Β分泌酶1 (Chinese Wikipedia)
Analysis of information sources in references of the Wikipedia article "Β分泌酶1" in Chinese language version.
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adam.com
pennstatehershey.adam.com
- Alzheimer's-fighting gene may inspire treatments. July 2012 [2022-10-05]. （原始内容存档于2012-05-15）.
alzforum.org
- CoMentis BACE Inhibitor Debuts. April 2008 [2022-10-05]. （原始内容存档于2013-09-26）.
archive.org
- Walker LC, Rosen RF. Alzheimer therapeutics-what after the cholinesterase inhibitors?. Age and Ageing. Jul 2006, 35 (4): 332–5. PMID 16644763. doi:10.1093/ageing/afl009
.
astrazeneca.com
- AstraZeneca and Lilly announce alliance to develop and commercialise BACE inhibitor AZD3293 for Alzheimer's disease. 16 Sep 2014 [8 Oct 2014]. （原始内容存档于2015-09-23）.
- Update on Phase III Clinical Trials of lanabecestat. 12 June 2018 [20 June 2018]. （原始内容存档于2022-06-05）.
doi.org
- Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. Oct 1999, 286 (5440): 735–41 [2022-10-04]. PMID 10531052. doi:10.1126/science.286.5440.735. （原始内容存档于2019-04-09）.
- Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. Oct 2006, 314 (5799): 664–6. Bibcode:2006Sci...314..664W. PMID 16990514. S2CID 8432207. doi:10.1126/science.1132341.
- Capell, Anja; Steiner, Harald; Willem, Michael; Kaiser, Hartmut; Meyer, Carmen; Walter, Jochen; Lammich, Sven; Multhaup, Gerd; Haass, Christian. Maturation and Pro-peptide Cleavage of β-Secretase. Journal of Biological Chemistry. 2000-10-06, 275 (40): 30849–30854. ISSN 0021-9258. PMID 10801872. doi:10.1074/jbc.M003202200 .
- Cai, Huaibin; Wang, Yanshu; McCarthy, Diane; Wen, Hongjin; Borchelt, David R.; Price, Donald L.; Wong, Philip C. BACE1 is the major β-secretase for generation of Aβ peptides by neurons. Nature Neuroscience. March 2001, 4 (3): 233–234. ISSN 1546-1726. PMID 11224536. S2CID 11973104. doi:10.1038/85064.
- Kim, Doo Yeon; Carey, Bryce W.; Wang, Haibin; Ingano, Laura A. M.; Binshtok, Alexander M.; Wertz, Mary H.; Pettingell, Warren H.; He, Ping; Lee, Virginia M.-Y.; Woolf, Clifford J.; Kovacs, Dora M. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biology. July 2007, 9 (7): 755–764. ISSN 1465-7392. PMC 2747787 . PMID 17576410. doi:10.1038/ncb1602.
- Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. Aug 2012, 488 (7409): 96–9. Bibcode:2012Natur.488...96J. PMID 22801501. S2CID 4333449. doi:10.1038/nature11283.
- Pradeepkiran, JA; Reddy, AP; Yin, X; Manczak, M; Reddy, PH. Protective Effects of BACE1 Inhibitory Ligand Molecules Against Amyloid Beta-Induced Synaptic and Mitochondrial Toxicities in Alzheimer's Disease.. Human Molecular Genetics. 2020, 29 (1): 49–69. PMC 7001603 . PMID 31595293. doi:10.1093/hmg/ddz227.
- Walker LC, Rosen RF. Alzheimer therapeutics-what after the cholinesterase inhibitors?. Age and Ageing. Jul 2006, 35 (4): 332–5. PMID 16644763. doi:10.1093/ageing/afl009 .
- Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. Journal of Medicinal Chemistry. Sep 2007, 50 (18): 4261–4. PMID 17685503. doi:10.1021/jm0705408.
- Cheret, Cecil; Michael Willem; Florence R Fricker; Hagen Wende. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO Journal. June 2013, 32 (14): 2015–28. PMC 3715864 . PMID 23792428. doi:10.1038/emboj.2013.146.
- Pettersson, A.F.; Olsson, E.; Wahlund, L.-O. Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. 2005, 19 (5–6): 299–304. ISSN 1420-8008. PMID 15785030. S2CID 36382718. doi:10.1159/000084555 （英语）.
- Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Human Molecular Genetics. Jun 2001, 10 (12): 1317–24. PMID 11406613. doi:10.1093/hmg/10.12.1317 .
- Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature. Feb 2010, 463 (7281): 632–6. Bibcode:2010Natur.463..632R. PMC 2826791 . PMID 20130644. doi:10.1038/nature08726.
ensembl.org
May2017.archive.ensembl.org
- GRCh38: Ensembl release 89: ENSG00000186318 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000032086 - Ensembl, May 2017
escholarship.org
- Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. Oct 1999, 286 (5440): 735–41 [2022-10-04]. PMID 10531052. doi:10.1126/science.286.5440.735. （原始内容存档于2019-04-09）.
harvard.edu
ui.adsabs.harvard.edu
- Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. Oct 2006, 314 (5799): 664–6. Bibcode:2006Sci...314..664W. PMID 16990514. S2CID 8432207. doi:10.1126/science.1132341.
- Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. Aug 2012, 488 (7409): 96–9. Bibcode:2012Natur.488...96J. PMID 22801501. S2CID 4333449. doi:10.1038/nature11283.
- Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature. Feb 2010, 463 (7281): 632–6. Bibcode:2010Natur.463..632R. PMC 2826791 . PMID 20130644. doi:10.1038/nature08726.
merck.com
mercknewsroom.com
- Merck Initiates Phase II/III Study of Investigational BACE Inhibitor, MK-8931, for Treatment of Alzheimer's Disease. December 2012 [2022-10-05]. （原始内容存档于2017-02-27）.
nih.gov
ncbi.nlm.nih.gov
- Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. Oct 1999, 286 (5440): 735–41 [2022-10-04]. PMID 10531052. doi:10.1126/science.286.5440.735. （原始内容存档于2019-04-09）.
- Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. Oct 2006, 314 (5799): 664–6. Bibcode:2006Sci...314..664W. PMID 16990514. S2CID 8432207. doi:10.1126/science.1132341.
- Capell, Anja; Steiner, Harald; Willem, Michael; Kaiser, Hartmut; Meyer, Carmen; Walter, Jochen; Lammich, Sven; Multhaup, Gerd; Haass, Christian. Maturation and Pro-peptide Cleavage of β-Secretase. Journal of Biological Chemistry. 2000-10-06, 275 (40): 30849–30854. ISSN 0021-9258. PMID 10801872. doi:10.1074/jbc.M003202200 .
- Cai, Huaibin; Wang, Yanshu; McCarthy, Diane; Wen, Hongjin; Borchelt, David R.; Price, Donald L.; Wong, Philip C. BACE1 is the major β-secretase for generation of Aβ peptides by neurons. Nature Neuroscience. March 2001, 4 (3): 233–234. ISSN 1546-1726. PMID 11224536. S2CID 11973104. doi:10.1038/85064.
- Kim, Doo Yeon; Carey, Bryce W.; Wang, Haibin; Ingano, Laura A. M.; Binshtok, Alexander M.; Wertz, Mary H.; Pettingell, Warren H.; He, Ping; Lee, Virginia M.-Y.; Woolf, Clifford J.; Kovacs, Dora M. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biology. July 2007, 9 (7): 755–764. ISSN 1465-7392. PMC 2747787 . PMID 17576410. doi:10.1038/ncb1602.
- Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. Aug 2012, 488 (7409): 96–9. Bibcode:2012Natur.488...96J. PMID 22801501. S2CID 4333449. doi:10.1038/nature11283.
- Pradeepkiran, JA; Reddy, AP; Yin, X; Manczak, M; Reddy, PH. Protective Effects of BACE1 Inhibitory Ligand Molecules Against Amyloid Beta-Induced Synaptic and Mitochondrial Toxicities in Alzheimer's Disease.. Human Molecular Genetics. 2020, 29 (1): 49–69. PMC 7001603 . PMID 31595293. doi:10.1093/hmg/ddz227.
- Walker LC, Rosen RF. Alzheimer therapeutics-what after the cholinesterase inhibitors?. Age and Ageing. Jul 2006, 35 (4): 332–5. PMID 16644763. doi:10.1093/ageing/afl009 .
- Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. Journal of Medicinal Chemistry. Sep 2007, 50 (18): 4261–4. PMID 17685503. doi:10.1021/jm0705408.
- Cheret, Cecil; Michael Willem; Florence R Fricker; Hagen Wende. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO Journal. June 2013, 32 (14): 2015–28. PMC 3715864 . PMID 23792428. doi:10.1038/emboj.2013.146.
- Pettersson, A.F.; Olsson, E.; Wahlund, L.-O. Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. 2005, 19 (5–6): 299–304. ISSN 1420-8008. PMID 15785030. S2CID 36382718. doi:10.1159/000084555 （英语）.
- Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Human Molecular Genetics. Jun 2001, 10 (12): 1317–24. PMID 11406613. doi:10.1093/hmg/10.12.1317 .
- Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature. Feb 2010, 463 (7281): 632–6. Bibcode:2010Natur.463..632R. PMC 2826791 . PMID 20130644. doi:10.1038/nature08726.
reuters.com
- AstraZeneca and Lilly move Alzheimer's drug into big trial. Reuters. December 2014 [2017-06-30]. （原始内容存档于2015-10-25）.
semanticscholar.org
api.semanticscholar.org
- Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. Oct 2006, 314 (5799): 664–6. Bibcode:2006Sci...314..664W. PMID 16990514. S2CID 8432207. doi:10.1126/science.1132341.
- Cai, Huaibin; Wang, Yanshu; McCarthy, Diane; Wen, Hongjin; Borchelt, David R.; Price, Donald L.; Wong, Philip C. BACE1 is the major β-secretase for generation of Aβ peptides by neurons. Nature Neuroscience. March 2001, 4 (3): 233–234. ISSN 1546-1726. PMID 11224536. S2CID 11973104. doi:10.1038/85064.
- Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. Aug 2012, 488 (7409): 96–9. Bibcode:2012Natur.488...96J. PMID 22801501. S2CID 4333449. doi:10.1038/nature11283.
- Pettersson, A.F.; Olsson, E.; Wahlund, L.-O. Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. 2005, 19 (5–6): 299–304. ISSN 1420-8008. PMID 15785030. S2CID 36382718. doi:10.1159/000084555 （英语）.
web.archive.org
- Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. Oct 1999, 286 (5440): 735–41 [2022-10-04]. PMID 10531052. doi:10.1126/science.286.5440.735. （原始内容存档于2019-04-09）.
- Alzheimer's-fighting gene may inspire treatments. July 2012 [2022-10-05]. （原始内容存档于2012-05-15）.
- CoMentis BACE Inhibitor Debuts. April 2008 [2022-10-05]. （原始内容存档于2013-09-26）.
- Merck Presents Results of a Phase I Clinical Trial Evaluating Investigational BACE inhibitor MK-8931 at American Academy of Neurology. April 2012. （原始内容存档于2012-07-28）.
- Merck Initiates Phase II/III Study of Investigational BACE Inhibitor, MK-8931, for Treatment of Alzheimer's Disease. December 2012 [2022-10-05]. （原始内容存档于2017-02-27）.
- AstraZeneca and Lilly announce alliance to develop and commercialise BACE inhibitor AZD3293 for Alzheimer's disease. 16 Sep 2014 [8 Oct 2014]. （原始内容存档于2015-09-23）.
- AstraZeneca and Lilly move Alzheimer's drug into big trial. Reuters. December 2014 [2017-06-30]. （原始内容存档于2015-10-25）.
- Update on Phase III Clinical Trials of lanabecestat. 12 June 2018 [20 June 2018]. （原始内容存档于2022-06-05）.
worldcat.org
- Capell, Anja; Steiner, Harald; Willem, Michael; Kaiser, Hartmut; Meyer, Carmen; Walter, Jochen; Lammich, Sven; Multhaup, Gerd; Haass, Christian. Maturation and Pro-peptide Cleavage of β-Secretase. Journal of Biological Chemistry. 2000-10-06, 275 (40): 30849–30854. ISSN 0021-9258. PMID 10801872. doi:10.1074/jbc.M003202200 .
- Cai, Huaibin; Wang, Yanshu; McCarthy, Diane; Wen, Hongjin; Borchelt, David R.; Price, Donald L.; Wong, Philip C. BACE1 is the major β-secretase for generation of Aβ peptides by neurons. Nature Neuroscience. March 2001, 4 (3): 233–234. ISSN 1546-1726. PMID 11224536. S2CID 11973104. doi:10.1038/85064.
- Kim, Doo Yeon; Carey, Bryce W.; Wang, Haibin; Ingano, Laura A. M.; Binshtok, Alexander M.; Wertz, Mary H.; Pettingell, Warren H.; He, Ping; Lee, Virginia M.-Y.; Woolf, Clifford J.; Kovacs, Dora M. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biology. July 2007, 9 (7): 755–764. ISSN 1465-7392. PMC 2747787 . PMID 17576410. doi:10.1038/ncb1602.
- Pettersson, A.F.; Olsson, E.; Wahlund, L.-O. Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders. 2005, 19 (5–6): 299–304. ISSN 1420-8008. PMID 15785030. S2CID 36382718. doi:10.1159/000084555 （英语）.