Ensaio clínico número NCT00633087 para "A Phase I/II Trial of 2-Deoxyglucose (2DG) for the Treatment of Advanced Cancer and Hormone Refractory Prostate Cancer (2-Deoxyglucose)" em ClinicalTrials.gov
Ensaio clínico número NCT01791595 para "A Phase I Trial of AZD3965 in Patients With Advanced Cancer" em ClinicalTrials.gov
Alfarouk KO (Dezembro de 2016). «Tumor metabolism, cancer cell transporters, and microenvironmental resistance». Journal of Enzyme Inhibition and Medicinal Chemistry. 31 (6): 859–66. PMID26864256. doi:10.3109/14756366.2016.1140753
Grandér D (Abril de 1998). «How do mutated oncogenes and tumor suppressor genes cause cancer?». Medical Oncology. 15 (1): 20–6. PMID9643526. doi:10.1007/BF02787340
López-Lázaro M (Abril de 2008). «The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen?». Anti-Cancer Agents in Medicinal Chemistry. 8 (3): 305–12. PMID18393789. doi:10.2174/187152008783961932
Unwin RD, Craven RA, Harnden P, Hanrahan S, Totty N, Knowles M, et al. (Agosto de 2003). «Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect». Proteomics. 3 (8): 1620–32. PMID12923786. doi:10.1002/pmic.200300464
Gogvadze V, Zhivotovsky B, Orrenius S (Fevereiro de 2010). «The Warburg effect and mitochondrial stability in cancer cells». Molecular Aspects of Medicine. 31 (1): 60–74. PMID19995572. doi:10.1016/j.mam.2009.12.004
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. (Janeiro de 2007). «A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth». Cancer Cell. 11 (1): 37–51. PMID17222789. doi:10.1016/j.ccr.2006.10.020
Pan JG, Mak TW (Abril de 2007). «Metabolic targeting as an anticancer strategy: dawn of a new era?». Science's STKE. 2007 (381): pe14. PMID17426345. doi:10.1126/stke.3812007pe14
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, et al. (Março de 2008). «The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth». Nature. 452 (7184): 230–3. Bibcode:2008Natur.452..230C. PMID18337823. doi:10.1038/nature06734
Pedersen PL (Junho de 2007). «Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen». Journal of Bioenergetics and Biomembranes. 39 (3): 211–22. PMID17879147. doi:10.1007/s10863-007-9094-x
Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, et al. (Dezembro de 2009). «The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma». Cell Cycle. 8 (23): 3984–4001. PMID19923890. doi:10.4161/cc.8.23.10238
Luis C, Duarte F, Faria I, Jarak I, Oliveira PF, Alves MG, et al. (Abril de 2019). «Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells». Life Sciences. 223: 38–46. PMID30862570. doi:10.1016/j.lfs.2019.03.016. hdl:10400.22/14163
Gupta V, Gopinath P, Iqbal MA, Mazurek S, Wellen KE, Bamezai RN (2013). «Interplay between epigenetics & cancer metabolism». Current Pharmaceutical Design. 20 (11): 1706–14. PMID23888952. doi:10.2174/13816128113199990536
Medzhitov R (Outubro de 2015). «Bringing Warburg to lymphocytes». Nature Reviews. Immunology. 15 (10). 598 páginas. PMID26403193. doi:10.1038/nri3918
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, et al. (Junho de 2002). «The CD28 signaling pathway regulates glucose metabolism». Immunity. 16 (6): 769–77. PMID12121659. doi:10.1016/S1074-7613(02)00323-0
handle.net
hdl.handle.net
Luis C, Duarte F, Faria I, Jarak I, Oliveira PF, Alves MG, et al. (Abril de 2019). «Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells». Life Sciences. 223: 38–46. PMID30862570. doi:10.1016/j.lfs.2019.03.016. hdl:10400.22/14163
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, et al. (Março de 2008). «The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth». Nature. 452 (7184): 230–3. Bibcode:2008Natur.452..230C. PMID18337823. doi:10.1038/nature06734
Alfarouk KO (Dezembro de 2016). «Tumor metabolism, cancer cell transporters, and microenvironmental resistance». Journal of Enzyme Inhibition and Medicinal Chemistry. 31 (6): 859–66. PMID26864256. doi:10.3109/14756366.2016.1140753
Batra S, Adekola KU, Rosen ST, Shanmugam M (Maio de 2013). «Cancer metabolism as a therapeutic target». Williston Park, N.Y. Oncology. 27 (5): 460–467. PMID25184270
Grandér D (Abril de 1998). «How do mutated oncogenes and tumor suppressor genes cause cancer?». Medical Oncology. 15 (1): 20–6. PMID9643526. doi:10.1007/BF02787340
López-Lázaro M (Abril de 2008). «The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen?». Anti-Cancer Agents in Medicinal Chemistry. 8 (3): 305–12. PMID18393789. doi:10.2174/187152008783961932
Unwin RD, Craven RA, Harnden P, Hanrahan S, Totty N, Knowles M, et al. (Agosto de 2003). «Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect». Proteomics. 3 (8): 1620–32. PMID12923786. doi:10.1002/pmic.200300464
Gogvadze V, Zhivotovsky B, Orrenius S (Fevereiro de 2010). «The Warburg effect and mitochondrial stability in cancer cells». Molecular Aspects of Medicine. 31 (1): 60–74. PMID19995572. doi:10.1016/j.mam.2009.12.004
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. (Janeiro de 2007). «A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth». Cancer Cell. 11 (1): 37–51. PMID17222789. doi:10.1016/j.ccr.2006.10.020
Pan JG, Mak TW (Abril de 2007). «Metabolic targeting as an anticancer strategy: dawn of a new era?». Science's STKE. 2007 (381): pe14. PMID17426345. doi:10.1126/stke.3812007pe14
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, et al. (Março de 2008). «The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth». Nature. 452 (7184): 230–3. Bibcode:2008Natur.452..230C. PMID18337823. doi:10.1038/nature06734
Pedersen PL (Junho de 2007). «Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen». Journal of Bioenergetics and Biomembranes. 39 (3): 211–22. PMID17879147. doi:10.1007/s10863-007-9094-x
Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, et al. (Dezembro de 2009). «The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma». Cell Cycle. 8 (23): 3984–4001. PMID19923890. doi:10.4161/cc.8.23.10238
Luis C, Duarte F, Faria I, Jarak I, Oliveira PF, Alves MG, et al. (Abril de 2019). «Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells». Life Sciences. 223: 38–46. PMID30862570. doi:10.1016/j.lfs.2019.03.016. hdl:10400.22/14163
Gupta V, Gopinath P, Iqbal MA, Mazurek S, Wellen KE, Bamezai RN (2013). «Interplay between epigenetics & cancer metabolism». Current Pharmaceutical Design. 20 (11): 1706–14. PMID23888952. doi:10.2174/13816128113199990536
Medzhitov R (Outubro de 2015). «Bringing Warburg to lymphocytes». Nature Reviews. Immunology. 15 (10). 598 páginas. PMID26403193. doi:10.1038/nri3918
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, et al. (Junho de 2002). «The CD28 signaling pathway regulates glucose metabolism». Immunity. 16 (6): 769–77. PMID12121659. doi:10.1016/S1074-7613(02)00323-0