623. PMID 15801827.
Lu, Ai-jun; Zhang, Zhen-shan; Zheng, Ming-yue; Zou, Han-jun; Luo, Xiao-min; Jiang, Hua-liang (February 2007). “3D-QSAR study of 20 ( S )-camptothecin analogs” (英語). Acta Pharmacologica Sinica 28 (2): 307–314. doi:10.1111/j.1745-7254.2007.00477.x. ISSN 1745-7254. PMID 17241535.
Ulukan, Hulya; Swaan, Peter W. (2002-10-01). “Camptothecins” (英語). Drugs 62 (14): 2039–2057. doi:10.2165/00003495-200262140-00004. ISSN 1179-1950. PMID 12269849.
HOPKINS, R. P. (1983-12-01). “Principles of Biochemistry, Seventh Edition (two volumes): General Aspects, Mammalian Biochemistry”. Biochemical Society Transactions 11 (6): 829–830. doi:10.1042/bst0110829a. ISSN 0300-5127. https://doi.org/10.1042/bst0110829a.
Lynch, T (1996-12-01). “Topotecan today.”. Journal of Clinical Oncology 14 (12): 3053–3055. doi:10.1200/JCO.1996.14.12.3053. ISSN 0732-183X. PMID 8955649.
Hu, Guohua; Zekria, David; Cai, Xun; Ni, Xiaoling (June 2015). “Current status of CPT and its analogues in the treatment of malignancies” (英語). Phytochemistry Reviews 14 (3): 429–441. doi:10.1007/s11101-015-9397-1. ISSN 1568-7767.
Pommier, Yves; Pourquier, Philippe; Urasaki, Yoshimasa; Wu, Jiaxi; Laco, Gary S. (October 1999). “Topoisomerase I inhibitors: selectivity and cellular resistance”. Drug Resistance Updates 2 (5): 307–318. doi:10.1054/drup.1999.0102. ISSN 1368-7646. PMID 11504505.
Pommier, Yves (2006-10). “Topoisomerase I inhibitors: camptothecins and beyond”. Nature Reviews. Cancer 6 (10): 789–802. doi:10.1038/nrc1977. ISSN 1474-175X. PMID 16990856.
Long, Byron H.; Rose, William C.; Vyas, Dolatrai M.; Matson, James A.; Forenza, Salvatore (March 2002). “Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles”. Current Medicinal Chemistry. Anti-Cancer Agents 2 (2): 255–266. doi:10.2174/1568011023354218. ISSN 1568-0118. PMID 12678746.
Li, Tsai-Kun; Houghton, Peter J.; Desai, Shyamal D.; Daroui, Parima; Liu, Angela A.; Hars, Eszter S.; Ruchelman, Alexander L.; LaVoie, Edmond J. et al. (2003-12-01). “Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug”. Cancer Research 63 (23): 8400–8407. ISSN 0008-5472. PMID 14679002.
Yamashita, Yoshinori; Fujii, Noboru; Murakata, Chikara; Ashizawa, Tadashi; Okabe, Masami; Nakano, Hirofumi (1992-12-08). “Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives” (英語). Biochemistry 31 (48): 12069–12075. doi:10.1021/bi00163a015. ISSN 0006-2960. PMID 1333791.
Cushman, Mark; Cheng, Leung (September 1978). “Stereoselective oxidation by thionyl chloride leading to the indeno[1,2-cisoquinoline system”] (英語). The Journal of Organic Chemistry 43 (19): 3781–3783. doi:10.1021/jo00413a036. ISSN 0022-3263.
Cui, Yue; Wu, Linhui; Cao, Ruoxue; Xu, Hui; Xia, Jun; Wang, Z Peter; Ma, Jia (2020). “Antitumor functions and mechanisms of nitidine chloride in human cancers” (英語). Journal of Cancer 11 (5): 1250–1256. doi:10.7150/jca.37890. ISSN 1837-9664. PMC 6959075. PMID 31956371. http://www.jcancer.org/v11p1250.htm.
Xu, Yang; Her, Chengtao (2015-07-22). “Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy” (英語). Biomolecules 5 (3): 1652–1670. doi:10.3390/biom5031652. ISSN 2218-273X. PMC 4598769. PMID 26287259.
Aldred, Katie J.; Kerns, Robert J.; Osheroff, Neil (2014-03-18). “Mechanism of Quinolone Action and Resistance”. Biochemistry 53 (10): 1565–1574. doi:10.1021/bi5000564. ISSN 0006-2960. PMC 3985860. PMID 24576155.
Hevener, KirkE.; Verstak, Tatsiana A.; Lutat, Katie E.; Riggsbee, Daniel L.; Mooney, Jeremiah W. (October 2018). “Recent developments in topoisomerase-targeted cancer chemotherapy”. Acta Pharmaceutica Sinica B 8 (6): 844–861. doi:10.1016/j.apsb.2018.07.008. ISSN 2211-3835. PMC 6251812. PMID 30505655.
Kampranis, S. C.; Gormley, N. A.; Tranter, R.; Orphanides, G.; Maxwell, A. (1999-02-16). “Probing the binding of coumarins and cyclothialidines to DNA gyrase”. Biochemistry 38 (7): 1967–1976. doi:10.1021/bi982320p. ISSN 0006-2960. PMID 10026280.
Classen, Scott; Olland, Stephane; Berger, James M. (2003-09-16). “Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187” (英語). Proceedings of the National Academy of Sciences 100 (19): 10629–10634. Bibcode: 2003PNAS..10010629C. doi:10.1073/pnas.1832879100. ISSN 0027-8424. PMC 196855. PMID 12963818.
Thorn, Caroline F.; Oshiro, Connie; Marsh, Sharon; Hernandez-Boussard, Tina; McLeod, Howard; Klein, Teri E.; Altman, Russ B. (July 2011). “Doxorubicin pathways: pharmacodynamics and adverse effects” (英語). Pharmacogenetics and Genomics 21 (7): 440–446. doi:10.1097/FPC.0b013e32833ffb56. ISSN 1744-6872. PMC 3116111. PMID 21048526.
Montecucco, Alessandra; Zanetta, Francesca; Biamonti, Giuseppe (2015-01-19). “Molecular mechanisms of etoposide”. EXCLI Journal 14: 95–108. doi:10.17179/excli2014-561. ISSN 1611-2156. PMC 4652635. PMID 26600742.
Lewis, R J; Singh, O M; Smith, C V; Skarzynski, T; Maxwell, A; Wonacott, A J; Wigley, D B (1996-03-15). “The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.”. The EMBO Journal 15 (6): 1412–1420. doi:10.1002/j.1460-2075.1996.tb00483.x. ISSN 0261-4189. PMC 450046. PMID 8635474.
Anderson, V. E.; Osheroff, N. (March 2001). “Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde”. Current Pharmaceutical Design 7 (5): 337–353. doi:10.2174/1381612013398013. ISSN 1381-6128. PMID 11254893.
Collin, Frédéric; Karkare, Shantanu; Maxwell, Anthony (2011-11). “Exploiting bacterial DNA gyrase as a drug target: current state and perspectives”. Applied Microbiology and Biotechnology 92 (3): 479–497. doi:10.1007/s00253-011-3557-z. ISSN 1432-0614. PMC 3189412. PMID 21904817.
Waksman, S. A.; Woodruff, H. B. (1941-08). “Actinomyces antibioticus, a New Soil Organism Antagonistic to Pathogenic and Non-pathogenic Bacteria”. Journal of Bacteriology 42 (2): 231–249. doi:10.1128/jb.42.2.231-249.1941. ISSN 0021-9193. PMC PMC374755. PMID 16560451.
Li, Qun; Mitscher, Lester A.; Shen, Linus L. (2000). “The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors” (英語). Medicinal Research Reviews 20 (4): 231–293. doi:10.1002/1098-1128(200007)20:4<231::AID-MED1>3.0.CO;2-N. ISSN 1098-1128. PMID 10861727.
Bisacchi, Gregory S. (2015-06-25). “Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story"”. Journal of Medicinal Chemistry 58 (12): 4874–4882. doi:10.1021/jm501881c. ISSN 1520-4804. PMID 25738967.
Laponogov, Ivan; Sohi, Maninder K; Veselkov, Dennis A; Pan, Xiao-Su; Sawhney, Ritica; Thompson, Andrew W; McAuley, Katherine E; Fisher, L Mark et al. (June 2009). “Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases” (英語). Nature Structural & Molecular Biology 16 (6): 667–669. doi:10.1038/nsmb.1604. ISSN 1545-9993. PMID 19448616.
Wolfson, John S.; Hooper, David C. (1991-12-30). “Overview of fluoroquinolone safety” (英語). The American Journal of Medicine. Fluoroquinolones in the Treatment of Human Infection: The Role of Temafloxacin 91 (6, Supplement 1): S153–S161. doi:10.1016/0002-9343(91)90330-Z. ISSN 0002-9343. PMID 1767803.
Drlica, Karl; Hiasa, Hiroshi; Kerns, Robert; Malik, Muhammad; Mustaev, Arkady; Zhao, Xilin (August 2009). “Quinolones: Action and Resistance Updated”. Current Topics in Medicinal Chemistry 9 (11): 981–998. doi:10.2174/156802609789630947. ISSN 1568-0266. PMC 3182077. PMID 19747119.
Yoshida, H.; Bogaki, M.; Nakamura, M.; Yamanaka, L. M.; Nakamura, S. (1991-08-01). “Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.” (英語). Antimicrobial Agents and Chemotherapy 35 (8): 1647–1650. doi:10.1128/AAC.35.8.1647. ISSN 0066-4804. PMC 245234. PMID 1656869.
Shen, Linus L.; Mitscher, Lester A.; Sharma, Padam N.; O'Donnell, T. J.; Chu, Daniel W. T.; Cooper, Curt S.; Rosen, Terry; Pernet, Andre G. (1989-05-02). “Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model” (英語). Biochemistry 28 (9): 3886–3894. doi:10.1021/bi00435a039. ISSN 0006-2960. PMID 2546585.
Nitiss, John L. (May 2009). “Targeting DNA topoisomerase II in cancer chemotherapy”. Nature Reviews. Cancer 9 (5): 338–350. doi:10.1038/nrc2607. ISSN 1474-175X. PMC 2748742. PMID 19377506.
Wohlkonig, Alexandre; Chan, Pan F; Fosberry, Andrew P; Homes, Paul; Huang, Jianzhong; Kranz, Michael; Leydon, Vaughan R; Miles, Timothy J et al. (2010-08-29). “Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance”. Nature Structural & Molecular Biology 17 (9): 1152–1153. doi:10.1038/nsmb.1892. ISSN 1545-9993. PMID 20802486. https://doi.org/10.1038/nsmb.1892.
Leo, Elisabetta; Gould, Katherine A.; Pan, Xiao-Su; Capranico, Giovanni; Sanderson, Mark R.; Palumbo, Manlio; Fisher, L. Mark (2005-01-18). “Novel Symmetric and Asymmetric DNA Scission Determinants forStreptococcus pneumoniaeTopoisomerase IV and Gyrase Are Clustered at the DNA Breakage Site”. Journal of Biological Chemistry 280 (14): 14252–14263. doi:10.1074/jbc.m500156200. ISSN 0021-9258. PMID 15659402.
Atwal, Mandeep; Swan, Rebecca L.; Rowe, Chloe; Lee, Ka C.; Lee, David C.; Armstrong, Lyle; Cowell, Ian G.; Austin, Caroline A. (October 2019). “Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations”. Molecular Pharmacology 96 (4): 475–484. doi:10.1124/mol.119.117259. ISSN 0026-895X. PMC 6744389. PMID 31399497.
McGowan, John V; Chung, Robin; Maulik, Angshuman; Piotrowska, Izabela; Walker, J Malcolm; Yellon, Derek M (February 2017). “Anthracycline Chemotherapy and Cardiotoxicity” (英語). Cardiovascular Drugs and Therapy 31 (1): 63–75. doi:10.1007/s10557-016-6711-0. ISSN 0920-3206. PMC 5346598. PMID 28185035.
Imbert, T. F. (March 1998). “Discovery of podophyllotoxins”. Biochimie 80 (3): 207–222. doi:10.1016/s0300-9084(98)80004-7. ISSN 0300-9084. PMID 9615861.
Clark, Peter I.; Slevin, Maurice L. (1987-04-01). “The Clinical Pharmacology of Etoposide and Teniposide” (英語). Clinical Pharmacokinetics 12 (4): 223–252. doi:10.2165/00003088-198712040-00001. ISSN 1179-1926. PMID 3297462.
Vogelzang, N. J.; Raghavan, D.; Kennedy, B. J. (January 1982). “VP-16-213 (etoposide): the mandrake root from Issyk-Kul”. The American Journal of Medicine 72 (1): 136–144. doi:10.1016/0002-9343(82)90600-3. ISSN 0002-9343. PMID 6277188.
Guryanova, Olga A.; Shank, Kaitlyn; Spitzer, Barbara; Luciani, Luisa; Koche, Richard P.; Garrett-Bakelman, Francine E.; Ganzel, Chezi; Durham, Benjamin H. et al. (December 2016). “DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling”. Nature Medicine 22 (12): 1488–1495. doi:10.1038/nm.4210. ISSN 1546-170X. PMC 5359771. PMID 27841873.
Ganapathi, R.; Constantinou, A.; Kamath, N.; Dubyak, G.; Grabowski, D.; Krivacic, K. (1996-08-01). “Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.” (英語). Molecular Pharmacology 50 (2): 243–248. ISSN 0026-895X. PMID 8700130.
Ganapathi, Ram N.; Ganapathi, Mahrukh K. (2013-08-01). “Mechanisms regulating resistance to inhibitors of topoisomerase II”. Frontiers in Pharmacology 4: 89. doi:10.3389/fphar.2013.00089. ISSN 1663-9812. PMC 3729981. PMID 23914174.
Matsumoto, Yoshihito; Takano, Hiroshi; Kunishio, Katsuzo; Nagao, Seigo; Fojo, Tito (2001). “Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines” (英語). Japanese Journal of Cancer Research 92 (10): 1133–1137. doi:10.1111/j.1349-7006.2001.tb01069.x. ISSN 1349-7006. PMC 5926608. PMID 11676865.
Andoh, Toshiwo; Ishida, Ryoji (1998-10-01). “Catalytic inhibitors of DNA topoisomerase II” (英語). Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1400 (1): 155–171. doi:10.1016/S0167-4781(98)00133-X. ISSN 0167-4781. PMID 9748552.
Kerrigan, D.; Pommier, Y.; Kohn, K. W. (1987). “Protein-linked DNA strand breaks produced by etoposide and teniposide in mouse L1210 and human VA-13 and HT-29 cell lines: relationship to cytotoxicity”. NCI Monographs (4): 117–121. ISSN 0893-2751. PMID 3041238.
Andoh, T. (March 1998). “Bis(2,6-dioxopiperazines), catalytic inhibitors of DNA topoisomerase II, as molecular probes, cardioprotectors and antitumor drugs”. Biochimie 80 (3): 235–246. doi:10.1016/s0300-9084(98)80006-0. ISSN 0300-9084. PMID 9615863.
Langer, Seppo W (2014-09-15). “Dexrazoxane for the treatment of chemotherapy-related side effects”. Cancer Management and Research 6: 357–363. doi:10.2147/CMAR.S47238. ISSN 1179-1322. PMC 4168851. PMID 25246808.
Weiss, G.; Loyevsky, M.; Gordeuk, V. R. (January 1999). “Dexrazoxane (ICRF-187)”. General Pharmacology 32 (1): 155–158. doi:10.1016/s0306-3623(98)00100-1. ISSN 0306-3623. PMID 9888268.