References analysis of the Wikipedia article "MTOR" in the Portuguese version

adsabs.harvard.edu (Global: 14^th place; Portuguese: 25^th place)

ui.adsabs.harvard.edu

Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL (Junho de 1994). «A mammalian protein targeted by G1-arresting rapamycin-receptor complex». Nature. 369 (6483): 756–8. Bibcode:1994Natur.369..756B. PMID 8008069. doi:10.1038/369756a0

Heitman J, Movva NR, Hall MN (Agosto de 1991). «Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast». Science. 253 (5022): 905–9. Bibcode:1991Sci...253..905H. PMID 1715094. doi:10.1126/science.1715094

Bierer BE, Mattila PS, Standaert RF, Herzenberg LA, Burakoff SJ, Crabtree G, Schreiber SL (Dezembro de 1990). «Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin». Proceedings of the National Academy of Sciences of the United States of America. 87 (23): 9231–5. Bibcode:1990PNAS...87.9231B. PMC 55138

. PMID 2123553. doi:10.1073/pnas.87.23.9231

Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL (Outubro de 1990). «Probing immunosuppressant action with a nonnatural immunophilin ligand». Science. 250 (4980): 556–9. Bibcode:1990Sci...250..556B. PMID 1700475. doi:10.1126/science.1700475

Harding MW, Galat A, Uehling DE, Schreiber SL (Outubro de 1989). «A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase». Nature. 341 (6244): 758–60. Bibcode:1989Natur.341..758H. PMID 2477715. doi:10.1038/341758a0

Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J (Novembro de 2001). «Phosphatidic acid-mediated mitogenic activation of mTOR signaling». Science. 294 (5548): 1942–5. Bibcode:2001Sci...294.1942F. PMID 11729323. doi:10.1126/science.1066015

Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM (Setembro de 2006). «mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s». Current Biology. 16 (18): 1865–70. Bibcode:2006CBio...16.1865F. PMID 16919458. doi:10.1016/j.cub.2006.08.001

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (Setembro de 2006). «Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton». Current Biology. 14 (14): 1296–302. Bibcode:2004CBio...14.1296D. PMID 15268862. doi:10.1016/j.cub.2004.06.054

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (Fevereiro de 2005). «Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex». Science. 307 (5712): 1098–101. Bibcode:2005Sci...307.1098S. PMID 15718470. doi:10.1126/science.1106148

Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT (Fevereiro de 2005). «Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B». Science. 279 (5351): 710–4. Bibcode:1998Sci...279..710S. PMID 9445477. doi:10.1126/science.279.5351.710

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA (Março de 2012). «Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity». Science. 335 (6076): 1638–43. Bibcode:2012Sci...335.1638L. PMC 3324089

. PMID 22461615. doi:10.1126/science.1215135

Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T (1 de janeiro de 2013). «Haploinsufficiency of akt1 prolongs the lifespan of mice». PLOS ONE. 8 (7): e69178. Bibcode:2013PLoSO...869178N. PMC 3728301

. PMID 23935948. doi:10.1371/journal.pone.0069178

Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (Novembro de 2005). «Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients». Science. 310 (5751): 1193–6. Bibcode:2005Sci...310.1193K. PMID 16293764. doi:10.1126/science.1115535

Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S (Maio de 2004). «Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway». Current Biology. 14 (10): 885–90. Bibcode:2004CBio...14..885K. PMC 2754830

. PMID 15186745. doi:10.1016/j.cub.2004.03.059

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA (Julho de 2009). «Rapamycin fed late in life extends lifespan in genetically heterogeneous mice». Nature. 460 (7253): 392–5. Bibcode:2009Natur.460..392H. PMC 2786175

. PMID 19587680. doi:10.1038/nature08221

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH, Zhang Y, Becker KG, Pérez VI, Richardson A (1 de janeiro de 2014). «Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome». PLOS ONE. 9 (1): e83988. Bibcode:2014PLoSO...983988F. PMC 3883653

. PMID 24409289. doi:10.1371/journal.pone.0083988

Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ (Maio de 2006). «Hypothalamic mTOR signaling regulates food intake». Science. 312 (5775): 927–30. Bibcode:2006Sci...312..927C. PMID 16690869. doi:10.1126/science.1124147

Kriete A, Bosl WJ, Booker G (Junho de 2010). «Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses». PLOS Computational Biology. 6 (6): e1000820. Bibcode:2010PLSCB...6E0820K. PMC 2887462

. PMID 20585546. doi:10.1371/journal.pcbi.1000820

Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR (Maio de 2012). «Sustained translational repression by eIF2α-P mediates prion neurodegeneration». Nature. 485 (7399): 507–11. Bibcode:2012Natur.485..507M. PMC 3378208

. PMID 22622579. doi:10.1038/nature11058

Rubinsztein DC (Outubro de 2006). «The roles of intracellular protein-degradation pathways in neurodegeneration». Nature. 443 (7113): 780–6. Bibcode:2006Natur.443..780R. PMID 17051204. doi:10.1038/nature05291

Salto R, Vílchez JD, Girón MD, Cabrera E, Campos N, Manzano M, Rueda R, López-Pedrosa JM (2015). «β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells». PLOS ONE. 10 (8): e0135614. Bibcode:2015PLoSO..1035614S. PMC 4534402

. PMID 26267903. doi:10.1371/journal.pone.0135614

Schalm SS, Fingar DC, Sabatini DM, Blenis J (Maio de 2003). «TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function». Current Biology. 13 (10): 797–806. Bibcode:2003CBio...13..797S. PMID 12747827. doi:10.1016/S0960-9822(03)00329-4

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (Abril de 2005). «Rheb binds and regulates the mTOR kinase». Current Biology. 15 (8): 702–13. Bibcode:2005CBio...15..702L. PMID 15854902. doi:10.1016/j.cub.2005.02.053

Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM (Fevereiro de 1998). «RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1». Proceedings of the National Academy of Sciences of the United States of America. 95 (4): 1432–7. Bibcode:1998PNAS...95.1432B. PMC 19032

. PMID 9465032. doi:10.1073/pnas.95.4.1432

Choi J, Chen J, Schreiber SL, Clardy J (Julho de 1996). «Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP». Science. 273 (5272): 239–42. Bibcode:1996Sci...273..239C. PMID 8662507. doi:10.1126/science.273.5272.239

Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D (Agosto de 2004). «Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals». Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12288–93. Bibcode:2004PNAS..10112288L. PMC 514471

. PMID 15284440. doi:10.1073/pnas.0404041101

Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr BA, Kirsch J, Betz H, Snyder SH (Maio de 1999). «Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling». Science. 284 (5417): 1161–4. Bibcode:1999Sci...284.1161S. PMID 10325225. doi:10.1126/science.284.5417.1161

Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP (Agosto de 2006). «PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR». Nature. 442 (7104): 779–85. Bibcode:2006Natur.442..779B. PMID 16915281. doi:10.1038/nature05029

Yokogami K, Wakisaka S, Avruch J, Reeves SA (Janeiro de 2000). «Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR». Current Biology. 10 (1): 47–50. Bibcode:2000CBio...10...47Y. PMID 10660304. doi:10.1016/S0960-9822(99)00268-7

doi.org (Global: 2^nd place; Portuguese: 4^th place)

dx.doi.org

Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT (Jan 1995). «Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells». J. Biol. Chem. 270 (2): 815–22. PMID 7822316. doi:10.1074/jbc.270.2.815

Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH (Julho de 1994). «RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs». Cell. 78 (1): 35–43. PMID 7518356. doi:10.1016/0092-8674(94)90570-3

Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT (Janeiro de 1995). «Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells». The Journal of Biological Chemistry. 270 (2): 815–22. PMID 7822316. doi:10.1074/jbc.270.2.815

Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri S, Fiorentino D, Raychaudhuri SP, Maverakis E (Novembro de 2015). «Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma». The Journal of Investigative Dermatology. 135 (11): 2873–6. PMC 4640976

. PMID 26134944. doi:10.1038/jid.2015.252

Lipton JO, Sahin M (Outubro de 2014). «The neurology of mTOR». Neuron. 84 (2): 275–291. PMC 4223653

. PMID 25374355. doi:10.1016/j.neuron.2014.09.034. A via de sinalização mTOR atua como um integrador de sistemas moleculares para apoiar as interações celulares e do organismo com o ambiente. A via da mTOR regula a homeostase influenciando diretamente a síntese de proteínas, a transcrição, a autofagia, o metabolismo e a biogênese e manutenção de organelas. Não é de surpreender, portanto, que a sinalização mTOR esteja envolvida em toda a hierarquia da função cerebral, incluindo a proliferação de células-tronco neurais, a montagem e a manutenção de circuitos, a plasticidade dependente da experiência e a regulação de comportamentos complexos como alimentação, sono e ritmos circadianos...
A função da mTOR é mediada por dois grandes complexos bioquímicos definidos por sua respectiva composição proteica e foram amplamente revisados em outros lugares (Dibble e Manning, 2013; Laplante e Sabatini, 2012 - Figura 1B). Em resumo, são comuns ao complexo mTOR 1 (mTORC1) e ao complexo mTOR 2 (mTORC2): o próprio mTOR, a proteína 8 letal de mamíferos com sec13 (mLST8; também conhecida como GβL) e a proteína de interação com mTOR contendo domínio DEP inibitório (DEPTOR). Específica para mTORC1 é a proteína associada ao regulador do alvo de rapamicina em mamíferos (Raptor) e substrato de Akt rico em prolina de 40 kDa (PRAS40) (Kim et al., 2002; Laplante e Sabatini, 2012). O Raptor é essencial para a atividade do mTORC1. O complexo mTORC2 inclui o companheiro insensível à rapamicina do mTOR (Rictor), a proteína 1 (mSIN1) que interage com a MAP quinase ativada por estresse em mamíferos e as proteínas observadas com o rictor 1 e 2 (PROTOR 1 e 2) (Jacinto et al., 2006; Jacinto et al., 2004; Pearce et al., 2007; Sarbassov et al., 2004 - Figura 1B). Rictor e mSIN1 são essenciais para a função de mTORC2. Figure 1: Domain structure of the mTOR kinase and components of mTORC1 and mTORC2 Figure 2: The mTOR Signaling Pathway

Hay N, Sonenberg N (Agosto de 2004). «Upstream and downstream of mTOR». Genes & Development. 18 (16): 1926–45. PMID 15314020. doi:10.1101/gad.1212704

Yin Y, Hua H, Li M, Liu S, Kong Q, Shao T, Wang J, Luo Y, Wang Q, Luo T, Jiang Y (Janeiro de 2016). «mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR». Cell Research. 26 (1): 46–65. PMC 4816127

. PMID 26584640. doi:10.1038/cr.2015.133

Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN (Novembro de 2004). «Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive». Nature Cell Biology. 6 (11): 1122–8. PMID 15467718. doi:10.1038/ncb1183

Sehgal, S. N.; Baker, H.; VéZina, Claude (1975). «Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.». The Journal of Antibiotics (em inglês). 28 (10): 727–732. ISSN 0021-8820. doi:10.7164/antibiotics.28.727

Powers, Ted (1 de novembro de 2022). Kellogg, Doug, ed. «The origin story of rapamycin: systemic bias in biomedical research and cold war politics». Molecular Biology of the Cell (em inglês). 33 (13). ISSN 1059-1524. PMID 36228182. doi:10.1091/mbc.E22-08-0377

Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Movva NR, and Hall MN (Maio de 1993). «Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression». Cell. 73 (3): 585–596. PMID 8387896. doi:10.1016/0092-8674(93)90144-F

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. PMID 8413204. doi:10.1128/MCB.13.10.6012

Magnuson B, Ekim B, Fingar DC (Janeiro de 2012). «Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signaling networks». The Biochemical Journal. 441 (1): 1–21. PMID 22168436. doi:10.1042/BJ20110892

Abraham RT, Wiederrecht GJ (1996). «Immunopharmacology of rapamycin». Annual Review of Immunology. 14: 483–510. PMID 8717522. doi:10.1146/annurev.immunol.14.1.483

. PMID 2123553. doi:10.1073/pnas.87.23.9231

Dumont FJ, Melino MR, Staruch MJ, Koprak SL, Fischer PA, Sigal NH (Fevereiro de 1990). «The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells». J Immunol. 144 (4): 1418–24. PMID 1689353. doi:10.4049/jimmunol.144.4.1418

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Heitman J (Novembro de 2015). «On the discovery of TOR as the target of rapamycin». PLOS Pathogens. 11 (11): e1005245. PMC 4634758

. PMID 26540102. doi:10.1371/journal.ppat.1005245

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. PMID 27304501. doi:10.1016/j.cmet.2016.05.009

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Wipperman MF, Montrose DC, Gotto AM, Hajjar DP (2019). «Mammalian Target of Rapamycin: A Metabolic Rheostat for Regulating Adipose Tissue Function and Cardiovascular Health». The American Journal of Pathology. 189 (3): 492–501. PMC 6412382

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Kennedy BK, Lamming DW (Junho de 2016). «The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging». Cell Metabolism. 23 (6): 990–1003. PMC 4910876

. PMID 27304501. doi:10.1016/j.cmet.2016.05.009

Huang S, Houghton PJ (Dezembro de 2001). «Mechanisms of resistance to rapamycins». Drug Resistance Updates. 4 (6): 378–91. PMID 12030785. doi:10.1054/drup.2002.0227

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Ingargiola C, Turqueto Duarte G, Robaglia C, Leprince AS, Meyer C (Outubro de 2020). «The Plant Target of Rapamycin: A Conduc TOR of Nutrition and Metabolism in Photosynthetic Organisms». Genes. 11 (11). 1285 páginas. PMC 7694126

. PMID 33138108. doi:10.3390/genes11111285

Shi L, Wu Y, Sheen J (Julho de 2018). «TOR signaling in plants: conservation and innovation». Development. 145 (13). PMC 6053665

. PMID 29986898. doi:10.1242/dev.160887

Xiong Y, Sheen J (Fevereiro de 2014). «The role of target of rapamycin signaling networks in plant growth and metabolism». Plant Physiology. 164 (2): 499–512. PMC 3912084

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Betz C, Hall MN (Novembro de 2013). «Where is mTOR and what is it doing there?». The Journal of Cell Biology. 203 (4): 563–74. PMC 3840941

. PMID 24385483. doi:10.1083/jcb.201306041

Groenewoud MJ, Zwartkruis FJ (Agosto de 2013). «Rheb and Rags come together at the lysosome to activate mTORC1». Biochemical Society Transactions. 41 (4): 951–5. PMID 23863162. doi:10.1042/bst20130037

Efeyan A, Zoncu R, Sabatini DM (Setembro de 2012). «Amino acids and mTORC1: from lysosomes to disease». Trends in Molecular Medicine. 18 (9): 524–33. PMC 3432651

. PMID 22749019. doi:10.1016/j.molmed.2012.05.007

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (Julho de 2002). «mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery». Cell. 110 (2): 163–75. PMID 12150925. doi:10.1016/S0092-8674(02)00808-5

Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM (Abril de 2003). «GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR». Molecular Cell. 11 (4): 895–904. PMID 12718876. doi:10.1016/S1097-2765(03)00114-X

Bond P (Março de 2016). «Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance». J. Int. Soc. Sports Nutr. 13. 8 páginas. PMC 4774173

. PMID 26937223. doi:10.1186/s12970-016-0118-y

Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N, Hall MN (Julho de 2013). «Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology». Proceedings of the National Academy of Sciences of the United States of America. 110 (31): 12526–34. PMC 3732980

. PMID 23852728. doi:10.1073/pnas.1302455110

Carosi JM, Fourrier C, Bensalem J, Sargeant TJ (2022). «The mTOR-lysosome axis at the centre of ageing». FEBS Open Bio. 12 (4): 739–757. PMC 8972043

. PMID 34878722. doi:10.1002/2211-5463.13347

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. PMID 30574122. doi:10.3389/fendo.2018.00748

Baechle JJ, Chen N, Winer DA (2023). «Chronic inflammation and the hallmarks of aging». Molecular Metabolism. 74. 101755 páginas. doi:10.1016/j.molmet.2023.101755

. PMID 22461615. doi:10.1126/science.1215135

Zinzalla V, Stracka D, Oppliger W, Hall MN (Março de 2011). «Activation of mTORC2 by association with the ribosome». Cell. 144 (5): 757–68. PMID 21376236. doi:10.1016/j.cell.2011.02.014

Zhang F, Zhang X, Li M, Chen P, Zhang B, Guo H, Cao W, Wei X, Cao X, Hao X, Zhang N (Novembro de 2010). «mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis». Cancer Research. 70 (22): 9360–70. PMID 20978191. doi:10.1158/0008-5472.CAN-10-0207

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM (Março de 2011). «Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1». Developmental Cell. 11 (6): 859–71. PMID 17141160. doi:10.1016/j.devcel.2006.10.007

Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA (Março de 2011). «Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size». Diabetes. 60 (3): 827–37. PMC 3046843

. PMID 21266327. doi:10.2337/db10-1194

Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA (Janeiro de 2014). «Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)». FASEB Journal. 28 (1): 300–15. PMC 3868844

. PMID 24072782. doi:10.1096/fj.13-237743

Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE (Junho de 2010). «Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism». Diabetes. 59 (6): 1397–406. PMC 2874700

. PMID 20332342. doi:10.2337/db09-1061

Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM (Outubro de 2014). «Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan». Aging Cell. 13 (5): 911–7. PMC 4172536

. PMID 25059582. doi:10.1111/acel.12256

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM (Fevereiro de 2009). «Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2». PLOS Biology. 7 (2): e38. PMC 2637922

. PMID 19209957. doi:10.1371/journal.pbio.1000038

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MTOR (Portuguese Wikipedia)

adsabs.harvard.edu (Global: 14th place; Portuguese: 25th place)

ui.adsabs.harvard.edu

archives-ouvertes.fr (Global: 1,143rd place; Portuguese: 2,285th place)

hal.archives-ouvertes.fr

cshlp.org (Global: low place; Portuguese: 7,327th place)

genesdev.cshlp.org

doi.org (Global: 2nd place; Portuguese: 4th place)

dx.doi.org

doi.org

genenames.org (Global: 5,471st place; Portuguese: low place)

hdl.handle.net (Global: 66th place; Portuguese: 183rd place)

hprd.org (Global: low place; Portuguese: low place)

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joi.jlc.jst.go.jp

medscape.com (Global: 1,078th place; Portuguese: 890th place)

emedicine.medscape.com

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nih.gov (Global: 5th place; Portuguese: 6th place)

ncbi.nlm.nih.gov

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cshlp.org (Global: low place; Portuguese: 7,327^th place)

doi.org (Global: 2^nd place; Portuguese: 4^th place)

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medscape.com (Global: 1,078^th place; Portuguese: 890^th place)

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nih.gov (Global: 5^th place; Portuguese: 6^th place)

web.archive.org (Global: 1^st place; Portuguese: 1^st place)

worldcat.org (Global: 4^th place; Portuguese: 5^th place)