Mizuki N., Kimura M., Ohno S., Miyata S., Sato M., Ando H., Ishihara M., Goto K., Watanabe S., Yamazaki M., Ono A., Taguchi S., Okumura K., Nogami M., Taguchi T., Ando A., Inoko H. Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36 (англ.) // Genomics : journal. — Academic Press, 1996. — December (vol. 34, no. 1). — P. 114—118. — doi:10.1006/geno.1996.0248. — PMID8661031.
Karbowniczek, Magdalena; Cash Timothy; Cheung Mitchell; Robertson Gavin P; Astrinidis Aristotelis; Henske Elizabeth Petri. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent (англ.) // Journal of Biological Chemistry : journal. — United States, 2004. — July (vol. 279, no. 29). — P. 29930—29937. — ISSN0021-9258. — doi:10.1074/jbc.M402591200. — PMID15150271.
Long, Xiaomeng; Ortiz-Vega Sara, Lin Yenshou, Avruch Joseph. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency (англ.) // Journal of Biological Chemistry : journal. — United States, 2005. — June (vol. 280, no. 25). — P. 23433—23436. — ISSN0021-9258. — doi:10.1074/jbc.C500169200. — PMID15878852.
Smith, Ewan M; Finn Stephen G; Tee Andrew R; Browne Gareth J; Proud Christopher G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses (англ.) // Journal of Biological Chemistry : journal. — United States, 2005. — May (vol. 280, no. 19). — P. 18717—18727. — ISSN0021-9258. — doi:10.1074/jbc.M414499200. — PMID15772076.
Bernardi, Rosa; Guernah Ilhem, Jin David, Grisendi Silvia, Alimonti Andrea, Teruya-Feldstein Julie, Cordon-Cardo Carlos, Simon M Celeste, Rafii Shahin, Pandolfi Pier Paolo. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR (англ.) // Nature : journal. — England, 2006. — August (vol. 442, no. 7104). — P. 779—785. — doi:10.1038/nature05029. — PMID16915281.
Castro, Ariel F; Rebhun John F; Clark Geoffrey J; Quilliam Lawrence A. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner (англ.) // Journal of Biological Chemistry : journal. — United States, 2003. — August (vol. 278, no. 35). — P. 32493—32496. — ISSN0021-9258. — doi:10.1074/jbc.C300226200. — PMID12842888.
Inoki, Ken; Li Yong; Xu Tian; Guan Kun-Liang. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling (англ.) // Genes & Development : journal. — United States, 2003. — August (vol. 17, no. 15). — P. 1829—1834. — ISSN0890-9369. — doi:10.1101/gad.1110003. — PMID12869586. — PMC196227.
Garami, Attila; Zwartkruis Fried J T; Nobukuni Takahiro; Joaquin Manel; Roccio Marta; Stocker Hugo; Kozma Sara C; Hafen Ernst; Bos Johannes L; Thomas George. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 (англ.) // Molecular Cell[англ.] : journal. — United States, 2003. — June (vol. 11, no. 6). — P. 1457—1466. — ISSN1097-2765. — doi:10.1016/S1097-2765(03)00220-X. — PMID12820960.
Zhang, Yong; Gao Xinsheng; Saucedo Leslie J; Ru Binggen; Edgar Bruce A; Pan Duojia. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins (англ.) // Nature Cell Biology : journal. — England, 2003. — June (vol. 5, no. 6). — P. 578—581. — ISSN1465-7392. — doi:10.1038/ncb999. — PMID12771962.
Cao, Yongheng; Kamioka Yuji; Yokoi Norihide; Kobayashi Toshiyuki; Hino Okio; Onodera Masafumi; Mochizuki Naoki; Nakae Jun. Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway (англ.) // Journal of Biological Chemistry : journal. — United States, 2006. — December (vol. 281, no. 52). — P. 40242—40251. — ISSN0021-9258. — doi:10.1074/jbc.M608116200. — PMID17077083.
nih.gov
ncbi.nlm.nih.gov
Mizuki N., Kimura M., Ohno S., Miyata S., Sato M., Ando H., Ishihara M., Goto K., Watanabe S., Yamazaki M., Ono A., Taguchi S., Okumura K., Nogami M., Taguchi T., Ando A., Inoko H. Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36 (англ.) // Genomics : journal. — Academic Press, 1996. — December (vol. 34, no. 1). — P. 114—118. — doi:10.1006/geno.1996.0248. — PMID8661031.
Karbowniczek, Magdalena; Cash Timothy; Cheung Mitchell; Robertson Gavin P; Astrinidis Aristotelis; Henske Elizabeth Petri. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent (англ.) // Journal of Biological Chemistry : journal. — United States, 2004. — July (vol. 279, no. 29). — P. 29930—29937. — ISSN0021-9258. — doi:10.1074/jbc.M402591200. — PMID15150271.
Yee, W M; Worley P F. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals (англ.) // Molecular and Cellular Biology[англ.] : journal. — UNITED STATES, 1997. — February (vol. 17, no. 2). — P. 921—933. — ISSN0270-7306. — PMID9001246. — PMC231818.
Long, Xiaomeng; Ortiz-Vega Sara, Lin Yenshou, Avruch Joseph. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency (англ.) // Journal of Biological Chemistry : journal. — United States, 2005. — June (vol. 280, no. 25). — P. 23433—23436. — ISSN0021-9258. — doi:10.1074/jbc.C500169200. — PMID15878852.
Smith, Ewan M; Finn Stephen G; Tee Andrew R; Browne Gareth J; Proud Christopher G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses (англ.) // Journal of Biological Chemistry : journal. — United States, 2005. — May (vol. 280, no. 19). — P. 18717—18727. — ISSN0021-9258. — doi:10.1074/jbc.M414499200. — PMID15772076.
Bernardi, Rosa; Guernah Ilhem, Jin David, Grisendi Silvia, Alimonti Andrea, Teruya-Feldstein Julie, Cordon-Cardo Carlos, Simon M Celeste, Rafii Shahin, Pandolfi Pier Paolo. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR (англ.) // Nature : journal. — England, 2006. — August (vol. 442, no. 7104). — P. 779—785. — doi:10.1038/nature05029. — PMID16915281.
Castro, Ariel F; Rebhun John F; Clark Geoffrey J; Quilliam Lawrence A. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner (англ.) // Journal of Biological Chemistry : journal. — United States, 2003. — August (vol. 278, no. 35). — P. 32493—32496. — ISSN0021-9258. — doi:10.1074/jbc.C300226200. — PMID12842888.
Inoki, Ken; Li Yong; Xu Tian; Guan Kun-Liang. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling (англ.) // Genes & Development : journal. — United States, 2003. — August (vol. 17, no. 15). — P. 1829—1834. — ISSN0890-9369. — doi:10.1101/gad.1110003. — PMID12869586. — PMC196227.
Garami, Attila; Zwartkruis Fried J T; Nobukuni Takahiro; Joaquin Manel; Roccio Marta; Stocker Hugo; Kozma Sara C; Hafen Ernst; Bos Johannes L; Thomas George. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 (англ.) // Molecular Cell[англ.] : journal. — United States, 2003. — June (vol. 11, no. 6). — P. 1457—1466. — ISSN1097-2765. — doi:10.1016/S1097-2765(03)00220-X. — PMID12820960.
Zhang, Yong; Gao Xinsheng; Saucedo Leslie J; Ru Binggen; Edgar Bruce A; Pan Duojia. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins (англ.) // Nature Cell Biology : journal. — England, 2003. — June (vol. 5, no. 6). — P. 578—581. — ISSN1465-7392. — doi:10.1038/ncb999. — PMID12771962.
Cao, Yongheng; Kamioka Yuji; Yokoi Norihide; Kobayashi Toshiyuki; Hino Okio; Onodera Masafumi; Mochizuki Naoki; Nakae Jun. Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway (англ.) // Journal of Biological Chemistry : journal. — United States, 2006. — December (vol. 281, no. 52). — P. 40242—40251. — ISSN0021-9258. — doi:10.1074/jbc.M608116200. — PMID17077083.
wikipedia.org
en.wikipedia.org
Yee, W M; Worley P F. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals (англ.) // Molecular and Cellular Biology[англ.] : journal. — UNITED STATES, 1997. — February (vol. 17, no. 2). — P. 921—933. — ISSN0270-7306. — PMID9001246. — PMC231818.
Garami, Attila; Zwartkruis Fried J T; Nobukuni Takahiro; Joaquin Manel; Roccio Marta; Stocker Hugo; Kozma Sara C; Hafen Ernst; Bos Johannes L; Thomas George. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 (англ.) // Molecular Cell[англ.] : journal. — United States, 2003. — June (vol. 11, no. 6). — P. 1457—1466. — ISSN1097-2765. — doi:10.1016/S1097-2765(03)00220-X. — PMID12820960.
Karbowniczek, Magdalena; Cash Timothy; Cheung Mitchell; Robertson Gavin P; Astrinidis Aristotelis; Henske Elizabeth Petri. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent (англ.) // Journal of Biological Chemistry : journal. — United States, 2004. — July (vol. 279, no. 29). — P. 29930—29937. — ISSN0021-9258. — doi:10.1074/jbc.M402591200. — PMID15150271.
Yee, W M; Worley P F. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals (англ.) // Molecular and Cellular Biology[англ.] : journal. — UNITED STATES, 1997. — February (vol. 17, no. 2). — P. 921—933. — ISSN0270-7306. — PMID9001246. — PMC231818.
Long, Xiaomeng; Ortiz-Vega Sara, Lin Yenshou, Avruch Joseph. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency (англ.) // Journal of Biological Chemistry : journal. — United States, 2005. — June (vol. 280, no. 25). — P. 23433—23436. — ISSN0021-9258. — doi:10.1074/jbc.C500169200. — PMID15878852.
Smith, Ewan M; Finn Stephen G; Tee Andrew R; Browne Gareth J; Proud Christopher G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses (англ.) // Journal of Biological Chemistry : journal. — United States, 2005. — May (vol. 280, no. 19). — P. 18717—18727. — ISSN0021-9258. — doi:10.1074/jbc.M414499200. — PMID15772076.
Castro, Ariel F; Rebhun John F; Clark Geoffrey J; Quilliam Lawrence A. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner (англ.) // Journal of Biological Chemistry : journal. — United States, 2003. — August (vol. 278, no. 35). — P. 32493—32496. — ISSN0021-9258. — doi:10.1074/jbc.C300226200. — PMID12842888.
Inoki, Ken; Li Yong; Xu Tian; Guan Kun-Liang. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling (англ.) // Genes & Development : journal. — United States, 2003. — August (vol. 17, no. 15). — P. 1829—1834. — ISSN0890-9369. — doi:10.1101/gad.1110003. — PMID12869586. — PMC196227.
Garami, Attila; Zwartkruis Fried J T; Nobukuni Takahiro; Joaquin Manel; Roccio Marta; Stocker Hugo; Kozma Sara C; Hafen Ernst; Bos Johannes L; Thomas George. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 (англ.) // Molecular Cell[англ.] : journal. — United States, 2003. — June (vol. 11, no. 6). — P. 1457—1466. — ISSN1097-2765. — doi:10.1016/S1097-2765(03)00220-X. — PMID12820960.
Zhang, Yong; Gao Xinsheng; Saucedo Leslie J; Ru Binggen; Edgar Bruce A; Pan Duojia. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins (англ.) // Nature Cell Biology : journal. — England, 2003. — June (vol. 5, no. 6). — P. 578—581. — ISSN1465-7392. — doi:10.1038/ncb999. — PMID12771962.
Cao, Yongheng; Kamioka Yuji; Yokoi Norihide; Kobayashi Toshiyuki; Hino Okio; Onodera Masafumi; Mochizuki Naoki; Nakae Jun. Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway (англ.) // Journal of Biological Chemistry : journal. — United States, 2006. — December (vol. 281, no. 52). — P. 40242—40251. — ISSN0021-9258. — doi:10.1074/jbc.M608116200. — PMID17077083.