Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., ... & Guo, Y. (2017). Rhizoma coptidis and berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation. Aging and disease, 8(6), 760. doi:10.14336/AD.2016.0620PMC5758350PMID29344415
Gao, Y., Wang, F., Song, Y., & Liu, H. (2020). The status of and trends in the pharmacology of berberine: a bibliometric review [1985–2018]. Chinese medicine, 15(1), 1-13. PMID31988653PMC6971869doi:10.1186/s13020-020-0288-z
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Wang, K. F., Chen, Q., Wu, N., Li, Y., Zhang, R., Wang, J., ... & Chen, J. (2019). Berberine ameliorates spatial learning memory impairment and modulates cholinergic anti-inflammatory pathway in diabetic rats. Frontiers in pharmacology, 10, 1003. doi:10.3389/fphar.2019.01003PMC6743342
Yang, X. J., Liu, F., Feng, N., Ding, X. S., Chen, Y., Zhu, S. X., ... & Feng, X. F. (2020). Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway. Journal of Cardiovascular Pharmacology, 75(1), 45-53. PMID31895879doi:10.1097/FJC.0000000000000769
Navrotskaya VV, Oxenkrug G, Vorobyova LI, Summergrad P. (2012). Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster. American journal of plant sciences. 3(7A): 1037. doi:10.4236/ajps.2012.327123PMC4498586
Letašiová, S., Jantová, S., Čipák, L. U., & Múčková, M. (2006). Berberine—antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer letters, 239(2), 254-262. PMID16229943doi:10.1016/j.canlet.2005.08.024
Wang, J., Qi, Q., Feng, Z., Zhang, X., Huang, B., Chen, A., ... & Wang, J. (2016). Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. Oncotarget, 7(41), 66944–66958. doi:10.18632/oncotarget.11396PMC5341849PMID27557493
Yang, X., & Huang, N. (2013). Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma. Molecular medicine reports, 8(2), 505-510. PMID23732865doi:10.3892/mmr.2013.1506
Palmieri, A., Scapoli, L., Iapichino, A., Mercolini, L., Mandrone, M., Poli, F., ... & Martinelli, M. (2019). Berberine and Tinospora cordifolia exert a potential anticancer effect on colon cancer cells by acting on specific pathways. International journal of immunopathology and pharmacology, 33, 2058738419855567. doi:10.1177/2058738419855567PMC6822188PMID31663444
Hu, H. Y., Li, K. P., Wang, X. J., Liu, Y., Lu, Z. G., Dong, R. H., ... & Zhang, M. X. (2013). Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells. Acta Pharmacologica Sinica, 34(1), 157-166. doi:10.1038/aps.2012.161PMC4086496PMID23247593
Al-Kuraishy, H. M., Al-Gareeb, A. I., & Hussien, N. R. (2019). Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury. International journal of critical illness and injury science, 9(2), 69–74. doi:10.4103/IJCIIS.IJCIIS_85_18PMC6625331PMID31334048
Shinji, S., Umezawa, K., Nihashi, Y., Nakamura, S., Shimosato, T., & Takaya, T. (2021). Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin. Frontiers in cell and developmental biology, 8, 1683. PMID33585451PMC7874222doi:10.3389/fcell.2020.616706
Li, C., Ai, G., Wang, Y., Lu, Q., Luo, C., Tan, L., ... & Su, Z. (2020). Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway. Pharmacological research, 152, 104603. PMID31863867doi:10.1016/j.phrs.2019.104603
Li, C. L., Tan, L. H., Wang, Y. F., Luo, C. D., Chen, H. B., Lu, Q., ... & Su, Z. R. (2019). Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. Phytomedicine, 52, 272-283. PMID30599908doi:10.1016/j.phymed.2018.09.228
Dou, Y., Huang, R., Li, Q., Liu, Y., Li, Y., Chen, H., ... & Su, Z. (2021). Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways. Biomedicine & Pharmacotherapy, 137, 111312. PMID33524788doi:10.1016/j.biopha.2021.111312
Gong, L. L., Fang, L. H., Wang, S. B., Sun, J. L., Qin, H. L., Li, X. X., ... & Du, G. H. (2012). Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis, 222(1), 50-58. PMID22387061doi:10.1016/j.atherosclerosis.2012.01.046
Wu, J., Luo, Y., Deng, D., Su, S., Li, S., Xiang, L., ... & Meng, X. (2019). Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review. Journal of cellular and molecular medicine, 23(12), 7946-7960. PMID31622015PMC6850926doi:10.1111/jcmm.14725
Dostál, J., Man, S., Sečkářová, P., Hulová, D., Nečas, M., Potáček, M., ... & Marek, R. (2004). Berberine and coptisine free bases. Journal of Molecular Structure, 687(1-3), 135-142. https://doi.org/10.1016/j.molstruc.2003.09.018
nih.gov
ncbi.nlm.nih.gov
Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., ... & Guo, Y. (2017). Rhizoma coptidis and berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation. Aging and disease, 8(6), 760. doi:10.14336/AD.2016.0620PMC5758350PMID29344415
Gao, Y., Wang, F., Song, Y., & Liu, H. (2020). The status of and trends in the pharmacology of berberine: a bibliometric review [1985–2018]. Chinese medicine, 15(1), 1-13. PMID31988653PMC6971869doi:10.1186/s13020-020-0288-z
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., ... & Sychrova, A. (2019). Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics, 9(7), 1923. PMC6485276
Wang, K. F., Chen, Q., Wu, N., Li, Y., Zhang, R., Wang, J., ... & Chen, J. (2019). Berberine ameliorates spatial learning memory impairment and modulates cholinergic anti-inflammatory pathway in diabetic rats. Frontiers in pharmacology, 10, 1003. doi:10.3389/fphar.2019.01003PMC6743342
Yang, X. J., Liu, F., Feng, N., Ding, X. S., Chen, Y., Zhu, S. X., ... & Feng, X. F. (2020). Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway. Journal of Cardiovascular Pharmacology, 75(1), 45-53. PMID31895879doi:10.1097/FJC.0000000000000769
Navrotskaya VV, Oxenkrug G, Vorobyova LI, Summergrad P. (2012). Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster. American journal of plant sciences. 3(7A): 1037. doi:10.4236/ajps.2012.327123PMC4498586
Lin CC, Lin SY, Chung JG, Lin JP, Chen GW, Kao ST. (2006). Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle. Anticancer Res.;26(2a), 1097–104. PMID16619512
Letašiová, S., Jantová, S., Čipák, L. U., & Múčková, M. (2006). Berberine—antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer letters, 239(2), 254-262. PMID16229943doi:10.1016/j.canlet.2005.08.024
Wang, J., Qi, Q., Feng, Z., Zhang, X., Huang, B., Chen, A., ... & Wang, J. (2016). Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. Oncotarget, 7(41), 66944–66958. doi:10.18632/oncotarget.11396PMC5341849PMID27557493
Yang, X., & Huang, N. (2013). Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma. Molecular medicine reports, 8(2), 505-510. PMID23732865doi:10.3892/mmr.2013.1506
Palmieri, A., Scapoli, L., Iapichino, A., Mercolini, L., Mandrone, M., Poli, F., ... & Martinelli, M. (2019). Berberine and Tinospora cordifolia exert a potential anticancer effect on colon cancer cells by acting on specific pathways. International journal of immunopathology and pharmacology, 33, 2058738419855567. doi:10.1177/2058738419855567PMC6822188PMID31663444
Hu, H. Y., Li, K. P., Wang, X. J., Liu, Y., Lu, Z. G., Dong, R. H., ... & Zhang, M. X. (2013). Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells. Acta Pharmacologica Sinica, 34(1), 157-166. doi:10.1038/aps.2012.161PMC4086496PMID23247593
Al-Kuraishy, H. M., Al-Gareeb, A. I., & Hussien, N. R. (2019). Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury. International journal of critical illness and injury science, 9(2), 69–74. doi:10.4103/IJCIIS.IJCIIS_85_18PMC6625331PMID31334048
Shinji, S., Umezawa, K., Nihashi, Y., Nakamura, S., Shimosato, T., & Takaya, T. (2021). Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin. Frontiers in cell and developmental biology, 8, 1683. PMID33585451PMC7874222doi:10.3389/fcell.2020.616706
Li, C., Ai, G., Wang, Y., Lu, Q., Luo, C., Tan, L., ... & Su, Z. (2020). Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway. Pharmacological research, 152, 104603. PMID31863867doi:10.1016/j.phrs.2019.104603
Li, C. L., Tan, L. H., Wang, Y. F., Luo, C. D., Chen, H. B., Lu, Q., ... & Su, Z. R. (2019). Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. Phytomedicine, 52, 272-283. PMID30599908doi:10.1016/j.phymed.2018.09.228
Dou, Y., Huang, R., Li, Q., Liu, Y., Li, Y., Chen, H., ... & Su, Z. (2021). Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways. Biomedicine & Pharmacotherapy, 137, 111312. PMID33524788doi:10.1016/j.biopha.2021.111312
Gong, L. L., Fang, L. H., Wang, S. B., Sun, J. L., Qin, H. L., Li, X. X., ... & Du, G. H. (2012). Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis, 222(1), 50-58. PMID22387061doi:10.1016/j.atherosclerosis.2012.01.046
Wu, J., Luo, Y., Deng, D., Su, S., Li, S., Xiang, L., ... & Meng, X. (2019). Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review. Journal of cellular and molecular medicine, 23(12), 7946-7960. PMID31622015PMC6850926doi:10.1111/jcmm.14725
