Mapping of the human IL10 gene and further characterization of the 5' flanking sequence. Immunogenetics. 1997, 46 (2): 120–8. PMID 9162098. doi:10.1007/s002510050250.
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure. June 1995, 3 (6): 591–601. PMID 8590020. doi:10.1016/S0969-2126(01)00193-9.
The regulation of IL-10 production by immune cells. Nature Reviews. Immunology. March 2010, 10 (3): 170–81. PMID 20154735. doi:10.1038/nri2711.
Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. European Journal of Immunology. October 2005, 35 (10): 2991–3001. PMID 16184516. doi:10.1002/eji.200526192.
Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region. Journal of Immunology. July 2000, 165 (1): 292–6. PMID 10861064. doi:10.4049/jimmunol.165.1.292.
Opp MR, Smith EM, Hughes TK. Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. Journal of Neuroimmunology. July 1995, 60 (1–2): 165–8. PMID 7642744. doi:10.1016/0165-5728(95)00066-b.
Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10. Journal of Immunotherapy. 2000-04-01, 23 (2): 208–14. PMID 10746547. doi:10.1097/00002371-200003000-00005.
Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ. Blood. October 2001, 98 (7): 2143–51. PMID 11568001. doi:10.1182/blood.v98.7.2143.
IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs. Cancer Research. July 2012, 72 (14): 3570–81. PMID 22581824. doi:10.1158/0008-5472.CAN-12-0721.
The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells. Journal of Interferon & Cytokine Research. December 2015, 35 (12): 948–55. PMID 26309093. doi:10.1089/jir.2014.0221.
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nature Immunology. October 2007, 8 (10): 1095–104. PMID 17767162. doi:10.1038/ni1503.
Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment. Scandinavian Journal of Immunology. May 1999, 49 (5): 554–61. PMID 10320650. doi:10.1046/j.1365-3083.1999.00546.x.
Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. European Journal of Immunology. April 2008, 38 (4): 1106–17. PMID 18383040. doi:10.1002/eji.200737821.
Current concepts in multiple sclerosis: autoimmunity versus oligodendrogliopathy. Clinical Reviews in Allergy & Immunology. February 2012, 42 (1): 26–34. PMID 22189514. doi:10.1007/s12016-011-8287-6.
Interleukin 10 decreases MICA expression on melanoma cell surface. Immunology and Cell Biology. March 2011, 89 (3): 447–57. PMID 20714339. doi:10.1038/icb.2010.100.
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clinical Gastroenterology and Hepatology. June 2006, 4 (6): 754–9. PMID 16716759. doi:10.1016/j.cgh.2006.03.028.
Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial. Archives of Dermatology. February 1999, 135 (2): 187–92. PMID 10052405. doi:10.1001/archderm.135.2.187.
Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10. Archives of Dermatology. October 2002, 138 (10): 1341–6. PMID 12374540. doi:10.1001/archderm.138.10.1341.
Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. Journal of Neuroimmunology. July 1995, 60 (1–2): 165–8. PMID 7642744. doi:10.1016/0165-5728(95)00066-b.
Characterization of recombinant extracellular domain of human interleukin-10 receptor. The Journal of Biological Chemistry. May 1995, 270 (21): 12906–11. PMID 7759550. doi:10.1074/jbc.270.21.12906.
Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. Acta Crystallographica Section D. December 2001, 57 (Pt 12): 1908–11. PMID 11717514. doi:10.1107/S0907444901016249.
Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization. European Journal of Biochemistry. May 1999, 262 (1): 134–41. PMID 10231374. doi:10.1046/j.1432-1327.1999.00363.x.
Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
Mapping of the human IL10 gene and further characterization of the 5' flanking sequence. Immunogenetics. 1997, 46 (2): 120–8. PMID 9162098. doi:10.1007/s002510050250.
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure. June 1995, 3 (6): 591–601. PMID 8590020. doi:10.1016/S0969-2126(01)00193-9.
The regulation of IL-10 production by immune cells. Nature Reviews. Immunology. March 2010, 10 (3): 170–81. PMID 20154735. doi:10.1038/nri2711.
Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. European Journal of Immunology. October 2005, 35 (10): 2991–3001. PMID 16184516. doi:10.1002/eji.200526192.
Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region. Journal of Immunology. July 2000, 165 (1): 292–6. PMID 10861064. doi:10.4049/jimmunol.165.1.292.
Opp MR, Smith EM, Hughes TK. Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. Journal of Neuroimmunology. July 1995, 60 (1–2): 165–8. PMID 7642744. doi:10.1016/0165-5728(95)00066-b.
Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10. Journal of Immunotherapy. 2000-04-01, 23 (2): 208–14. PMID 10746547. doi:10.1097/00002371-200003000-00005.
Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ. Blood. October 2001, 98 (7): 2143–51. PMID 11568001. doi:10.1182/blood.v98.7.2143.
Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice. Journal of Immunology. July 1996, 157 (1): 231–8. PMID 8683120.
IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs. Cancer Research. July 2012, 72 (14): 3570–81. PMID 22581824. doi:10.1158/0008-5472.CAN-12-0721.
The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells. Journal of Interferon & Cytokine Research. December 2015, 35 (12): 948–55. PMID 26309093. doi:10.1089/jir.2014.0221.
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nature Immunology. October 2007, 8 (10): 1095–104. PMID 17767162. doi:10.1038/ni1503.
Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment. Scandinavian Journal of Immunology. May 1999, 49 (5): 554–61. PMID 10320650. doi:10.1046/j.1365-3083.1999.00546.x.
Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. European Journal of Immunology. April 2008, 38 (4): 1106–17. PMID 18383040. doi:10.1002/eji.200737821.
Current concepts in multiple sclerosis: autoimmunity versus oligodendrogliopathy. Clinical Reviews in Allergy & Immunology. February 2012, 42 (1): 26–34. PMID 22189514. doi:10.1007/s12016-011-8287-6.
Interleukin 10 decreases MICA expression on melanoma cell surface. Immunology and Cell Biology. March 2011, 89 (3): 447–57. PMID 20714339. doi:10.1038/icb.2010.100.
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clinical Gastroenterology and Hepatology. June 2006, 4 (6): 754–9. PMID 16716759. doi:10.1016/j.cgh.2006.03.028.
Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial. Archives of Dermatology. February 1999, 135 (2): 187–92. PMID 10052405. doi:10.1001/archderm.135.2.187.
Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10. Archives of Dermatology. October 2002, 138 (10): 1341–6. PMID 12374540. doi:10.1001/archderm.138.10.1341.
Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. Journal of Neuroimmunology. July 1995, 60 (1–2): 165–8. PMID 7642744. doi:10.1016/0165-5728(95)00066-b.
Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. Journal of Immunology. June 1998, 160 (12): 5936–44. PMID 9637507.
Characterization of recombinant extracellular domain of human interleukin-10 receptor. The Journal of Biological Chemistry. May 1995, 270 (21): 12906–11. PMID 7759550. doi:10.1074/jbc.270.21.12906.
Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. Acta Crystallographica Section D. December 2001, 57 (Pt 12): 1908–11. PMID 11717514. doi:10.1107/S0907444901016249.
Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization. European Journal of Biochemistry. May 1999, 262 (1): 134–41. PMID 10231374. doi:10.1046/j.1432-1327.1999.00363.x.