O’Connell et al., Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol, 1997. 15(1). http://jco.ascopubs.org/content/15/1/246.long
Poultsides, G.A., et al., Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment. J Clin Oncol, 2009. 27. http://jco.ascopubs.org/content/27/20/3379.long
Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: a randomized trial. Nordic Gastrointestinal Tumor Adjuvant Therapy Group. J Clin Oncol, 1992. 10(6). http://jco.ascopubs.org/content/10/6/904.long
Giacchetti et al., Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol, 2000. http://jco.ascopubs.org/content/18/1/136.long
Colucci et al., Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell’Italia Meridionale. J Clin Oncol, 2005. 23(22). http://jco.ascopubs.org/content/23/22/4866.long
Parc et al. Prognostic significance of microsatellite instability determined by immunohistochemical staining of MSH2 and MLH1 in sporadic T3N0M0 colon cancer. Gut, 2004. 53(3). http://gut.bmj.com/content/53/3/371.long
Bjelakovic et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta – analysis. JAMA. 2007 Feb 28;297(8):842-57. http://jama.jamanetwork.com/article.aspx?articleid=205797
Ogino et al., Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction. Am J Gastroenterol, 2010. 105(2). http://www.nature.com/ajg/journal/v105/n2/full/ajg2009578a.html
Routine aspirin or nonsteroidal antiinflammatory drugs for the primary prevention of colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med, 2007. 146(5). http://www.ncbi.nlm.nih.gov/pubmed/17339621
Gill et al., Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol, 2004. 22(10). http://www.ncbi.nlm.nih.gov/pubmed/15067028
Habr-Gama et al., Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg, 2004. 240(4). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356472/
Mulier, S., et al., Radiofrequency ablation versus resection for resectable colorectal liver metastases: time for a randomized trial? Ann Surg Oncol, 2008. 15(1). http://www.ncbi.nlm.nih.gov/pubmed/17906898
Poon et al., Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol, 1989. 7. http://www.ncbi.nlm.nih.gov/pubmed/2476530
Cunningham et al. Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial.
Lancet Oncol. 2013 Oct;14(11):1077-85. doi: 10.1016/S1470-2045(13)70154-2. Epub 2013 Sep 10.
http://www.ncbi.nlm.nih.gov/pubmed/24028813
Tabernero et al. Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: Prespecified subgroup analyses from the VELOUR trial. Eur J Cancer. 2013 Oct 16. pii: S0959-8049(13)00853-8. doi: 10.1016/j.ejca.2013.09.013. http://www.ncbi.nlm.nih.gov/pubmed/24140268
Zhang et al. Risk of colon cancer and coffee, tea, and sugar – sweetened soft drink intake: pooled analysis of prospective cohort studies. J Natl Cancer Inst, 2010. http://jnci.oxfordjournals.org/content/102/11/771.long