Analysis of information sources in references of the Wikipedia article "Обходные пути биосинтеза андрогенов у человека" in Russian language version.
[...] steroidogenic research has focused on the metabolism of the C11-oxy C21 steroids in backdoor pathway yielding potent androgens (Fig. 1). Increased activation of the pathway and elevated enzyme expression levels are more frequently reported in the human fetus and ovaries and in clinical conditions which include 21OHD and adrenocortical tumours. [...] The detection of C11-oxy steroids in clinical conditions associated with increased backdoor pathway activity led us to investigate the catalytic activity of CYP17A1 towards the C11-oxy C21 steroids potentially contributing to the androgen pool.
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)progesterone (4-pregnene-3,20-dione, C21H30O2)
The downstream metabolism of 21dF and 21dE by the enzymes in the backdoor pathway, SRD5A and AKR1C2, was investigated and the resulting novel C11‐oxy C21 steroids, 5α‐pregnan-3α, 11β, 17-triol-20-one (11OHPdiol) and 5α-pregnan-3α, 17-diol-11, 20-dione (11KPdiol), were shown to be suitable substrates for the lyase activity of CYP17A1, resulting in the production of C11-oxy C19 steroid metabolites 11β‐hydroxyandrosterone (11OHAST) and 11‐ketoandrosterone (11KAST) [...] The interconversion of 21dF and 21dE by 11βHSD yielded two C11-oxy C21 steroids which our in vitro assays showed are metabolised by steroidogenic enzymes in the backdoor pathway to yield C11-oxy C19 androgens. [...] the backdoor pathway may include the 5α-reduction of 21dF and 21dE in these patients and, as a consequence, the production of potent androgens, 11OHDHT and 11KDHT.
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)The prefix oxo- should also be used in connection with generic terms, e.g., 17-oxo steroids. The term '17-keto steroids', often used in the medical literature, is incorrect because C-17 is specified twice, as the term keto denotes C=O
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка){{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)[...] steroidogenic research has focused on the metabolism of the C11-oxy C21 steroids in backdoor pathway yielding potent androgens (Fig. 1). Increased activation of the pathway and elevated enzyme expression levels are more frequently reported in the human fetus and ovaries and in clinical conditions which include 21OHD and adrenocortical tumours. [...] The detection of C11-oxy steroids in clinical conditions associated with increased backdoor pathway activity led us to investigate the catalytic activity of CYP17A1 towards the C11-oxy C21 steroids potentially contributing to the androgen pool.
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)progesterone (4-pregnene-3,20-dione, C21H30O2)
The downstream metabolism of 21dF and 21dE by the enzymes in the backdoor pathway, SRD5A and AKR1C2, was investigated and the resulting novel C11‐oxy C21 steroids, 5α‐pregnan-3α, 11β, 17-triol-20-one (11OHPdiol) and 5α-pregnan-3α, 17-diol-11, 20-dione (11KPdiol), were shown to be suitable substrates for the lyase activity of CYP17A1, resulting in the production of C11-oxy C19 steroid metabolites 11β‐hydroxyandrosterone (11OHAST) and 11‐ketoandrosterone (11KAST) [...] The interconversion of 21dF and 21dE by 11βHSD yielded two C11-oxy C21 steroids which our in vitro assays showed are metabolised by steroidogenic enzymes in the backdoor pathway to yield C11-oxy C19 androgens. [...] the backdoor pathway may include the 5α-reduction of 21dF and 21dE in these patients and, as a consequence, the production of potent androgens, 11OHDHT and 11KDHT.
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)The prefix oxo- should also be used in connection with generic terms, e.g., 17-oxo steroids. The term '17-keto steroids', often used in the medical literature, is incorrect because C-17 is specified twice, as the term keto denotes C=O
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка){{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)[...] steroidogenic research has focused on the metabolism of the C11-oxy C21 steroids in backdoor pathway yielding potent androgens (Fig. 1). Increased activation of the pathway and elevated enzyme expression levels are more frequently reported in the human fetus and ovaries and in clinical conditions which include 21OHD and adrenocortical tumours. [...] The detection of C11-oxy steroids in clinical conditions associated with increased backdoor pathway activity led us to investigate the catalytic activity of CYP17A1 towards the C11-oxy C21 steroids potentially contributing to the androgen pool.
The downstream metabolism of 21dF and 21dE by the enzymes in the backdoor pathway, SRD5A and AKR1C2, was investigated and the resulting novel C11‐oxy C21 steroids, 5α‐pregnan-3α, 11β, 17-triol-20-one (11OHPdiol) and 5α-pregnan-3α, 17-diol-11, 20-dione (11KPdiol), were shown to be suitable substrates for the lyase activity of CYP17A1, resulting in the production of C11-oxy C19 steroid metabolites 11β‐hydroxyandrosterone (11OHAST) and 11‐ketoandrosterone (11KAST) [...] The interconversion of 21dF and 21dE by 11βHSD yielded two C11-oxy C21 steroids which our in vitro assays showed are metabolised by steroidogenic enzymes in the backdoor pathway to yield C11-oxy C19 androgens. [...] the backdoor pathway may include the 5α-reduction of 21dF and 21dE in these patients and, as a consequence, the production of potent androgens, 11OHDHT and 11KDHT.
{{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка){{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка){{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка){{cite journal}}: Википедия:Обслуживание CS1 (не помеченный открытым DOI) (ссылка)