刺猬信号通路 (Chinese Wikipedia)
Analysis of information sources in references of the Wikipedia article "刺猬信号通路" in Chinese language version.
refsWebsite
Global rank
Chinese rank
11th place
332nd place
18th place
57th place
1st place
1st place
6th place
4th place
5,225th place
4,888th place
301st place
262nd place
low place
low place
3,174th place
2,458th place
archive.org
- Collins RT, Cohen SM. A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics. May 2005, 170 (1): 173–84. PMC 1449730
. PMID 15744048. doi:10.1534/genetics.104.039420. - Keeler RF. Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects. Lipids. October 1978, 13 (10): 708–15. PMID 723484. S2CID 1119899. doi:10.1007/BF02533750.
- Chen MH, Gao N, Kawakami T, Chuang PT. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Molecular and Cellular Biology. August 2005, 25 (16): 7042–53. PMC 1190231 . PMID 16055716. doi:10.1128/MCB.25.16.7042-7053.2005.
asu.edu
embryo.asu.edu
- Hedgehog Signaling Pathway | The Embryo Project Encyclopedia. embryo.asu.edu. [2023-01-10]. （原始内容存档于2023-01-10）.
clinicaltrials.gov
- Clinical trial number NCT00636610 for "A Study of GDC-0449 (Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer" at ClinicalTrials.gov
- Clinical trial number NCT01108094 for "Pilot Biomarker Trial to Evaluate the Efficacy of Itraconazole in Patients w/ Basal Cell Carcinomas" at ClinicalTrials.gov
corporate-ir.net
phx.corporate-ir.net
doi.org
- Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nature Reviews Genetics. June 2011, 12 (6): 393–406. PMID 21502959. S2CID 33769324. doi:10.1038/nrg2984.
- Jamieson C, Martinelli G, Cortes J. Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia. Blood Cancer Discovery. September 2020, 1 (2): 134–145. PMC 8447269 . PMID 34661144. doi:10.1158/2643-3230.BCD-20-0007 .
- Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. October 1980, 287 (5785): 795–801. Bibcode:1980Natur.287..795N. PMID 6776413. S2CID 4337658. doi:10.1038/287795a0.
- Arthur W. The emerging conceptual framework of evolutionary developmental biology. Nature. February 2002, 415 (6873): 757–64. Bibcode:2002Natur.415..757A. PMID 11845200. S2CID 4432164. doi:10.1038/415757a.
- Mohler J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics. December 1988, 120 (4): 1061–72. PMC 1203569 . PMID 3147217. doi:10.1093/genetics/120.4.1061.
- Collins RT, Cohen SM. A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics. May 2005, 170 (1): 173–84. PMC 1449730 . PMID 15744048. doi:10.1534/genetics.104.039420.
- Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. June 2004, 304 (5678): 1755–9. Bibcode:2004Sci...304.1755L. CiteSeerX 10.1.1.476.3902 . PMID 15205520. S2CID 13949436. doi:10.1126/science.1098020.
- Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science. December 2004, 306 (5705): 2257–60. Bibcode:2004Sci...306.2257C. PMID 15618519. S2CID 12823611. doi:10.1126/science.1104135.
- Alcedo J, Zou Y, Noll M. Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Molecular Cell. August 2000, 6 (2): 457–65. PMID 10983991. doi:10.1016/S1097-2765(00)00044-7 .
- Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nature Cell Biology. January 2005, 7 (1): 86–92. PMID 15592457. S2CID 5958856. doi:10.1038/ncb1210.
- Ho KS, Suyama K, Fish M, Scott MP. Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development. March 2005, 132 (6): 1401–12. PMID 15750186. doi:10.1242/dev.01689 .
- Von Ohlen T, Lessing D, Nusse R, Hooper JE. Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proceedings of the National Academy of Sciences of the United States of America. March 1997, 94 (6): 2404–9. Bibcode:1997PNAS...94.2404V. PMC 20100 . PMID 9122207. doi:10.1073/pnas.94.6.2404 .
- Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes & Development. December 2001, 15 (23): 3059–87. PMID 11731473. doi:10.1101/gad.938601 .
- Aspiras AC, Prasad R, Fong DW, Carlini DB, Angelini DR. Parallel reduction in expression of the eye development gene hedgehog in separately derived cave populations of the amphipod Gammarus minus. Journal of Evolutionary Biology. May 2012, 25 (5): 995–1001. PMID 22462461. S2CID 37541721. doi:10.1111/j.1420-9101.2012.02481.x.
- Dray N, Tessmar-Raible K, Le Gouar M, Vibert L, Christodoulou F, Schipany K, Guillou A, Zantke J, Snyman H, Béhague J, Vervoort M, Arendt D, Balavoine G. Hedgehog signaling regulates segment formation in the annelid Platynereis. Science. July 2010, 329 (5989): 339–42. Bibcode:2010Sci...329..339D. PMC 3182550 . PMID 20647470. doi:10.1126/science.1188913.
- Banavali NK. The Mechanism of Cholesterol Modification of Hedgehog Ligand. Journal of Computational Chemistry. November 2019, 41 (6): 520–527. PMID 31823413. doi:10.1002/jcc.26097 .
- Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. August 2002, 418 (6900): 892–7. Bibcode:2002Natur.418..892T. PMID 12192414. S2CID 4362029. doi:10.1038/nature00989.
- Davies JP, Chen FW, Ioannou YA. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science. December 2000, 290 (5500): 2295–8. Bibcode:2000Sci...290.2295D. PMID 11125140. doi:10.1126/science.290.5500.2295.
- Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Current Biology. April 2001, 11 (8): 608–13. PMID 11369206. S2CID 235311937. doi:10.1016/S0960-9822(01)00179-8 .
- Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. May 2006, 103 (22): 8408–13. Bibcode:2006PNAS..103.8408C. PMC 1462959 . PMID 16707575. doi:10.1073/pnas.0602852103 .
- Rahnama F, Shimokawa T, Lauth M, Finta C, Kogerman P, Teglund S, Toftgård R, Zaphiropoulos PG. Inhibition of GLI1 gene activation by Patched1. The Biochemical Journal. February 2006, 394 (Pt 1): 19–26. PMC 1385998 . PMID 16229683. doi:10.1042/BJ20050941.
- Carpenter D, Stone DM, Brush J, Ryan A, Armanini M, Frantz G, Rosenthal A, de Sauvage FJ. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proceedings of the National Academy of Sciences of the United States of America. November 1998, 95 (23): 13630–4. Bibcode:1998PNAS...9513630C. PMC 24870 . PMID 9811851. doi:10.1073/pnas.95.23.13630 .
- Rahnama F, Toftgård R, Zaphiropoulos PG. Distinct roles of PTCH2 splice variants in Hedgehog signalling. The Biochemical Journal. March 2004, 378 (Pt 2): 325–34. PMC 1223965 . PMID 14613484. doi:10.1042/BJ20031200.
- Incardona JP, Lee JH, Robertson CP, Enga K, Kapur RP, Roelink H. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proceedings of the National Academy of Sciences of the United States of America. October 2000, 97 (22): 12044–9. Bibcode:2000PNAS...9712044I. PMC 17291 . PMID 11027307. doi:10.1073/pnas.220251997 .
- Jeong J, McMahon AP. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. January 2005, 132 (1): 143–54. PMID 15576403. doi:10.1242/dev.01566 .
- Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. August 2004, 118 (4): 517–28. PMID 15315763. S2CID 16280983. doi:10.1016/j.cell.2004.07.024 .
- Bhardwaj G, Murdoch B, Wu D, Baker DP, Williams KP, Chadwick K, Ling LE, Karanu FN, Bhatia M. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nature Immunology. February 2001, 2 (2): 172–80. PMID 11175816. S2CID 27907370. doi:10.1038/84282.
- Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research. June 2006, 66 (12): 6063–71. PMC 4386278 . PMID 16778178. doi:10.1158/0008-5472.CAN-06-0054.
- Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. October 2005, 437 (7060): 894–7. Bibcode:2005Natur.437..894A. PMID 16208373. S2CID 4431022. doi:10.1038/nature03994.
- Paladini RD, Saleh J, Qian C, Xu GX, Rubin LL. Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. The Journal of Investigative Dermatology. October 2005, 125 (4): 638–46. PMID 16185261. doi:10.1111/j.0022-202X.2005.23867.x .
- Keeler RF. Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects. Lipids. October 1978, 13 (10): 708–15. PMID 723484. S2CID 1119899. doi:10.1007/BF02533750.
- Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. January 1998, 391 (6662): 90–2. Bibcode:1998Natur.391...90X. PMID 9422511. S2CID 205003240. doi:10.1038/34201.
- Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proceedings of the National Academy of Sciences of the United States of America. October 2002, 99 (22): 14071–6. Bibcode:2002PNAS...9914071C. PMC 137838 . PMID 12391318. doi:10.1073/pnas.182542899 .
- Skoda AM, Simovic D, Karin V, Kardum V, Vranic S, Serman L. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosnian Journal of Basic Medical Sciences. February 2018, 18 (1): 8–20. PMC 5826678 . PMID 29274272. doi:10.17305/bjbms.2018.2756.
- Cigna N, Farrokhi Moshai E, Brayer S, Marchal-Somme J, Wémeau-Stervinou L, Fabre A, et al. The hedgehog system machinery controls transforming growth factor-β-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis. The American Journal of Pathology. December 2012, 181 (6): 2126–37. PMID 23031257. doi:10.1016/j.ajpath.2012.08.019 .
- Wang C, de Mochel NS, Christenson SA, Cassandras M, Moon R, Brumwell AN, et al. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. The Journal of Clinical Investigation. October 2018, 128 (10): 4343–4358. PMC 6159975 . PMID 29999500. doi:10.1172/JCI99435.
- Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, et al. Sonic hedgehog signalling as a potential endobronchial biomarker in COPD. Respiratory Research. August 2020, 21 (1): 207. PMC 7412648 . PMID 32767976. doi:10.1186/s12931-020-01478-x.
- Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin JM, Germain A, et al. Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD. EBioMedicine. January 2020, 51: 102572. PMC 6931110 . PMID 31877414. doi:10.1016/j.ebiom.2019.11.033.
- Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. April 2010, 17 (4): 388–99. PMC 4039177 . PMID 20385363. doi:10.1016/j.ccr.2010.02.027.
- Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, Kim J, Chen B, King EM, Borodovsky A, Riggins GJ, Epstein EH, Beachy PA, Rudin CM. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. January 2013, 23 (1): 23–34. PMC 3548977 . PMID 23291299. doi:10.1016/j.ccr.2012.11.017.
- Hunt R, Bragina O, Drews M, Kasak L, Timmusk S, Valkna A, Kogerman P, Järvekülg L. Generation and characterization of mouse monoclonal antibody 5E1 against human transcription factor GLI3. Hybridoma. August 2007, 26 (4): 231–40. PMID 17725385. doi:10.1089/hyb.2007.0507.
- Stecca B, Mas C, Ruiz i Altaba A. Interference with HH-GLI signaling inhibits prostate cancer. Trends in Molecular Medicine. May 2005, 11 (5): 199–203. PMID 15882606. doi:10.1016/j.molmed.2005.03.004.
- Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, Peaceman D, Ozdemirli M, Rodriguez O, Macdonald TJ, Albanese C, Toretsky JA, Uren A. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. The Journal of Clinical Investigation. January 2011, 121 (1): 148–60. PMC 3007144 . PMID 21183792. doi:10.1172/JCI42874.
- Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proceedings of the National Academy of Sciences of the United States of America. July 2010, 107 (30): 13432–7. Bibcode:2010PNAS..10713432K. PMC 2922148 . PMID 20624968. doi:10.1073/pnas.1006822107 .
- Lipinski RJ, Bushman W. Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening. Toxicology in Vitro (Toxicol In Vitro). August 2010, 24 (5): 1404–9. PMC 2891024 . PMID 20434536. doi:10.1016/j.tiv.2010.04.011.
- Elamin MH, Shinwari Z, Hendrayani SF, Al-Hindi H, Al-Shail E, Khafaga Y, et al. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Molecular Carcinogenesis. March 2010, 49 (3): 302–14. PMID 20025076. S2CID 31459213. doi:10.1002/mc.20604.
- Wang J, Lu J, Mook RA, Zhang M, Zhao S, Barak LS, et al. The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks. Toxicological Sciences. August 2012, 128 (2): 517–23. PMC 3493191 . PMID 22552772. doi:10.1093/toxsci/kfs165.
- Everson JL, Sun MR, Fink DM, Heyne GW, Melberg CG, Nelson KF, Doroodchi P, Colopy LJ, Ulschmid CM, Martin AA, McLaughlin MT, Lipinski RJ. Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study. Environmental Health Perspectives. October 2019, 127 (10): 107006. PMC 6867268 . PMID 31642701. doi:10.1289/EHP5260 .
- Li X, Deng W, Nail CD, Bailey SK, Kraus MH, Ruppert JM, Lobo-Ruppert SM. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene. January 2006, 25 (4): 609–21. PMC 1361531 . PMID 16158046. doi:10.1038/sj.onc.1209077.
- Lee SW, Moskowitz MA, Sims JR. Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. International Journal of Molecular Medicine. March 2007, 19 (3): 445–51. PMID 17273793. doi:10.3892/ijmm.19.3.445 .
- Adolphe C, Hetherington R, Ellis T, Wainwright B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Research. February 2006, 66 (4): 2081–8. PMID 16489008. doi:10.1158/0008-5472.CAN-05-2146 .
- Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, Tyring SK, Kopelovich L, Hebert J, Epstein EH, Bickers DR, Xie J. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Research. October 2004, 64 (20): 7545–52. PMID 15492281. doi:10.1158/0008-5472.CAN-04-1393 .
- Wada H, Makabe K. Genome duplications of early vertebrates as a possible chronicle of the evolutionary history of the neural crest. International Journal of Biological Sciences. 2006, 2 (3): 133–41. PMC 1474148 . PMID 16763673. doi:10.7150/ijbs.2.133.
- Stark DR, Gates PB, Brockes JP, Ferretti P. Hedgehog family member is expressed throughout regenerating and developing limbs. Developmental Dynamics. July 1998, 212 (3): 352–63. PMID 9671939. doi:10.1002/(SICI)1097-0177(199807)212:3<352::AID-AJA3>3.0.CO;2-G .
- Dorus S, Anderson JR, Vallender EJ, Gilbert SL, Zhang L, Chemnick LG, Ryder OA, Li W, Lahn BT. Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates. Human Molecular Genetics. July 2006, 15 (13): 2031–7. PMID 16687440. doi:10.1093/hmg/ddl123 .
- Graul RC, Sadée W. Evolutionary relationships among G protein-coupled receptors using a clustered database approach. AAPS PharmSci. 2001, 3 (2): 25–42. PMC 2779559 . PMID 11741263. doi:10.1208/ps030212.
- Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development. November 2003, 130 (22): 5297–305. PMID 14530294. doi:10.1242/dev.00821 .
- Varjosalo M, Li SP, Taipale J. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Developmental Cell. February 2006, 10 (2): 177–86. PMID 16459297. doi:10.1016/j.devcel.2005.12.014 .
- Chen MH, Gao N, Kawakami T, Chuang PT. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Molecular and Cellular Biology. August 2005, 25 (16): 7042–53. PMC 1190231 . PMID 16055716. doi:10.1128/MCB.25.16.7042-7053.2005.
- Huangfu D, Anderson KV. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development. January 2006, 133 (1): 3–14. PMID 16339192. doi:10.1242/dev.02169 .
- Matus DQ, Magie CR, Pang K, Martindale MQ, Thomsen GH. The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution. Developmental Biology. January 2008, 313 (2): 501–18. PMC 2288667 . PMID 18068698. doi:10.1016/j.ydbio.2007.09.032.
- Adamska M, Matus DQ, Adamski M, Green K, Rokhsar DS, Martindale MQ, Degnan BM. The evolutionary origin of hedgehog proteins. Current Biology. October 2007, 17 (19): R836–7. PMID 17925209. S2CID 15158554. doi:10.1016/j.cub.2007.08.010 .
- Snell EA, Brooke NM, Taylor WR, Casane D, Philippe H, Holland PW. An unusual choanoflagellate protein released by Hedgehog autocatalytic processing. Proceedings. Biological Sciences. February 2006, 273 (1585): 401–7. PMC 1560198 . PMID 16615205. doi:10.1098/rspb.2005.3263.
- Bürglin TR. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif. BMC Genomics. March 2008, 9 (127): 127. PMC 2362128 . PMID 18334026. doi:10.1186/1471-2164-9-127.
- Bürglin TR. The Hedgehog protein family. Genome Biology. 2008, 9 (11): 241. PMC 2614485 . PMID 19040769. doi:10.1186/gb-2008-9-11-241.
- Zugasti O, Rajan J, Kuwabara PE. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Genome Research. October 2005, 15 (10): 1402–10. PMC 1240083 . PMID 16204193. doi:10.1101/gr.3935405.
- Bürglin TR, Kuwabara PE. Homologs of the Hh signalling network in C. elegans. WormBook. January 2006: 1–14. PMC 4781598 . PMID 18050469. doi:10.1895/wormbook.1.76.1.
- Hausmann G, von Mering C, Basler K. The hedgehog signaling pathway: where did it come from?. PLOS Biology. June 2009, 7 (6): e1000146. PMC 2698682 . PMID 19564910. doi:10.1371/journal.pbio.1000146.
epa.gov
archive.epa.gov
- Reregistration Eligibility Decision for Piperonyl Butoxide (PDF). USEPA. [2022-12-21]. （原始内容存档 (PDF)于2022-05-31）.
genetics.org
- Mohler J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics. December 1988, 120 (4): 1061–72. PMC 1203569 . PMID 3147217. doi:10.1093/genetics/120.4.1061.
harvard.edu
ui.adsabs.harvard.edu
- Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. October 1980, 287 (5785): 795–801. Bibcode:1980Natur.287..795N. PMID 6776413. S2CID 4337658. doi:10.1038/287795a0.
- Arthur W. The emerging conceptual framework of evolutionary developmental biology. Nature. February 2002, 415 (6873): 757–64. Bibcode:2002Natur.415..757A. PMID 11845200. S2CID 4432164. doi:10.1038/415757a.
- Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. June 2004, 304 (5678): 1755–9. Bibcode:2004Sci...304.1755L. CiteSeerX 10.1.1.476.3902 . PMID 15205520. S2CID 13949436. doi:10.1126/science.1098020.
- Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science. December 2004, 306 (5705): 2257–60. Bibcode:2004Sci...306.2257C. PMID 15618519. S2CID 12823611. doi:10.1126/science.1104135.
- Von Ohlen T, Lessing D, Nusse R, Hooper JE. Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proceedings of the National Academy of Sciences of the United States of America. March 1997, 94 (6): 2404–9. Bibcode:1997PNAS...94.2404V. PMC 20100 . PMID 9122207. doi:10.1073/pnas.94.6.2404 .
- Dray N, Tessmar-Raible K, Le Gouar M, Vibert L, Christodoulou F, Schipany K, Guillou A, Zantke J, Snyman H, Béhague J, Vervoort M, Arendt D, Balavoine G. Hedgehog signaling regulates segment formation in the annelid Platynereis. Science. July 2010, 329 (5989): 339–42. Bibcode:2010Sci...329..339D. PMC 3182550 . PMID 20647470. doi:10.1126/science.1188913.
- Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. August 2002, 418 (6900): 892–7. Bibcode:2002Natur.418..892T. PMID 12192414. S2CID 4362029. doi:10.1038/nature00989.
- Davies JP, Chen FW, Ioannou YA. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science. December 2000, 290 (5500): 2295–8. Bibcode:2000Sci...290.2295D. PMID 11125140. doi:10.1126/science.290.5500.2295.
- Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. May 2006, 103 (22): 8408–13. Bibcode:2006PNAS..103.8408C. PMC 1462959 . PMID 16707575. doi:10.1073/pnas.0602852103 .
- Carpenter D, Stone DM, Brush J, Ryan A, Armanini M, Frantz G, Rosenthal A, de Sauvage FJ. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proceedings of the National Academy of Sciences of the United States of America. November 1998, 95 (23): 13630–4. Bibcode:1998PNAS...9513630C. PMC 24870 . PMID 9811851. doi:10.1073/pnas.95.23.13630 .
- Incardona JP, Lee JH, Robertson CP, Enga K, Kapur RP, Roelink H. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proceedings of the National Academy of Sciences of the United States of America. October 2000, 97 (22): 12044–9. Bibcode:2000PNAS...9712044I. PMC 17291 . PMID 11027307. doi:10.1073/pnas.220251997 .
- Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. October 2005, 437 (7060): 894–7. Bibcode:2005Natur.437..894A. PMID 16208373. S2CID 4431022. doi:10.1038/nature03994.
- Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. January 1998, 391 (6662): 90–2. Bibcode:1998Natur.391...90X. PMID 9422511. S2CID 205003240. doi:10.1038/34201.
- Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proceedings of the National Academy of Sciences of the United States of America. October 2002, 99 (22): 14071–6. Bibcode:2002PNAS...9914071C. PMC 137838 . PMID 12391318. doi:10.1073/pnas.182542899 .
- Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proceedings of the National Academy of Sciences of the United States of America. July 2010, 107 (30): 13432–7. Bibcode:2010PNAS..10713432K. PMC 2922148 . PMID 20624968. doi:10.1073/pnas.1006822107 .
nih.gov
ncbi.nlm.nih.gov
- Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nature Reviews Genetics. June 2011, 12 (6): 393–406. PMID 21502959. S2CID 33769324. doi:10.1038/nrg2984.
- Jamieson C, Martinelli G, Cortes J. Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia. Blood Cancer Discovery. September 2020, 1 (2): 134–145. PMC 8447269 . PMID 34661144. doi:10.1158/2643-3230.BCD-20-0007 .
- Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. October 1980, 287 (5785): 795–801. Bibcode:1980Natur.287..795N. PMID 6776413. S2CID 4337658. doi:10.1038/287795a0.
- Arthur W. The emerging conceptual framework of evolutionary developmental biology. Nature. February 2002, 415 (6873): 757–64. Bibcode:2002Natur.415..757A. PMID 11845200. S2CID 4432164. doi:10.1038/415757a.
- Mohler J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics. December 1988, 120 (4): 1061–72. PMC 1203569 . PMID 3147217. doi:10.1093/genetics/120.4.1061.
- Collins RT, Cohen SM. A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics. May 2005, 170 (1): 173–84. PMC 1449730 . PMID 15744048. doi:10.1534/genetics.104.039420.
- Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. June 2004, 304 (5678): 1755–9. Bibcode:2004Sci...304.1755L. CiteSeerX 10.1.1.476.3902 . PMID 15205520. S2CID 13949436. doi:10.1126/science.1098020.
- Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science. December 2004, 306 (5705): 2257–60. Bibcode:2004Sci...306.2257C. PMID 15618519. S2CID 12823611. doi:10.1126/science.1104135.
- Alcedo J, Zou Y, Noll M. Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Molecular Cell. August 2000, 6 (2): 457–65. PMID 10983991. doi:10.1016/S1097-2765(00)00044-7 .
- Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nature Cell Biology. January 2005, 7 (1): 86–92. PMID 15592457. S2CID 5958856. doi:10.1038/ncb1210.
- Ho KS, Suyama K, Fish M, Scott MP. Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development. March 2005, 132 (6): 1401–12. PMID 15750186. doi:10.1242/dev.01689 .
- Von Ohlen T, Lessing D, Nusse R, Hooper JE. Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proceedings of the National Academy of Sciences of the United States of America. March 1997, 94 (6): 2404–9. Bibcode:1997PNAS...94.2404V. PMC 20100 . PMID 9122207. doi:10.1073/pnas.94.6.2404 .
- Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes & Development. December 2001, 15 (23): 3059–87. PMID 11731473. doi:10.1101/gad.938601 .
- Aspiras AC, Prasad R, Fong DW, Carlini DB, Angelini DR. Parallel reduction in expression of the eye development gene hedgehog in separately derived cave populations of the amphipod Gammarus minus. Journal of Evolutionary Biology. May 2012, 25 (5): 995–1001. PMID 22462461. S2CID 37541721. doi:10.1111/j.1420-9101.2012.02481.x.
- Dray N, Tessmar-Raible K, Le Gouar M, Vibert L, Christodoulou F, Schipany K, Guillou A, Zantke J, Snyman H, Béhague J, Vervoort M, Arendt D, Balavoine G. Hedgehog signaling regulates segment formation in the annelid Platynereis. Science. July 2010, 329 (5989): 339–42. Bibcode:2010Sci...329..339D. PMC 3182550 . PMID 20647470. doi:10.1126/science.1188913.
- Banavali NK. The Mechanism of Cholesterol Modification of Hedgehog Ligand. Journal of Computational Chemistry. November 2019, 41 (6): 520–527. PMID 31823413. doi:10.1002/jcc.26097 .
- Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. August 2002, 418 (6900): 892–7. Bibcode:2002Natur.418..892T. PMID 12192414. S2CID 4362029. doi:10.1038/nature00989.
- Davies JP, Chen FW, Ioannou YA. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science. December 2000, 290 (5500): 2295–8. Bibcode:2000Sci...290.2295D. PMID 11125140. doi:10.1126/science.290.5500.2295.
- Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Current Biology. April 2001, 11 (8): 608–13. PMID 11369206. S2CID 235311937. doi:10.1016/S0960-9822(01)00179-8 .
- Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. May 2006, 103 (22): 8408–13. Bibcode:2006PNAS..103.8408C. PMC 1462959 . PMID 16707575. doi:10.1073/pnas.0602852103 .
- Rahnama F, Shimokawa T, Lauth M, Finta C, Kogerman P, Teglund S, Toftgård R, Zaphiropoulos PG. Inhibition of GLI1 gene activation by Patched1. The Biochemical Journal. February 2006, 394 (Pt 1): 19–26. PMC 1385998 . PMID 16229683. doi:10.1042/BJ20050941.
- Carpenter D, Stone DM, Brush J, Ryan A, Armanini M, Frantz G, Rosenthal A, de Sauvage FJ. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proceedings of the National Academy of Sciences of the United States of America. November 1998, 95 (23): 13630–4. Bibcode:1998PNAS...9513630C. PMC 24870 . PMID 9811851. doi:10.1073/pnas.95.23.13630 .
- Rahnama F, Toftgård R, Zaphiropoulos PG. Distinct roles of PTCH2 splice variants in Hedgehog signalling. The Biochemical Journal. March 2004, 378 (Pt 2): 325–34. PMC 1223965 . PMID 14613484. doi:10.1042/BJ20031200.
- Zaphiropoulos PG, Undén AB, Rahnama F, Hollingsworth RE, Toftgård R. PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Cancer Research. February 1999, 59 (4): 787–92. PMID 10029063.
- Incardona JP, Lee JH, Robertson CP, Enga K, Kapur RP, Roelink H. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proceedings of the National Academy of Sciences of the United States of America. October 2000, 97 (22): 12044–9. Bibcode:2000PNAS...9712044I. PMC 17291 . PMID 11027307. doi:10.1073/pnas.220251997 .
- Jeong J, McMahon AP. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. January 2005, 132 (1): 143–54. PMID 15576403. doi:10.1242/dev.01566 .
- SAUNDERS JW Jr. The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J Exp Zool. 1948 Aug;108(3):363-403. doi: 10.1002/jez.1401080304. PMID 18882505.
- Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. August 2004, 118 (4): 517–28. PMID 15315763. S2CID 16280983. doi:10.1016/j.cell.2004.07.024 .
- Bhardwaj G, Murdoch B, Wu D, Baker DP, Williams KP, Chadwick K, Ling LE, Karanu FN, Bhatia M. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nature Immunology. February 2001, 2 (2): 172–80. PMID 11175816. S2CID 27907370. doi:10.1038/84282.
- Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research. June 2006, 66 (12): 6063–71. PMC 4386278 . PMID 16778178. doi:10.1158/0008-5472.CAN-06-0054.
- Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. October 2005, 437 (7060): 894–7. Bibcode:2005Natur.437..894A. PMID 16208373. S2CID 4431022. doi:10.1038/nature03994.
- Paladini RD, Saleh J, Qian C, Xu GX, Rubin LL. Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. The Journal of Investigative Dermatology. October 2005, 125 (4): 638–46. PMID 16185261. doi:10.1111/j.0022-202X.2005.23867.x .
- Keeler RF. Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects. Lipids. October 1978, 13 (10): 708–15. PMID 723484. S2CID 1119899. doi:10.1007/BF02533750.
- Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. January 1998, 391 (6662): 90–2. Bibcode:1998Natur.391...90X. PMID 9422511. S2CID 205003240. doi:10.1038/34201.
- Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proceedings of the National Academy of Sciences of the United States of America. October 2002, 99 (22): 14071–6. Bibcode:2002PNAS...9914071C. PMC 137838 . PMID 12391318. doi:10.1073/pnas.182542899 .
- Skoda AM, Simovic D, Karin V, Kardum V, Vranic S, Serman L. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosnian Journal of Basic Medical Sciences. February 2018, 18 (1): 8–20. PMC 5826678 . PMID 29274272. doi:10.17305/bjbms.2018.2756.
- Cigna N, Farrokhi Moshai E, Brayer S, Marchal-Somme J, Wémeau-Stervinou L, Fabre A, et al. The hedgehog system machinery controls transforming growth factor-β-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis. The American Journal of Pathology. December 2012, 181 (6): 2126–37. PMID 23031257. doi:10.1016/j.ajpath.2012.08.019 .
- Wang C, de Mochel NS, Christenson SA, Cassandras M, Moon R, Brumwell AN, et al. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. The Journal of Clinical Investigation. October 2018, 128 (10): 4343–4358. PMC 6159975 . PMID 29999500. doi:10.1172/JCI99435.
- Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, et al. Sonic hedgehog signalling as a potential endobronchial biomarker in COPD. Respiratory Research. August 2020, 21 (1): 207. PMC 7412648 . PMID 32767976. doi:10.1186/s12931-020-01478-x.
- Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin JM, Germain A, et al. Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD. EBioMedicine. January 2020, 51: 102572. PMC 6931110 . PMID 31877414. doi:10.1016/j.ebiom.2019.11.033.
- Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. April 2010, 17 (4): 388–99. PMC 4039177 . PMID 20385363. doi:10.1016/j.ccr.2010.02.027.
- Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, Kim J, Chen B, King EM, Borodovsky A, Riggins GJ, Epstein EH, Beachy PA, Rudin CM. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. January 2013, 23 (1): 23–34. PMC 3548977 . PMID 23291299. doi:10.1016/j.ccr.2012.11.017.
- Nakamura M, Kubo M, Yanai K, Mikami Y, Ikebe M, Nagai S, Yamaguchi K, Tanaka M, Katano M. Anti-patched-1 antibodies suppress hedgehog signaling pathway and pancreatic cancer proliferation. Anticancer Research. 2007, 27 (6A): 3743–7. PMID 17970037.
- Hunt R, Bragina O, Drews M, Kasak L, Timmusk S, Valkna A, Kogerman P, Järvekülg L. Generation and characterization of mouse monoclonal antibody 5E1 against human transcription factor GLI3. Hybridoma. August 2007, 26 (4): 231–40. PMID 17725385. doi:10.1089/hyb.2007.0507.
- Stecca B, Mas C, Ruiz i Altaba A. Interference with HH-GLI signaling inhibits prostate cancer. Trends in Molecular Medicine. May 2005, 11 (5): 199–203. PMID 15882606. doi:10.1016/j.molmed.2005.03.004.
- Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, Peaceman D, Ozdemirli M, Rodriguez O, Macdonald TJ, Albanese C, Toretsky JA, Uren A. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. The Journal of Clinical Investigation. January 2011, 121 (1): 148–60. PMC 3007144 . PMID 21183792. doi:10.1172/JCI42874.
- Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proceedings of the National Academy of Sciences of the United States of America. July 2010, 107 (30): 13432–7. Bibcode:2010PNAS..10713432K. PMC 2922148 . PMID 20624968. doi:10.1073/pnas.1006822107 .
- Lipinski RJ, Bushman W. Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening. Toxicology in Vitro (Toxicol In Vitro). August 2010, 24 (5): 1404–9. PMC 2891024 . PMID 20434536. doi:10.1016/j.tiv.2010.04.011.
- Elamin MH, Shinwari Z, Hendrayani SF, Al-Hindi H, Al-Shail E, Khafaga Y, et al. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Molecular Carcinogenesis. March 2010, 49 (3): 302–14. PMID 20025076. S2CID 31459213. doi:10.1002/mc.20604.
- Wang J, Lu J, Mook RA, Zhang M, Zhao S, Barak LS, et al. The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks. Toxicological Sciences. August 2012, 128 (2): 517–23. PMC 3493191 . PMID 22552772. doi:10.1093/toxsci/kfs165.
- Everson JL, Sun MR, Fink DM, Heyne GW, Melberg CG, Nelson KF, Doroodchi P, Colopy LJ, Ulschmid CM, Martin AA, McLaughlin MT, Lipinski RJ. Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study. Environmental Health Perspectives. October 2019, 127 (10): 107006. PMC 6867268 . PMID 31642701. doi:10.1289/EHP5260 .
- Li X, Deng W, Nail CD, Bailey SK, Kraus MH, Ruppert JM, Lobo-Ruppert SM. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene. January 2006, 25 (4): 609–21. PMC 1361531 . PMID 16158046. doi:10.1038/sj.onc.1209077.
- Lee SW, Moskowitz MA, Sims JR. Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. International Journal of Molecular Medicine. March 2007, 19 (3): 445–51. PMID 17273793. doi:10.3892/ijmm.19.3.445 .
- Adolphe C, Hetherington R, Ellis T, Wainwright B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Research. February 2006, 66 (4): 2081–8. PMID 16489008. doi:10.1158/0008-5472.CAN-05-2146 .
- Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, Tyring SK, Kopelovich L, Hebert J, Epstein EH, Bickers DR, Xie J. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Research. October 2004, 64 (20): 7545–52. PMID 15492281. doi:10.1158/0008-5472.CAN-04-1393 .
- Wada H, Makabe K. Genome duplications of early vertebrates as a possible chronicle of the evolutionary history of the neural crest. International Journal of Biological Sciences. 2006, 2 (3): 133–41. PMC 1474148 . PMID 16763673. doi:10.7150/ijbs.2.133.
- Stark DR, Gates PB, Brockes JP, Ferretti P. Hedgehog family member is expressed throughout regenerating and developing limbs. Developmental Dynamics. July 1998, 212 (3): 352–63. PMID 9671939. doi:10.1002/(SICI)1097-0177(199807)212:3<352::AID-AJA3>3.0.CO;2-G .
- Dorus S, Anderson JR, Vallender EJ, Gilbert SL, Zhang L, Chemnick LG, Ryder OA, Li W, Lahn BT. Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates. Human Molecular Genetics. July 2006, 15 (13): 2031–7. PMID 16687440. doi:10.1093/hmg/ddl123 .
- Graul RC, Sadée W. Evolutionary relationships among G protein-coupled receptors using a clustered database approach. AAPS PharmSci. 2001, 3 (2): 25–42. PMC 2779559 . PMID 11741263. doi:10.1208/ps030212.
- Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development. November 2003, 130 (22): 5297–305. PMID 14530294. doi:10.1242/dev.00821 .
- Varjosalo M, Li SP, Taipale J. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Developmental Cell. February 2006, 10 (2): 177–86. PMID 16459297. doi:10.1016/j.devcel.2005.12.014 .
- Chen MH, Gao N, Kawakami T, Chuang PT. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Molecular and Cellular Biology. August 2005, 25 (16): 7042–53. PMC 1190231 . PMID 16055716. doi:10.1128/MCB.25.16.7042-7053.2005.
- Huangfu D, Anderson KV. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development. January 2006, 133 (1): 3–14. PMID 16339192. doi:10.1242/dev.02169 .
- Matus DQ, Magie CR, Pang K, Martindale MQ, Thomsen GH. The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution. Developmental Biology. January 2008, 313 (2): 501–18. PMC 2288667 . PMID 18068698. doi:10.1016/j.ydbio.2007.09.032.
- Adamska M, Matus DQ, Adamski M, Green K, Rokhsar DS, Martindale MQ, Degnan BM. The evolutionary origin of hedgehog proteins. Current Biology. October 2007, 17 (19): R836–7. PMID 17925209. S2CID 15158554. doi:10.1016/j.cub.2007.08.010 .
- Snell EA, Brooke NM, Taylor WR, Casane D, Philippe H, Holland PW. An unusual choanoflagellate protein released by Hedgehog autocatalytic processing. Proceedings. Biological Sciences. February 2006, 273 (1585): 401–7. PMC 1560198 . PMID 16615205. doi:10.1098/rspb.2005.3263.
- Bürglin TR. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif. BMC Genomics. March 2008, 9 (127): 127. PMC 2362128 . PMID 18334026. doi:10.1186/1471-2164-9-127.
- Bürglin TR. The Hedgehog protein family. Genome Biology. 2008, 9 (11): 241. PMC 2614485 . PMID 19040769. doi:10.1186/gb-2008-9-11-241.
- Zugasti O, Rajan J, Kuwabara PE. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Genome Research. October 2005, 15 (10): 1402–10. PMC 1240083 . PMID 16204193. doi:10.1101/gr.3935405.
- Bürglin TR, Kuwabara PE. Homologs of the Hh signalling network in C. elegans. WormBook. January 2006: 1–14. PMC 4781598 . PMID 18050469. doi:10.1895/wormbook.1.76.1.
- Hausmann G, von Mering C, Basler K. The hedgehog signaling pathway: where did it come from?. PLOS Biology. June 2009, 7 (6): e1000146. PMC 2698682 . PMID 19564910. doi:10.1371/journal.pbio.1000146.
nobelprize.org
- 1995 Nobel Prize for discovery of the genetic control of early embryonic development （页面存档备份，存于互联网档案馆）
omim.org
psu.edu
citeseerx.ist.psu.edu
- Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. June 2004, 304 (5678): 1755–9. Bibcode:2004Sci...304.1755L. CiteSeerX 10.1.1.476.3902 . PMID 15205520. S2CID 13949436. doi:10.1126/science.1098020.
rcn.com
users.rcn.com
- Kimball's Biology Pages 互联网档案馆的存檔，存档日期26 June 2008., The Hedgehog Signaling Pathway
semanticscholar.org
api.semanticscholar.org
- Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nature Reviews Genetics. June 2011, 12 (6): 393–406. PMID 21502959. S2CID 33769324. doi:10.1038/nrg2984.
- Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. October 1980, 287 (5785): 795–801. Bibcode:1980Natur.287..795N. PMID 6776413. S2CID 4337658. doi:10.1038/287795a0.
- Arthur W. The emerging conceptual framework of evolutionary developmental biology. Nature. February 2002, 415 (6873): 757–64. Bibcode:2002Natur.415..757A. PMID 11845200. S2CID 4432164. doi:10.1038/415757a.
- Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. June 2004, 304 (5678): 1755–9. Bibcode:2004Sci...304.1755L. CiteSeerX 10.1.1.476.3902 . PMID 15205520. S2CID 13949436. doi:10.1126/science.1098020.
- Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science. December 2004, 306 (5705): 2257–60. Bibcode:2004Sci...306.2257C. PMID 15618519. S2CID 12823611. doi:10.1126/science.1104135.
- Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nature Cell Biology. January 2005, 7 (1): 86–92. PMID 15592457. S2CID 5958856. doi:10.1038/ncb1210.
- Aspiras AC, Prasad R, Fong DW, Carlini DB, Angelini DR. Parallel reduction in expression of the eye development gene hedgehog in separately derived cave populations of the amphipod Gammarus minus. Journal of Evolutionary Biology. May 2012, 25 (5): 995–1001. PMID 22462461. S2CID 37541721. doi:10.1111/j.1420-9101.2012.02481.x.
- Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. August 2002, 418 (6900): 892–7. Bibcode:2002Natur.418..892T. PMID 12192414. S2CID 4362029. doi:10.1038/nature00989.
- Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Current Biology. April 2001, 11 (8): 608–13. PMID 11369206. S2CID 235311937. doi:10.1016/S0960-9822(01)00179-8 .
- Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. August 2004, 118 (4): 517–28. PMID 15315763. S2CID 16280983. doi:10.1016/j.cell.2004.07.024 .
- Bhardwaj G, Murdoch B, Wu D, Baker DP, Williams KP, Chadwick K, Ling LE, Karanu FN, Bhatia M. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nature Immunology. February 2001, 2 (2): 172–80. PMID 11175816. S2CID 27907370. doi:10.1038/84282.
- Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. October 2005, 437 (7060): 894–7. Bibcode:2005Natur.437..894A. PMID 16208373. S2CID 4431022. doi:10.1038/nature03994.
- Keeler RF. Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects. Lipids. October 1978, 13 (10): 708–15. PMID 723484. S2CID 1119899. doi:10.1007/BF02533750.
- Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. January 1998, 391 (6662): 90–2. Bibcode:1998Natur.391...90X. PMID 9422511. S2CID 205003240. doi:10.1038/34201.
- Elamin MH, Shinwari Z, Hendrayani SF, Al-Hindi H, Al-Shail E, Khafaga Y, et al. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Molecular Carcinogenesis. March 2010, 49 (3): 302–14. PMID 20025076. S2CID 31459213. doi:10.1002/mc.20604.
- Adamska M, Matus DQ, Adamski M, Green K, Rokhsar DS, Martindale MQ, Degnan BM. The evolutionary origin of hedgehog proteins. Current Biology. October 2007, 17 (19): R836–7. PMID 17925209. S2CID 15158554. doi:10.1016/j.cub.2007.08.010 .
web.archive.org
- Kimball's Biology Pages 互联网档案馆的存檔，存档日期26 June 2008., The Hedgehog Signaling Pathway
- 1995 Nobel Prize for discovery of the genetic control of early embryonic development （页面存档备份，存于互联网档案馆）
- Hedgehog Signaling Pathway | The Embryo Project Encyclopedia. embryo.asu.edu. [2023-01-10]. （原始内容存档于2023-01-10）.
- Reregistration Eligibility Decision for Piperonyl Butoxide (PDF). USEPA. [2022-12-21]. （原始内容存档 (PDF)于2022-05-31）.