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Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009). Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol, 7(2), e1000038. PMID19209957PMC2637922doi:10.1371/journal.pbio.1000038
Lu, Z., Shi, X., Gong, F., Li, S., Wang, Y., Ren, Y., ... & Hou, G. (2020). RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. Acta Pharmaceutica Sinica B, 10(6), 1004 -1019. PMID32642408PMC7332809doi:10.1016/j.apsb.2020.01.010
Voss, M. H., Gordon, M. S., Mita, M., Rini, B., Makker, V., Macarulla, T., ... & Burris, H. A. (2020). Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer. British journal of cancer, 123(11), 1590-1598. PMID32913286PMC7686313doi:10.1038/s41416-020-01041-x
Budanov, A. V., & Karin, M. (2008). p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling. Cell, 134(3), 451–460. doi:10.1016/j.cell.2008.06.028
Kishimoto, Y., Kondo, K., & Momiyama, Y. (2021). The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases. International Journal of Molecular Sciences, 22(3), 1200. PMID33530433PMC7865804doi:10.3390/ijms22031200
Dumas, S. N., & Lamming, D. W. (2020). Next generation strategies for geroprotection via mTORC1 inhibition. The Journals of Gerontology: Series A, 75(1), 14-23. PMID30794726PMC6909887doi:10.1093 / gerona / glz056
Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., ... & Ehninger, D. (2013). Rapamycin extends murine lifespan but has limited effects on aging. The Journal of clinical investigation, 123(8), 3272-3291. PMID3863708PMC3726163doi:10.1172/JCI67674
Unnikrishnan, A., Kurup, K., Salmon, A. B., & Richardson, A. (2020). Is rapamycin a dietary restriction mimetic?. The Journals of Gerontology: Series A, 75(1), 4-13. PMID30854544PMC6909904doi:10.1093/gerona/glz060
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ncbi.nlm.nih.gov
Heitman J., Movva N. R., Hall M. N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast (англ.) // Science : journal. — 1991. — August (vol. 253, no. 5022). — P. 905—909. — doi:10.1126/science.1715094. — PMID1715094.
Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009). Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol, 7(2), e1000038. PMID19209957PMC2637922doi:10.1371/journal.pbio.1000038
Lu, Z., Shi, X., Gong, F., Li, S., Wang, Y., Ren, Y., ... & Hou, G. (2020). RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. Acta Pharmaceutica Sinica B, 10(6), 1004 -1019. PMID32642408PMC7332809doi:10.1016/j.apsb.2020.01.010
Voss, M. H., Gordon, M. S., Mita, M., Rini, B., Makker, V., Macarulla, T., ... & Burris, H. A. (2020). Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer. British journal of cancer, 123(11), 1590-1598. PMID32913286PMC7686313doi:10.1038/s41416-020-01041-x
Kishimoto, Y., Kondo, K., & Momiyama, Y. (2021). The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases. International Journal of Molecular Sciences, 22(3), 1200. PMID33530433PMC7865804doi:10.3390/ijms22031200
Dumas, S. N., & Lamming, D. W. (2020). Next generation strategies for geroprotection via mTORC1 inhibition. The Journals of Gerontology: Series A, 75(1), 14-23. PMID30794726PMC6909887doi:10.1093 / gerona / glz056
Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., ... & Ehninger, D. (2013). Rapamycin extends murine lifespan but has limited effects on aging. The Journal of clinical investigation, 123(8), 3272-3291. PMID3863708PMC3726163doi:10.1172/JCI67674
Unnikrishnan, A., Kurup, K., Salmon, A. B., & Richardson, A. (2020). Is rapamycin a dietary restriction mimetic?. The Journals of Gerontology: Series A, 75(1), 4-13. PMID30854544PMC6909904doi:10.1093/gerona/glz060
