Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. „Nature Genetics”. 18. 1, s. 38-43, 1998. DOI: 10.1038/ng0198-38. PMID: 9425897.
Hemminki A, Markie D, Tomlinson I, Avizienyte , Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Höglund P, Järvinen H, Kristo P, Pelin K., Ridanpää M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. „Nature”. 391. 6663, s. 184-7, 1998. DOI: 10.1038/34432. PMID: 9428765.
Ossipova O, Bardeesy N, DePinho RA, Green JB. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.. „Nat Cell Biol”. 5. 10, s. 889-94, 2003. DOI: 10.1038/ncb1048. PMID: 12973359.
Spicer J, Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. „Curr Biol”. 14. 10, s. R383-5, 2004. DOI: 10.1016/j.cub.2004.05.012. PMID: 15186763.
Martin SG, St Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. „Nature”. 421. 6921, s. 379-84, 2003. DOI: 10.1038/nature01296. PMID: 12540903.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. „EMBO J”. 23. 4, s. 833-43, 2004. DOI: 10.1038/sj.emboj.7600110. PMID: 14976552.
Lee H, Cho JS, Lambacher N, Lee J, Lee SJ, Lee TH, Gartner A, Koo HS. The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. „J Biol Chem”. 283. 22, s. 14988-93, 2008. DOI: 10.1074/jbc.M709115200. PMID: 18408008.
Hong SP, Leiper FC, Woods A, Carling D, Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.. „Proc Natl Acad Sci U S A”. 100. 15, s. 8839-43, 2003. DOI: 10.1073/pnas.1533136100. PMID: 12847291.
Hearle NC, Tomlinson I, Lim W, Murday V, Swarbrick E, Lim G, Phillips R, Lee P, O'Donohue J, Trembath RC, Morrison PJ, Norman A, Taylor R, Hodgson S, Lucassen A, Houlston RS. Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome. „BMC Genomics”. 6. 1, s. 38, 2005. DOI: 10.1186/1471-2164-6-38. PMID: 15774015.
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. „Biochem J”. 368. Pt 2, s. 507-16, 2002. DOI: 10.1042/BJ20021284. PMID: 12234250.
Nony P, Gaude H, Rossel M, Fournier L, Rouault JP, Billaud M. Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. „Oncogene”. 22. 57, s. 9165-75, 2003. DOI: 10.1038/sj.onc.1207179. PMID: 14668798.
Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. „Biochem J”. 370. Pt 3, s. 849-57, 2003. DOI: 10.1042/BJ20021813. PMID: 12489981.
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. „EMBO J”. 22. 12, s. 3062-72, 2003. DOI: 10.1093/emboj/cdg292. PMID: 12805220.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. „EMBO J”. 22. 19, s. 5102-14, 2003. DOI: 10.1093/emboj/cdg490. PMID: 14517248.
Marignani PA, Kanai F, Carpenter CL. LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. „J Biol Chem”. 276. 35, s. 32415-8, 2001. DOI: 10.1074/jbc.C100207200. PMID: 11445556.
Blumer JB, Bernard ML, Peterson YK, Nezu J, Chung P, Dunican DJ, Knoblich JA, Lanier SM. Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. „J Biol Chem”. 278. 26, s. 23217-20, 2003. DOI: 10.1074/jbc.C200686200. PMID: 12719437.
Liu WK, Chien CY, Chou CK, Su JY. An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation. „J Biomed Sci”. 10. 2, s. 242-52, 2003. DOI: 10.1159/000068708. PMID: 12595760.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. „J Biol Chem”. 279. 13, s. 12804-11, 2004. DOI: 10.1074/jbc.M312171200. PMID: 14676191.
Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE. LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. „Hum Mol Genet”. 14. 15, s. 2209-19, 2005. DOI: 10.1093/hmg/ddi225. PMID: 15987703.
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.. „FEBS Lett”. 579. 6, s. 1417-23, 2005. DOI: 10.1016/j.febslet.2005.01.042. PMID: 15733851.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. „Proc Natl Acad Sci U S A”. 101. 10, s. 3329-35, 2004. DOI: 10.1073/pnas.0308061100. PMID: 14985505.
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. „J Biol”. 2. 4, s. 28, 2004. DOI: 10.1186/1475-4924-2-28. PMID: 14511394.
Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. „Oncogene”. 22. 30, s. 4752-6, 2003. DOI: 10.1038/sj.onc.1206669. PMID: 12879020.
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. „Nat Cell Biol”. 3. 7, s. 628-36, 2001. DOI: 10.1038/35083016. PMID: 11433294.
Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Mäkelä TP. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. „Science”. 293. 5533, s. 1323-6, 2001. DOI: 10.1126/science.1062074. PMID: 11509733.
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. „Proc Natl Acad Sci U S A”. 99. 13, s. 8903-8, 2002. DOI: 10.1073/pnas.122254599. PMID: 12060709.
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. „Nature”. 419. 6903, s. 162-7, 2002. DOI: 10.1038/nature01045. PMID: 12226664.
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Mäkelä TP. The LKB1 tumor suppressor kinase in human disease. „Biochim Biophys Acta”. 1775. 1, s. 63-75, 2006. DOI: 10.1016/j.bbcan.2006.08.003. PMID: 17010524.
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. „Nature”. 448. 7155, s. 807-10, 2007. DOI: 10.1038/nature06030. PMID: 17676035.
Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR. Lkb1 deficiency causes prostate neoplasia in the mouse. „Cancer Res”. 68. 7, s. 2223-32, 2008. DOI: 10.1158/0008-5472.CAN-07-5169. PMID: 18381428.
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Näätsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Mäkelä TP, Launonen V. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome. „Br J Cancer”. 92. 6, s. 1126-9, 2005. DOI: 10.1038/sj.bjc.6602454. PMID: 15756273.
de Leng WW, Keller JJ, Luiten S, Musler AR, Jansen M, Baas AF, de Rooij FW, Gille JJ, Menko FH, Offerhaus GJ, Weterman MA. STRAD in Peutz-Jeghers syndrome and sporadic cancers. „J Clin Pathol”. 58. 10, s. 1091-5, 2005. DOI: 10.1136/jcp.2005.026013. PMID: 16189157.
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C, McLeod DR, Graham GE, Mangold E, Santer R, Propping P, Friedl W. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. „Hum Mutat”. 26. 6, s. 513-9, 2005. DOI: 10.1002/humu.20253. PMID: 16287113.
Chow E, Meldrum CJ, Crooks R, Macrae F, Spigelman AD, Scott RJ. An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus. „Clin Genet”. 70. 5, s. 409-14, 2006. DOI: 10.1111/j.1399-0004.2006.00704.x. PMID: 17026623.
Hearle NC, Rudd MF, Lim W, Murday V, Lim AG, Phillips RK, Lee PW, O'donohue J, Morrison PJ, Norman A, Hodgson SV, Lucassen A, Houlston RS. Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome. „J Med Genet”. 43. 4, s. e15, 2006. DOI: 10.1136/jmg.2005.036830. PMID: 16582077.
Volikos E, Robinson J, Aittomäki K, Mecklin JP, Järvinen H, Westerman AM, de Rooji FW, Vogel T, Moeslein G, Launonen V, Tomlinson IP, Silver AR, Aaltonen LA. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. „J Med Genet”. 43. 5, s. e18, 2006. DOI: 10.1136/jmg.2005.039875. PMID: 16648371.
Keshavarz P, Inoue H, Nakamura N, Yoshikawa T, Tanahashi T, Itakura M. Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes. „Molecular genetics and metabolism”. 2 (93), s. 200–9, luty 2008. DOI: 10.1016/j.ymgme.2007.08.125. PMID: 17950019.
Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W, Tomlinson I. Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. „J Invest Dermatol”. 112. 4, s. 509-11, 1999. DOI: 10.1046/j.1523-1747.1999.00551.x. PMID: 10201537.
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C, McLeod DR, Graham GE, Mangold E, Santer R, Propping P, Friedl W. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. „Hum Mutat”. 26. 6, s. 513-9, 2005. DOI: 10.1002/humu.20253. PMID: 16287113.
Resta N, Stella A, Susca FC, Di Giacomo M, Forleo G, Miccolis I, Rossini FP, Genuardi M, Piepoli A, Grammatico P, Guanti G. Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients. „Hum Mutat”. 20. 1, s. 78-9, 2002. DOI: 10.1002/humu.9046. PMID: 12112668.
Guldberg P, thor Straten P, Ahrenkiel V, Seremet T, Kirkin AF, Zeuthen J. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. „Oncogene”. 18. 9, s. 1777-80, 1999. DOI: 10.1038/sj.onc.1202486. PMID: 10208439.
Yoon KA, Ku JL, Choi HS, Heo SC, Jeong SY, Park YJ, Kim NK, Kim JC, Jung PM, Park JG. Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients. „Br J Cancer”. 82. 8, s. 1403-6, 2000. DOI: 10.1054/bjoc.1999.1125. PMID: 10780518.
Schumacher V, Vogel T, Leube B, Driemel C, Goecke T, Möslein G, Royer-Pokora B. STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. „J Med Genet”. 42. 5, s. 428-35, 2005. DOI: 10.1136/jmg.2004.026294. PMID: 15863673.
Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H, Billaud M. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. „Hum Mol Genet”. 14. 10, s. 1283-92, 2005. DOI: 10.1093/hmg/ddi139. PMID: 15800014.
Schumacher V, Vogel T, Leube B, Driemel C, Goecke T, Möslein G, Royer-Pokora B. STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. „J Med Genet”. 42. 5, s. 428-35, 2005. DOI: 10.1136/jmg.2004.026294. PMID: 15863673.
Fernandez P, Carretero J, Medina PP, Jimenez AI, Rodriguez-Perales S, Paz MF, Cigudosa JC, Esteller M, Lombardia L, Morente M, Sanchez-Verde L, Sotelo T, Sanchez-Cespedes M. Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. „Oncogene”. 23. 29, s. 5084-91, 2004. DOI: 10.1038/sj.onc.1207665. PMID: 15077168.
Abed AA, Günther K, Kraus C, Hohenberger W, Ballhausen WG. Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4). „Hum Mutat”. 18. 5, s. 397-410, 2001. DOI: 10.1002/humu.1211. PMID: 11668633.
Hernan I, Roig I, Martin B, Gamundi MJ, Martinez-Gimeno M, Carballo M. De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome. „Clin Genet”. 66. 1, s. 58-62, 2004. DOI: 10.1111/j.0009-9163.2004.00266.x. PMID: 15200509.
Trojan J, Brieger A, Raedle J, Roth WK, Zeuzem S. Peutz-Jeghers syndrome: molecular analysis of a three-generation kindred with a novel defect in the serine threonine kinase gene STK11. „The American journal of gastroenterology”. 1 (94), s. 257–61, styczeń 1999. DOI: 10.1111/j.1572-0241.1999.00810.x. PMID: 9934767.
Lim W, Hearle N, Shah B, Murday V, Hodgson SV, Lucassen A, Eccles D, Talbot I, Neale K, Lim AG, O'Donohue J, Donaldson A, Macdonald RC, Young ID, Robinson MH., Lee PW, Stoodley BJ, Tomlinson I, Alderson D, Holbrook AG, Vyas S, Swarbrick ET, Lewis AA, Phillips RK, Houlston RS. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. „Br J Cancer”. 89. 2, s. 308-13, 2003. DOI: 10.1038/sj.bjc.6601030. PMID: 12865922.
Nakamura T, Suzuki S, Yokoi Y, Kashiwabara H, Maruyama K, Baba S, Nakagawa H, Nakamura S. Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis. „Journal of gastroenterology”. 5 (37), s. 376–80, sierpień 2002. DOI: 10.1007/s005350200052. PMID: 12051537.
Shinmura K, Goto M, Tao H, Shimizu S, Otsuki Y, Kobayashi H, Ushida S, Suzuki K, Tsuneyoshi T, Sugimura H. A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer. „Clin Genet”. 67. 1, s. 81-6, 2004. DOI: 10.1111/j.1399-0004.2005.00380.x. PMID: 15617552.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. „J Clin Invest”. 108. 8, s. 1167-74, 2001. DOI: 10.1172/JCI13505. PMID: 11602624.
Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. „J Biol Chem”. 277. 28, s. 25226-32, 2002. DOI: 10.1074/jbc.M202489200. PMID: 11994296.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. „Cancer Cell”. 6. 1, s. 91-9, 2004. DOI: 10.1016/j.ccr.2004.06.007. PMID: 15261145.
Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. „Clin Cancer Res”. 14. 4, s. 1167-71, 2008. DOI: 10.1158/1078-0432.CCR-07-4007. PMID: 18281551.
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N, Urbanowitz G, Berg WJ, Kay A, Lebwohl D, Ravaud A, Davis I, Gurney H, Pittman K, Goldstein D, osobny artykułwaring P, Knox J, Ades S, Cheng T, Hotte S, Ko YJ, MacKenzie M, North S, Caty A, Rolland F, Chevreau C, Duclos B, Negrier S, Gschwend J, Albers P, Bergmann L, Beck J, Bajetta E, Passalacqua R, Sternberg C, Boccardo F, Carteni G, Conte PF, Shinohara N, Tsuchiya N, Akaza H, Fujimoto H, Niwakawa M., Uemura H, Kanayama H, Eto M, Sumiyoshi Y, Tsukamoto T, Usami M, Terai A, Hamamoto Y, Maruoka M., Osanto S, Van Herpen C, Van Den Eertwegh F, Groenewegen G, Szczylik C, Pikiel J, Pluzanska A, Zdrojowy R, del Muro F, Climent M, Castellano D, Calvo E, Maroto P, Gabrail N, Appleman L, George D, Hamm J, Hussain A, Hajdenberg J, Vogelzang N, Logan T, Beck J, Rathmell K, Lara P, Dudek A, Vaishampayan U, Gordon M, Anderson T, Danso M, Berry W, Gersh R, Guzley G, Loesch D, Schlossman D, Smith D. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. „Lancet”. 372. 9637, s. 449-56, 2008. DOI: 10.1016/S0140-6736(08)61039-9. PMID: 18653228.
Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. „N Engl J Med”. 358. 2, s. 140-51, 2008. DOI: 10.1056/NEJMoa063564. PMID: 18184959.
Sugimoto R, Nakao A, Yamane M, Toyooka S, Okazaki M, Aoe M, Seyama K, Date H, Oto T, Sano Y. Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation. „J Heart Lung Transplant”. 27. 8, s. 921-4, 2008. DOI: 10.1016/j.healun.2008.05.012. PMID: 18656809.
dx.doi.org
Kevin MK.M.ZbukKevin MK.M., CharisCh.EngCharisCh., Hamartomatous polyposis syndromes, „Nature Clinical Practice Gastroenterology & Hepatology”, 4 (9), 2007, s. 492-502, DOI: 10.1038/ncpgasthep0902, PMID: 17768394.
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. „Nature Genetics”. 18. 1, s. 38-43, 1998. DOI: 10.1038/ng0198-38. PMID: 9425897.
Hemminki A, Markie D, Tomlinson I, Avizienyte , Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Höglund P, Järvinen H, Kristo P, Pelin K., Ridanpää M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. „Nature”. 391. 6663, s. 184-7, 1998. DOI: 10.1038/34432. PMID: 9428765.
Ossipova O, Bardeesy N, DePinho RA, Green JB. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.. „Nat Cell Biol”. 5. 10, s. 889-94, 2003. DOI: 10.1038/ncb1048. PMID: 12973359.
Spicer J, Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. „Curr Biol”. 14. 10, s. R383-5, 2004. DOI: 10.1016/j.cub.2004.05.012. PMID: 15186763.
Martin SG, St Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. „Nature”. 421. 6921, s. 379-84, 2003. DOI: 10.1038/nature01296. PMID: 12540903.
Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. „Cell”. 116. 3, s. 457-66, 2004. PMID: 15016379.
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. „Curr Biol”. Nov 11;13. 22, s. 2004-8, 2003. PMID: 14614828.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. „EMBO J”. 23. 4, s. 833-43, 2004. DOI: 10.1038/sj.emboj.7600110. PMID: 14976552.
Smith DP, Spicer J, Smith A, Swift S, Ashworth A. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. „Hum Mol Genet”. 8. 8, s. 1479-85, 1999. PMID: 10400995.
Su JY, Erikson E, Maller JL. Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos. „J Biol Chem”. 271. 24, s. 14430-7, 1996. PMID: 8662877.
Lee H, Cho JS, Lambacher N, Lee J, Lee SJ, Lee TH, Gartner A, Koo HS. The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. „J Biol Chem”. 283. 22, s. 14988-93, 2008. DOI: 10.1074/jbc.M709115200. PMID: 18408008.
Hong SP, Leiper FC, Woods A, Carling D, Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.. „Proc Natl Acad Sci U S A”. 100. 15, s. 8839-43, 2003. DOI: 10.1073/pnas.1533136100. PMID: 12847291.
Sutherland CM, Hawley SA, McCartney RR, Leech A, Stark MJ, Schmidt MC, Hardie DG. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. „Curr Biol”. 13. 15, s. 1299-305, 2003. PMID: 12906789.
Nath N, McCartney RR, Schmidt MC. Yeast Pak1 kinase associates with and activates Snf1. „Mol Cell Biol”. 23. 11, s. 3909-17, 2003. PMID: 12748292.
Hearle NC, Tomlinson I, Lim W, Murday V, Swarbrick E, Lim G, Phillips R, Lee P, O'Donohue J, Trembath RC, Morrison PJ, Norman A, Taylor R, Hodgson S, Lucassen A, Houlston RS. Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome. „BMC Genomics”. 6. 1, s. 38, 2005. DOI: 10.1186/1471-2164-6-38. PMID: 15774015.
Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. „Biochem J”. 362. Pt 2, s. 481-90, 2002. PMID: 11853558.
Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. „Mol Cell”. 7. 6, s. 1307-19, 2001. PMID: 11430832.
Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. „Biochem J”. 345 Pt 3, s. 673-80, 2000. PMID: 10642527.
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. „Biochem J”. 368. Pt 2, s. 507-16, 2002. DOI: 10.1042/BJ20021284. PMID: 12234250.
Moores SL, Schaber MD, Mosser SD, Rands E, O'Hara MB, Garsky VM, Marshall MS, Pompliano DL, Gibbs JB. Sequence dependence of protein isoprenylation.. „J Biol Chem”. 266. 22, s. 14603-10, 1991. PMID: 1860864.
Nony P, Gaude H, Rossel M, Fournier L, Rouault JP, Billaud M. Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. „Oncogene”. 22. 57, s. 9165-75, 2003. DOI: 10.1038/sj.onc.1207179. PMID: 14668798.
Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. „Biochem J”. 370. Pt 3, s. 849-57, 2003. DOI: 10.1042/BJ20021813. PMID: 12489981.
Smith CM, Radzio-Andzelm E, Madhusudan P, Akamine SS, Taylor. The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication.. „Prog Biophys Mol Biol”. 71. 3-4, s. 313-41, 1999. PMID: 10354702.
Tiainen M, Vaahtomeri K, Ylikorkala A, Mäkelä TP. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). „Hum Mol Genet”. Jun 15;11. 13, s. 1497-504, 2002. PMID: 12045203.
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. „EMBO J”. 22. 12, s. 3062-72, 2003. DOI: 10.1093/emboj/cdg292. PMID: 12805220.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. „EMBO J”. 22. 19, s. 5102-14, 2003. DOI: 10.1093/emboj/cdg490. PMID: 14517248.
Smith DP, Rayter SI, Niederlander C, Spicer J, Jones CM, Ashworth A. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. „Hum Mol Genet”. 10. 25, s. 2869-77, 2001. PMID: 11741830.
Marignani PA, Kanai F, Carpenter CL. LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. „J Biol Chem”. 276. 35, s. 32415-8, 2001. DOI: 10.1074/jbc.C100207200. PMID: 11445556.
Blumer JB, Bernard ML, Peterson YK, Nezu J, Chung P, Dunican DJ, Knoblich JA, Lanier SM. Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. „J Biol Chem”. 278. 26, s. 23217-20, 2003. DOI: 10.1074/jbc.C200686200. PMID: 12719437.
Liu WK, Chien CY, Chou CK, Su JY. An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation. „J Biomed Sci”. 10. 2, s. 242-52, 2003. DOI: 10.1159/000068708. PMID: 12595760.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. „J Biol Chem”. 279. 13, s. 12804-11, 2004. DOI: 10.1074/jbc.M312171200. PMID: 14676191.
Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE. LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. „Hum Mol Genet”. 14. 15, s. 2209-19, 2005. DOI: 10.1093/hmg/ddi225. PMID: 15987703.
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.. „FEBS Lett”. 579. 6, s. 1417-23, 2005. DOI: 10.1016/j.febslet.2005.01.042. PMID: 15733851.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. „Proc Natl Acad Sci U S A”. 101. 10, s. 3329-35, 2004. DOI: 10.1073/pnas.0308061100. PMID: 14985505.
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. „J Biol”. 2. 4, s. 28, 2004. DOI: 10.1186/1475-4924-2-28. PMID: 14511394.
Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. „Oncogene”. 22. 30, s. 4752-6, 2003. DOI: 10.1038/sj.onc.1206669. PMID: 12879020.
Watts JL, Morton DG, Bestman J, Kemphues KJ. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.. „Development”. Apr;127. 7, s. 1467-75, 2000. PMID: 10704392.
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. „Nat Cell Biol”. 3. 7, s. 628-36, 2001. DOI: 10.1038/35083016. PMID: 11433294.
Tiainen M, Ylikorkala A, Mäkelä TP. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. „Proc Natl Acad Sci U S A”. 96. 16, s. 9248-51, 1999. PMID: 10430928.
Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN, Knudsen ES. BRG-1 is required for RB-mediated cell cycle arrest. „Proc Natl Acad Sci U S A”. 97. 14, s. 7748-53, 2000. PMID: 10884406.
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E. Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. „Mol Cell Biol”. 19. 2, s. 1460-9, 1999. PMID: 9891079.
Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Mäkelä TP. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. „Science”. 293. 5533, s. 1323-6, 2001. DOI: 10.1126/science.1062074. PMID: 11509733.
Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. „Cancer Res”. 62. 8, s. 2261-6, 2002. PMID: 11956081.
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. „Proc Natl Acad Sci U S A”. 99. 13, s. 8903-8, 2002. DOI: 10.1073/pnas.122254599. PMID: 12060709.
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. „Nature”. 419. 6903, s. 162-7, 2002. DOI: 10.1038/nature01045. PMID: 12226664.
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Mäkelä TP. The LKB1 tumor suppressor kinase in human disease. „Biochim Biophys Acta”. 1775. 1, s. 63-75, 2006. DOI: 10.1016/j.bbcan.2006.08.003. PMID: 17010524.
Allen BA, Terdiman JP. Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer. „Best Pract Res Clin Gastroenterol”. 17. 2, s. 237-58, 2003. PMID: 12676117.
Udd L, Katajisto P, Rossi DJ, Lepistö A, Lahesmaa AM, Ylikorkala A, Järvinen HJ, Ristimäki AP, Mäkelä TP. Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. „Gastroenterology”. 127. 4, s. 1030-7, 2004. PMID: 15480979.
Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. „Cancer Res”. 62. 16, s. 4549-53, 2002. PMID: 12183403.
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. „Nature”. 448. 7155, s. 807-10, 2007. DOI: 10.1038/nature06030. PMID: 17676035.
Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR. Lkb1 deficiency causes prostate neoplasia in the mouse. „Cancer Res”. 68. 7, s. 2223-32, 2008. DOI: 10.1158/0008-5472.CAN-07-5169. PMID: 18381428.
Kevin MK.M.ZbukKevin MK.M., CharisCh.EngCharisCh., Hamartomatous polyposis syndromes, „Nature Clinical Practice Gastroenterology & Hepatology”, 4 (9), 2007, s. 492-502, DOI: 10.1038/ncpgasthep0902, PMID: 17768394.
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Näätsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Mäkelä TP, Launonen V. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome. „Br J Cancer”. 92. 6, s. 1126-9, 2005. DOI: 10.1038/sj.bjc.6602454. PMID: 15756273.
de Leng WW, Keller JJ, Luiten S, Musler AR, Jansen M, Baas AF, de Rooij FW, Gille JJ, Menko FH, Offerhaus GJ, Weterman MA. STRAD in Peutz-Jeghers syndrome and sporadic cancers. „J Clin Pathol”. 58. 10, s. 1091-5, 2005. DOI: 10.1136/jcp.2005.026013. PMID: 16189157.
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C, McLeod DR, Graham GE, Mangold E, Santer R, Propping P, Friedl W. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. „Hum Mutat”. 26. 6, s. 513-9, 2005. DOI: 10.1002/humu.20253. PMID: 16287113.
Chow E, Meldrum CJ, Crooks R, Macrae F, Spigelman AD, Scott RJ. An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus. „Clin Genet”. 70. 5, s. 409-14, 2006. DOI: 10.1111/j.1399-0004.2006.00704.x. PMID: 17026623.
Hearle NC, Rudd MF, Lim W, Murday V, Lim AG, Phillips RK, Lee PW, O'donohue J, Morrison PJ, Norman A, Hodgson SV, Lucassen A, Houlston RS. Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome. „J Med Genet”. 43. 4, s. e15, 2006. DOI: 10.1136/jmg.2005.036830. PMID: 16582077.
Volikos E, Robinson J, Aittomäki K, Mecklin JP, Järvinen H, Westerman AM, de Rooji FW, Vogel T, Moeslein G, Launonen V, Tomlinson IP, Silver AR, Aaltonen LA. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. „J Med Genet”. 43. 5, s. e18, 2006. DOI: 10.1136/jmg.2005.039875. PMID: 16648371.
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, Westra WH, Herman JG, Sidransky D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. „Cancer Res”. 62. 13, s. 3659-62, 2002. PMID: 12097271.
Keshavarz P, Inoue H, Nakamura N, Yoshikawa T, Tanahashi T, Itakura M. Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes. „Molecular genetics and metabolism”. 2 (93), s. 200–9, luty 2008. DOI: 10.1016/j.ymgme.2007.08.125. PMID: 17950019.
Kuragaki C, Enomoto T, Ueno Y, Sun H, Fujita M, Nakashima R, Ueda Y, Wada H, Murata Y, Toki T, Konishi I, Fujii S. Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. „Lab Invest”. 83. 1, s. 35-45, 2003. PMID: 12533684.
Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W, Tomlinson I. Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. „J Invest Dermatol”. 112. 4, s. 509-11, 1999. DOI: 10.1046/j.1523-1747.1999.00551.x. PMID: 10201537.
Amos CI, Keitheri-Cheteri MB, Sabripour M, Wei C, McGarrity TJ, Seldin MF, Nations L, Lynch PM, Fidder HH, Friedman E, Frazier ML. Genotype-phenotype correlations in Peutz-Jeghers syndrome. „J Med Genet”. 41. 5, s. 327-33, 2004. PMID: 15121768.
Olschwang S, Boisson C, Thomas G. Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. „J Med Genet”. Jun;38. 6, s. 356-60, 2001. PMID: 11389158.
Ylikorkala A, Avizienyte E, Tomlinson IP, Tiainen M, Roth S, Loukola A, Hemminki A, Johansson M, Sistonen P, Markie D, Neale K, Phillips R, Zauber P., Twama T, Sampson J, Järvinen H, Mäkelä TP, Aaltonen LA. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. „Hum Mol Genet”. 8. 1, s. 45-51, 1999. PMID: 9887330.
Westerman AM, Entius MM, Boor PP, Koole R, de Baar E, Offerhaus GJ, Lubinski J, Lindhout D, Halley DJ, de Rooij FW, Wilson JH. Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families. „Hum Mutat”. 13. 6, s. 476-81, 1999. PMID: 10408777.
Lim W, Olschwang S, Keller JJ, Westerman AM, Menko FH, Boardman LA, Scott RJ, Trimbath J, Giardiello FM, Gruber SB, Gille JJ, Offerhaus GJ, de Rooij FW, Wilson JH, Spigelman AD, Phillips RK, Houlston RS. Relative frequency and morphology of cancers in STK11 mutation carriers. „Gastroenterology”. 126. 7, s. 1788-94, 2004. PMID: 15188174.
Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE, Fosså SD, Salovaara R, Aaltonen LA. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. „Cancer Res”. 58. 10, s. 2087-90, 1998. PMID: 9605748.
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C, McLeod DR, Graham GE, Mangold E, Santer R, Propping P, Friedl W. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. „Hum Mutat”. 26. 6, s. 513-9, 2005. DOI: 10.1002/humu.20253. PMID: 16287113.
Dong SM, Kim KM, Kim SY, Shin MS, Na EY, Lee SH, Park WS, Yoo NJ, Jang JJ, Yoon CY, Kim JW, Kim SY, Yang YM, Kim SH, Kim CS, Lee JY. Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer. „Cancer Res”. 58. 17, s. 3787-90, 1998. PMID: 9731485.
Mehenni H, Gehrig C, Nezu J, Oku A, Shimane M, Rossier C, Guex N, Blouin JL, Scott HS, Antonarakis SE. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. „Am J Hum Genet”. 63. 6, s. 1641-50, 1999. PMID: 9837816.
Resta N, Stella A, Susca FC, Di Giacomo M, Forleo G, Miccolis I, Rossini FP, Genuardi M, Piepoli A, Grammatico P, Guanti G. Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients. „Hum Mutat”. 20. 1, s. 78-9, 2002. DOI: 10.1002/humu.9046. PMID: 12112668.
Connolly DC, Katabuchi H, Cliby WA, Cho KR. Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome. „Am J Pathol”. 156. 1, s. 339-45, 2000. PMID: 10623683.
Guldberg P, thor Straten P, Ahrenkiel V, Seremet T, Kirkin AF, Zeuthen J. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. „Oncogene”. 18. 9, s. 1777-80, 1999. DOI: 10.1038/sj.onc.1202486. PMID: 10208439.
Yoon KA, Ku JL, Choi HS, Heo SC, Jeong SY, Park YJ, Kim NK, Kim JC, Jung PM, Park JG. Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients. „Br J Cancer”. 82. 8, s. 1403-6, 2000. DOI: 10.1054/bjoc.1999.1125. PMID: 10780518.
Scott RJ, Crooks R, Meldrum CJ, Thomas L, Smith CJ, Mowat D, McPhillips M, Spigelman AD. Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients. „Clin Genet”. 62. 4, s. 282-287, 2002. PMID: 12372054.
Schumacher V, Vogel T, Leube B, Driemel C, Goecke T, Möslein G, Royer-Pokora B. STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. „J Med Genet”. 42. 5, s. 428-35, 2005. DOI: 10.1136/jmg.2004.026294. PMID: 15863673.
Resta N, Simone C, Mareni C, Montera M, Gentile M, Susca F, Gristina R, Pozzi S, Bertario L, Bufo P, Carlomagno N, Ingrosso M, Rossini FP, Tenconi R, Guanti G. STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.. „Cancer Res”. Nov 1;58. 21, s. 4799-801, 1998. PMID: 9809980.
Nishioka Y, Kobayashi K, Sagae S, Sugimura M, Ishioka S, Nagata M, Terasawa K, Tokino T, Kudo R. Mutational analysis of STK11 gene in ovarian carcinomas. „Jpn J Cancer Res”. Jun;90. 6, s. 629-32, 1999. PMID: 10429654.
Kim CJ, Cho YG, Park JY, Kim TY, Lee JH, Kim HS, Lee JW, Song YH, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS. Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas. „Eur J Cancer”. 40. 1, s. 136-41, 2003. PMID: 14687797.
Park WS, Moon YW, Yang YM, Kim YS, Kim YD, Fuller BG, Vortmeyer AO, Fogt F, Lubensky IA, Zhuang Z. Mutations of the STK11 gene in sporadic gastric carcinoma. „Int J Oncol”. 13. 3, s. 601-4, 1998. PMID: 9683800.
Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H, Billaud M. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. „Hum Mol Genet”. 14. 10, s. 1283-92, 2005. DOI: 10.1093/hmg/ddi139. PMID: 15800014.
Schumacher V, Vogel T, Leube B, Driemel C, Goecke T, Möslein G, Royer-Pokora B. STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. „J Med Genet”. 42. 5, s. 428-35, 2005. DOI: 10.1136/jmg.2004.026294. PMID: 15863673.
Su GH, Hruban RH, Bansal RK, Bova GS, Tang DJ, Shekher MC, Westerman AM, Entius MM, Goggins M, Yeo CJ, Kern SE. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. „Am J Pathol”. 154. 6, s. 1835-40, 1999. PMID: 10362809.
Wang ZJ, Churchman M, Avizienyte E, McKeown C, Davies S, Evans DG, Ferguson A, Ellis I, Xu WH, Yan ZY, Aaltonen LA, Tomlinson IP. Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients. „J Med Genet”. May;36. 5, s. 365-8, 1999. PMID: 10353780.
Gruber SB, Entius MM, Petersen GM, Laken SJ, Longo PA, Boyer R, Levin AM, Mujumdar UJ, Trent JM, Kinzler KW, Vogelstein B, Hamilton SR, Polymeropoulos MH, Offerhaus GJ, Giardiello FM. Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. „Cancer Res”. 58. 23, s. 5267-70, 1998. PMID: 9850045.
Fernandez P, Carretero J, Medina PP, Jimenez AI, Rodriguez-Perales S, Paz MF, Cigudosa JC, Esteller M, Lombardia L, Morente M, Sanchez-Verde L, Sotelo T, Sanchez-Cespedes M. Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. „Oncogene”. 23. 29, s. 5084-91, 2004. DOI: 10.1038/sj.onc.1207665. PMID: 15077168.
Wei C, Amos CI, Rashid A, Sabripour M, Nations L, McGarrity TJ, Frazier ML. Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. „J Histochem Cytochem”. 51. 12, s. 1665-72, 2003. PMID: 14623934.
Abed AA, Günther K, Kraus C, Hohenberger W, Ballhausen WG. Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4). „Hum Mutat”. 18. 5, s. 397-410, 2001. DOI: 10.1002/humu.1211. PMID: 11668633.
Hernan I, Roig I, Martin B, Gamundi MJ, Martinez-Gimeno M, Carballo M. De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome. „Clin Genet”. 66. 1, s. 58-62, 2004. DOI: 10.1111/j.0009-9163.2004.00266.x. PMID: 15200509.
Nakagawa H, Koyama K, Miyoshi Y, Ando H, Baba S, Watatani M, Yasutomi M, Matsuura N, Monden M, Nakamura Y. Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome. „Hum Genet”. 103. 2, s. 168-72, 1998. PMID: 9760200.
Miyaki M, Iijima T, Hosono K, Ishii R, Yasuno M, Mori T, Toi M, Hishima T, Shitara N, Tamura K, Utsunomiya J, Kobayashi N, Kuroki T, Iwama T. Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. „Cancer Res”. 60. 22, s. 6311-3, 2000. PMID: 11103790.
Trojan J, Brieger A, Raedle J, Roth WK, Zeuzem S. Peutz-Jeghers syndrome: molecular analysis of a three-generation kindred with a novel defect in the serine threonine kinase gene STK11. „The American journal of gastroenterology”. 1 (94), s. 257–61, styczeń 1999. DOI: 10.1111/j.1572-0241.1999.00810.x. PMID: 9934767.
Jiang CY, Esufali S, Berk T, Gallinger S, Cohen Z, Tobi M, Redston M, Bapat B. STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients. „Clinical genetics”. 2 (56), s. 136–41, sierpień 1999. PMID: 10517250.
Lim W, Hearle N, Shah B, Murday V, Hodgson SV, Lucassen A, Eccles D, Talbot I, Neale K, Lim AG, O'Donohue J, Donaldson A, Macdonald RC, Young ID, Robinson MH., Lee PW, Stoodley BJ, Tomlinson I, Alderson D, Holbrook AG, Vyas S, Swarbrick ET, Lewis AA, Phillips RK, Houlston RS. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. „Br J Cancer”. 89. 2, s. 308-13, 2003. DOI: 10.1038/sj.bjc.6601030. PMID: 12865922.
Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. „Am J Pathol”. 159. 6, s. 2017-22, 2001. PMID: 11733352.
Nakamura T, Suzuki S, Yokoi Y, Kashiwabara H, Maruyama K, Baba S, Nakagawa H, Nakamura S. Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis. „Journal of gastroenterology”. 5 (37), s. 376–80, sierpień 2002. DOI: 10.1007/s005350200052. PMID: 12051537.
Tate G, Suzuki T, Mitsuya T. A new mutation of LKB1 gene in a Japanese patient with Peutz-Jeghers syndrome. „Acta medica Okayama”. 6 (57), s. 305–8, grudzień 2003. PMID: 14726968.
Shinmura K, Goto M, Tao H, Shimizu S, Otsuki Y, Kobayashi H, Ushida S, Suzuki K, Tsuneyoshi T, Sugimura H. A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer. „Clin Genet”. 67. 1, s. 81-6, 2004. DOI: 10.1111/j.1399-0004.2005.00380.x. PMID: 15617552.
Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. „Diabetes”. 51. 7, s. 2074-81, 2002. PMID: 12086935.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. „J Clin Invest”. 108. 8, s. 1167-74, 2001. DOI: 10.1172/JCI13505. PMID: 11602624.
El-Mir MY, Nogueira V, Fontaine E, Avéret N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. „J Biol Chem”. 275. 1, s. 223-8, 2000. PMID: 10617608.
Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. „J Biol Chem”. 277. 28, s. 25226-32, 2002. DOI: 10.1074/jbc.M202489200. PMID: 11994296.
Hawley SA, Gadalla AE, Olsen GS, Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. „Diabetes”. 51. 8, s. 2420-5, 2002. PMID: 12145153.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. „Cancer Cell”. 6. 1, s. 91-9, 2004. DOI: 10.1016/j.ccr.2004.06.007. PMID: 15261145.
Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. „Clin Cancer Res”. 14. 4, s. 1167-71, 2008. DOI: 10.1158/1078-0432.CCR-07-4007. PMID: 18281551.
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N, Urbanowitz G, Berg WJ, Kay A, Lebwohl D, Ravaud A, Davis I, Gurney H, Pittman K, Goldstein D, osobny artykułwaring P, Knox J, Ades S, Cheng T, Hotte S, Ko YJ, MacKenzie M, North S, Caty A, Rolland F, Chevreau C, Duclos B, Negrier S, Gschwend J, Albers P, Bergmann L, Beck J, Bajetta E, Passalacqua R, Sternberg C, Boccardo F, Carteni G, Conte PF, Shinohara N, Tsuchiya N, Akaza H, Fujimoto H, Niwakawa M., Uemura H, Kanayama H, Eto M, Sumiyoshi Y, Tsukamoto T, Usami M, Terai A, Hamamoto Y, Maruoka M., Osanto S, Van Herpen C, Van Den Eertwegh F, Groenewegen G, Szczylik C, Pikiel J, Pluzanska A, Zdrojowy R, del Muro F, Climent M, Castellano D, Calvo E, Maroto P, Gabrail N, Appleman L, George D, Hamm J, Hussain A, Hajdenberg J, Vogelzang N, Logan T, Beck J, Rathmell K, Lara P, Dudek A, Vaishampayan U, Gordon M, Anderson T, Danso M, Berry W, Gersh R, Guzley G, Loesch D, Schlossman D, Smith D. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. „Lancet”. 372. 9637, s. 449-56, 2008. DOI: 10.1016/S0140-6736(08)61039-9. PMID: 18653228.
Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. „N Engl J Med”. 358. 2, s. 140-51, 2008. DOI: 10.1056/NEJMoa063564. PMID: 18184959.
Sugimoto R, Nakao A, Yamane M, Toyooka S, Okazaki M, Aoe M, Seyama K, Date H, Oto T, Sano Y. Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation. „J Heart Lung Transplant”. 27. 8, s. 921-4, 2008. DOI: 10.1016/j.healun.2008.05.012. PMID: 18656809.
