药物发现 (Chinese Wikipedia)

Analysis of information sources in references of the Wikipedia article "药物发现" in Chinese language version.

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Elion GB. The quest for a cure. Annual Review of Pharmacology and Toxicology. 1993, 33: 1–23. PMID 8494337. doi:10.1146/annurev.pa.33.040193.000245.
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Cartwright, Anthony C. The British Pharmacopoeia, 1864 to 2014: Medicines, International Standards and the State. Routledge. 2016: 183 [2016-12-22]. ISBN 9781317039792. （原始内容存档于2017-09-08）（英语）.

cell.com

米勒·路易斯（Louis H. Miller）和苏新专（Xin-zhuan Su）. 青蒿素：源自中草药园的发现. 《细胞》 (CAMBRIDGE, MA 02139, USA: Cell Press). 2011-09-16, 146 (6): 855–858 [2011-09-26]. ISSN 0092-8674. PMID 21907397. doi:10.1016/j.cell.2011.08.024. （原始内容存档于2011-09-24）.

doi.org

Helleboid S, Haug C, Lamottke K, et al. The Identification of Naturally Occurring Neoruscogenin as a Bioavailable, Potent, and High-Affinity Agonist of the Nuclear Receptor RORα (NR1F1). Journal of Biomolecular Screening. 2014;19(3):399–406. https://doi.org/10.1177/1087057113497095.
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Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Reviews. Drug Discovery. March 2010, 9 (3): 203–14. PMID 20168317. S2CID 1299234. doi:10.1038/nrd3078 .
Warren J. Drug discovery: lessons from evolution. British Journal of Clinical Pharmacology. April 2011, 71 (4): 497–503. PMC 3080636 . PMID 21395642. doi:10.1111/j.1365-2125.2010.03854.x.
Hall, Anthony K; Carlson, Marilyn R. The current status of orphan drug development in Europe and the US. Intractable and Rare Diseases Research. 2014, 3 (1): 1–7. ISSN 2186-3644. PMC 4204542 . PMID 25343119. doi:10.5582/irdr.3.1.
All natural. Nature Chemical Biology. July 2007, 3 (7): 351. PMID 17576412. doi:10.1038/nchembio0707-351 . The simplest definition for a natural product is a small molecule that is produced by a biological source.
K. C. Nicolaou; D. Vourloumis; N. Winssinger and P. S. Baran. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century (PDF). Angewandte Chemie International Edition. 2000, 39 (1): 44–122 [2020-06-25]. PMID 10649349. doi:10.1002/(SICI)1521-3773(20000103)39:1<44::AID-ANIE44>3.0.CO;2-L. （原始内容 (reprint)存档于2017-05-17）.
Takenaka T. Classical vs reverse pharmacology in drug discovery. BJU International. September 2001, 88 (Suppl 2): 7–10; discussion 49–50. PMID 11589663. doi:10.1111/j.1464-410X.2001.00112.x .
Lee JA, Uhlik MT, Moxham CM, Tomandl D, Sall DJ. Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. Journal of Medicinal Chemistry. May 2012, 55 (10): 4527–38. PMID 22409666. doi:10.1021/jm201649s.
Elion GB. The quest for a cure. Annual Review of Pharmacology and Toxicology. 1993, 33: 1–23. PMID 8494337. doi:10.1146/annurev.pa.33.040193.000245.
Watts G. Obituary: Sir David Jack. The Lancet. 2012, 379 (9811): 116. S2CID 54305535. doi:10.1016/S0140-6736(12)60053-1 .
Mary Ellen Avery. Gertrude Belle Elion. 23 January 1918 — 21 February 1999. Biographical Memoirs of Fellows of the Royal Society. 2008-12-12, 54: 161–168 [2018-04-02]. ISSN 0080-4606. doi:10.1098/rsbm.2007.0051. （原始内容存档于2017-04-01）（英语）.
Rask-Andersen M, Almén MS, Schiöth HB. Trends in the exploitation of novel drug targets. Nature Reviews. Drug Discovery. August 2011, 10 (8): 579–90. PMID 21804595. S2CID 3328752. doi:10.1038/nrd3478.
Jacobson KA. New paradigms in GPCR drug discovery. Biochemical Pharmacology. December 2015, 98 (4): 541–555. PMC 4967540 . PMID 26265138. doi:10.1016/j.bcp.2015.08.085.
Chen, Ya; Kirchmair, Johannes. Cheminformatics in natural product‐based drug discovery. Molecular Informatics. 2020-09-06, 39 (12): 2000171. ISSN 1868-1743. PMC 7757247 . PMID 32725781. doi:10.1002/minf.202000171.
Baker M. Deceptive curcumin offers cautionary tale for chemists. Nature. 9 January 2017, 541 (7636): 144–145. Bibcode:2017Natur.541..144B. PMID 28079090. doi:10.1038/541144a .
Dahlin JL, Walters MA. The essential roles of chemistry in high-throughput screening triage. Future Medicinal Chemistry. July 2014, 6 (11): 1265–90. PMC 4465542 . PMID 25163000. doi:10.4155/fmc.14.60.
Baell JB, Holloway GA. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Journal of Medicinal Chemistry. April 2010, 53 (7): 2719–40. CiteSeerX 10.1.1.394.9155 . PMID 20131845. doi:10.1021/jm901137j.
Hughes, JP; Rees, S; Kalindjian, SB; Philpott, KL. Principles of early drug discovery. British Journal of Pharmacology. March 2011, 162 (6): 1239–1249. PMC 3058157 . PMID 21091654. doi:10.1111/j.1476-5381.2010.01127.x.
Gouriet, F; Saby, L; Delaunay, E; Cammilleri, S; le Dolley, Y; Riberi, A; Casalta, JP; Habib, G; Raoult, D. Incidental diagnosis of colonic tumor by PET/CT in infectious endocarditis.. The Journal of infection. 2013-07, 67 (1): 88–90 [2019-12-17]. PMID 23523828. doi:10.1016/j.jinf.2013.03.004. （原始内容存档于2019-12-17）.
Artursson, P; Palm, K; Luthman, K. Caco-2 monolayers in experimental and theoretical predictions of drug transport.. Advanced drug delivery reviews. 2001-03-01, 46 (1-3): 27–43 [2019-12-17]. PMID 11259831. doi:10.1016/s0169-409x(00)00128-9. （原始内容存档于2019-12-17）.
Ottaviani, Giorgio; Martel, Sophie; Carrupt, Pierre-Alain. Parallel Artificial Membrane Permeability Assay: A New Membrane for the Fast Prediction of Passive Human Skin Permeability. Journal of Medicinal Chemistry. 2006, 49 (13): 3948–3954. ISSN 0022-2623. PMID 16789751. doi:10.1021/jm060230+.
Edward HK, Li D. Druglike Properties: Concepts Structure Design and Methods from ADME to Toxicity Optimization. August 2008. doi:10.1016/C2013-0-18378-X.
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews. March 2001, 46 (1–3): 3–26. PMID 11259830. doi:10.1016/S0169-409X(00)00129-0.
Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies. December 2004, 1 (4): 337–341. PMID 24981612. doi:10.1016/j.ddtec.2004.11.007.
Hopkins AL, Groom CR, Alex A. Ligand efficiency: a useful metric for lead selection. Drug Discovery Today. May 2004, 9 (10): 430–1. PMID 15109945. doi:10.1016/S1359-6446(04)03069-7.
Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, Thompson LR, Tran I, Tutt MF, Young T. Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis. Bioorganic & Medicinal Chemistry Letters. August 2009, 19 (15): 4406–9. PMID 19500981. doi:10.1016/j.bmcl.2009.05.062.
Leeson PD, Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Reviews. Drug Discovery. November 2007, 6 (11): 881–90. PMID 17971784. S2CID 205476574. doi:10.1038/nrd2445.
Tetko IV, Bruneau P, Mewes HW, Rohrer DC, Poda GI. Can we estimate the accuracy of ADME-Tox predictions? (PDF). Drug Discovery Today. August 2006, 11 (15–16): 700–707 [2023-05-02]. PMID 16846797. doi:10.1016/j.drudis.2006.06.013. （原始内容 (pre-print)存档于2013-09-12）.
Rollinger JM, Stuppner H, Langer T. Natural Compounds as Drugs Volume I. Progress in Drug Research 65. 2008: 211, 213–49. ISBN 978-3-7643-8098-4. PMC 7124045 . PMID 18084917. doi:10.1007/978-3-7643-8117-2_6.
Barcellos GB, Pauli I, Caceres RA, Timmers LF, Dias R, de Azevedo WF. Molecular modeling as a tool for drug discovery. Current Drug Targets. December 2008, 9 (12): 1084–91. PMID 19128219. doi:10.2174/138945008786949388.
Durrant JD, McCammon JA. Molecular dynamics simulations and drug discovery. BMC Biology. October 2011, 9: 71. PMC 3203851 . PMID 22035460. doi:10.1186/1741-7007-9-71.
Borhani DW, Shaw DE. The future of molecular dynamics simulations in drug discovery. Journal of Computer-Aided Molecular Design. January 2012, 26 (1): 15–26. Bibcode:2012JCAMD..26...15B. PMC 3268975 . PMID 22183577. doi:10.1007/s10822-011-9517-y.
Ciemny M, Kurcinski M, Kamel K, Kolinski A, Alam N, Schueler-Furman O, Kmiecik S. Protein-peptide docking: opportunities and challenges. Drug Discovery Today. May 2018, 23 (8): 1530–1537. PMID 29733895. doi:10.1016/j.drudis.2018.05.006 .
Erlanson DA, McDowell RS, O'Brien T. Fragment-based drug discovery. Journal of Medicinal Chemistry. July 2004, 47 (14): 3463–82. PMID 15214773. doi:10.1021/jm040031v.
Erlanson DA. Introduction to fragment-based drug discovery. Topics in Current Chemistry 317. June 2011: 1–32. ISBN 978-3-642-27539-5. PMID 21695633. doi:10.1007/128_2011_180.
Huang R, Leung IK. Protein-directed dynamic combinatorial chemistry: a guide to protein ligand and inhibitor discovery. Molecules. July 2016, 21 (7): 910. PMC 6273345 . PMID 27438816. doi:10.3390/molecules21070910 .
Mondal M, Hirsch AK. Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets. Chemical Society Reviews. April 2015, 44 (8): 2455–88. PMID 25706945. doi:10.1039/c4cs00493k .
Herrmann A. Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures. Chemical Society Reviews. March 2014, 43 (6): 1899–933. PMID 24296754. doi:10.1039/c3cs60336a.
Caliandro R, Belviso DB, Aresta BM, de Candia M, Altomare CD. Protein crystallography and fragment-based drug design. Future Medicinal Chemistry. June 2013, 5 (10): 1121–40. PMID 23795969. doi:10.4155/fmc.13.84.
Chilingaryan Z, Yin Z, Oakley AJ. Fragment-based screening by protein crystallography: successes and pitfalls. International Journal of Molecular Sciences. October 2012, 13 (10): 12857–79. PMC 3497300 . PMID 23202926. doi:10.3390/ijms131012857 .
Valade A, Urban D, Beau JM. Two galactosyltransferases' selection of different binders from the same uridine-based dynamic combinatorial library. Journal of Combinatorial Chemistry. Jan–Feb 2007, 9 (1): 1–4. PMID 17206823. doi:10.1021/cc060033w.
Zheng W, Thorne N, McKew JC. Phenotypic screens as a renewed approach for drug discovery. Drug Discovery Today. November 2013, 18 (21–22): 1067–1073. PMC 4531371 . PMID 23850704. doi:10.1016/j.drudis.2013.07.001.
Swinney DC, Anthony J. How were new medicines discovered?. Nature Reviews. Drug Discovery. June 2011, 10 (7): 507–519. PMID 21701501. S2CID 19171881. doi:10.1038/nrd3480.
Brown DG, Wobst HJ. Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research. Journal of Medicinal Chemistry. March 2020, 63 (5): 1823–1840. PMID 31268707. S2CID 195798523. doi:10.1021/acs.jmedchem.9b00797.
Moellering RE, Cravatt BF. How chemoproteomics can enable drug discovery and development. Chemistry & Biology. January 2012, 19 (1): 11–22. PMC 3312051 . PMID 22284350. doi:10.1016/j.chembiol.2012.01.001.
Marshall SF, Burghaus R, Cosson V, Cheung SY, Chenel M, DellaPasqua O, et al. Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation. CPT. March 2016, 5 (3): 93–122. PMC 4809625 . PMID 27069774. doi:10.1002/psp4.12049 .
Marshall S, Madabushi R, Manolis E, Krudys K, Staab A, Dykstra K, Visser SA. Model-Informed Drug Discovery and Development: Current Industry Good Practice and Regulatory Expectations and Future Perspectives. CPT. February 2019, 8 (2): 87–96. PMC 6389350 . PMID 30411538. doi:10.1002/psp4.12372 .
Van Wijk RC. Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations. Applied Sciences. 2020, 10 (2376): 2376. doi:10.3390/app10072376 .
Balatti, Galo, E.; Barletta, Patricio, G.; Perez, Andres, D.; Giudicessi, Silvana, L.; Martínez‐Ceron, María, C., Inamuddin; Altalhi, Tariq; Cruz, Jorddy N.; Refat, Moamen Salah El‐Deen , 编, Machine Learning Approaches to Improve Prediction of Target‐Drug Interactions, Drug Design Using Machine Learning 1 (Wiley), 2022-10-10: 21–96 [2023-01-27], ISBN 978-1-394-16628-2, doi:10.1002/9781394167258.ch2, （原始内容存档于2023-01-27）（英语）
Feher M, Schmidt JM. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. Journal of Chemical Information and Computer Sciences. 2003, 43 (1): 218–27. PMID 12546556. doi:10.1021/ci0200467.
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. Journal of Natural Products. March 2007, 70 (3): 461–77. PMID 17309302. doi:10.1021/np068054v.
von Nussbaum F, Brands M, Hinzen B, Weigand S, Häbich D. Antibacterial natural products in medicinal chemistry—exodus or revival?. Angewandte Chemie. August 2006, 45 (31): 5072–129. PMID 16881035. doi:10.1002/anie.200600350. The handling of natural products is cumbersome, requiring nonstandardized workflows and extended timelines. Revisiting natural products with modern chemistry and target-finding tools from biology (reversed genomics) is one option for their revival.
Li JW, Vederas JC. Drug discovery and natural products: end of an era or an endless frontier?. Science. July 2009, 325 (5937): 161–5. Bibcode:2009Sci...325..161L. PMID 19589993. S2CID 207777087. doi:10.1126/science.1168243. With the current framework of HTS in major pharmaceutical industries and increasing government restrictions on drug approvals, it is possible that the number of new natural product–derived drugs could go to zero. However, this is likely to be temporary, as the potential for new discoveries in the longer term is enormous.
Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era (PDF). Nature Reviews. Drug Discovery. 2015, 14 (2): 111–29 [2023-05-28]. PMID 25614221. S2CID 12369182. doi:10.1038/nrd4510. hdl:10072/141449 . （原始内容存档 (PDF)于2023-01-31）. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced [technical barriers to screening natural products in high-throughput assays]. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery.
Newman DJ, Cragg GM. Natural Products as Sources of New Drugs from 1981 to 2014. Journal of Natural Products. 2016, 79 (3): 629–61. PMID 26852623. doi:10.1021/acs.jnatprod.5b01055 . ... the utilization of natural products and/or their novel structures, in order to discover and develop the final drug entity, is still alive and well. For example, in the area of cancer, over the time frame from around the 1940s to the end of 2014, of the 175 small molecules approved, 131, or 75%, are other than "S" (synthetic), with 85, or 49%, actually being either natural products or directly derived therefrom.
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米勒·路易斯（Louis H. Miller）和苏新专（Xin-zhuan Su）. 青蒿素：源自中草药园的发现. 《细胞》 (CAMBRIDGE, MA 02139, USA: Cell Press). 2011-09-16, 146 (6): 855–858 [2011-09-26]. ISSN 0092-8674. PMID 21907397. doi:10.1016/j.cell.2011.08.024. （原始内容存档于2011-09-24）.
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Machida, Kodai; Masutan, Mamiko; Imatak, Hiroaki. Protein Synthesis in vitro: Cell-Free Systems Derived from Human Cells. Cell-Free Protein Synthesis. InTech. 2012-10-10. ISBN 978-953-51-0803-0.

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