Analysis of information sources in references of the Wikipedia article "Vacina contra a COVID-19" in Portuguese language version.
De acordo com os dados, na prática, a eficácia de 50% significa que quem não tomar a vacina terá o dobro de chances de desenvolver a covid-19 caso pegue o vírus
Current evidence indicates that the level of protection may not be the same for all viral variants.
The global nature of a pandemic means that any vaccine or medicine that is successfully developed will be needed immediately all over the world. That means that the challenge we face is not only one of R&D but one of manufacturing at scale, and equitable access.
The Omicron variant evades the protection rendered by vaccine-induced antibodies and natural infection
Using this method, we rapidly characterized the profile of RBD escaping mutations for a total of 247 neutralizing antibodies (Supplementary Data 1). Half of the neutralizing antibodies were part of the antibodies identified by us using single-cell V(D)J sequencing of antigen-specific memory B cells from individuals who had been infected with SARS-CoV-2 (hereafter, SARS-CoV-2 convalescent individuals); individuals who had been vaccinated against SARS-CoV-2; and individuals with a previous infection of SARS-CoV-1 (SARS-CoV-1 convalescent individuals) who had recently been vaccinated against SARS-CoV-2 (Supplementary Data 2). The other half of the neutralizing antibodies were identified by groups worldwide3,5,6,11,17–40 (Supplementary Table 1).
The Omicron variant evades the protection rendered by vaccine-induced antibodies and natural infection
Using this method, we rapidly characterized the profile of RBD escaping mutations for a total of 247 neutralizing antibodies (Supplementary Data 1). Half of the neutralizing antibodies were part of the antibodies identified by us using single-cell V(D)J sequencing of antigen-specific memory B cells from individuals who had been infected with SARS-CoV-2 (hereafter, SARS-CoV-2 convalescent individuals); individuals who had been vaccinated against SARS-CoV-2; and individuals with a previous infection of SARS-CoV-1 (SARS-CoV-1 convalescent individuals) who had recently been vaccinated against SARS-CoV-2 (Supplementary Data 2). The other half of the neutralizing antibodies were identified by groups worldwide3,5,6,11,17–40 (Supplementary Table 1).
CEPI estimates that developing up to three vaccines in the next 12–18 months will require an investment of at least US$ 2 billion. This estimate includes phase 1 clinical trials of eight vaccine candidates, progression of up to six candidates through phase 2 and 3 trials, completion of regulatory and quality requirements for at least three vaccines, and enhancing global manufacturing capacity for three vaccines.
Current evidence indicates that the level of protection may not be the same for all viral variants.
It is vital that we evaluate as many vaccines as possible as we cannot predict how many will turn out to be viable. To increase the chances of success (given the high level of attrition during vaccine development), we must test all candidate vaccines until they fail. [The] WHO is working to ensure that all of them have the chance of being tested at the initial stage of development. The results for the efficacy of each vaccine are expected within three to six months and this evidence, combined with data on safety, will inform decisions about whether it can be used on a wider scale.
The global nature of a pandemic means that any vaccine or medicine that is successfully developed will be needed immediately all over the world. That means that the challenge we face is not only one of R&D but one of manufacturing at scale, and equitable access.
It is vital that we evaluate as many vaccines as possible as we cannot predict how many will turn out to be viable. To increase the chances of success (given the high level of attrition during vaccine development), we must test all candidate vaccines until they fail. [The] WHO is working to ensure that all of them have the chance of being tested at the initial stage of development. The results for the efficacy of each vaccine are expected within three to six months and this evidence, combined with data on safety, will inform decisions about whether it can be used on a wider scale.