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A. Shulla, T. Heald-Sargent, G. Subramanya, J. Zhao, S. Perlman, T. Gallagher: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. In: Journal of Virology. Band 85, Nummer 2, Januar 2011, S.873–882, doi:10.1128/JVI.02062-10, PMID 21068237, PMC3020023.
Shirato K, Kanou K, Kawase M, Matsuyama S.: "Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry." In: J Virol. Dec 2016, doi:10.1128/JVI.01387-16, PMID 27733646 .
A. Zumla, J. F. Chan, E. I. Azhar, D. S. Hui, K. Y. Yuen: Coronaviruses - drug discovery and therapeutic options. In: Nature reviews. Drug discovery. Band 15, Nummer 5, 05 2016, S.327–347, doi:10.1038/nrd.2015.37, PMID 26868298 (Review).
J. K. Sai, M. Suyama, Y. Kubokawa, Y. Matsumura, K. Inami, S. Watanabe: Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease. In: Journal of gastroenterology. Band 45, Nummer 3, März 2010, S.335–341, doi:10.1007/s00535-009-0148-1, PMID 19876587.
R. Talukdar, R. K. Tandon: Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. In: Journal of gastroenterology and hepatology. Band 23, Nummer 1, Januar 2008, S.34–41, doi:10.1111/j.1440-1746.2007.05206.x, PMID 17995943 (Review).
A. V. Ovcharenko, O.P. Zhirnov: Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice. In: Antiviral research. Band 23, Nummer 2, Februar 1994, S.107–118, doi:10.1016/0166-3542(94)90038-8, PMID 7511880.
A. Shulla, T. Heald-Sargent, G. Subramanya, J. Zhao, S. Perlman, T. Gallagher: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. In: Journal of Virology. Band 85, Nummer 2, Januar 2011, S.873–882, doi:10.1128/JVI.02062-10, PMID 21068237, PMC3020023.
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M. Yamamoto, S. Matsuyama, X. Li, M. Takeda, Y. Kawaguchi, J. I. Inoue, Z. Matsuda: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. In: Antimicrobial agents and chemotherapy. Band 60, Nummer 11, 11 2016, S.6532–6539, doi:10.1128/AAC.01043-16, PMID 27550352, PMC5075056.
J. M. Lucas, C. Heinlein, T. Kim, S. A. Hernandez, M. S. Malik, L. D. True, C. Morrissey, E. Corey, B. Montgomery, E. Mostaghel, N. Clegg, I. Coleman, C. M. Brown, E. L. Schneider, C. Craik, J. A. Simon, A. Bedalov, P. S. Nelson: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. In: Cancer discovery. Band 4, Nummer 11, November 2014, S.1310–1325, doi:10.1158/2159-8290.CD-13-1010, PMID 25122198, PMC4409786.
M. Yamamoto, S. Matsuyama, X. Li, M. Takeda, Y. Kawaguchi, J. I. Inoue, Z. Matsuda: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. In: Antimicrobial agents and chemotherapy. Band 60, Nummer 11, 11 2016, S.6532–6539, doi:10.1128/AAC.01043-16, PMID 27550352, PMC5075056.
E. Böttcher, C. Freuer, T. Steinmetzer, H. D. Klenk, W. Garten: MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. In: Vaccine. Band 27, Nummer 45, Oktober 2009, S.6324–6329, doi:10.1016/j.vaccine.2009.03.029, PMID 19840668.
G. Simmons, S. Bertram, I. Glowacka, I. Steffen, C. Chaipan, J. Agudelo, K. Lu, A. J. Rennekamp, H. Hofmann, P. Bates, S. Pöhlmann: Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion. In: Virology. Band 413, Nummer 2, Mai 2011, S.265–274, doi:10.1016/j.virol.2011.02.020, PMID 21435673, PMC3086175.
E. Böttcher, C. Freuer, T. Steinmetzer, H. D. Klenk, W. Garten: MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. In: Vaccine. Band 27, Nummer 45, Oktober 2009, S.6324–6329, doi:10.1016/j.vaccine.2009.03.029, PMID 19840668.
D. Meyer, F. Sielaff, M. Hammami, E. Böttcher-Friebertshäuser, W. Garten, T. Steinmetzer: Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. In: The Biochemical journal. Band 452, Nummer 2, Juni 2013, S.331–343, doi:10.1042/BJ20130101, PMID 23527573.
E. Böttcher-Friebertshäuser, C. Freuer, F. Sielaff, S. Schmidt, M. Eickmann, J. Uhlendorff, T. Steinmetzer, H. D. Klenk, W. Garten: Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. In: Journal of Virology. Band 84, Nummer 11, Juni 2010, S.5605–5614, doi:10.1128/JVI.00140-10, PMID 20237084, PMC2876594.
Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S. Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche, Marcel A. Müller, Christian Drosten,Stefan Pöhlmann: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell (2020), doi:10.1016/j.cell.2020.02.052
“Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
“Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
A. Shulla, T. Heald-Sargent, G. Subramanya, J. Zhao, S. Perlman, T. Gallagher: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. In: Journal of Virology. Band 85, Nummer 2, Januar 2011, S.873–882, doi:10.1128/JVI.02062-10, PMID 21068237, PMC3020023.
Shirato K, Kanou K, Kawase M, Matsuyama S.: "Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry." In: J Virol. Dec 2016, doi:10.1128/JVI.01387-16, PMID 27733646 .
A. Zumla, J. F. Chan, E. I. Azhar, D. S. Hui, K. Y. Yuen: Coronaviruses - drug discovery and therapeutic options. In: Nature reviews. Drug discovery. Band 15, Nummer 5, 05 2016, S.327–347, doi:10.1038/nrd.2015.37, PMID 26868298 (Review).
J. K. Sai, M. Suyama, Y. Kubokawa, Y. Matsumura, K. Inami, S. Watanabe: Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease. In: Journal of gastroenterology. Band 45, Nummer 3, März 2010, S.335–341, doi:10.1007/s00535-009-0148-1, PMID 19876587.
R. Talukdar, R. K. Tandon: Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. In: Journal of gastroenterology and hepatology. Band 23, Nummer 1, Januar 2008, S.34–41, doi:10.1111/j.1440-1746.2007.05206.x, PMID 17995943 (Review).
A. V. Ovcharenko, O.P. Zhirnov: Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice. In: Antiviral research. Band 23, Nummer 2, Februar 1994, S.107–118, doi:10.1016/0166-3542(94)90038-8, PMID 7511880.
A. Shulla, T. Heald-Sargent, G. Subramanya, J. Zhao, S. Perlman, T. Gallagher: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. In: Journal of Virology. Band 85, Nummer 2, Januar 2011, S.873–882, doi:10.1128/JVI.02062-10, PMID 21068237, PMC3020023.
M. Yamamoto, S. Matsuyama, X. Li, M. Takeda, Y. Kawaguchi, J. I. Inoue, Z. Matsuda: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. In: Antimicrobial agents and chemotherapy. Band 60, Nummer 11, 11 2016, S.6532–6539, doi:10.1128/AAC.01043-16, PMID 27550352, PMC5075056.
J. M. Lucas, C. Heinlein, T. Kim, S. A. Hernandez, M. S. Malik, L. D. True, C. Morrissey, E. Corey, B. Montgomery, E. Mostaghel, N. Clegg, I. Coleman, C. M. Brown, E. L. Schneider, C. Craik, J. A. Simon, A. Bedalov, P. S. Nelson: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. In: Cancer discovery. Band 4, Nummer 11, November 2014, S.1310–1325, doi:10.1158/2159-8290.CD-13-1010, PMID 25122198, PMC4409786.
M. Yamamoto, S. Matsuyama, X. Li, M. Takeda, Y. Kawaguchi, J. I. Inoue, Z. Matsuda: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. In: Antimicrobial agents and chemotherapy. Band 60, Nummer 11, 11 2016, S.6532–6539, doi:10.1128/AAC.01043-16, PMID 27550352, PMC5075056.
E. Böttcher, C. Freuer, T. Steinmetzer, H. D. Klenk, W. Garten: MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. In: Vaccine. Band 27, Nummer 45, Oktober 2009, S.6324–6329, doi:10.1016/j.vaccine.2009.03.029, PMID 19840668.
G. Simmons, S. Bertram, I. Glowacka, I. Steffen, C. Chaipan, J. Agudelo, K. Lu, A. J. Rennekamp, H. Hofmann, P. Bates, S. Pöhlmann: Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion. In: Virology. Band 413, Nummer 2, Mai 2011, S.265–274, doi:10.1016/j.virol.2011.02.020, PMID 21435673, PMC3086175.
E. Böttcher, C. Freuer, T. Steinmetzer, H. D. Klenk, W. Garten: MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. In: Vaccine. Band 27, Nummer 45, Oktober 2009, S.6324–6329, doi:10.1016/j.vaccine.2009.03.029, PMID 19840668.
D. Meyer, F. Sielaff, M. Hammami, E. Böttcher-Friebertshäuser, W. Garten, T. Steinmetzer: Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. In: The Biochemical journal. Band 452, Nummer 2, Juni 2013, S.331–343, doi:10.1042/BJ20130101, PMID 23527573.
E. Böttcher-Friebertshäuser, C. Freuer, F. Sielaff, S. Schmidt, M. Eickmann, J. Uhlendorff, T. Steinmetzer, H. D. Klenk, W. Garten: Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. In: Journal of Virology. Band 84, Nummer 11, Juni 2010, S.5605–5614, doi:10.1128/JVI.00140-10, PMID 20237084, PMC2876594.