Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R (Aug 1995). „Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2”. Eur J Neurosci7 (4): 622–9. DOI:10.1111/j.1460-9568.1995.tb00666.x. PMID7620613.
Fraley ME (September 2009). „Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia”. Expert Opin Ther Pat19 (9): 1259–75. DOI:10.1517/13543770903045009. PMID19552508.
D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP (January 2010). „The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2”. Bioorg. Med. Chem. Lett.20 (2): 759–62. DOI:10.1016/j.bmcl.2009.11.032. PMID20005096.
Tresadern G, Cid JM, Macdonald GJ, Vega JA, de Lucas AI, García A, Matesanz E, Linares ML, Oehlrich D, Lavreysen H, Biesmans I, Trabanco AA (January 2010). „Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor”. Bioorg. Med. Chem. Lett.20 (1): 175–9. DOI:10.1016/j.bmcl.2009.11.008. PMID19932615.
Zhang L, Rogers BN, Duplantier AJ et al. (2008). „3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators”. Bioorganic & Medicinal Chemistry Letters18 (20): 5493–6. DOI:10.1016/j.bmcl.2008.09.026. PMID18812259.
Galici R, Jones CK, Hemstapat K et al. (2006). „Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice”. J. Pharmacol. Exp. Ther.318 (1): 173–85. DOI:10.1124/jpet.106.102046. PMID16608916.
Bonnefous C, Vernier JM, Hutchinson JH et al. (2005). „Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor”. Bioorg. Med. Chem. Lett.15 (19): 4354–8. DOI:10.1016/j.bmcl.2005.06.062. PMID16046122.
Johnson MP, Baez M, Jagdmann GE et al. (2003). „Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine”. J. Med. Chem.46 (15): 3189–92. DOI:10.1021/jm034015u. PMID12852748.
Johnson MP, Barda D, Britton TC et al. (2005). „Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)”. Psychopharmacology (Berl.)179 (1): 271–83. DOI:10.1007/s00213-004-2099-9. PMID15717213.
Schaffhauser H, Rowe BA, Morales S et al. (2003). „Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2”. Mol. Pharmacol.64 (4): 798–810. DOI:10.1124/mol.64.4.798. PMID14500736.
Barda DA, Wang ZQ, Britton TC et al. (2004). (2004). „SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide”. Bioorg. Med. Chem. Lett.14 (12): 3099–102. DOI:10.1016/j.bmcl.2004.04.017. PMID15149652.
Pinkerton AB, Vernier JM, Schaffhauser H et al. (2004). „Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor”. J. Med. Chem.47 (18): 4595–9. DOI:10.1021/jm040088h. PMID15317469.
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ncbi.nlm.nih.gov
Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R (Aug 1995). „Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2”. Eur J Neurosci7 (4): 622–9. DOI:10.1111/j.1460-9568.1995.tb00666.x. PMID7620613.
Fraley ME (September 2009). „Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia”. Expert Opin Ther Pat19 (9): 1259–75. DOI:10.1517/13543770903045009. PMID19552508.
D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP (January 2010). „The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2”. Bioorg. Med. Chem. Lett.20 (2): 759–62. DOI:10.1016/j.bmcl.2009.11.032. PMID20005096.
Tresadern G, Cid JM, Macdonald GJ, Vega JA, de Lucas AI, García A, Matesanz E, Linares ML, Oehlrich D, Lavreysen H, Biesmans I, Trabanco AA (January 2010). „Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor”. Bioorg. Med. Chem. Lett.20 (1): 175–9. DOI:10.1016/j.bmcl.2009.11.008. PMID19932615.
Zhang L, Rogers BN, Duplantier AJ et al. (2008). „3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators”. Bioorganic & Medicinal Chemistry Letters18 (20): 5493–6. DOI:10.1016/j.bmcl.2008.09.026. PMID18812259.
Galici R, Jones CK, Hemstapat K et al. (2006). „Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice”. J. Pharmacol. Exp. Ther.318 (1): 173–85. DOI:10.1124/jpet.106.102046. PMID16608916.
Bonnefous C, Vernier JM, Hutchinson JH et al. (2005). „Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor”. Bioorg. Med. Chem. Lett.15 (19): 4354–8. DOI:10.1016/j.bmcl.2005.06.062. PMID16046122.
Johnson MP, Baez M, Jagdmann GE et al. (2003). „Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine”. J. Med. Chem.46 (15): 3189–92. DOI:10.1021/jm034015u. PMID12852748.
Johnson MP, Barda D, Britton TC et al. (2005). „Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)”. Psychopharmacology (Berl.)179 (1): 271–83. DOI:10.1007/s00213-004-2099-9. PMID15717213.
Schaffhauser H, Rowe BA, Morales S et al. (2003). „Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2”. Mol. Pharmacol.64 (4): 798–810. DOI:10.1124/mol.64.4.798. PMID14500736.
Barda DA, Wang ZQ, Britton TC et al. (2004). (2004). „SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide”. Bioorg. Med. Chem. Lett.14 (12): 3099–102. DOI:10.1016/j.bmcl.2004.04.017. PMID15149652.
Pinkerton AB, Vernier JM, Schaffhauser H et al. (2004). „Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor”. J. Med. Chem.47 (18): 4595–9. DOI:10.1021/jm040088h. PMID15317469.