References analysis of the Wikipedia article "MTOR" in the Portuguese version

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Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT (Janeiro de 1995). «Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells». The Journal of Biological Chemistry. 270 (2): 815–22. PMID 7822316. doi:10.1074/jbc.270.2.815

Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri S, Fiorentino D, Raychaudhuri SP, Maverakis E (Novembro de 2015). «Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma». The Journal of Investigative Dermatology. 135 (11): 2873–6. PMC 4640976

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Lipton JO, Sahin M (Outubro de 2014). «The neurology of mTOR». Neuron. 84 (2): 275–291. PMC 4223653

. PMID 25374355. doi:10.1016/j.neuron.2014.09.034. A via de sinalização mTOR atua como um integrador de sistemas moleculares para apoiar as interações celulares e do organismo com o ambiente. A via da mTOR regula a homeostase influenciando diretamente a síntese de proteínas, a transcrição, a autofagia, o metabolismo e a biogênese e manutenção de organelas. Não é de surpreender, portanto, que a sinalização mTOR esteja envolvida em toda a hierarquia da função cerebral, incluindo a proliferação de células-tronco neurais, a montagem e a manutenção de circuitos, a plasticidade dependente da experiência e a regulação de comportamentos complexos como alimentação, sono e ritmos circadianos...
A função da mTOR é mediada por dois grandes complexos bioquímicos definidos por sua respectiva composição proteica e foram amplamente revisados em outros lugares (Dibble e Manning, 2013; Laplante e Sabatini, 2012 - Figura 1B). Em resumo, são comuns ao complexo mTOR 1 (mTORC1) e ao complexo mTOR 2 (mTORC2): o próprio mTOR, a proteína 8 letal de mamíferos com sec13 (mLST8; também conhecida como GβL) e a proteína de interação com mTOR contendo domínio DEP inibitório (DEPTOR). Específica para mTORC1 é a proteína associada ao regulador do alvo de rapamicina em mamíferos (Raptor) e substrato de Akt rico em prolina de 40 kDa (PRAS40) (Kim et al., 2002; Laplante e Sabatini, 2012). O Raptor é essencial para a atividade do mTORC1. O complexo mTORC2 inclui o companheiro insensível à rapamicina do mTOR (Rictor), a proteína 1 (mSIN1) que interage com a MAP quinase ativada por estresse em mamíferos e as proteínas observadas com o rictor 1 e 2 (PROTOR 1 e 2) (Jacinto et al., 2006; Jacinto et al., 2004; Pearce et al., 2007; Sarbassov et al., 2004 - Figura 1B). Rictor e mSIN1 são essenciais para a função de mTORC2. Figure 1: Domain structure of the mTOR kinase and components of mTORC1 and mTORC2 Figure 2: The mTOR Signaling Pathway

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MTOR (Portuguese Wikipedia)

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