リガンド (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "リガンド" in Japanese language version.

refsWebsite

Global rank Japanese rank

58nih.gov

4^th place

24^th place

30doi.org

2^nd place

6^th place

7harvard.edu

18^th place

107^th place

3jstor.org

26^th place

275^th place

2web.archive.org

1^st place

1arxiv.org

69^th place

227^th place

1sciencesnail.com

low place

1graphpad.com

low place

1ufl.edu

921^st place

2,186^th place

1books.google.com

3^rd place

61^st place

arxiv.org

Teif VB, Rippe K (October 2010). “Statistical-mechanical lattice models for protein-DNA binding in chromatin”. Journal of Physics: Condensed Matter 22 (41): 414105. arXiv:1004.5514. Bibcode: 2010JPCM...22O4105T. doi:10.1088/0953-8984/22/41/414105. PMID 21386588.

books.google.com

Kenakin, Terrance P. (November 2006). A pharmacology primer: theory, applications, and methods. Academic Press. p. 79. ISBN 978-0-12-370599-0

doi.org

Teif VB (October 2005). “Ligand-induced DNA condensation: choosing the model”. Biophysical Journal 89 (4): 2574–87. Bibcode: 2005BpJ....89.2574T. doi:10.1529/biophysj.105.063909. PMC 1366757. PMID 16085765.
Teif VB, Rippe K (October 2010). “Statistical-mechanical lattice models for protein-DNA binding in chromatin”. Journal of Physics: Condensed Matter 22 (41): 414105. arXiv:1004.5514. Bibcode: 2010JPCM...22O4105T. doi:10.1088/0953-8984/22/41/414105. PMID 21386588.
Baron R, Setny P, McCammon JA (September 2010). “Water in cavity-ligand recognition”. Journal of the American Chemical Society 132 (34): 12091–7. doi:10.1021/ja1050082. PMC 2933114. PMID 20695475.
Baaske P, Wienken CJ, Reineck P, Duhr S, Braun D (March 2010). “Optical thermophoresis for quantifying the buffer dependence of aptamer binding”. Angewandte Chemie 49 (12): 2238–41. doi:10.1002/anie.200903998. PMID 20186894 (February 24, 2010).
Wienken CJ, Baaske P, Rothbauer U, Braun D, Duhr S (October 2010). “Protein-binding assays in biological liquids using microscale thermophoresis”. Nature Communications 1 (7): 100. Bibcode: 2010NatCo...1..100W. doi:10.1038/ncomms1093. PMID 20981028.
Cabanos, C; Wang, M; Han, X; Hansen, SB (8 August 2017). “A Soluble Fluorescent Binding Assay Reveals PIP₂ Antagonism of TREK-1 Channels.”. Cell Reports 20 (6): 1287–1294. doi:10.1016/j.celrep.2017.07.034. PMC 5586213. PMID 28793254.
Matera, Carlo; Pucci, Luca; Fiorentini, Chiara; Fucile, Sergio; Missale, Cristina; Grazioso, Giovanni; Clementi, Francesco; Zoli, Michele et al. (2015-08-28). “Bifunctional compounds targeting both D2 and non-α7 nACh receptors: Design, synthesis and pharmacological characterization”. European Journal of Medicinal Chemistry 101: 367–383. doi:10.1016/j.ejmech.2015.06.039. PMID 26164842.
Matera, Carlo; Flammini, Lisa; Quadri, Marta; Vivo, Valentina; Ballabeni, Vigilio; Holzgrabe, Ulrike; Mohr, Klaus; De Amici, Marco et al. (2014-03-21). “Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity”. European Journal of Medicinal Chemistry 75: 222–232. doi:10.1016/j.ejmech.2014.01.032. PMID 24534538.
Erez M, Takemori AE, Portoghese PS (July 1982). “Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites”. Journal of Medicinal Chemistry 25 (7): 847–9. doi:10.1021/jm00349a016. PMID 7108900.
Portoghese PS, Ronsisvalle G, Larson DL, Yim CB, Sayre LM, Takemori AE (1982). “Opioid agonist and antagonist bivalent ligands as receptor probes”. Life Sciences 31 (12–13): 1283–6. doi:10.1016/0024-3205(82)90362-9. PMID 6292615.
Portoghese PS, Akgün E, Lunzer MM (January 2017). “Heteromer Induction: An Approach to Unique Pharmacology?”. ACS Chemical Neuroscience 8 (3): 426–428. doi:10.1021/acschemneuro.7b00002. PMID 28139906.
Blum JJ, Conn PM (December 1982). “Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model”. Proceedings of the National Academy of Sciences of the United States of America 79 (23): 7307–11. Bibcode: 1982PNAS...79.7307B. doi:10.1073/pnas.79.23.7307. JSTOR 13076. PMC 347328. PMID 6296828.
Conn PM, Rogers DC, Stewart JM, Niedel J, Sheffield T (April 1982). “Conversion of a gonadotropin-releasing hormone antagonist to an agonist”. Nature 296 (5858): 653–5. Bibcode: 1982Natur.296..653C. doi:10.1038/296653a0. PMID 6280058.
Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M (August 2014). “Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties”. Bioorganic & Medicinal Chemistry 22 (15): 3938–46. doi:10.1016/j.bmc.2014.06.008. PMID 24984935.
Russo O, Berthouze M, Giner M, Soulier JL, Rivail L, Sicsic S, Lezoualc'h F, Jockers R, Berque-Bestel I (September 2007). “Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers”. Journal of Medicinal Chemistry 50 (18): 4482–92. doi:10.1021/jm070552t. PMID 17676726.
Soulier JL, Russo O, Giner M, Rivail L, Berthouze M, Ongeri S, Maigret B, Fischmeister R, Lezoualc'h F, Sicsic S, Berque-Bestel I (October 2005). “Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies”. Journal of Medicinal Chemistry 48 (20): 6220–8. doi:10.1021/jm050234z. PMID 16190749.
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B (August 2016). “Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure”. Journal of Medicinal Chemistry 59 (15): 7152–66. doi:10.1021/acs.jmedchem.6b00564. PMID 27420737.
Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C (February 2017). “A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage”. ACS Chemical Neuroscience 8 (6): 1262–1278. doi:10.1021/acschemneuro.6b00399. PMC 5679024. PMID 28128928.
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ (December 2012). “Heterobivalent ligands target cell-surface receptor combinations in vivo”. Proceedings of the National Academy of Sciences of the United States of America 109 (52): 21295–300. Bibcode: 2012PNAS..10921295X. doi:10.1073/pnas.1211762109. JSTOR 42553664. PMC 3535626. PMID 23236171.
Lensing CJ, Freeman KT, Schnell SM, Adank DN, Speth RC, Haskell-Luevano C (April 2016). “An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers”. Journal of Medicinal Chemistry 59 (7): 3112–28. doi:10.1021/acs.jmedchem.5b01894. PMC 5679017. PMID 26959173.
Shonberg J, Scammells PJ, Capuano B (June 2011). “Design strategies for bivalent ligands targeting GPCRs”. ChemMedChem 6 (6): 963–74. doi:10.1002/cmdc.201100101. PMID 21520422.
Berque-Bestel I, Lezoualc'h F, Jockers R (December 2008). “Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers”. Current Drug Discovery Technologies 5 (4): 312–8. doi:10.2174/157016308786733591. PMID 19075611.
Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS (November 2015). “Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)”. Journal of Medicinal Chemistry 58 (21): 8647–57. doi:10.1021/acs.jmedchem.5b01245. PMC 5055304. PMID 26451468.
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS (December 2005). “Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series”. Proceedings of the National Academy of Sciences of the United States of America 102 (52): 19208–13. Bibcode: 2005PNAS..10219208D. doi:10.1073/pnas.0506627102. JSTOR 4152590. PMC 1323165. PMID 16365317.
Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS (November 2014). “Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model”. European Journal of Pharmacology 743: 48–52. doi:10.1016/j.ejphar.2014.09.008. PMC 4259840. PMID 25239072.
Abrusan G, Marsh JA (2019). “Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes.”. Journal of Molecular Biology 431 (19): 3871-3888. doi:10.1016/j.jmb.2019.07.014. PMC 6739599. PMID 31306664.
Abrusan G, Marsh JA (2018). “Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.”. Cell Reports 22 (12): 3265-3276. doi:10.1016/j.celrep.2018.02.085. PMC 5873459. PMID 29562182.
Abrusan G, Marsh JA (2019). “Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes.”. Molecular Biology and Evolution 36 (8): 1711-1727. doi:10.1093/molbev/msz093. PMC 6657754. PMID 31004156.
Welsch ME, Snyder SA, Stockwell BR (June 2010). “Privileged scaffolds for library design and drug discovery”. Current Opinion in Chemical Biology 14 (3): 347–61. doi:10.1016/j.cbpa.2010.02.018. PMC 2908274. PMID 20303320.
Kombarov R, Altieri A, Genis D, Kirpichenok M, Kochubey V, Rakitina N, Titarenko Z (February 2010). “BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery”. Molecular Diversity 14 (1): 193–200. doi:10.1007/s11030-009-9157-5. PMID 19468851.

graphpad.com

See Homologous competitive binding curves Archived 2007-12-19 at the Wayback Machine., A complete guide to nonlinear regression, curvefit.com.

harvard.edu

ui.adsabs.harvard.edu

Teif VB (October 2005). “Ligand-induced DNA condensation: choosing the model”. Biophysical Journal 89 (4): 2574–87. Bibcode: 2005BpJ....89.2574T. doi:10.1529/biophysj.105.063909. PMC 1366757. PMID 16085765.
Teif VB, Rippe K (October 2010). “Statistical-mechanical lattice models for protein-DNA binding in chromatin”. Journal of Physics: Condensed Matter 22 (41): 414105. arXiv:1004.5514. Bibcode: 2010JPCM...22O4105T. doi:10.1088/0953-8984/22/41/414105. PMID 21386588.
Wienken CJ, Baaske P, Rothbauer U, Braun D, Duhr S (October 2010). “Protein-binding assays in biological liquids using microscale thermophoresis”. Nature Communications 1 (7): 100. Bibcode: 2010NatCo...1..100W. doi:10.1038/ncomms1093. PMID 20981028.
Blum JJ, Conn PM (December 1982). “Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model”. Proceedings of the National Academy of Sciences of the United States of America 79 (23): 7307–11. Bibcode: 1982PNAS...79.7307B. doi:10.1073/pnas.79.23.7307. JSTOR 13076. PMC 347328. PMID 6296828.
Conn PM, Rogers DC, Stewart JM, Niedel J, Sheffield T (April 1982). “Conversion of a gonadotropin-releasing hormone antagonist to an agonist”. Nature 296 (5858): 653–5. Bibcode: 1982Natur.296..653C. doi:10.1038/296653a0. PMID 6280058.
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ (December 2012). “Heterobivalent ligands target cell-surface receptor combinations in vivo”. Proceedings of the National Academy of Sciences of the United States of America 109 (52): 21295–300. Bibcode: 2012PNAS..10921295X. doi:10.1073/pnas.1211762109. JSTOR 42553664. PMC 3535626. PMID 23236171.
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS (December 2005). “Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series”. Proceedings of the National Academy of Sciences of the United States of America 102 (52): 19208–13. Bibcode: 2005PNAS..10219208D. doi:10.1073/pnas.0506627102. JSTOR 4152590. PMC 1323165. PMID 16365317.

jstor.org

Blum JJ, Conn PM (December 1982). “Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model”. Proceedings of the National Academy of Sciences of the United States of America 79 (23): 7307–11. Bibcode: 1982PNAS...79.7307B. doi:10.1073/pnas.79.23.7307. JSTOR 13076. PMC 347328. PMID 6296828.
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ (December 2012). “Heterobivalent ligands target cell-surface receptor combinations in vivo”. Proceedings of the National Academy of Sciences of the United States of America 109 (52): 21295–300. Bibcode: 2012PNAS..10921295X. doi:10.1073/pnas.1211762109. JSTOR 42553664. PMC 3535626. PMID 23236171.
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS (December 2005). “Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series”. Proceedings of the National Academy of Sciences of the United States of America 102 (52): 19208–13. Bibcode: 2005PNAS..10219208D. doi:10.1073/pnas.0506627102. JSTOR 4152590. PMC 1323165. PMID 16365317.

nih.gov

pubmed.ncbi.nlm.nih.gov

Teif VB (October 2005). “Ligand-induced DNA condensation: choosing the model”. Biophysical Journal 89 (4): 2574–87. Bibcode: 2005BpJ....89.2574T. doi:10.1529/biophysj.105.063909. PMC 1366757. PMID 16085765.
Teif VB, Rippe K (October 2010). “Statistical-mechanical lattice models for protein-DNA binding in chromatin”. Journal of Physics: Condensed Matter 22 (41): 414105. arXiv:1004.5514. Bibcode: 2010JPCM...22O4105T. doi:10.1088/0953-8984/22/41/414105. PMID 21386588.
Baron R, Setny P, McCammon JA (September 2010). “Water in cavity-ligand recognition”. Journal of the American Chemical Society 132 (34): 12091–7. doi:10.1021/ja1050082. PMC 2933114. PMID 20695475.
Baaske P, Wienken CJ, Reineck P, Duhr S, Braun D (March 2010). “Optical thermophoresis for quantifying the buffer dependence of aptamer binding”. Angewandte Chemie 49 (12): 2238–41. doi:10.1002/anie.200903998. PMID 20186894 (February 24, 2010).
Wienken CJ, Baaske P, Rothbauer U, Braun D, Duhr S (October 2010). “Protein-binding assays in biological liquids using microscale thermophoresis”. Nature Communications 1 (7): 100. Bibcode: 2010NatCo...1..100W. doi:10.1038/ncomms1093. PMID 20981028.
Cabanos, C; Wang, M; Han, X; Hansen, SB (8 August 2017). “A Soluble Fluorescent Binding Assay Reveals PIP₂ Antagonism of TREK-1 Channels.”. Cell Reports 20 (6): 1287–1294. doi:10.1016/j.celrep.2017.07.034. PMC 5586213. PMID 28793254.
Matera, Carlo; Pucci, Luca; Fiorentini, Chiara; Fucile, Sergio; Missale, Cristina; Grazioso, Giovanni; Clementi, Francesco; Zoli, Michele et al. (2015-08-28). “Bifunctional compounds targeting both D2 and non-α7 nACh receptors: Design, synthesis and pharmacological characterization”. European Journal of Medicinal Chemistry 101: 367–383. doi:10.1016/j.ejmech.2015.06.039. PMID 26164842.
Matera, Carlo; Flammini, Lisa; Quadri, Marta; Vivo, Valentina; Ballabeni, Vigilio; Holzgrabe, Ulrike; Mohr, Klaus; De Amici, Marco et al. (2014-03-21). “Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity”. European Journal of Medicinal Chemistry 75: 222–232. doi:10.1016/j.ejmech.2014.01.032. PMID 24534538.
Erez M, Takemori AE, Portoghese PS (July 1982). “Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites”. Journal of Medicinal Chemistry 25 (7): 847–9. doi:10.1021/jm00349a016. PMID 7108900.
Portoghese PS, Ronsisvalle G, Larson DL, Yim CB, Sayre LM, Takemori AE (1982). “Opioid agonist and antagonist bivalent ligands as receptor probes”. Life Sciences 31 (12–13): 1283–6. doi:10.1016/0024-3205(82)90362-9. PMID 6292615.
Portoghese PS, Akgün E, Lunzer MM (January 2017). “Heteromer Induction: An Approach to Unique Pharmacology?”. ACS Chemical Neuroscience 8 (3): 426–428. doi:10.1021/acschemneuro.7b00002. PMID 28139906.
Blum JJ, Conn PM (December 1982). “Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model”. Proceedings of the National Academy of Sciences of the United States of America 79 (23): 7307–11. Bibcode: 1982PNAS...79.7307B. doi:10.1073/pnas.79.23.7307. JSTOR 13076. PMC 347328. PMID 6296828.
Conn PM, Rogers DC, Stewart JM, Niedel J, Sheffield T (April 1982). “Conversion of a gonadotropin-releasing hormone antagonist to an agonist”. Nature 296 (5858): 653–5. Bibcode: 1982Natur.296..653C. doi:10.1038/296653a0. PMID 6280058.
Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M (August 2014). “Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties”. Bioorganic & Medicinal Chemistry 22 (15): 3938–46. doi:10.1016/j.bmc.2014.06.008. PMID 24984935.
Russo O, Berthouze M, Giner M, Soulier JL, Rivail L, Sicsic S, Lezoualc'h F, Jockers R, Berque-Bestel I (September 2007). “Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers”. Journal of Medicinal Chemistry 50 (18): 4482–92. doi:10.1021/jm070552t. PMID 17676726.
Soulier JL, Russo O, Giner M, Rivail L, Berthouze M, Ongeri S, Maigret B, Fischmeister R, Lezoualc'h F, Sicsic S, Berque-Bestel I (October 2005). “Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies”. Journal of Medicinal Chemistry 48 (20): 6220–8. doi:10.1021/jm050234z. PMID 16190749.
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B (August 2016). “Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure”. Journal of Medicinal Chemistry 59 (15): 7152–66. doi:10.1021/acs.jmedchem.6b00564. PMID 27420737.
Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C (February 2017). “A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage”. ACS Chemical Neuroscience 8 (6): 1262–1278. doi:10.1021/acschemneuro.6b00399. PMC 5679024. PMID 28128928.
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ (December 2012). “Heterobivalent ligands target cell-surface receptor combinations in vivo”. Proceedings of the National Academy of Sciences of the United States of America 109 (52): 21295–300. Bibcode: 2012PNAS..10921295X. doi:10.1073/pnas.1211762109. JSTOR 42553664. PMC 3535626. PMID 23236171.
Lensing CJ, Freeman KT, Schnell SM, Adank DN, Speth RC, Haskell-Luevano C (April 2016). “An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers”. Journal of Medicinal Chemistry 59 (7): 3112–28. doi:10.1021/acs.jmedchem.5b01894. PMC 5679017. PMID 26959173.
Shonberg J, Scammells PJ, Capuano B (June 2011). “Design strategies for bivalent ligands targeting GPCRs”. ChemMedChem 6 (6): 963–74. doi:10.1002/cmdc.201100101. PMID 21520422.
Berque-Bestel I, Lezoualc'h F, Jockers R (December 2008). “Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers”. Current Drug Discovery Technologies 5 (4): 312–8. doi:10.2174/157016308786733591. PMID 19075611.
Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS (November 2015). “Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)”. Journal of Medicinal Chemistry 58 (21): 8647–57. doi:10.1021/acs.jmedchem.5b01245. PMC 5055304. PMID 26451468.
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS (December 2005). “Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series”. Proceedings of the National Academy of Sciences of the United States of America 102 (52): 19208–13. Bibcode: 2005PNAS..10219208D. doi:10.1073/pnas.0506627102. JSTOR 4152590. PMC 1323165. PMID 16365317.
Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS (November 2014). “Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model”. European Journal of Pharmacology 743: 48–52. doi:10.1016/j.ejphar.2014.09.008. PMC 4259840. PMID 25239072.
Abrusan G, Marsh JA (2019). “Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes.”. Journal of Molecular Biology 431 (19): 3871-3888. doi:10.1016/j.jmb.2019.07.014. PMC 6739599. PMID 31306664.
Abrusan G, Marsh JA (2018). “Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.”. Cell Reports 22 (12): 3265-3276. doi:10.1016/j.celrep.2018.02.085. PMC 5873459. PMID 29562182.
Abrusan G, Marsh JA (2019). “Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes.”. Molecular Biology and Evolution 36 (8): 1711-1727. doi:10.1093/molbev/msz093. PMC 6657754. PMID 31004156.
Welsch ME, Snyder SA, Stockwell BR (June 2010). “Privileged scaffolds for library design and drug discovery”. Current Opinion in Chemical Biology 14 (3): 347–61. doi:10.1016/j.cbpa.2010.02.018. PMC 2908274. PMID 20303320.
Kombarov R, Altieri A, Genis D, Kirpichenok M, Kochubey V, Rakitina N, Titarenko Z (February 2010). “BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery”. Molecular Diversity 14 (1): 193–200. doi:10.1007/s11030-009-9157-5. PMID 19468851.

ncbi.nlm.nih.gov

Teif VB (October 2005). “Ligand-induced DNA condensation: choosing the model”. Biophysical Journal 89 (4): 2574–87. Bibcode: 2005BpJ....89.2574T. doi:10.1529/biophysj.105.063909. PMC 1366757. PMID 16085765.
Baron R, Setny P, McCammon JA (September 2010). “Water in cavity-ligand recognition”. Journal of the American Chemical Society 132 (34): 12091–7. doi:10.1021/ja1050082. PMC 2933114. PMID 20695475.
Cabanos, C; Wang, M; Han, X; Hansen, SB (8 August 2017). “A Soluble Fluorescent Binding Assay Reveals PIP₂ Antagonism of TREK-1 Channels.”. Cell Reports 20 (6): 1287–1294. doi:10.1016/j.celrep.2017.07.034. PMC 5586213. PMID 28793254.
Blum JJ, Conn PM (December 1982). “Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model”. Proceedings of the National Academy of Sciences of the United States of America 79 (23): 7307–11. Bibcode: 1982PNAS...79.7307B. doi:10.1073/pnas.79.23.7307. JSTOR 13076. PMC 347328. PMID 6296828.
Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C (February 2017). “A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage”. ACS Chemical Neuroscience 8 (6): 1262–1278. doi:10.1021/acschemneuro.6b00399. PMC 5679024. PMID 28128928.
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ (December 2012). “Heterobivalent ligands target cell-surface receptor combinations in vivo”. Proceedings of the National Academy of Sciences of the United States of America 109 (52): 21295–300. Bibcode: 2012PNAS..10921295X. doi:10.1073/pnas.1211762109. JSTOR 42553664. PMC 3535626. PMID 23236171.
Lensing CJ, Freeman KT, Schnell SM, Adank DN, Speth RC, Haskell-Luevano C (April 2016). “An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers”. Journal of Medicinal Chemistry 59 (7): 3112–28. doi:10.1021/acs.jmedchem.5b01894. PMC 5679017. PMID 26959173.
Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS (November 2015). “Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)”. Journal of Medicinal Chemistry 58 (21): 8647–57. doi:10.1021/acs.jmedchem.5b01245. PMC 5055304. PMID 26451468.
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS (December 2005). “Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series”. Proceedings of the National Academy of Sciences of the United States of America 102 (52): 19208–13. Bibcode: 2005PNAS..10219208D. doi:10.1073/pnas.0506627102. JSTOR 4152590. PMC 1323165. PMID 16365317.
Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS (November 2014). “Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model”. European Journal of Pharmacology 743: 48–52. doi:10.1016/j.ejphar.2014.09.008. PMC 4259840. PMID 25239072.
Abrusan G, Marsh JA (2019). “Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes.”. Journal of Molecular Biology 431 (19): 3871-3888. doi:10.1016/j.jmb.2019.07.014. PMC 6739599. PMID 31306664.
Abrusan G, Marsh JA (2018). “Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.”. Cell Reports 22 (12): 3265-3276. doi:10.1016/j.celrep.2018.02.085. PMC 5873459. PMID 29562182.
Abrusan G, Marsh JA (2019). “Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes.”. Molecular Biology and Evolution 36 (8): 1711-1727. doi:10.1093/molbev/msz093. PMC 6657754. PMID 31004156.
Welsch ME, Snyder SA, Stockwell BR (June 2010). “Privileged scaffolds for library design and drug discovery”. Current Opinion in Chemical Biology 14 (3): 347–61. doi:10.1016/j.cbpa.2010.02.018. PMC 2908274. PMID 20303320.

pmc.ncbi.nlm.nih.gov

Teif VB (October 2005). “Ligand-induced DNA condensation: choosing the model”. Biophysical Journal 89 (4): 2574–87. Bibcode: 2005BpJ....89.2574T. doi:10.1529/biophysj.105.063909. PMC 1366757. PMID 16085765.
Baron R, Setny P, McCammon JA (September 2010). “Water in cavity-ligand recognition”. Journal of the American Chemical Society 132 (34): 12091–7. doi:10.1021/ja1050082. PMC 2933114. PMID 20695475.
Cabanos, C; Wang, M; Han, X; Hansen, SB (8 August 2017). “A Soluble Fluorescent Binding Assay Reveals PIP₂ Antagonism of TREK-1 Channels.”. Cell Reports 20 (6): 1287–1294. doi:10.1016/j.celrep.2017.07.034. PMC 5586213. PMID 28793254.
Blum JJ, Conn PM (December 1982). “Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model”. Proceedings of the National Academy of Sciences of the United States of America 79 (23): 7307–11. Bibcode: 1982PNAS...79.7307B. doi:10.1073/pnas.79.23.7307. JSTOR 13076. PMC 347328. PMID 6296828.
Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C (February 2017). “A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage”. ACS Chemical Neuroscience 8 (6): 1262–1278. doi:10.1021/acschemneuro.6b00399. PMC 5679024. PMID 28128928.
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ (December 2012). “Heterobivalent ligands target cell-surface receptor combinations in vivo”. Proceedings of the National Academy of Sciences of the United States of America 109 (52): 21295–300. Bibcode: 2012PNAS..10921295X. doi:10.1073/pnas.1211762109. JSTOR 42553664. PMC 3535626. PMID 23236171.
Lensing CJ, Freeman KT, Schnell SM, Adank DN, Speth RC, Haskell-Luevano C (April 2016). “An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers”. Journal of Medicinal Chemistry 59 (7): 3112–28. doi:10.1021/acs.jmedchem.5b01894. PMC 5679017. PMID 26959173.
Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS (November 2015). “Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)”. Journal of Medicinal Chemistry 58 (21): 8647–57. doi:10.1021/acs.jmedchem.5b01245. PMC 5055304. PMID 26451468.
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS (December 2005). “Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series”. Proceedings of the National Academy of Sciences of the United States of America 102 (52): 19208–13. Bibcode: 2005PNAS..10219208D. doi:10.1073/pnas.0506627102. JSTOR 4152590. PMC 1323165. PMID 16365317.
Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS (November 2014). “Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model”. European Journal of Pharmacology 743: 48–52. doi:10.1016/j.ejphar.2014.09.008. PMC 4259840. PMID 25239072.
Abrusan G, Marsh JA (2019). “Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes.”. Journal of Molecular Biology 431 (19): 3871-3888. doi:10.1016/j.jmb.2019.07.014. PMC 6739599. PMID 31306664.
Abrusan G, Marsh JA (2018). “Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.”. Cell Reports 22 (12): 3265-3276. doi:10.1016/j.celrep.2018.02.085. PMC 5873459. PMID 29562182.
Abrusan G, Marsh JA (2019). “Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes.”. Molecular Biology and Evolution 36 (8): 1711-1727. doi:10.1093/molbev/msz093. PMC 6657754. PMID 31004156.
Welsch ME, Snyder SA, Stockwell BR (June 2010). “Privileged scaffolds for library design and drug discovery”. Current Opinion in Chemical Biology 14 (3): 347–61. doi:10.1016/j.cbpa.2010.02.018. PMC 2908274. PMID 20303320.

sciencesnail.com

“The difference between K_i, K_d, IC₅₀, and EC₅₀ values”. The Science Snail (31 December 2019). 2020年7月19日閲覧。

ufl.edu

clesm.mae.ufl.edu

Vu-Quoc, L., Configuration integral (statistical mechanics), 2008. this wiki site is down; see this article in the web archive on 2012 April 28.

web.archive.org

See Homologous competitive binding curves Archived 2007-12-19 at the Wayback Machine., A complete guide to nonlinear regression, curvefit.com.
Vu-Quoc, L., Configuration integral (statistical mechanics), 2008. this wiki site is down; see this article in the web archive on 2012 April 28.