Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, Thompson LR, Tran I, Tutt MF, Young T. Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis. Bioorganic & Medicinal Chemistry Letters. August 2009, 19 (15): 4406–9. PMID 19500981. doi:10.1016/j.bmcl.2009.05.062.
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Leeson PD, Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Reviews. Drug Discovery. November 2007, 6 (11): 881–90. PMID 17971784. S2CID 205476574. doi:10.1038/nrd2445.
Uetrecht J. Idiosyncratic drug reactions: past, present, and future. Chemical Research in Toxicology. January 2008, 21 (1): 84–92. PMID 18052104. doi:10.1021/tx700186p.
Hughes JD, Blagg J, Price DA, Bailey S, Decrescenzo GA, Devraj RV, Ellsworth E, Fobian YM, Gibbs ME, Gilles RW, Greene N, Huang E, Krieger-Burke T, Loesel J, Wager T, Whiteley L, Zhang Y. Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorganic & Medicinal Chemistry Letters. September 2008, 18 (17): 4872–5. PMID 18691886. doi:10.1016/j.bmcl.2008.07.071.
García-Sosa AT, Hetényi C, Maran U. Drug efficiency indices for improvement of molecular docking scoring functions. Journal of Computational Chemistry. January 2010, 31 (1): 174–84. PMID 19422000. S2CID 19092197. doi:10.1002/jcc.21306.
Shultz MD. Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters. Bioorganic & Medicinal Chemistry Letters. November 2013, 23 (21): 5980–91. PMID 24018190. doi:10.1016/j.bmcl.2013.08.029.
nih.gov
ncbi.nlm.nih.gov
Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, Thompson LR, Tran I, Tutt MF, Young T. Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis. Bioorganic & Medicinal Chemistry Letters. August 2009, 19 (15): 4406–9. PMID 19500981. doi:10.1016/j.bmcl.2009.05.062.
Leeson PD, Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Reviews. Drug Discovery. November 2007, 6 (11): 881–90. PMID 17971784. S2CID 205476574. doi:10.1038/nrd2445.
Uetrecht J. Prediction of a new drug's potential to cause idiosyncratic reactions. Current Opinion in Drug Discovery & Development. January 2001, 4 (1): 55–9. PMID 11727323.
Uetrecht J. Idiosyncratic drug reactions: past, present, and future. Chemical Research in Toxicology. January 2008, 21 (1): 84–92. PMID 18052104. doi:10.1021/tx700186p.
Hughes JD, Blagg J, Price DA, Bailey S, Decrescenzo GA, Devraj RV, Ellsworth E, Fobian YM, Gibbs ME, Gilles RW, Greene N, Huang E, Krieger-Burke T, Loesel J, Wager T, Whiteley L, Zhang Y. Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorganic & Medicinal Chemistry Letters. September 2008, 18 (17): 4872–5. PMID 18691886. doi:10.1016/j.bmcl.2008.07.071.
García-Sosa AT, Hetényi C, Maran U. Drug efficiency indices for improvement of molecular docking scoring functions. Journal of Computational Chemistry. January 2010, 31 (1): 174–84. PMID 19422000. S2CID 19092197. doi:10.1002/jcc.21306.
Shultz MD. Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters. Bioorganic & Medicinal Chemistry Letters. November 2013, 23 (21): 5980–91. PMID 24018190. doi:10.1016/j.bmcl.2013.08.029.
semanticscholar.org
api.semanticscholar.org
Leeson PD, Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Reviews. Drug Discovery. November 2007, 6 (11): 881–90. PMID 17971784. S2CID 205476574. doi:10.1038/nrd2445.
García-Sosa AT, Hetényi C, Maran U. Drug efficiency indices for improvement of molecular docking scoring functions. Journal of Computational Chemistry. January 2010, 31 (1): 174–84. PMID 19422000. S2CID 19092197. doi:10.1002/jcc.21306.
