Nicolaes GA, Dahlbäck B (fevereiro de 2003). «Congenital and acquired activated protein C resistance». Seminars in Vascular Medicine. 3 (1): 33–46. PMID15199491. doi:10.1055/s-2003-38331
Eichacker PQ, Natanson C, Danner RL (outubro de 2006). «Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly». The New England Journal of Medicine. 355 (16): 1640–2. PMID17050887. doi:10.1056/NEJMp068197
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (12 de dezembro de 2012). «Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients». The Cochrane Database of Systematic Reviews. 12: CD004388. ISSN1469-493X. PMID23235609. doi:10.1002/14651858.CD004388.pub6
Kylat, Ranjit; Ohlsson, Arne (18 de abril de 2012). «Recombinant human activated protein C for severe sepsis in neonates.». Cochrane Database of Systematic Reviews (4): CD005385. doi:10.1002/14651858.CD005385.pub3
Kisiel W, Ericsson LH, Davie EW (novembro de 1976). «Proteolytic activation of protein C from bovine plasma». Biochemistry. 15 (22): 4893–900. PMID990250. doi:10.1021/bi00667a022
Mosnier LO, Griffin JH (2006). «Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities». Frontiers in Bioscience. 11: 2381–99. PMID16720321. doi:10.2741/1977
Kisiel W, Canfield WM, Ericsson LH, Davie EW (dezembro de 1977). «Anticoagulant properties of bovine plasma protein C following activation by thrombin». Biochemistry. 16 (26): 5824–31. PMID588557. doi:10.1021/bi00645a029
Vehar GA, Davie EW (fevereiro de 1980). «Preparation and properties of bovine factor VIII (antihemophilic factor)». Biochemistry. 19 (3): 401–10. PMID7356933. doi:10.1021/bi00544a001
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH (maio de 1994). «Mutation in blood coagulation factor V associated with resistance to activated protein C». Nature. 369 (6475): 64–7. PMID8164741. doi:10.1038/369064a0
PROWESS: recombinant Human Activated PROtein C Worldwide Evaluation in Severe Sepsis; Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ (março de 2001). «Efficacy and safety of recombinant human activated protein C for severe sepsis». The New England Journal of Medicine. 344 (10): 699–709. PMID11236773. doi:10.1056/NEJM200103083441001
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (junho de 2002). «Activation of endothelial cell protease activated receptor 1 by the protein C pathway». Science. 296 (5574): 1880–2. PMID12052963. doi:10.1126/science.1071699
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA (dezembro de 2011). «The structure-function relationship of activated protein C. Lessons from natural and engineered mutations». Thrombosis and Haemostasis. 106 (6): 1034–45. PMID22072231. doi:10.1160/TH11-08-0522
Gu JM, Crawley JT, Ferrell G, Zhang F, Li W, Esmon NL, Esmon CT (novembro de 2002). «Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality». The Journal of Biological Chemistry. 277 (45): 43335–43. PMID12218060. doi:10.1074/jbc.M207538200
España F, Berrettini M, Griffin JH (agosto de 1989). «Purification and characterization of plasma protein C inhibitor». Thrombosis Research. 55 (3): 369–84. PMID2551064. doi:10.1016/0049-3848(89)90069-8
Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J (setembro de 1995). «Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C». The Journal of Biological Chemistry. 270 (36): 21158–66. PMID7673148. doi:10.1074/jbc.270.36.21158
Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G (junho de 2008). «Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)». Chest. 133 (6 Suppl): 160S-198S. PMID18574265. doi:10.1378/chest.08-0670
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, François B, Guy JS, Brückmann M, Rea-Neto A, Rossaint R, Perrotin D, Sablotzki A, Arkins N, Utterback BG, Macias WL (setembro de 2005). «Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death». The New England Journal of Medicine. 353 (13): 1332–41. PMID16192478. doi:10.1056/NEJMoa050935
Martí-Carvajal AJ, Solà I, Lathyris D, Cardona AF (13 de abril de 2011). Martí-Carvajal AJ, ed. «Human recombinant activated protein C for severe sepsis». The Cochrane Database of Systematic Reviews (4): CD004388. PMID21491390. doi:10.1002/14651858.CD004388.pub4
Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV (2006). «The promise of protein C». Blood Cells, Molecules & Diseases. 36 (2): 211–6. PMID16464623. doi:10.1016/j.bcmd.2005.12.023
nih.gov
ncbi.nlm.nih.gov
Nicolaes GA, Dahlbäck B (fevereiro de 2003). «Congenital and acquired activated protein C resistance». Seminars in Vascular Medicine. 3 (1): 33–46. PMID15199491. doi:10.1055/s-2003-38331
Eichacker PQ, Natanson C, Danner RL (outubro de 2006). «Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly». The New England Journal of Medicine. 355 (16): 1640–2. PMID17050887. doi:10.1056/NEJMp068197
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (12 de dezembro de 2012). «Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients». The Cochrane Database of Systematic Reviews. 12: CD004388. ISSN1469-493X. PMID23235609. doi:10.1002/14651858.CD004388.pub6
Stenflo J (janeiro de 1976). «A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization». The Journal of Biological Chemistry. 251 (2): 355–63. PMID1245477
Kisiel W, Ericsson LH, Davie EW (novembro de 1976). «Proteolytic activation of protein C from bovine plasma». Biochemistry. 15 (22): 4893–900. PMID990250. doi:10.1021/bi00667a022
Mosnier LO, Griffin JH (2006). «Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities». Frontiers in Bioscience. 11: 2381–99. PMID16720321. doi:10.2741/1977
Kisiel W, Canfield WM, Ericsson LH, Davie EW (dezembro de 1977). «Anticoagulant properties of bovine plasma protein C following activation by thrombin». Biochemistry. 16 (26): 5824–31. PMID588557. doi:10.1021/bi00645a029
Vehar GA, Davie EW (fevereiro de 1980). «Preparation and properties of bovine factor VIII (antihemophilic factor)». Biochemistry. 19 (3): 401–10. PMID7356933. doi:10.1021/bi00544a001
Walker FJ (junho de 1980). «Regulation of activated protein C by a new protein. A possible function for bovine protein S». The Journal of Biological Chemistry. 255 (12): 5521–4. PMID6892911
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH (maio de 1994). «Mutation in blood coagulation factor V associated with resistance to activated protein C». Nature. 369 (6475): 64–7. PMID8164741. doi:10.1038/369064a0
Esmon NL, DeBault LE, Esmon CT (maio de 1983). «Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C». The Journal of Biological Chemistry. 258 (9): 5548–53. PMID6304092
PROWESS: recombinant Human Activated PROtein C Worldwide Evaluation in Severe Sepsis; Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ (março de 2001). «Efficacy and safety of recombinant human activated protein C for severe sepsis». The New England Journal of Medicine. 344 (10): 699–709. PMID11236773. doi:10.1056/NEJM200103083441001
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (junho de 2002). «Activation of endothelial cell protease activated receptor 1 by the protein C pathway». Science. 296 (5574): 1880–2. PMID12052963. doi:10.1126/science.1071699
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA (dezembro de 2011). «The structure-function relationship of activated protein C. Lessons from natural and engineered mutations». Thrombosis and Haemostasis. 106 (6): 1034–45. PMID22072231. doi:10.1160/TH11-08-0522
Gu JM, Crawley JT, Ferrell G, Zhang F, Li W, Esmon NL, Esmon CT (novembro de 2002). «Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality». The Journal of Biological Chemistry. 277 (45): 43335–43. PMID12218060. doi:10.1074/jbc.M207538200
España F, Berrettini M, Griffin JH (agosto de 1989). «Purification and characterization of plasma protein C inhibitor». Thrombosis Research. 55 (3): 369–84. PMID2551064. doi:10.1016/0049-3848(89)90069-8
Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J (setembro de 1995). «Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C». The Journal of Biological Chemistry. 270 (36): 21158–66. PMID7673148. doi:10.1074/jbc.270.36.21158
Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G (junho de 2008). «Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)». Chest. 133 (6 Suppl): 160S-198S. PMID18574265. doi:10.1378/chest.08-0670
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, François B, Guy JS, Brückmann M, Rea-Neto A, Rossaint R, Perrotin D, Sablotzki A, Arkins N, Utterback BG, Macias WL (setembro de 2005). «Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death». The New England Journal of Medicine. 353 (13): 1332–41. PMID16192478. doi:10.1056/NEJMoa050935
Martí-Carvajal AJ, Solà I, Lathyris D, Cardona AF (13 de abril de 2011). Martí-Carvajal AJ, ed. «Human recombinant activated protein C for severe sepsis». The Cochrane Database of Systematic Reviews (4): CD004388. PMID21491390. doi:10.1002/14651858.CD004388.pub4
Martí-Carvajal AJ1, Solà I, Gluud C, Lathyris D, Cardona AF. Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients.Cochrane Database Syst Rev. 2012 Dec 12;12:CD004388. doi: 10.1002/14651858.CD004388.pub6. PMID 23235609update
Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV (2006). «The promise of protein C». Blood Cells, Molecules & Diseases. 36 (2): 211–6. PMID16464623. doi:10.1016/j.bcmd.2005.12.023
worldcat.org
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (12 de dezembro de 2012). «Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients». The Cochrane Database of Systematic Reviews. 12: CD004388. ISSN1469-493X. PMID23235609. doi:10.1002/14651858.CD004388.pub6