Analysis of information sources in references of the Wikipedia article "Transtorno depressivo maior" in Portuguese language version.
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ignorado (ajuda)Despite advances in our understanding of the neuro-biology of MDD, no established mechanism can explain all aspects of the disease.
Although genes are an important cause of major depression and bipolar disorder, we have not confirmed the identity of the responsible genes.
Depression is highly heritable, as youths with a parent with a history of depression are approximately 4 times as likely to develop the disorder as youths who do not have a parent with depression.
It is clear from studies of families that major depression is not caused by any single gene but is a disease with complex genetic features.
The heritability of major depression is likely to be in the range of 31%–42%. This is probably the lower bound, and the level of heritability is likely to be substantially higher for reliably diagnosed major depression or for subtypes such as recurrent major depression. In comparison, the heritabilities of schizophrenia and bipolar disorder are estimated to be approximately 70%.
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(ajuda). doi:10.1002/14651858.CD013866.pub2|pmc=
(ajuda). PMID 33146667. doi:10.1001/jamapsychiatry.2020.3285. Consultado em 27 de setembro de 2023|data de acesso=
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(ajuda). PMID 33146667. doi:10.1001/jamapsychiatry.2020.3285. Consultado em 27 de setembro de 2023Despite advances in our understanding of the neuro-biology of MDD, no established mechanism can explain all aspects of the disease.
Despite advances in our understanding of the neuro-biology of MDD, no established mechanism can explain all aspects of the disease.
It is clear from studies of families that major depression is not caused by any single gene but is a disease with complex genetic features.
The heritability of major depression is likely to be in the range of 31%–42%. This is probably the lower bound, and the level of heritability is likely to be substantially higher for reliably diagnosed major depression or for subtypes such as recurrent major depression. In comparison, the heritabilities of schizophrenia and bipolar disorder are estimated to be approximately 70%.
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(ajuda). doi:10.1002/14651858.CD013866.pub2|pmc=
(ajuda). PMID 33146667. doi:10.1001/jamapsychiatry.2020.3285. Consultado em 27 de setembro de 2023|data de acesso=
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ignorado (ajuda)A Quinta Edição do Manual Diagnóstico e Estatístico de Transtornos Mentais, Revisão de Texto (DSM-5-TR) apresenta as atualizações de texto mais recentes com base na literatura científica, com contribuições de mais de 200 especialistas em diversos assuntos.
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ignorado (ajuda)... a versão mais recente do CID, a CID-11, foi adotada pela 72ª Assembleia Mundial da Saúde em 2019 e entrou em vigor em 1 de janeiro de 2022.
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ignorado (ajuda) «6A71 Recurrent depressive disorder». International Classification of Diseases 11th Revision. World Health Organization. Fevereiro de 2022. Consultado em 9 de julho de 2022 Parâmetro desconhecido |orig-date=
ignorado (ajuda)Although there is no single unifying theory, several theories have emerged over the last century that attempt to account for the various clinical, psychological, and biologic findings in depression.
A number of risk factors for depression are known or suspected, but only in rare cases is the link to disease strong.
Although genes are an important cause of major depression and bipolar disorder, we have not confirmed the identity of the responsible genes.
Depression is highly heritable, as youths with a parent with a history of depression are approximately 4 times as likely to develop the disorder as youths who do not have a parent with depression.
Thus it appears that bipolar disorder is more strongly influenced by genetic factors than is major depressive disorder.
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(ajuda). PMID 33146667. doi:10.1001/jamapsychiatry.2020.3285. Consultado em 27 de setembro de 2023