Clinical trial number NCT01928394 for "A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors" at ClinicalTrials.gov
Gardner TA, Elzey BD, Hahn NM. Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer. Human Vaccines & Immunotherapeutics. April 2012, 8 (4): 534–9. PMID 22832254. doi:10.4161/hv.19795.
Sims RB. Development of sipuleucel-T: autologous cellular immunotherapy for the treatment of metastatic castrate resistant prostate cancer. Vaccine. June 2012, 30 (29): 4394–7. PMID 22122856. doi:10.1016/j.vaccine.2011.11.058.
Shore ND, Mantz CA, Dosoretz DE, Fernandez E, Myslicki FA, McCoy C, Finkelstein SE, Fishman MN. Building on sipuleucel-T for immunologic treatment of castration-resistant prostate cancer. Cancer Control. January 2013, 20 (1): 7–16. PMID 23302902. doi:10.1177/107327481302000103.
Scott AM, Wolchok JD, Old LJ. Antibody therapy of cancer. Nature Reviews. Cancer. March 2012, 12 (4): 278–87. PMID 22437872. doi:10.1038/nrc3236.
Pincetic A, Bournazos S, DiLillo DJ, Maamary J, Wang TT, Dahan R, Fiebiger BM, Ravetch JV. Type I and type II Fc receptors regulate innate and adaptive immunity. Nature Immunology. August 2014, 15 (8): 707–16. PMID 25045879. doi:10.1038/ni.2939.
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. The New England Journal of Medicine. June 2012, 366 (26): 2443–54. PMC 3544539. PMID 22658127. doi:10.1056/NEJMoa1200690.
Dahan R, Sega E, Engelhardt J, Selby M, Korman AJ, Ravetch JV. FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis. Cancer Cell. October 2015, 28 (4): 543. PMID 28854351. doi:10.1016/j.ccell.2015.09.011.
Gelderman KA, Tomlinson S, Ross GD, Gorter A. Complement function in mAb-mediated cancer immunotherapy. Trends in Immunology. March 2004, 25 (3): 158–64. PMID 15036044. doi:10.1016/j.it.2004.01.008.
Demko S, Summers J, Keegan P, Pazdur R. FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. The Oncologist. February 2008, 13 (2): 167–74. PMID 18305062. doi:10.1634/theoncologist.2007-0218.
Lemery SJ, Zhang J, Rothmann MD, Yang J, Earp J, Zhao H, McDougal A, Pilaro A, Chiang R, Gootenberg JE, Keegan P, Pazdur R. U.S. Food and Drug Administration approval: ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab. Clinical Cancer Research. September 2010, 16 (17): 4331–8. PMID 20601446. doi:10.1158/1078-0432.CCR-10-0570.
Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annual Review of Immunology. 2001, 19: 565–94. PMID 11244047. doi:10.1146/annurev.immunol.19.1.565.
Keating GM. Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma. Drugs. July 2010, 70 (11): 1445–76. PMID 20614951. doi:10.2165/11201110-000000000-00000.
Plosker GL, Figgitt DP. Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Drugs. 2003, 63 (8): 803–43. PMID 12662126. doi:10.2165/00003495-200363080-00005.
Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nature Reviews. Cancer. January 2004, 4 (1): 11–22. PMID 14708024. doi:10.1038/nrc1252.
Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nature Reviews. Immunology. November 2006, 6 (11): 836–48. PMID 17063185. doi:10.1038/nri1961.
Razaghi A, Owens L, Heimann K. Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation. Journal of Biotechnology. December 2016, 240: 48–60. PMID 27794496. doi:10.1016/j.jbiotec.2016.10.022.
Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nature Reviews. Drug Discovery. August 2015, 14 (8): 561–84. PMID 26228759. doi:10.1038/nrd4591.
Tang J, Shalabi A, Hubbard-Lucey VM. Comprehensive analysis of the clinical immuno-oncology landscape. Annals of Oncology. January 2018, 29 (1): 84–91. PMID 29228097. doi:10.1093/annonc/mdx755.
Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. The Journal of Experimental Medicine. March 2018, 215 (3): 877–893. PMID 29436395. doi:10.1084/jem.20171435.
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nature Biomedical Engineering. 2018-05-21. doi:10.1038/s41551-018-0236-8.
Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nature Reviews. Immunology. March 2012, 12 (4): 269–81. PMID 22437939. doi:10.1038/nri3191.
Andersen R, Borch TH, Draghi A, Gokuldass A, Rana MA, Pedersen M, Nielsen M, Kongsted P, Kjeldsen JW, Westergaard MC, Radic HD, Chamberlain CA, Holmich LR, Hendel HW, Larsen MS, Met O, Svane IM, Donia M. T cells isolated from patients with checkpoint inhibitor resistant-melanoma are functional and can mediate tumor regression.. Ann. Oncol. April 2018. PMID 29688262. doi:10.1093/annonc/mdy139.
Matlung HL, Szilagyi K, Barclay NA, van den Berg TK. The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer. Immunological Reviews. March 2017, 276 (1): 145–164. PMID 28258703. doi:10.1111/imr.12527.
Veillette A, Chen J. SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy. Trends in Immunology. March 2018, 39 (3): 173–184. PMID 29336991. doi:10.1016/j.it.2017.12.005.
Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. Journal of Clinical Oncology. June 2012, 30 (17): 2046–54. PMID 22547592. doi:10.1200/JCO.2011.38.4032.
van Hooren L, Sandin LC, Moskalev I, Ellmark P, Dimberg A, Black P, Tötterman TH, Mangsbo SM. Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer. European Journal of Immunology. February 2017, 47 (2): 385–393. PMID 27873300. doi:10.1002/eji.201646583.
Aleem E. β-Glucans and their applications in cancer therapy: focus on human studies. Anti-Cancer Agents in Medicinal Chemistry. June 2013, 13 (5): 709–19. PMID 23140353. doi:10.2174/1871520611313050007.
Gardner TA, Elzey BD, Hahn NM. Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer. Human Vaccines & Immunotherapeutics. April 2012, 8 (4): 534–9. PMID 22832254. doi:10.4161/hv.19795.
Sims RB. Development of sipuleucel-T: autologous cellular immunotherapy for the treatment of metastatic castrate resistant prostate cancer. Vaccine. June 2012, 30 (29): 4394–7. PMID 22122856. doi:10.1016/j.vaccine.2011.11.058.
Shore ND, Mantz CA, Dosoretz DE, Fernandez E, Myslicki FA, McCoy C, Finkelstein SE, Fishman MN. Building on sipuleucel-T for immunologic treatment of castration-resistant prostate cancer. Cancer Control. January 2013, 20 (1): 7–16. PMID 23302902. doi:10.1177/107327481302000103.
Scott AM, Wolchok JD, Old LJ. Antibody therapy of cancer. Nature Reviews. Cancer. March 2012, 12 (4): 278–87. PMID 22437872. doi:10.1038/nrc3236.
Pincetic A, Bournazos S, DiLillo DJ, Maamary J, Wang TT, Dahan R, Fiebiger BM, Ravetch JV. Type I and type II Fc receptors regulate innate and adaptive immunity. Nature Immunology. August 2014, 15 (8): 707–16. PMID 25045879. doi:10.1038/ni.2939.
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. The New England Journal of Medicine. June 2012, 366 (26): 2443–54. PMC 3544539. PMID 22658127. doi:10.1056/NEJMoa1200690.
Dahan R, Sega E, Engelhardt J, Selby M, Korman AJ, Ravetch JV. FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis. Cancer Cell. October 2015, 28 (4): 543. PMID 28854351. doi:10.1016/j.ccell.2015.09.011.
Gelderman KA, Tomlinson S, Ross GD, Gorter A. Complement function in mAb-mediated cancer immunotherapy. Trends in Immunology. March 2004, 25 (3): 158–64. PMID 15036044. doi:10.1016/j.it.2004.01.008.
Demko S, Summers J, Keegan P, Pazdur R. FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. The Oncologist. February 2008, 13 (2): 167–74. PMID 18305062. doi:10.1634/theoncologist.2007-0218.
Lemery SJ, Zhang J, Rothmann MD, Yang J, Earp J, Zhao H, McDougal A, Pilaro A, Chiang R, Gootenberg JE, Keegan P, Pazdur R. U.S. Food and Drug Administration approval: ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab. Clinical Cancer Research. September 2010, 16 (17): 4331–8. PMID 20601446. doi:10.1158/1078-0432.CCR-10-0570.
James JS, Dubs G. FDA approves new kind of lymphoma treatment. Food and Drug Administration. AIDS Treatment News. December 1997, (284): 2–3. PMID 11364912.
Domagała A, Kurpisz M. CD52 antigen--a review. Medical Science Monitor. Mar–Apr 2001, 7 (2): 325–31. PMID 11257744.
Thumar JR, Kluger HM. Ipilimumab: a promising immunotherapy for melanoma. Oncology. December 2010, 24 (14): 1280–8. PMID 21294471.
Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annual Review of Immunology. 2001, 19: 565–94. PMID 11244047. doi:10.1146/annurev.immunol.19.1.565.
Keating GM. Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma. Drugs. July 2010, 70 (11): 1445–76. PMID 20614951. doi:10.2165/11201110-000000000-00000.
Plosker GL, Figgitt DP. Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Drugs. 2003, 63 (8): 803–43. PMID 12662126. doi:10.2165/00003495-200363080-00005.
Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nature Reviews. Cancer. January 2004, 4 (1): 11–22. PMID 14708024. doi:10.1038/nrc1252.
Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nature Reviews. Immunology. November 2006, 6 (11): 836–48. PMID 17063185. doi:10.1038/nri1961.
Razaghi A, Owens L, Heimann K. Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation. Journal of Biotechnology. December 2016, 240: 48–60. PMID 27794496. doi:10.1016/j.jbiotec.2016.10.022.
Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nature Reviews. Drug Discovery. August 2015, 14 (8): 561–84. PMID 26228759. doi:10.1038/nrd4591.
Tang J, Shalabi A, Hubbard-Lucey VM. Comprehensive analysis of the clinical immuno-oncology landscape. Annals of Oncology. January 2018, 29 (1): 84–91. PMID 29228097. doi:10.1093/annonc/mdx755.
Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. The Journal of Experimental Medicine. March 2018, 215 (3): 877–893. PMID 29436395. doi:10.1084/jem.20171435.
Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nature Reviews. Immunology. March 2012, 12 (4): 269–81. PMID 22437939. doi:10.1038/nri3191.
Andersen R, Borch TH, Draghi A, Gokuldass A, Rana MA, Pedersen M, Nielsen M, Kongsted P, Kjeldsen JW, Westergaard MC, Radic HD, Chamberlain CA, Holmich LR, Hendel HW, Larsen MS, Met O, Svane IM, Donia M. T cells isolated from patients with checkpoint inhibitor resistant-melanoma are functional and can mediate tumor regression.. Ann. Oncol. April 2018. PMID 29688262. doi:10.1093/annonc/mdy139.
Matlung HL, Szilagyi K, Barclay NA, van den Berg TK. The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer. Immunological Reviews. March 2017, 276 (1): 145–164. PMID 28258703. doi:10.1111/imr.12527.
Veillette A, Chen J. SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy. Trends in Immunology. March 2018, 39 (3): 173–184. PMID 29336991. doi:10.1016/j.it.2017.12.005.
Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. Journal of Clinical Oncology. June 2012, 30 (17): 2046–54. PMID 22547592. doi:10.1200/JCO.2011.38.4032.
van Hooren L, Sandin LC, Moskalev I, Ellmark P, Dimberg A, Black P, Tötterman TH, Mangsbo SM. Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer. European Journal of Immunology. February 2017, 47 (2): 385–393. PMID 27873300. doi:10.1002/eji.201646583.
Aleem E. β-Glucans and their applications in cancer therapy: focus on human studies. Anti-Cancer Agents in Medicinal Chemistry. June 2013, 13 (5): 709–19. PMID 23140353. doi:10.2174/1871520611313050007.