Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ (2002). „Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin”. J. Biol. Chem.277 (38): 35364–70. DOI:10.1074/jbc.M205838200. PMID12167664.
Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J (2006). „Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway”. J. Biol. Chem.281 (52): 40242–51. DOI:10.1074/jbc.M608116200. PMID17077083.
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL (2006). „TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth”. Cell126 (5): 955–68. DOI:10.1016/j.cell.2006.06.055. PMID16959574.
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005). „Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis”. Cell121 (2): 179–93. DOI:10.1016/j.cell.2005.02.031. PMID15851026.
Gan B, Yoo Y, Guan JL (2006). „Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth”. J. Biol. Chem.281 (49): 37321–9. DOI:10.1074/jbc.M605241200. PMID17043358.
Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V (2004). „Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex”. J. Biol. Chem.279 (2): 1351–8. DOI:10.1074/jbc.M310208200. PMID14559897.
Inoki K, Zhu T, Guan KL (2003). „TSC2 mediates cellular energy response to control cell growth and survival”. Cell115 (5): 577–90. DOI:10.1016/S0092-8674(03)00929-2. PMID14651849.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC (2004). „The LKB1 tumor suppressor negatively regulates mTOR signaling”. Cancer Cell6 (1): 91–9. DOI:10.1016/j.ccr.2004.06.007. PMID15261145.
Castro AF, Rebhun JF, Clark GJ, Quilliam LA (2003). „Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner”. J. Biol. Chem.278 (35): 32493–6. DOI:10.1074/jbc.C300226200. PMID12842888.
Yamamoto Y, Jones KA, Mak BC, Muehlenbachs A, Yeung RS (2002). „Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin”. Arch. Biochem. Biophys.404 (2): 210–7. DOI:10.1016/S0003-9861(02)00300-4. PMID12147258.
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G (2003). „Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2”. Mol. Cell11 (6): 1457–66. DOI:10.1016/S1097-2765(03)00220-X. PMID12820960.
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003). „Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins”. Nat. Cell Biol.5 (6): 578–81. DOI:10.1038/ncb999. PMID12771962.
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (2005). „Rheb binds and regulates the mTOR kinase”. Curr. Biol.15 (8): 702–13. DOI:10.1016/j.cub.2005.02.053. PMID15854902.
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y (2004). „Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin”. J. Biol. Chem.279 (34): 35664–70. DOI:10.1074/jbc.M403385200. PMID15175323.
Zheng L, Ding H, Lu Z, Li Y, Pan Y, Ning T, Ke Y (2008). „E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6”. Genes Cells13 (3): 285–94. DOI:10.1111/j.1365-2443.2008.01162.x. PMID18298802.
Nellist M, Goedbloed MA, de Winter C, Verhaaf B, Jankie A, Reuser AJ, van den Ouweland AM, van der Sluijs P, Halley DJ (2002). „Identification and characterization of the interaction between tuberin and 14-3-3zeta”. J. Biol. Chem.277 (42): 39417–24. DOI:10.1074/jbc.M204802200. PMID12176984.
Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ (2002). „Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin”. J. Biol. Chem.277 (38): 35364–70. DOI:10.1074/jbc.M205838200. PMID12167664.
Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J (2006). „Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway”. J. Biol. Chem.281 (52): 40242–51. DOI:10.1074/jbc.M608116200. PMID17077083.
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL (2006). „TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth”. Cell126 (5): 955–68. DOI:10.1016/j.cell.2006.06.055. PMID16959574.
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005). „Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis”. Cell121 (2): 179–93. DOI:10.1016/j.cell.2005.02.031. PMID15851026.
Gan B, Yoo Y, Guan JL (2006). „Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth”. J. Biol. Chem.281 (49): 37321–9. DOI:10.1074/jbc.M605241200. PMID17043358.
Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V (2004). „Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex”. J. Biol. Chem.279 (2): 1351–8. DOI:10.1074/jbc.M310208200. PMID14559897.
Inoki K, Zhu T, Guan KL (2003). „TSC2 mediates cellular energy response to control cell growth and survival”. Cell115 (5): 577–90. DOI:10.1016/S0092-8674(03)00929-2. PMID14651849.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC (2004). „The LKB1 tumor suppressor negatively regulates mTOR signaling”. Cancer Cell6 (1): 91–9. DOI:10.1016/j.ccr.2004.06.007. PMID15261145.
Castro AF, Rebhun JF, Clark GJ, Quilliam LA (2003). „Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner”. J. Biol. Chem.278 (35): 32493–6. DOI:10.1074/jbc.C300226200. PMID12842888.
Yamamoto Y, Jones KA, Mak BC, Muehlenbachs A, Yeung RS (2002). „Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin”. Arch. Biochem. Biophys.404 (2): 210–7. DOI:10.1016/S0003-9861(02)00300-4. PMID12147258.
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G (2003). „Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2”. Mol. Cell11 (6): 1457–66. DOI:10.1016/S1097-2765(03)00220-X. PMID12820960.
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003). „Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins”. Nat. Cell Biol.5 (6): 578–81. DOI:10.1038/ncb999. PMID12771962.
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (2005). „Rheb binds and regulates the mTOR kinase”. Curr. Biol.15 (8): 702–13. DOI:10.1016/j.cub.2005.02.053. PMID15854902.
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y (2004). „Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin”. J. Biol. Chem.279 (34): 35664–70. DOI:10.1074/jbc.M403385200. PMID15175323.
Zheng L, Ding H, Lu Z, Li Y, Pan Y, Ning T, Ke Y (2008). „E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6”. Genes Cells13 (3): 285–94. DOI:10.1111/j.1365-2443.2008.01162.x. PMID18298802.
Nellist M, Goedbloed MA, de Winter C, Verhaaf B, Jankie A, Reuser AJ, van den Ouweland AM, van der Sluijs P, Halley DJ (2002). „Identification and characterization of the interaction between tuberin and 14-3-3zeta”. J. Biol. Chem.277 (42): 39417–24. DOI:10.1074/jbc.M204802200. PMID12176984.