The NAT1 lineage tree is rooted in Eurasia with a coalescence time of 2.0 Mya that cannot be explained by balancing selection and with the NAT1*11A haplotype absent from subsaharan Africa. Patin, E.; Barreiro, L. B.; Sabeti, P. C.; Austerlitz, F.; Luca, F.; Sajantila, A.; Behar, D. M. Semino, O.; Sakuntabhai, A.; Guiso, N.; Gicquel, B.; Mcelreavey, K.; Harding, R. M.; Heyer, E.; Quintana-Murci, L. (March 2006). „Deciphering the Ancient and Complex Evolutionary History of Human Arylamine N-Acetyltransferase Genes”. American Journal of Human Genetics78 (3): 423–36. DOI:10.1086/500614. ISSN0002-9297. PMC1380286. PMID16416399.
Wolpoff, M. H.; J. N. Spuhler, F. H. Smith, J. Radovcic, G. Pope, D. W. Frayer, R. Eckhardt and G. Clark (1988). "Modern Human Origins" Science 241 (4867) 772–4. http://dx.doi.org/10.1126%2Fscience.3136545
Pearson, Osbjorn M. (2004). „Has the Combination of Genetic and Fossil Evidence Solved the Riddle of Modern Human Origins?”. Evolutionary Anthropology13 (4): 145–159. DOI:10.1002/evan.20017.
Wolpoff, Milford; Bruce Mannheim, Alan Mann, John Hawks, Rachel Caspari, Karen R. Rosenberg, David W. Frayer, George W. Gill and Geoffrey Clark (2004). „Why not the Neandertals?”. World Archaeology36 (4): 527. DOI:10.1080/0043824042000303700.
Trinkaus, E.; Moldovan, O.; Milota, S.; Bîlgăr, A.; Sarcina, L.; Athreya, S.; Bailey, S. E.; Rodrigo, R.; Mircea, G.; Higham, T.; Ramsey, C. B.; van der Plicht, J. (September 2003). „An early modern human from the Peştera cu Oase, Romania” (free full text). Proceedings of the National Academy of Sciences of the United States of America100 (20): 11231–11236. Bibcode2003PNAS..10011231T. DOI:10.1073/pnas.2035108100. ISSN0027-8424. PMC208740. PMID14504393. »When multiple measurements are undertaken, the mean result can be determined through averaging the activity ratios. For Oase 1, this provides a weighted average activity ratio of 〈14a〉 = 1.29 ± 0.15%, resulting in a combined OxA-GrA 14C age of 34,950, +990, and −890 B.P.«
Relethford, J. H. (2008-03-05). „Genetic evidence and the modern human origins debate”. Heredity (Macmillan) 100 (6): 555–63. DOI:10.1038/hdy.2008.14. PMID18322457.
Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S (July 1997). „Neandertal DNA sequences and the origin of modern humans”. Cell90 (1): 19–30. DOI:10.1016/S0092-8674(00)80310-4. PMID9230299.
The PDHA1 (pyruvate dehydrogenase) locus on the X chromosome has an estimated coalescence time of 1.86 Mya, inconsistent with a recent species origin, although the worldwide lineage pattern is unlike other autosomal sites and may be consistent with recent dispersal from Africa. Rosalind M. Harding (March 16, 1999). „More on the X files”. Proceedings of the National Academy of Sciences96 (6): 2582–2584. Bibcode1999PNAS...96.2582H. DOI:10.1073/pnas.96.6.2582.
The ASAH1 gene has two recently differentiated lineages with a coalescence time 2.4±.4 Mya not explainable by balancing selection. The V lineage shows evidence of recent positive selection. The lineage pattern may be the result of hybridization during a recent range expansion from Africa with the V lineage tracing to archaic humans from outside Africa, though it is also consistent with a mixture of two long isolated groups within Africa; it is not consistent with a recent origination of a modern human species that replaced archaic forms without interbreeding. Kim, Hl; Satta, Y (March 2008). „Population Genetic Analysis of the N-Acylsphingosine Amidohydrolase Gene Associated With Mental Activity in Humans” (Free full text). Genetics178 (3): 1505–15. DOI:10.1534/genetics.107.083691. ISSN0016-6731. PMC2278054. PMID18245333. »"It is speculated that, when modern humans dispersed from Africa, admixture of the distinct V and M lineages occurred and the V lineage has since spread in the entire population by possible positive selection."«
The NAT1 lineage tree is rooted in Eurasia with a coalescence time of 2.0 Mya that cannot be explained by balancing selection and with the NAT1*11A haplotype absent from subsaharan Africa. Patin, E.; Barreiro, L. B.; Sabeti, P. C.; Austerlitz, F.; Luca, F.; Sajantila, A.; Behar, D. M. Semino, O.; Sakuntabhai, A.; Guiso, N.; Gicquel, B.; Mcelreavey, K.; Harding, R. M.; Heyer, E.; Quintana-Murci, L. (March 2006). „Deciphering the Ancient and Complex Evolutionary History of Human Arylamine N-Acetyltransferase Genes”. American Journal of Human Genetics78 (3): 423–36. DOI:10.1086/500614. ISSN0002-9297. PMC1380286. PMID16416399.
Almos, P. Z.; Horváth, S.; Czibula, A.; Raskó, I.; Sipos, B.; Bihari, P.; Béres, J.; Juhász, A.; Janka, Z.; Kálmán, J. (November 2008). „H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population”. Heredity101 (5): 416–9. DOI:10.1038/hdy.2008.70. ISSN0018-067X. PMID18648385.
Evans, P. D.; Gilbert, S. L.; Mekel-Bobrov, N.; Vallender, E. J.; Anderson, J. R.; Vaez-Azizi, L. M.; Tishkoff, S. A.; Hudson, R. R.; Lahn, B. T. (September 2005). „Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans”. Science309 (5741): 1717–20. Bibcode2005Sci...309.1717E. DOI:10.1126/science.1113722. ISSN0036-8075. PMID16151009.
Relethford. John. H. (2001-04-12). „Absence of Regional Affinities of Neandertal DNA with Living Humans Does Not Reject Multiregional Evolution”. Physical Anthropology115 (1): 95–98. DOI:10.1002/ajpa.1060.
Lahr, M. M. (1994). „The Multiregional Model of Modern Human Origins: A Reassessment of its Morphological Basis”. Journal of Human Evolution26: 23–56. DOI:10.1006/jhev.1994.1003.
The ASAH1 gene has two recently differentiated lineages with a coalescence time 2.4±.4 Mya not explainable by balancing selection. The V lineage shows evidence of recent positive selection. The lineage pattern may be the result of hybridization during a recent range expansion from Africa with the V lineage tracing to archaic humans from outside Africa, though it is also consistent with a mixture of two long isolated groups within Africa; it is not consistent with a recent origination of a modern human species that replaced archaic forms without interbreeding. Kim, Hl; Satta, Y (March 2008). „Population Genetic Analysis of the N-Acylsphingosine Amidohydrolase Gene Associated With Mental Activity in Humans” (Free full text). Genetics178 (3): 1505–15. DOI:10.1534/genetics.107.083691. ISSN0016-6731. PMC2278054. PMID18245333. »"It is speculated that, when modern humans dispersed from Africa, admixture of the distinct V and M lineages occurred and the V lineage has since spread in the entire population by possible positive selection."«
Trinkaus, E.; Moldovan, O.; Milota, S.; Bîlgăr, A.; Sarcina, L.; Athreya, S.; Bailey, S. E.; Rodrigo, R.; Mircea, G.; Higham, T.; Ramsey, C. B.; van der Plicht, J. (September 2003). „An early modern human from the Peştera cu Oase, Romania” (free full text). Proceedings of the National Academy of Sciences of the United States of America100 (20): 11231–11236. Bibcode2003PNAS..10011231T. DOI:10.1073/pnas.2035108100. ISSN0027-8424. PMC208740. PMID14504393. »When multiple measurements are undertaken, the mean result can be determined through averaging the activity ratios. For Oase 1, this provides a weighted average activity ratio of 〈14a〉 = 1.29 ± 0.15%, resulting in a combined OxA-GrA 14C age of 34,950, +990, and −890 B.P.«
The PDHA1 (pyruvate dehydrogenase) locus on the X chromosome has an estimated coalescence time of 1.86 Mya, inconsistent with a recent species origin, although the worldwide lineage pattern is unlike other autosomal sites and may be consistent with recent dispersal from Africa. Rosalind M. Harding (March 16, 1999). „More on the X files”. Proceedings of the National Academy of Sciences96 (6): 2582–2584. Bibcode1999PNAS...96.2582H. DOI:10.1073/pnas.96.6.2582.
Evans, P. D.; Gilbert, S. L.; Mekel-Bobrov, N.; Vallender, E. J.; Anderson, J. R.; Vaez-Azizi, L. M.; Tishkoff, S. A.; Hudson, R. R.; Lahn, B. T. (September 2005). „Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans”. Science309 (5741): 1717–20. Bibcode2005Sci...309.1717E. DOI:10.1126/science.1113722. ISSN0036-8075. PMID16151009.
Trinkaus, E.; Moldovan, O.; Milota, S.; Bîlgăr, A.; Sarcina, L.; Athreya, S.; Bailey, S. E.; Rodrigo, R.; Mircea, G.; Higham, T.; Ramsey, C. B.; van der Plicht, J. (September 2003). „An early modern human from the Peştera cu Oase, Romania” (free full text). Proceedings of the National Academy of Sciences of the United States of America100 (20): 11231–11236. Bibcode2003PNAS..10011231T. DOI:10.1073/pnas.2035108100. ISSN0027-8424. PMC208740. PMID14504393. »When multiple measurements are undertaken, the mean result can be determined through averaging the activity ratios. For Oase 1, this provides a weighted average activity ratio of 〈14a〉 = 1.29 ± 0.15%, resulting in a combined OxA-GrA 14C age of 34,950, +990, and −890 B.P.«
Relethford, J. H. (2008-03-05). „Genetic evidence and the modern human origins debate”. Heredity (Macmillan) 100 (6): 555–63. DOI:10.1038/hdy.2008.14. PMID18322457.
Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S (July 1997). „Neandertal DNA sequences and the origin of modern humans”. Cell90 (1): 19–30. DOI:10.1016/S0092-8674(00)80310-4. PMID9230299.
The ASAH1 gene has two recently differentiated lineages with a coalescence time 2.4±.4 Mya not explainable by balancing selection. The V lineage shows evidence of recent positive selection. The lineage pattern may be the result of hybridization during a recent range expansion from Africa with the V lineage tracing to archaic humans from outside Africa, though it is also consistent with a mixture of two long isolated groups within Africa; it is not consistent with a recent origination of a modern human species that replaced archaic forms without interbreeding. Kim, Hl; Satta, Y (March 2008). „Population Genetic Analysis of the N-Acylsphingosine Amidohydrolase Gene Associated With Mental Activity in Humans” (Free full text). Genetics178 (3): 1505–15. DOI:10.1534/genetics.107.083691. ISSN0016-6731. PMC2278054. PMID18245333. »"It is speculated that, when modern humans dispersed from Africa, admixture of the distinct V and M lineages occurred and the V lineage has since spread in the entire population by possible positive selection."«
The NAT1 lineage tree is rooted in Eurasia with a coalescence time of 2.0 Mya that cannot be explained by balancing selection and with the NAT1*11A haplotype absent from subsaharan Africa. Patin, E.; Barreiro, L. B.; Sabeti, P. C.; Austerlitz, F.; Luca, F.; Sajantila, A.; Behar, D. M. Semino, O.; Sakuntabhai, A.; Guiso, N.; Gicquel, B.; Mcelreavey, K.; Harding, R. M.; Heyer, E.; Quintana-Murci, L. (March 2006). „Deciphering the Ancient and Complex Evolutionary History of Human Arylamine N-Acetyltransferase Genes”. American Journal of Human Genetics78 (3): 423–36. DOI:10.1086/500614. ISSN0002-9297. PMC1380286. PMID16416399.
Almos, P. Z.; Horváth, S.; Czibula, A.; Raskó, I.; Sipos, B.; Bihari, P.; Béres, J.; Juhász, A.; Janka, Z.; Kálmán, J. (November 2008). „H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population”. Heredity101 (5): 416–9. DOI:10.1038/hdy.2008.70. ISSN0018-067X. PMID18648385.
Evans, P. D.; Gilbert, S. L.; Mekel-Bobrov, N.; Vallender, E. J.; Anderson, J. R.; Vaez-Azizi, L. M.; Tishkoff, S. A.; Hudson, R. R.; Lahn, B. T. (September 2005). „Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans”. Science309 (5741): 1717–20. Bibcode2005Sci...309.1717E. DOI:10.1126/science.1113722. ISSN0036-8075. PMID16151009.
Trinkaus, E.; Moldovan, O.; Milota, S.; Bîlgăr, A.; Sarcina, L.; Athreya, S.; Bailey, S. E.; Rodrigo, R.; Mircea, G.; Higham, T.; Ramsey, C. B.; van der Plicht, J. (September 2003). „An early modern human from the Peştera cu Oase, Romania” (free full text). Proceedings of the National Academy of Sciences of the United States of America100 (20): 11231–11236. Bibcode2003PNAS..10011231T. DOI:10.1073/pnas.2035108100. ISSN0027-8424. PMC208740. PMID14504393. »When multiple measurements are undertaken, the mean result can be determined through averaging the activity ratios. For Oase 1, this provides a weighted average activity ratio of 〈14a〉 = 1.29 ± 0.15%, resulting in a combined OxA-GrA 14C age of 34,950, +990, and −890 B.P.«
The PDHA1 (pyruvate dehydrogenase) locus on the X chromosome has an estimated coalescence time of 1.86 Mya, inconsistent with a recent species origin, although the worldwide lineage pattern is unlike other autosomal sites and may be consistent with recent dispersal from Africa. Rosalind M. Harding (March 16, 1999). „More on the X files”. Proceedings of the National Academy of Sciences96 (6): 2582–2584. Bibcode1999PNAS...96.2582H. DOI:10.1073/pnas.96.6.2582.
Trinkaus, E.; Moldovan, O.; Milota, S.; Bîlgăr, A.; Sarcina, L.; Athreya, S.; Bailey, S. E.; Rodrigo, R.; Mircea, G.; Higham, T.; Ramsey, C. B.; van der Plicht, J. (September 2003). „An early modern human from the Peştera cu Oase, Romania” (free full text). Proceedings of the National Academy of Sciences of the United States of America100 (20): 11231–11236. Bibcode2003PNAS..10011231T. DOI:10.1073/pnas.2035108100. ISSN0027-8424. PMC208740. PMID14504393. »When multiple measurements are undertaken, the mean result can be determined through averaging the activity ratios. For Oase 1, this provides a weighted average activity ratio of 〈14a〉 = 1.29 ± 0.15%, resulting in a combined OxA-GrA 14C age of 34,950, +990, and −890 B.P.«
The ASAH1 gene has two recently differentiated lineages with a coalescence time 2.4±.4 Mya not explainable by balancing selection. The V lineage shows evidence of recent positive selection. The lineage pattern may be the result of hybridization during a recent range expansion from Africa with the V lineage tracing to archaic humans from outside Africa, though it is also consistent with a mixture of two long isolated groups within Africa; it is not consistent with a recent origination of a modern human species that replaced archaic forms without interbreeding. Kim, Hl; Satta, Y (March 2008). „Population Genetic Analysis of the N-Acylsphingosine Amidohydrolase Gene Associated With Mental Activity in Humans” (Free full text). Genetics178 (3): 1505–15. DOI:10.1534/genetics.107.083691. ISSN0016-6731. PMC2278054. PMID18245333. »"It is speculated that, when modern humans dispersed from Africa, admixture of the distinct V and M lineages occurred and the V lineage has since spread in the entire population by possible positive selection."«
The NAT1 lineage tree is rooted in Eurasia with a coalescence time of 2.0 Mya that cannot be explained by balancing selection and with the NAT1*11A haplotype absent from subsaharan Africa. Patin, E.; Barreiro, L. B.; Sabeti, P. C.; Austerlitz, F.; Luca, F.; Sajantila, A.; Behar, D. M. Semino, O.; Sakuntabhai, A.; Guiso, N.; Gicquel, B.; Mcelreavey, K.; Harding, R. M.; Heyer, E.; Quintana-Murci, L. (March 2006). „Deciphering the Ancient and Complex Evolutionary History of Human Arylamine N-Acetyltransferase Genes”. American Journal of Human Genetics78 (3): 423–36. DOI:10.1086/500614. ISSN0002-9297. PMC1380286. PMID16416399.
Almos, P. Z.; Horváth, S.; Czibula, A.; Raskó, I.; Sipos, B.; Bihari, P.; Béres, J.; Juhász, A.; Janka, Z.; Kálmán, J. (November 2008). „H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population”. Heredity101 (5): 416–9. DOI:10.1038/hdy.2008.70. ISSN0018-067X. PMID18648385.
Evans, P. D.; Gilbert, S. L.; Mekel-Bobrov, N.; Vallender, E. J.; Anderson, J. R.; Vaez-Azizi, L. M.; Tishkoff, S. A.; Hudson, R. R.; Lahn, B. T. (September 2005). „Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans”. Science309 (5741): 1717–20. Bibcode2005Sci...309.1717E. DOI:10.1126/science.1113722. ISSN0036-8075. PMID16151009.