プロテインキナーゼR (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "プロテインキナーゼR" in Japanese language version.

refsWebsite

Global rank Japanese rank

98nih.gov

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24^th place

35doi.org

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18worldcat.org

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2ensembl.org

1,626^th place

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2wikipedia.org

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1canada.com

1,162^nd place

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canada.com

Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M (December 2011). “Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition”. Cell 147 (6): 1384–96. doi:10.1016/j.cell.2011.11.029. PMC 3569515. PMID 22153080. 非専門家向けの内容要旨 – canada.com.

doi.org

Feng GS, Chong K, Kumar A, Williams BR (June 1992). “Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase”. Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5447–51. doi:10.1073/pnas.89.12.5447. PMC 49309. PMID 1351683.
Patel, R. C.; Sen, G. C. (1998-08-03). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO journal 17 (15): 4379–4390. doi:10.1093/emboj/17.15.4379. ISSN 0261-4189. PMC 1170771. PMID 9687506.
Dey, Madhusudan; Cao, Chune; Dar, Arvin C.; Tamura, Tomohiko; Ozato, Keiko; Sicheri, Frank; Dever, Thomas E. (2005-09-23). “Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition”. Cell 122 (6): 901–913. doi:10.1016/j.cell.2005.06.041. ISSN 0092-8674. PMID 16179259.
García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M (December 2006). “Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action”. Microbiology and Molecular Biology Reviews 70 (4): 1032–60. doi:10.1128/MMBR.00027-06. PMC 1698511. PMID 17158706.
Hotamisligil GS (March 2010). “Endoplasmic reticulum stress and the inflammatory basis of metabolic disease”. Cell 140 (6): 900–17. doi:10.1016/j.cell.2010.02.034. PMC 2887297. PMID 20303879.
Iwakiri, Dai (2014-08-06). “Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis”. Cancers 6 (3): 1615–1630. doi:10.3390/cancers6031615. ISSN 2072-6694. PMC 4190559. PMID 25101570.
Maitra, R. K.; McMillan, N. A.; Desai, S.; McSwiggen, J.; Hovanessian, A. G.; Sen, G.; Williams, B. R.; Silverman, R. H. (1994-11-01). “HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes”. Virology 204 (2): 823–827. doi:10.1006/viro.1994.1601. ISSN 0042-6822. PMID 7524241.
Langland, Jeffrey O.; Jacobs, Bertram L. (2004-07-01). “Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L”. Virology 324 (2): 419–429. doi:10.1016/j.virol.2004.03.012. ISSN 0042-6822. PMID 15207627.
Schmechel, S.; Chute, M.; Skinner, P.; Anderson, R.; Schiff, L. (1997-05-26). “Preferential translation of reovirus mRNA by a sigma3-dependent mechanism”. Virology 232 (1): 62–73. doi:10.1006/viro.1997.8531. ISSN 0042-6822. PMID 9185589.
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M (December 2011). “Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition”. Cell 147 (6): 1384–96. doi:10.1016/j.cell.2011.11.029. PMC 3569515. PMID 22153080. 非専門家向けの内容要旨 – canada.com.
Chang RC, Wong AK, Ng HK, Hugon J (December 2002). “Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease”. NeuroReport 13 (18): 2429–32. doi:10.1097/01.wnr.0000048020.74602.bb. PMID 12499843.
Page G, Rioux Bilan A, Ingrand S, Lafay-Chebassier C, Pain S, Perault Pochat MC, Bouras C, Bayer T, Hugon J (2006). “Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease”. Neuroscience 139 (4): 1343–54. doi:10.1016/j.neuroscience.2006.01.047. PMID 16581193.
Paccalin M, Pain-Barc S, Pluchon C, Paul C, Besson MN, Carret-Rebillat AS, Rioux-Bilan A, Gil R, Hugon J (2006). “Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease”. Dementia and Geriatric Cognitive Disorders 22 (4): 320–6. doi:10.1159/000095562. PMID 16954686.
Mouton-Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche JL, Hugon J (May 2012). “Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease”. Biological Psychiatry 71 (9): 829–35. doi:10.1016/j.biopsych.2011.11.031. PMID 22281122.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ (2011-06-28). “Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression”. PLOS One 6 (6): e21456. doi:10.1371/journal.pone.0021456. PMC 3125189. PMID 21738672.
Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J (June 2012). “Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway”. Biochimica et Biophysica Acta 1822 (6): 885–96. doi:10.1016/j.bbadis.2012.01.009. PMID 22306812.
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA (May 2016). “Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease”. Molecular Psychiatry 21 (5): 707–16. doi:10.1038/mp.2015.97. PMC 4721948. PMID 26194181.
Kim SM, Yoon SY, Choi JE, Park JS, Choi JM, Nguyen T, Kim DH (September 2010). “Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons”. Neuroscience 169 (4): 1831–9. doi:10.1016/j.neuroscience.2010.06.016. PMID 20600673.
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J (March 2011). “Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease”. Brain Pathology 21 (2): 189–200. doi:10.1111/j.1750-3639.2010.00437.x. PMID 21029237.
Chen G, Ma C, Bower KA, Ke Z, Luo J (June 2006). “Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons”. The Journal of Biological Chemistry 281 (23): 15909–15. doi:10.1074/jbc.M600612200. PMID 16574643.
Takizawa T, Tatematsu C, Nakanishi Y (December 2002). “Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways”. European Journal of Biochemistry 269 (24): 6126–32. doi:10.1046/j.1432-1033.2002.03325.x. PMID 12473108.
Polyak SJ, Tang N, Wambach M, Barber GN, Katze MG (January 1996). “The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity”. The Journal of Biological Chemistry 271 (3): 1702–7. doi:10.1074/jbc.271.3.1702. PMID 8576172.
Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN (August 2001). “Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR”. The Journal of Biological Chemistry 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.
Langland JO, Kao PN, Jacobs BL (May 1999). “Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR”. Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.
Parker LM, Fierro-Monti I, Mathews MB (August 2001). “Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase”. The Journal of Biological Chemistry 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.
Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC (July 1999). “DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR”. The Journal of Biological Chemistry 274 (29): 20432–7. doi:10.1074/jbc.274.29.20432. PMID 10400669.
Gil J, Esteban M, Roth D (December 2000). “In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular glycoprotein p67”. Biochemistry 39 (51): 16016–25. doi:10.1021/bi001754t. PMID 11123929.
Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE (April 1999). “The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro”. Oncogene 18 (17): 2690–702. doi:10.1038/sj.onc.1202620. PMID 10348343.
Tan SL, Tareen SU, Melville MW, Blakely CM, Katze MG (September 2002). “The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation”. The Journal of Biological Chemistry 277 (39): 36109–17. doi:10.1074/jbc.M205109200. PMID 12138106.
Huang X, Hutchins B, Patel RC (August 2002). “The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)”. The Biochemical Journal 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496.
Patel RC, Sen GC (August 1998). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO Journal 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506.
Wong AH, Tam NW, Yang YL, Cuddihy AR, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas AE (March 1997). “Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways”. The EMBO Journal 16 (6): 1291–304. doi:10.1093/emboj/16.6.1291. PMC 1169727. PMID 9135145.
Wong AH, Durbin JE, Li S, Dever TE, Decker T, Koromilas AE (April 2001). “Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR”. The Journal of Biological Chemistry 276 (17): 13727–37. doi:10.1074/jbc.M011240200. PMID 11278865.
Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (October 1995). “Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo”. Proceedings of the National Academy of Sciences of the United States of America 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. PMC 40818. PMID 7568151.
Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A (September 2001). “Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression”. The Journal of Biological Chemistry 276 (36): 33899–905. doi:10.1074/jbc.M103584200. PMID 11438532.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000055332 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024079 - Ensembl, May 2017

nih.gov

pubmed.ncbi.nlm.nih.gov

Feng GS, Chong K, Kumar A, Williams BR (June 1992). “Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase”. Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5447–51. doi:10.1073/pnas.89.12.5447. PMC 49309. PMID 1351683.
Patel, R. C.; Sen, G. C. (1998-08-03). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO journal 17 (15): 4379–4390. doi:10.1093/emboj/17.15.4379. ISSN 0261-4189. PMC 1170771. PMID 9687506.
Hovanessian, A. G.; Galabru, J. (1987-09-15). “The double-stranded RNA-dependent protein kinase is also activated by heparin”. European Journal of Biochemistry 167 (3): 467–473. ISSN 0014-2956. PMID 3653103.
Dey, Madhusudan; Cao, Chune; Dar, Arvin C.; Tamura, Tomohiko; Ozato, Keiko; Sicheri, Frank; Dever, Thomas E. (2005-09-23). “Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition”. Cell 122 (6): 901–913. doi:10.1016/j.cell.2005.06.041. ISSN 0092-8674. PMID 16179259.
Meurs, E.; Chong, K.; Galabru, J.; Thomas, N. S.; Kerr, I. M.; Williams, B. R.; Hovanessian, A. G. (1990-07-27). “Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon”. Cell 62 (2): 379–390. ISSN 0092-8674. PMID 1695551.
Kumar, A.; Haque, J.; Lacoste, J.; Hiscott, J.; Williams, B. R. (1994-07-05). “Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B”. Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6288–6292. ISSN 0027-8424. PMC 44186. PMID 7912826.
Xu, Z.; Williams, B. R. (2000-7). “The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR”. Molecular and Cellular Biology 20 (14): 5285–5299. ISSN 0270-7306. PMC 85978. PMID 10866685.
García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M (December 2006). “Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action”. Microbiology and Molecular Biology Reviews 70 (4): 1032–60. doi:10.1128/MMBR.00027-06. PMC 1698511. PMID 17158706.
Hotamisligil GS (March 2010). “Endoplasmic reticulum stress and the inflammatory basis of metabolic disease”. Cell 140 (6): 900–17. doi:10.1016/j.cell.2010.02.034. PMC 2887297. PMID 20303879.
Iwakiri, Dai (2014-08-06). “Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis”. Cancers 6 (3): 1615–1630. doi:10.3390/cancers6031615. ISSN 2072-6694. PMC 4190559. PMID 25101570.
Clemens, M. J.; Laing, K. G.; Jeffrey, I. W.; Schofield, A.; Sharp, T. V.; Elia, A.; Matys, V.; James, M. C. et al. (1994). “Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs”. Biochimie 76 (8): 770–778. ISSN 0300-9084. PMID 7534482.
Maitra, R. K.; McMillan, N. A.; Desai, S.; McSwiggen, J.; Hovanessian, A. G.; Sen, G.; Williams, B. R.; Silverman, R. H. (1994-11-01). “HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes”. Virology 204 (2): 823–827. doi:10.1006/viro.1994.1601. ISSN 0042-6822. PMID 7524241.
Black, T. L.; Safer, B.; Hovanessian, A.; Katze, M. G. (1989-5). “The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation”. Journal of Virology 63 (5): 2244–2251. ISSN 0022-538X. PMC 250642. PMID 2539516.
Langland, Jeffrey O.; Jacobs, Bertram L. (2004-07-01). “Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L”. Virology 324 (2): 419–429. doi:10.1016/j.virol.2004.03.012. ISSN 0042-6822. PMID 15207627.
Schmechel, S.; Chute, M.; Skinner, P.; Anderson, R.; Schiff, L. (1997-05-26). “Preferential translation of reovirus mRNA by a sigma3-dependent mechanism”. Virology 232 (1): 62–73. doi:10.1006/viro.1997.8531. ISSN 0042-6822. PMID 9185589.
Lu, Y.; Wambach, M.; Katze, M. G.; Krug, R. M. (1995-12-01). “Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor”. Virology 214 (1): 222–228. ISSN 0042-6822. PMID 8525619.
Gale, M.; Tan, S. L.; Wambach, M.; Katze, M. G. (1996-8). “Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation”. Molecular and Cellular Biology 16 (8): 4172–4181. ISSN 0270-7306. PMC 231414. PMID 8754816.
Gale, M.; Blakely, C. M.; Kwieciszewski, B.; Tan, S. L.; Dossett, M.; Tang, N. M.; Korth, M. J.; Polyak, S. J. et al. (1998-9). “Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation”. Molecular and Cellular Biology 18 (9): 5208–5218. ISSN 0270-7306. PMC 109106. PMID 9710605.
Kawagishi-Kobayashi, M.; Silverman, J. B.; Ung, T. L.; Dever, T. E. (1997-7). “Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha”. Molecular and Cellular Biology 17 (7): 4146–4158. ISSN 0270-7306. PMC 232268. PMID 9199350.
Brand, S. R.; Kobayashi, R.; Mathews, M. B. (1997-03-28). “The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR”. The Journal of Biological Chemistry 272 (13): 8388–8395. ISSN 0021-9258. PMID 9079663.
He, B.; Gross, M.; Roizman, B. (1997-02-04). “The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase”. Proceedings of the National Academy of Sciences of the United States of America 94 (3): 843–848. ISSN 0027-8424. PMC 19601. PMID 9023344.
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M (December 2011). “Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition”. Cell 147 (6): 1384–96. doi:10.1016/j.cell.2011.11.029. PMC 3569515. PMID 22153080. 非専門家向けの内容要旨 – canada.com.
Chang RC, Wong AK, Ng HK, Hugon J (December 2002). “Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease”. NeuroReport 13 (18): 2429–32. doi:10.1097/01.wnr.0000048020.74602.bb. PMID 12499843.
Page G, Rioux Bilan A, Ingrand S, Lafay-Chebassier C, Pain S, Perault Pochat MC, Bouras C, Bayer T, Hugon J (2006). “Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease”. Neuroscience 139 (4): 1343–54. doi:10.1016/j.neuroscience.2006.01.047. PMID 16581193.
Paccalin M, Pain-Barc S, Pluchon C, Paul C, Besson MN, Carret-Rebillat AS, Rioux-Bilan A, Gil R, Hugon J (2006). “Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease”. Dementia and Geriatric Cognitive Disorders 22 (4): 320–6. doi:10.1159/000095562. PMID 16954686.
Mouton-Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche JL, Hugon J (May 2012). “Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease”. Biological Psychiatry 71 (9): 829–35. doi:10.1016/j.biopsych.2011.11.031. PMID 22281122.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ (2011-06-28). “Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression”. PLOS One 6 (6): e21456. doi:10.1371/journal.pone.0021456. PMC 3125189. PMID 21738672.
Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J (June 2012). “Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway”. Biochimica et Biophysica Acta 1822 (6): 885–96. doi:10.1016/j.bbadis.2012.01.009. PMID 22306812.
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA (May 2016). “Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease”. Molecular Psychiatry 21 (5): 707–16. doi:10.1038/mp.2015.97. PMC 4721948. PMID 26194181.
Peel AL, Bredesen DE (October 2003). “Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice”. Neurobiology of Disease 14 (1): 52–62. PMID 13678666.
Kim SM, Yoon SY, Choi JE, Park JS, Choi JM, Nguyen T, Kim DH (September 2010). “Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons”. Neuroscience 169 (4): 1831–9. doi:10.1016/j.neuroscience.2010.06.016. PMID 20600673.
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J (March 2011). “Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease”. Brain Pathology 21 (2): 189–200. doi:10.1111/j.1750-3639.2010.00437.x. PMID 21029237.
Chen G, Ma C, Bower KA, Ke Z, Luo J (June 2006). “Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons”. The Journal of Biological Chemistry 281 (23): 15909–15. doi:10.1074/jbc.M600612200. PMID 16574643.
Takizawa T, Tatematsu C, Nakanishi Y (December 2002). “Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways”. European Journal of Biochemistry 269 (24): 6126–32. doi:10.1046/j.1432-1033.2002.03325.x. PMID 12473108.
Polyak SJ, Tang N, Wambach M, Barber GN, Katze MG (January 1996). “The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity”. The Journal of Biological Chemistry 271 (3): 1702–7. doi:10.1074/jbc.271.3.1702. PMID 8576172.
Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN (August 2001). “Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR”. The Journal of Biological Chemistry 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.
Langland JO, Kao PN, Jacobs BL (May 1999). “Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR”. Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.
Parker LM, Fierro-Monti I, Mathews MB (August 2001). “Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase”. The Journal of Biological Chemistry 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.
Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC (July 1999). “DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR”. The Journal of Biological Chemistry 274 (29): 20432–7. doi:10.1074/jbc.274.29.20432. PMID 10400669.
Gil J, Esteban M, Roth D (December 2000). “In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular glycoprotein p67”. Biochemistry 39 (51): 16016–25. doi:10.1021/bi001754t. PMID 11123929.
Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE (April 1999). “The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro”. Oncogene 18 (17): 2690–702. doi:10.1038/sj.onc.1202620. PMID 10348343.
Tan SL, Tareen SU, Melville MW, Blakely CM, Katze MG (September 2002). “The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation”. The Journal of Biological Chemistry 277 (39): 36109–17. doi:10.1074/jbc.M205109200. PMID 12138106.
Huang X, Hutchins B, Patel RC (August 2002). “The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)”. The Biochemical Journal 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496.
Patel RC, Sen GC (August 1998). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO Journal 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506.
Wong AH, Tam NW, Yang YL, Cuddihy AR, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas AE (March 1997). “Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways”. The EMBO Journal 16 (6): 1291–304. doi:10.1093/emboj/16.6.1291. PMC 1169727. PMID 9135145.
Wong AH, Durbin JE, Li S, Dever TE, Decker T, Koromilas AE (April 2001). “Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR”. The Journal of Biological Chemistry 276 (17): 13727–37. doi:10.1074/jbc.M011240200. PMID 11278865.
Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (October 1995). “Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo”. Proceedings of the National Academy of Sciences of the United States of America 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. PMC 40818. PMID 7568151.
Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A (September 2001). “Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression”. The Journal of Biological Chemistry 276 (36): 33899–905. doi:10.1074/jbc.M103584200. PMID 11438532.

ncbi.nlm.nih.gov

Human PubMed Reference:
Mouse PubMed Reference:
“EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2019年2月1日閲覧。
Feng GS, Chong K, Kumar A, Williams BR (June 1992). “Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase”. Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5447–51. doi:10.1073/pnas.89.12.5447. PMC 49309. PMID 1351683.
Patel, R. C.; Sen, G. C. (1998-08-03). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO journal 17 (15): 4379–4390. doi:10.1093/emboj/17.15.4379. ISSN 0261-4189. PMC 1170771. PMID 9687506.
Hovanessian, A. G.; Galabru, J. (1987-09-15). “The double-stranded RNA-dependent protein kinase is also activated by heparin”. European Journal of Biochemistry 167 (3): 467–473. ISSN 0014-2956. PMID 3653103.
Dey, Madhusudan; Cao, Chune; Dar, Arvin C.; Tamura, Tomohiko; Ozato, Keiko; Sicheri, Frank; Dever, Thomas E. (2005-09-23). “Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition”. Cell 122 (6): 901–913. doi:10.1016/j.cell.2005.06.041. ISSN 0092-8674. PMID 16179259.
Meurs, E.; Chong, K.; Galabru, J.; Thomas, N. S.; Kerr, I. M.; Williams, B. R.; Hovanessian, A. G. (1990-07-27). “Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon”. Cell 62 (2): 379–390. ISSN 0092-8674. PMID 1695551.
Kumar, A.; Haque, J.; Lacoste, J.; Hiscott, J.; Williams, B. R. (1994-07-05). “Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B”. Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6288–6292. ISSN 0027-8424. PMC 44186. PMID 7912826.
Xu, Z.; Williams, B. R. (2000-7). “The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR”. Molecular and Cellular Biology 20 (14): 5285–5299. ISSN 0270-7306. PMC 85978. PMID 10866685.
García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M (December 2006). “Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action”. Microbiology and Molecular Biology Reviews 70 (4): 1032–60. doi:10.1128/MMBR.00027-06. PMC 1698511. PMID 17158706.
Hotamisligil GS (March 2010). “Endoplasmic reticulum stress and the inflammatory basis of metabolic disease”. Cell 140 (6): 900–17. doi:10.1016/j.cell.2010.02.034. PMC 2887297. PMID 20303879.
Iwakiri, Dai (2014-08-06). “Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis”. Cancers 6 (3): 1615–1630. doi:10.3390/cancers6031615. ISSN 2072-6694. PMC 4190559. PMID 25101570.
Clemens, M. J.; Laing, K. G.; Jeffrey, I. W.; Schofield, A.; Sharp, T. V.; Elia, A.; Matys, V.; James, M. C. et al. (1994). “Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs”. Biochimie 76 (8): 770–778. ISSN 0300-9084. PMID 7534482.
Maitra, R. K.; McMillan, N. A.; Desai, S.; McSwiggen, J.; Hovanessian, A. G.; Sen, G.; Williams, B. R.; Silverman, R. H. (1994-11-01). “HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes”. Virology 204 (2): 823–827. doi:10.1006/viro.1994.1601. ISSN 0042-6822. PMID 7524241.
Black, T. L.; Safer, B.; Hovanessian, A.; Katze, M. G. (1989-5). “The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation”. Journal of Virology 63 (5): 2244–2251. ISSN 0022-538X. PMC 250642. PMID 2539516.
Langland, Jeffrey O.; Jacobs, Bertram L. (2004-07-01). “Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L”. Virology 324 (2): 419–429. doi:10.1016/j.virol.2004.03.012. ISSN 0042-6822. PMID 15207627.
Schmechel, S.; Chute, M.; Skinner, P.; Anderson, R.; Schiff, L. (1997-05-26). “Preferential translation of reovirus mRNA by a sigma3-dependent mechanism”. Virology 232 (1): 62–73. doi:10.1006/viro.1997.8531. ISSN 0042-6822. PMID 9185589.
Lu, Y.; Wambach, M.; Katze, M. G.; Krug, R. M. (1995-12-01). “Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor”. Virology 214 (1): 222–228. ISSN 0042-6822. PMID 8525619.
Gale, M.; Tan, S. L.; Wambach, M.; Katze, M. G. (1996-8). “Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation”. Molecular and Cellular Biology 16 (8): 4172–4181. ISSN 0270-7306. PMC 231414. PMID 8754816.
Gale, M.; Blakely, C. M.; Kwieciszewski, B.; Tan, S. L.; Dossett, M.; Tang, N. M.; Korth, M. J.; Polyak, S. J. et al. (1998-9). “Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation”. Molecular and Cellular Biology 18 (9): 5208–5218. ISSN 0270-7306. PMC 109106. PMID 9710605.
Kawagishi-Kobayashi, M.; Silverman, J. B.; Ung, T. L.; Dever, T. E. (1997-7). “Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha”. Molecular and Cellular Biology 17 (7): 4146–4158. ISSN 0270-7306. PMC 232268. PMID 9199350.
Brand, S. R.; Kobayashi, R.; Mathews, M. B. (1997-03-28). “The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR”. The Journal of Biological Chemistry 272 (13): 8388–8395. ISSN 0021-9258. PMID 9079663.
He, B.; Gross, M.; Roizman, B. (1997-02-04). “The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase”. Proceedings of the National Academy of Sciences of the United States of America 94 (3): 843–848. ISSN 0027-8424. PMC 19601. PMID 9023344.
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M (December 2011). “Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition”. Cell 147 (6): 1384–96. doi:10.1016/j.cell.2011.11.029. PMC 3569515. PMID 22153080. 非専門家向けの内容要旨 – canada.com.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ (2011-06-28). “Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression”. PLOS One 6 (6): e21456. doi:10.1371/journal.pone.0021456. PMC 3125189. PMID 21738672.
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA (May 2016). “Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease”. Molecular Psychiatry 21 (5): 707–16. doi:10.1038/mp.2015.97. PMC 4721948. PMID 26194181.
Huang X, Hutchins B, Patel RC (August 2002). “The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)”. The Biochemical Journal 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496.
Patel RC, Sen GC (August 1998). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO Journal 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506.
Wong AH, Tam NW, Yang YL, Cuddihy AR, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas AE (March 1997). “Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways”. The EMBO Journal 16 (6): 1291–304. doi:10.1093/emboj/16.6.1291. PMC 1169727. PMID 9135145.
Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (October 1995). “Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo”. Proceedings of the National Academy of Sciences of the United States of America 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. PMC 40818. PMID 7568151.

pmc.ncbi.nlm.nih.gov

Feng GS, Chong K, Kumar A, Williams BR (June 1992). “Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase”. Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5447–51. doi:10.1073/pnas.89.12.5447. PMC 49309. PMID 1351683.
Patel, R. C.; Sen, G. C. (1998-08-03). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO journal 17 (15): 4379–4390. doi:10.1093/emboj/17.15.4379. ISSN 0261-4189. PMC 1170771. PMID 9687506.
Kumar, A.; Haque, J.; Lacoste, J.; Hiscott, J.; Williams, B. R. (1994-07-05). “Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B”. Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6288–6292. ISSN 0027-8424. PMC 44186. PMID 7912826.
Xu, Z.; Williams, B. R. (2000-7). “The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR”. Molecular and Cellular Biology 20 (14): 5285–5299. ISSN 0270-7306. PMC 85978. PMID 10866685.
García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M (December 2006). “Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action”. Microbiology and Molecular Biology Reviews 70 (4): 1032–60. doi:10.1128/MMBR.00027-06. PMC 1698511. PMID 17158706.
Hotamisligil GS (March 2010). “Endoplasmic reticulum stress and the inflammatory basis of metabolic disease”. Cell 140 (6): 900–17. doi:10.1016/j.cell.2010.02.034. PMC 2887297. PMID 20303879.
Iwakiri, Dai (2014-08-06). “Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis”. Cancers 6 (3): 1615–1630. doi:10.3390/cancers6031615. ISSN 2072-6694. PMC 4190559. PMID 25101570.
Black, T. L.; Safer, B.; Hovanessian, A.; Katze, M. G. (1989-5). “The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation”. Journal of Virology 63 (5): 2244–2251. ISSN 0022-538X. PMC 250642. PMID 2539516.
Gale, M.; Tan, S. L.; Wambach, M.; Katze, M. G. (1996-8). “Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation”. Molecular and Cellular Biology 16 (8): 4172–4181. ISSN 0270-7306. PMC 231414. PMID 8754816.
Gale, M.; Blakely, C. M.; Kwieciszewski, B.; Tan, S. L.; Dossett, M.; Tang, N. M.; Korth, M. J.; Polyak, S. J. et al. (1998-9). “Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation”. Molecular and Cellular Biology 18 (9): 5208–5218. ISSN 0270-7306. PMC 109106. PMID 9710605.
Kawagishi-Kobayashi, M.; Silverman, J. B.; Ung, T. L.; Dever, T. E. (1997-7). “Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha”. Molecular and Cellular Biology 17 (7): 4146–4158. ISSN 0270-7306. PMC 232268. PMID 9199350.
He, B.; Gross, M.; Roizman, B. (1997-02-04). “The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase”. Proceedings of the National Academy of Sciences of the United States of America 94 (3): 843–848. ISSN 0027-8424. PMC 19601. PMID 9023344.
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M (December 2011). “Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition”. Cell 147 (6): 1384–96. doi:10.1016/j.cell.2011.11.029. PMC 3569515. PMID 22153080. 非専門家向けの内容要旨 – canada.com.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ (2011-06-28). “Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression”. PLOS One 6 (6): e21456. doi:10.1371/journal.pone.0021456. PMC 3125189. PMID 21738672.
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA (May 2016). “Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease”. Molecular Psychiatry 21 (5): 707–16. doi:10.1038/mp.2015.97. PMC 4721948. PMID 26194181.
Huang X, Hutchins B, Patel RC (August 2002). “The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)”. The Biochemical Journal 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496.
Patel RC, Sen GC (August 1998). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO Journal 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506.
Wong AH, Tam NW, Yang YL, Cuddihy AR, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas AE (March 1997). “Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways”. The EMBO Journal 16 (6): 1291–304. doi:10.1093/emboj/16.6.1291. PMC 1169727. PMID 9135145.
Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N (October 1995). “Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo”. Proceedings of the National Academy of Sciences of the United States of America 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. PMC 40818. PMID 7568151.

wikipedia.org

en.wikipedia.org

GRCh38: Ensembl release 89: ENSG00000055332 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024079 - Ensembl, May 2017

worldcat.org

search.worldcat.org

Patel, R. C.; Sen, G. C. (1998-08-03). “PACT, a protein activator of the interferon-induced protein kinase, PKR”. The EMBO journal 17 (15): 4379–4390. doi:10.1093/emboj/17.15.4379. ISSN 0261-4189. PMC 1170771. PMID 9687506.
Hovanessian, A. G.; Galabru, J. (1987-09-15). “The double-stranded RNA-dependent protein kinase is also activated by heparin”. European Journal of Biochemistry 167 (3): 467–473. ISSN 0014-2956. PMID 3653103.
Dey, Madhusudan; Cao, Chune; Dar, Arvin C.; Tamura, Tomohiko; Ozato, Keiko; Sicheri, Frank; Dever, Thomas E. (2005-09-23). “Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition”. Cell 122 (6): 901–913. doi:10.1016/j.cell.2005.06.041. ISSN 0092-8674. PMID 16179259.
Meurs, E.; Chong, K.; Galabru, J.; Thomas, N. S.; Kerr, I. M.; Williams, B. R.; Hovanessian, A. G. (1990-07-27). “Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon”. Cell 62 (2): 379–390. ISSN 0092-8674. PMID 1695551.
Kumar, A.; Haque, J.; Lacoste, J.; Hiscott, J.; Williams, B. R. (1994-07-05). “Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B”. Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6288–6292. ISSN 0027-8424. PMC 44186. PMID 7912826.
Xu, Z.; Williams, B. R. (2000-7). “The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR”. Molecular and Cellular Biology 20 (14): 5285–5299. ISSN 0270-7306. PMC 85978. PMID 10866685.
Iwakiri, Dai (2014-08-06). “Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis”. Cancers 6 (3): 1615–1630. doi:10.3390/cancers6031615. ISSN 2072-6694. PMC 4190559. PMID 25101570.
Clemens, M. J.; Laing, K. G.; Jeffrey, I. W.; Schofield, A.; Sharp, T. V.; Elia, A.; Matys, V.; James, M. C. et al. (1994). “Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs”. Biochimie 76 (8): 770–778. ISSN 0300-9084. PMID 7534482.
Maitra, R. K.; McMillan, N. A.; Desai, S.; McSwiggen, J.; Hovanessian, A. G.; Sen, G.; Williams, B. R.; Silverman, R. H. (1994-11-01). “HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes”. Virology 204 (2): 823–827. doi:10.1006/viro.1994.1601. ISSN 0042-6822. PMID 7524241.
Black, T. L.; Safer, B.; Hovanessian, A.; Katze, M. G. (1989-5). “The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation”. Journal of Virology 63 (5): 2244–2251. ISSN 0022-538X. PMC 250642. PMID 2539516.
Langland, Jeffrey O.; Jacobs, Bertram L. (2004-07-01). “Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L”. Virology 324 (2): 419–429. doi:10.1016/j.virol.2004.03.012. ISSN 0042-6822. PMID 15207627.
Schmechel, S.; Chute, M.; Skinner, P.; Anderson, R.; Schiff, L. (1997-05-26). “Preferential translation of reovirus mRNA by a sigma3-dependent mechanism”. Virology 232 (1): 62–73. doi:10.1006/viro.1997.8531. ISSN 0042-6822. PMID 9185589.
Lu, Y.; Wambach, M.; Katze, M. G.; Krug, R. M. (1995-12-01). “Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor”. Virology 214 (1): 222–228. ISSN 0042-6822. PMID 8525619.
Gale, M.; Tan, S. L.; Wambach, M.; Katze, M. G. (1996-8). “Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation”. Molecular and Cellular Biology 16 (8): 4172–4181. ISSN 0270-7306. PMC 231414. PMID 8754816.
Gale, M.; Blakely, C. M.; Kwieciszewski, B.; Tan, S. L.; Dossett, M.; Tang, N. M.; Korth, M. J.; Polyak, S. J. et al. (1998-9). “Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation”. Molecular and Cellular Biology 18 (9): 5208–5218. ISSN 0270-7306. PMC 109106. PMID 9710605.
Kawagishi-Kobayashi, M.; Silverman, J. B.; Ung, T. L.; Dever, T. E. (1997-7). “Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha”. Molecular and Cellular Biology 17 (7): 4146–4158. ISSN 0270-7306. PMC 232268. PMID 9199350.
Brand, S. R.; Kobayashi, R.; Mathews, M. B. (1997-03-28). “The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR”. The Journal of Biological Chemistry 272 (13): 8388–8395. ISSN 0021-9258. PMID 9079663.
He, B.; Gross, M.; Roizman, B. (1997-02-04). “The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase”. Proceedings of the National Academy of Sciences of the United States of America 94 (3): 843–848. ISSN 0027-8424. PMC 19601. PMID 9023344.