Sinha, S., & Chen, J. K. (2006). Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nature chemical biology, 2(1), 29-30. PMID16408088doi:10.1038/nchembio753
Ruat, M., Hoch, L., Faure, H., & Rognan, D. (2014). Targeting of Smoothened for therapeutic gain. Trends in pharmacological sciences, 35(5), 237—246. PMID24703627doi:10.1016/j.tips.2014.03.002
Beloti, M. M., Bellesini, L. S., & Rosa, A. L. (2005). Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell biology international, 29(7), 537—541. PMID15979909doi:10.1016/j.cellbi.2005.02.007
Chechneva, O. V., Mayrhofer, F., Daugherty, D. J., Krishnamurty, R. G., Bannerman, P., Pleasure, D. E., & Deng, W. (2014). A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell death & disease, 5(10), e1481-e1481. PMID25341035PMC4649529doi:10.1038/cddis.2014.446
Gupta, R., Mehan, S., Sethi, P., Prajapati, A., Alshammari, A., Alharbi, M., … & Narula, A. S. (2022). Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder. Brain Sciences, 12(3), 342. PMID35326298PMC8946713doi:10.3390/brainsci12030342
Shao, S., Wang, G. L., Raymond, C., Deng, X. H., Zhu, X. L., Wang, D. I., & Hong, L. P. (2017). Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson’s disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway. Molecular medicine reports, 16(2), 1269—1277. PMID28627590PMC5562000doi:10.3892/mmr.2017.6751
Rahi, S., Gupta, R., Sharma, A., & Mehan, S. (2021). Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism. Human & Experimental Toxicology, 40(11), 1880—1898. PMID33906504doi:10.1177/09603271211013456
Liu, D., Bai, X., Ma, W., Xin, D., Chu, X., Yuan, H., … & Wang, Z. (2020). Purmorphamine attenuates neuro-inflammation and synaptic impairments after hypoxic-ischemic injury in neonatal mice via Shh signaling. Frontiers in Pharmacology, 11, 204. PMID32194421PMC7064623doi:10.3389/fphar.2020.00204
Sharma S, Kaur A, Sharma S (2018). Preconditioning potential of purmorphamine: a hedgehog activator against ischaemic reperfusion injury in ovariectomised rat heart. Perfusion. 33 (3): 209—218 PMID29065787doi:10.1177/0267659117732401
Palla, A. R., Hilgendorf, K. I., Yang, A. V., Kerr, J. P., Hinken, A. C., Demeter, J., … & Blau, H. M. (2022). Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging. Nature communications, 13(1), 1-12. PMID35301320PMC8931095doi:10.1038/s41467-022-29150-6
Park, S., Kim, H., Kim, K., & Roh, S. (2018). Sonic hedgehog signalling regulates the self‐renewal and proliferation of skin‐derived precursor cells in mice. Cell proliferation, 51(6), e12500. PMID30151845PMC6528853doi:10.1111/cpr.12500
Kang, P. J., Moon, J. H., Yoon, B. S., Hyeon, S., Jun, E. K., Park, G., … & You, S. (2014). Reprogramming of mouse somatic cells into pluripotent stem-like cells using a combination of small molecules. Biomaterials, 35(26), 7336-7345. PMID24881998doi:10.1016/j.biomaterials.2014.05.015
Hong, I. S., & Kang, K. S. (2013). The effects of Hedgehog on the RNA-binding protein Msi1 in the proliferation and apoptosis of mesenchymal stem cells. PLoS One, 8(2), e56496. PMID23418578PMC3572075doi:10.1371/journal.pone.0056496
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Sinha, S., & Chen, J. K. (2006). Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nature chemical biology, 2(1), 29-30. PMID16408088doi:10.1038/nchembio753
Ruat, M., Hoch, L., Faure, H., & Rognan, D. (2014). Targeting of Smoothened for therapeutic gain. Trends in pharmacological sciences, 35(5), 237—246. PMID24703627doi:10.1016/j.tips.2014.03.002
Beloti, M. M., Bellesini, L. S., & Rosa, A. L. (2005). Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell biology international, 29(7), 537—541. PMID15979909doi:10.1016/j.cellbi.2005.02.007
Chechneva, O. V., Mayrhofer, F., Daugherty, D. J., Krishnamurty, R. G., Bannerman, P., Pleasure, D. E., & Deng, W. (2014). A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell death & disease, 5(10), e1481-e1481. PMID25341035PMC4649529doi:10.1038/cddis.2014.446
Gupta, R., Mehan, S., Sethi, P., Prajapati, A., Alshammari, A., Alharbi, M., … & Narula, A. S. (2022). Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder. Brain Sciences, 12(3), 342. PMID35326298PMC8946713doi:10.3390/brainsci12030342
Shao, S., Wang, G. L., Raymond, C., Deng, X. H., Zhu, X. L., Wang, D. I., & Hong, L. P. (2017). Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson’s disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway. Molecular medicine reports, 16(2), 1269—1277. PMID28627590PMC5562000doi:10.3892/mmr.2017.6751
Rahi, S., Gupta, R., Sharma, A., & Mehan, S. (2021). Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism. Human & Experimental Toxicology, 40(11), 1880—1898. PMID33906504doi:10.1177/09603271211013456
Liu, D., Bai, X., Ma, W., Xin, D., Chu, X., Yuan, H., … & Wang, Z. (2020). Purmorphamine attenuates neuro-inflammation and synaptic impairments after hypoxic-ischemic injury in neonatal mice via Shh signaling. Frontiers in Pharmacology, 11, 204. PMID32194421PMC7064623doi:10.3389/fphar.2020.00204
Sharma S, Kaur A, Sharma S (2018). Preconditioning potential of purmorphamine: a hedgehog activator against ischaemic reperfusion injury in ovariectomised rat heart. Perfusion. 33 (3): 209—218 PMID29065787doi:10.1177/0267659117732401
Palla, A. R., Hilgendorf, K. I., Yang, A. V., Kerr, J. P., Hinken, A. C., Demeter, J., … & Blau, H. M. (2022). Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging. Nature communications, 13(1), 1-12. PMID35301320PMC8931095doi:10.1038/s41467-022-29150-6
Park, S., Kim, H., Kim, K., & Roh, S. (2018). Sonic hedgehog signalling regulates the self‐renewal and proliferation of skin‐derived precursor cells in mice. Cell proliferation, 51(6), e12500. PMID30151845PMC6528853doi:10.1111/cpr.12500
Kang, P. J., Moon, J. H., Yoon, B. S., Hyeon, S., Jun, E. K., Park, G., … & You, S. (2014). Reprogramming of mouse somatic cells into pluripotent stem-like cells using a combination of small molecules. Biomaterials, 35(26), 7336-7345. PMID24881998doi:10.1016/j.biomaterials.2014.05.015
Hong, I. S., & Kang, K. S. (2013). The effects of Hedgehog on the RNA-binding protein Msi1 in the proliferation and apoptosis of mesenchymal stem cells. PLoS One, 8(2), e56496. PMID23418578PMC3572075doi:10.1371/journal.pone.0056496