共有結合性阻害剤 (Japanese Wikipedia)

Analysis of information sources in references of the Wikipedia article "共有結合性阻害剤" in Japanese language version.

refsWebsite

Global rank Japanese rank

33nih.gov

4^th place

24^th place

23doi.org

2^nd place

6^th place

3wikipedia.org

low place

2harvard.edu

18^th place

107^th place

1clinicaltrials.gov

5,225^th place

low place

1fda.gov

447^th place

1,043^rd place

1europa.eu

68^th place

425^th place

1pfizer.com

low place

clinicaltrials.gov (Global: 5,225^th place; Japanese: low place)

臨床試験番号 NCT03600883 研究名 "A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of AMG 510 in Subjects With Solid Tumors With a Specific KRAS Mutation." - ClinicalTrials.gov

doi.org (Global: 2^nd place; Japanese: 6^th place)

Singh J, Petter RC, Baillie TA, Whitty A (April 2011). “The resurgence of covalent drugs”. Nature Reviews. Drug Discovery 10 (4): 307–317. doi:10.1038/nrd3410. PMID 21455239.
Robertson JG (April 2005). “Mechanistic basis of enzyme-targeted drugs”. Biochemistry 44 (15): 5561–5571. doi:10.1021/bi050247e. PMID 15823014.
Potashman MH, Duggan ME (March 2009). “Covalent modifiers: an orthogonal approach to drug design”. Journal of Medicinal Chemistry 52 (5): 1231–1246. doi:10.1021/jm8008597. PMID 19203292.
Liebler DC, Guengerich FP (May 2005). “Elucidating mechanisms of drug-induced toxicity”. Nature Reviews. Drug Discovery 4 (5): 410–420. doi:10.1038/nrd1720. PMID 15864270.
Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA (April 2011). “Managing the challenge of chemically reactive metabolites in drug development”. Nature Reviews. Drug Discovery 10 (4): 292–306. doi:10.1038/nrd3408. PMID 21455238.
Singh J, Petter RC, Kluge AF (August 2010). “Targeted covalent drugs of the kinase family”. Current Opinion in Chemical Biology 14 (4): 475–480. doi:10.1016/j.cbpa.2010.06.168. PMID 20609616.
Singh J, Dobrusin EM, Fry DW, Haske T, Whitty A, McNamara DJ (March 1997). “Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases”. Journal of Medicinal Chemistry 40 (7): 1130–1135. doi:10.1021/jm960380s. PMID 9089334.
Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM (September 1998). “Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor”. Proceedings of the National Academy of Sciences of the United States of America 95 (20): 12022–12027. Bibcode: 1998PNAS...9512022F. doi:10.1073/pnas.95.20.12022. PMC 21758. PMID 9751783.
Cohen MS, Zhang C, Shokat KM, Taunton J (May 2005). “Structural bioinformatics-based design of selective, irreversible kinase inhibitors”. Science 308 (5726): 1318–1321. doi:10.1126/science1108367. PMC 3641834. PMID 15919995.
Hagel M, Niu D, St Martin T, Sheets MP, Qiao L, Bernard H, Karp RM, Zhu Z, Labenski MT, Chaturvedi P, Nacht M, Westlin WF, Petter RC, Singh J (January 2011). “Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine”. Nature Chemical Biology 7 (1): 22–24. doi:10.1038/nchembio.492. PMID 21113170.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). “K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions”. Nature 503 (7477): 548–551. Bibcode: 2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
Holm L, Moody P, Howarth M (November 2009). “Electrophilic affibodies forming covalent bonds to protein targets”. The Journal of Biological Chemistry 284 (47): 32906–32913. doi:10.1074/jbc.M109.034322. PMC 2781706. PMID 19759009.
Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L (September 2013). “Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity”. Nature Methods 10 (9): 885–888. doi:10.1038/nmeth.2595. PMC 3882359. PMID 23913257.
Smith AJ, Zhang X, Leach AG, Houk KN (January 2009). “Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins”. Journal of Medicinal Chemistry 52 (2): 225–233. doi:10.1021/jm800498e. PMC 2646787. PMID 19053779.
Srinivasan B (March 2021). “Explicit Treatment of Non-Michaelis-Menten and Atypical Kinetics in Early Drug Discovery*”. ChemMedChem 16 (6): 899–918. doi:10.1002/cmdc.202000791. PMID 33231926.
Liu Q, Sabnis Y, Zhao Z, Zhang T, Buhrlage SJ, Jones LH, Gray NS (February 2013). “Developing irreversible inhibitors of the protein kinase cysteinome”. Chemistry & Biology 20 (2): 146–159. doi:10.1016/j.chembiol.2012.12.006. PMC 3583020. PMID 23438744.
Durham TB, Blanco MJ (March 2015). “Target engagement in lead generation”. Bioorganic & Medicinal Chemistry Letters 25 (5): 998–1008. doi:10.1016/j.bmcl.2014.12.076. PMID 25630223.
Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, Kolibaba KS, Furman RR, Rodriguez S, Chang BY, Sukbuntherng J, Izumi R, Hamdy A, Hedrick E, Fowler NH (January 2013). “Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies”. Journal of Clinical Oncology 31 (1): 88–94. doi:10.1200/JCO.2012.42.7906. PMC 5505166. PMID 23045577.
Izquierdo-Serra M, Bautista-Barrufet A, Trapero A, Garrido-Charles A, Díaz-Tahoces A, Camarero N, Pittolo S, Valbuena S, Pérez-Jiménez A, Gay M, García-Moll A, Rodríguez-Escrich C, Lerma J, de la Villa P, Fernández E, Pericàs MÀ, Llebaria A, Gorostiza P (July 2016). “Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches”. Nature Communications 7 (1): 12221. doi:10.1038/ncomms12221. PMC 4961765. PMID 27436051.
Garrido-Charles A, Huet A, Matera C, Thirumalai A, Hernando J, Llebaria A, Moser T, Gorostiza P (June 2022). “Fast Photoswitchable Molecular Prosthetics Control Neuronal Activity in the Cochlea”. Journal of the American Chemical Society 144 (21): 9229–9239. doi:10.1101/2021.05.25.445123. PMID 35584208.
Bauer RA (September 2015). “Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies”. Drug Discovery Today 20 (9): 1061–1073. doi:10.1016/j.drudis.2015.05.005. PMID 26002380.
Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O (September 2009). “A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding”. Drug Metabolism and Disposition 37 (9): 1970–1977. doi:10.1124/dmd.109.027797. PMID 19487250.
Tan CS, Kumarakulasinghe NB, Huang YQ, Ang YL, Choo JR, Goh BC, Soo RA (February 2018). “Third generation EGFR TKIs: current data and future directions”. Molecular Cancer 17 (1): 29. doi:10.1186/s12943-018-0778-0. PMC 5817792. PMID 29455654.

europa.eu (Global: 68^th place; Japanese: 425^th place)

ema.europa.eu

“Nerlynx EPAR”. European Medicines Agency (EMA). 2021年7月14日閲覧。

fda.gov (Global: 447^th place; Japanese: 1,043^rd place)

accessdata.fda.gov

“Nerlynx (neratinib maleate) Tablets”. U.S. Food and Drug Administration (FDA) (2017年8月21日). 2021年7月14日閲覧。

harvard.edu (Global: 18^th place; Japanese: 107^th place)

ui.adsabs.harvard.edu

Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM (September 1998). “Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor”. Proceedings of the National Academy of Sciences of the United States of America 95 (20): 12022–12027. Bibcode: 1998PNAS...9512022F. doi:10.1073/pnas.95.20.12022. PMC 21758. PMID 9751783.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). “K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions”. Nature 503 (7477): 548–551. Bibcode: 2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.

nih.gov (Global: 4^th place; Japanese: 24^th place)

pubmed.ncbi.nlm.nih.gov

Singh J, Petter RC, Baillie TA, Whitty A (April 2011). “The resurgence of covalent drugs”. Nature Reviews. Drug Discovery 10 (4): 307–317. doi:10.1038/nrd3410. PMID 21455239.
Robertson JG (April 2005). “Mechanistic basis of enzyme-targeted drugs”. Biochemistry 44 (15): 5561–5571. doi:10.1021/bi050247e. PMID 15823014.
Potashman MH, Duggan ME (March 2009). “Covalent modifiers: an orthogonal approach to drug design”. Journal of Medicinal Chemistry 52 (5): 1231–1246. doi:10.1021/jm8008597. PMID 19203292.
Liebler DC, Guengerich FP (May 2005). “Elucidating mechanisms of drug-induced toxicity”. Nature Reviews. Drug Discovery 4 (5): 410–420. doi:10.1038/nrd1720. PMID 15864270.
Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA (April 2011). “Managing the challenge of chemically reactive metabolites in drug development”. Nature Reviews. Drug Discovery 10 (4): 292–306. doi:10.1038/nrd3408. PMID 21455238.
Singh J, Petter RC, Kluge AF (August 2010). “Targeted covalent drugs of the kinase family”. Current Opinion in Chemical Biology 14 (4): 475–480. doi:10.1016/j.cbpa.2010.06.168. PMID 20609616.
Singh J, Dobrusin EM, Fry DW, Haske T, Whitty A, McNamara DJ (March 1997). “Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases”. Journal of Medicinal Chemistry 40 (7): 1130–1135. doi:10.1021/jm960380s. PMID 9089334.
Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM (September 1998). “Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor”. Proceedings of the National Academy of Sciences of the United States of America 95 (20): 12022–12027. Bibcode: 1998PNAS...9512022F. doi:10.1073/pnas.95.20.12022. PMC 21758. PMID 9751783.
Cohen MS, Zhang C, Shokat KM, Taunton J (May 2005). “Structural bioinformatics-based design of selective, irreversible kinase inhibitors”. Science 308 (5726): 1318–1321. doi:10.1126/science1108367. PMC 3641834. PMID 15919995.
Hagel M, Niu D, St Martin T, Sheets MP, Qiao L, Bernard H, Karp RM, Zhu Z, Labenski MT, Chaturvedi P, Nacht M, Westlin WF, Petter RC, Singh J (January 2011). “Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine”. Nature Chemical Biology 7 (1): 22–24. doi:10.1038/nchembio.492. PMID 21113170.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). “K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions”. Nature 503 (7477): 548–551. Bibcode: 2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
Holm L, Moody P, Howarth M (November 2009). “Electrophilic affibodies forming covalent bonds to protein targets”. The Journal of Biological Chemistry 284 (47): 32906–32913. doi:10.1074/jbc.M109.034322. PMC 2781706. PMID 19759009.
Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L (September 2013). “Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity”. Nature Methods 10 (9): 885–888. doi:10.1038/nmeth.2595. PMC 3882359. PMID 23913257.
Smith AJ, Zhang X, Leach AG, Houk KN (January 2009). “Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins”. Journal of Medicinal Chemistry 52 (2): 225–233. doi:10.1021/jm800498e. PMC 2646787. PMID 19053779.
Srinivasan B (March 2021). “Explicit Treatment of Non-Michaelis-Menten and Atypical Kinetics in Early Drug Discovery*”. ChemMedChem 16 (6): 899–918. doi:10.1002/cmdc.202000791. PMID 33231926.
Liu Q, Sabnis Y, Zhao Z, Zhang T, Buhrlage SJ, Jones LH, Gray NS (February 2013). “Developing irreversible inhibitors of the protein kinase cysteinome”. Chemistry & Biology 20 (2): 146–159. doi:10.1016/j.chembiol.2012.12.006. PMC 3583020. PMID 23438744.
Durham TB, Blanco MJ (March 2015). “Target engagement in lead generation”. Bioorganic & Medicinal Chemistry Letters 25 (5): 998–1008. doi:10.1016/j.bmcl.2014.12.076. PMID 25630223.
Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, Kolibaba KS, Furman RR, Rodriguez S, Chang BY, Sukbuntherng J, Izumi R, Hamdy A, Hedrick E, Fowler NH (January 2013). “Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies”. Journal of Clinical Oncology 31 (1): 88–94. doi:10.1200/JCO.2012.42.7906. PMC 5505166. PMID 23045577.
Izquierdo-Serra M, Bautista-Barrufet A, Trapero A, Garrido-Charles A, Díaz-Tahoces A, Camarero N, Pittolo S, Valbuena S, Pérez-Jiménez A, Gay M, García-Moll A, Rodríguez-Escrich C, Lerma J, de la Villa P, Fernández E, Pericàs MÀ, Llebaria A, Gorostiza P (July 2016). “Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches”. Nature Communications 7 (1): 12221. doi:10.1038/ncomms12221. PMC 4961765. PMID 27436051.
Garrido-Charles A, Huet A, Matera C, Thirumalai A, Hernando J, Llebaria A, Moser T, Gorostiza P (June 2022). “Fast Photoswitchable Molecular Prosthetics Control Neuronal Activity in the Cochlea”. Journal of the American Chemical Society 144 (21): 9229–9239. doi:10.1101/2021.05.25.445123. PMID 35584208.
Bauer RA (September 2015). “Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies”. Drug Discovery Today 20 (9): 1061–1073. doi:10.1016/j.drudis.2015.05.005. PMID 26002380.
Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O (September 2009). “A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding”. Drug Metabolism and Disposition 37 (9): 1970–1977. doi:10.1124/dmd.109.027797. PMID 19487250.
Tan CS, Kumarakulasinghe NB, Huang YQ, Ang YL, Choo JR, Goh BC, Soo RA (February 2018). “Third generation EGFR TKIs: current data and future directions”. Molecular Cancer 17 (1): 29. doi:10.1186/s12943-018-0778-0. PMC 5817792. PMID 29455654.

pmc.ncbi.nlm.nih.gov

Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM (September 1998). “Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor”. Proceedings of the National Academy of Sciences of the United States of America 95 (20): 12022–12027. Bibcode: 1998PNAS...9512022F. doi:10.1073/pnas.95.20.12022. PMC 21758. PMID 9751783.
Cohen MS, Zhang C, Shokat KM, Taunton J (May 2005). “Structural bioinformatics-based design of selective, irreversible kinase inhibitors”. Science 308 (5726): 1318–1321. doi:10.1126/science1108367. PMC 3641834. PMID 15919995.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). “K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions”. Nature 503 (7477): 548–551. Bibcode: 2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
Holm L, Moody P, Howarth M (November 2009). “Electrophilic affibodies forming covalent bonds to protein targets”. The Journal of Biological Chemistry 284 (47): 32906–32913. doi:10.1074/jbc.M109.034322. PMC 2781706. PMID 19759009.
Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L (September 2013). “Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity”. Nature Methods 10 (9): 885–888. doi:10.1038/nmeth.2595. PMC 3882359. PMID 23913257.
Smith AJ, Zhang X, Leach AG, Houk KN (January 2009). “Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins”. Journal of Medicinal Chemistry 52 (2): 225–233. doi:10.1021/jm800498e. PMC 2646787. PMID 19053779.
Liu Q, Sabnis Y, Zhao Z, Zhang T, Buhrlage SJ, Jones LH, Gray NS (February 2013). “Developing irreversible inhibitors of the protein kinase cysteinome”. Chemistry & Biology 20 (2): 146–159. doi:10.1016/j.chembiol.2012.12.006. PMC 3583020. PMID 23438744.
Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, Kolibaba KS, Furman RR, Rodriguez S, Chang BY, Sukbuntherng J, Izumi R, Hamdy A, Hedrick E, Fowler NH (January 2013). “Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies”. Journal of Clinical Oncology 31 (1): 88–94. doi:10.1200/JCO.2012.42.7906. PMC 5505166. PMID 23045577.
Izquierdo-Serra M, Bautista-Barrufet A, Trapero A, Garrido-Charles A, Díaz-Tahoces A, Camarero N, Pittolo S, Valbuena S, Pérez-Jiménez A, Gay M, García-Moll A, Rodríguez-Escrich C, Lerma J, de la Villa P, Fernández E, Pericàs MÀ, Llebaria A, Gorostiza P (July 2016). “Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches”. Nature Communications 7 (1): 12221. doi:10.1038/ncomms12221. PMC 4961765. PMID 27436051.
Tan CS, Kumarakulasinghe NB, Huang YQ, Ang YL, Choo JR, Goh BC, Soo RA (February 2018). “Third generation EGFR TKIs: current data and future directions”. Molecular Cancer 17 (1): 29. doi:10.1186/s12943-018-0778-0. PMC 5817792. PMID 29455654.

pfizer.com (Global: low place; Japanese: low place)

“Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study | Pfizer”. www.pfizer.com. 2022年11月21日閲覧。

wikipedia.org (Global: low place; Japanese: low place)

en.wikipedia.org

臨床試験番号 NCT03600883 研究名 "A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of AMG 510 in Subjects With Solid Tumors With a Specific KRAS Mutation." - ClinicalTrials.gov
“Nerlynx (neratinib maleate) Tablets”. U.S. Food and Drug Administration (FDA) (2017年8月21日). 2021年7月14日閲覧。
“Nerlynx EPAR”. European Medicines Agency (EMA). 2021年7月14日閲覧。

共有結合性阻害剤 (Japanese Wikipedia)

clinicaltrials.gov (Global: 5,225th place; Japanese: low place)

doi.org (Global: 2nd place; Japanese: 6th place)

europa.eu (Global: 68th place; Japanese: 425th place)

ema.europa.eu

fda.gov (Global: 447th place; Japanese: 1,043rd place)

accessdata.fda.gov

harvard.edu (Global: 18th place; Japanese: 107th place)

ui.adsabs.harvard.edu

nih.gov (Global: 4th place; Japanese: 24th place)

pubmed.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov

pfizer.com (Global: low place; Japanese: low place)

wikipedia.org (Global: low place; Japanese: low place)

en.wikipedia.org

clinicaltrials.gov (Global: 5,225^th place; Japanese: low place)

doi.org (Global: 2^nd place; Japanese: 6^th place)

europa.eu (Global: 68^th place; Japanese: 425^th place)

fda.gov (Global: 447^th place; Japanese: 1,043^rd place)

harvard.edu (Global: 18^th place; Japanese: 107^th place)

nih.gov (Global: 4^th place; Japanese: 24^th place)