| # | Website | Score in June 2020 | 1m changes |
|---|
| 1 | Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Prop... | 716,908 | -147,373 |
| 2 | Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods | 716,708 | -146,473 |
| 3 | Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices | 716,708 | -146,473 |
| 4 | DrugBank: a knowledgebase for drugs, drug actions and drug targets | 90,200 | -24,473 |
| 5 | DrugBank 3.0: a comprehensive resource for ’Omics’ research on drugs | 84,400 | -15,773 |
| 6 | Goodman & Gilman’s The Pharmacological Basis of Therapeutics | 29,613 | -6,163 |
| 7 | N. N. Greenwood, A. Earnshaw: Chemistry of the elements. Pergamon press oxford 1984, 1542 seiten, 7 anhänge Preis: US $ 34.95. ISBN 0–08–022057–6 | 17,057 | -18,688 |
| 8 | A New Skull of Early Homo from Dmanisi, Georgia | 17,030 | -94,636 |
| 9 | Applications and societal benefits of plastics | 15,277 | -23,345 |
| 10 | Electronic absorption spectrum of cobalt antipyrine complex | 13,050 | -27,000 |
| 11 | Internet encyclopaedias go head to head | 11,057 | -7,858 |
| 12 | The atmospheric budget of oxidized nitrogen and its role in ozone formation and deposition | 10,757 | -657 |
| 13 | Nitrogen Cycles: Past, Present, and Future | 10,757 | -657 |
| 14 | A global inventory of nitric oxide emissions from soils | 10,757 | -657 |
| 15 | Mandell, Douglas, and Bennett’s principles and practice of infectious diseases | 10,549 | -13,227 |
| 16 | Systems of acids and bases | 10,055 | -25,345 |
| 17 | Imperialism, Nationalism, Chauvinism | 9,200 | +200 |
| 18 | Affective Computing and Intelligent Interaction | 8,700 | -10,000 |
| 19 | The Near Eastern Origin of Cat Domestication | 8,200 | +800 |
| 20 | Primary Production of the Biosphere: Integrating Terrestrial and Oceanic Components | 8,100 | -12,700 |
| 21 | Cystic Fibrosis Adult Care | 7,600 | -3,800 |
| 22 | The architecture of virtual machines | 7,300 | -66 |
| 23 | Development of a rational scale to assess the harm of drugs of potential misuse | 6,450 | -14,100 |
| 24 | Crystal structure of dimeric KlHxk1 in crystal form I | 6,200 | +3,900 |
| 25 | Nomenclature of steroids (Recommendations 1989) | 6,000 | -7,700 |
| 26 | DrugBank: a comprehensive resource for in silico drug discovery and exploration | 5,800 | -8,700 |
| 27 | 10.1145/3366423.3380300 | 5,528 | +5,528 |
| 28 | Neuropsychological functioning in chronic Lyme disease | 5,333 | -9,533 |
| 29 | Linking to journal articles in an online teaching environment: The persistent link, DOI, and OpenURL | 5,016 | -3,567 |
| 30 | Digital Object Identifiers: Promise and Problems for Scholarly Publishing | 5,016 | -3,567 |
| 31 | Contractile vacuoles in cells of a fresh water sponge, Spongilla lacustris | 4,812 | +3,700 |
| 32 | The contractile vacuole and its membrane dynamics | 4,812 | +3,700 |
| 33 | Proton pumps populate the contractile vacuoles of Dictyostelium amoebae. | 4,812 | +3,700 |
| 34 | Presence of aquaporin and V-ATPase on the contractile vacuole of Amoeba proteus | 4,812 | +3,700 |
| 35 | Acidocalcisomes and the Contractile Vacuole Complex Are Involved in Osmoregulation inTrypanosoma cruzi | 4,812 | +3,700 |
| 36 | A proposal for further integration of the cyanobacteria under the Bacteriological Code | 4,600 | -10,000 |
| 37 | Why plants need more than one type of auxin | 4,500 | +1,450 |
| 38 | Indoor air pollution: a public health perspective | 4,400 | -25,600 |
| 39 | Evaluating the environmental impact of various dietary patterns combined with different food production systems | 4,180 | -11,405 |
| 40 | Genome Sequencing Highlights the Dynamic Early History of Dogs | 4,144 | -5,464 |
| 41 | Fossil dogs and wolves from Palaeolithic sites in Belgium, the Ukraine and Russia: osteometry, ancient DNA and stable isotopes | 4,144 | -5,464 |
| 42 | Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs | 4,144 | -5,464 |
| 43 | On the effects of domestication on canine social development and behavior | 4,144 | -5,464 |
| 44 | A 33,000-Year-Old Incipient Dog from the Altai Mountains of Siberia: Evidence of the Earliest Domestication Disrupted by the Last Glacial Maximum | 4,144 | -5,464 |
| 45 | Dogs Can Discriminate Emotional Expressions of Human Faces | 4,144 | -5,464 |
| 46 | Humans can judge a dog by its growl | 4,144 | -5,464 |
| 47 | A Global Outlook for Water Resources to the Year 2025 | 4,120 | -11,410 |
| 48 | Corrected Values for Boiling Points and Enthalpies of Vaporization of Elements in Handbooks | 4,115 | -6,863 |
| 49 | USE OF THERMAL DENATURATION STUDIES TO INVESTIGATE THE BASE SEQUENCE OF YEAST SERINE sRNA | 4,100 | -3,300 |
| 50 | Lexicon of lipid nutrition (IUPAC Technical Report) | 4,011 | -9,642 |
| 51 | The Blood Test Revisited: A New Look at German Casualty Counts in World War I | 4,000 | -2,000 |
| 52 | Vicilin and convicilin are potential major allergens from pea | 4,000 | -1,300 |
| 53 | THE IMMUNOLOGICAL SPECIFICITY OF THE EUGLOBULIN AND PSEUDOGLOBULIN FRACTIONS OF HORSE AND H^MAN SERUM | 4,000 | -1,300 |
| 54 | Alcohols, Aliphatic | 3,960 | -18,924 |
| 55 | Nomenclature of regular single-strand organic polymers (IUPAC Recommendations 2002) | 3,900 | +100 |
| 56 | Maslow’s Study of Self-Actualization | 3,900 | -1,580 |
| 57 | William Johannsen and the genotype concept | 3,859 | -8,301 |
| 58 | Hyperchloremic Metabolic Acidosis Is a Predictable Consequence of Intraoperative Infusion of 0.9% Saline | 3,800 | -2,733 |
| 59 | Erythrocyte Mean Cell Volume-Correlation to Drinking Pattern in Heavy Alcoholics | 3,800 | +1,400 |
| 60 | Crystal Structure and Hydrogen-Bonding System in Cellulose Iβ from Synchrotron X-ray and Neutron Fiber Diffraction | 3,500 | -21,200 |
| 61 | Dysthanasia: nursing professionals’ perception | 3,466 | -14,367 |
| 62 | Ironic technology: Old age and the implantable cardioverter defibrillator in US health care | 3,466 | -14,367 |
| 63 | Pharmacokinetics and Pharmacodynamics of Cannabinoids | 3,428 | -3,786 |
| 64 | Recommendations for euthanasia of experimental animals: Part 1 | 3,400 | -3,700 |
| 65 | The formation of Cu2S from the elements | 3,363 | -4,477 |
| 66 | My Days with Gandhi.Nirmal Kumar | 3,300 | +800 |
| 67 | Political Opportunities and Local Grassroots Environmental Movements: The Case of Minamata | 3,281 | -15,491 |
| 68 | Fyn Is Required for Haloperidol-induced Catalepsy in Mice | 3,250 | -1,050 |
| 69 | Organization and Retrieval of Records Generated in a Large-Scale Engineering Project | 3,180 | -40 |
| 70 | Standard solution for redox potential measurements | 3,150 | 0 |
| 71 | An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG III | 3,138 | -1,109 |
| 72 | Thermodynamics of black holes | 3,100 | -8,700 |
| 73 | VII. On the means of discovering the distance, magnitude, &c. of the fixed stars, in consequence of the diminution of the velocity of their light, in ... | 3,100 | -8,700 |
| 74 | Functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and pituitary gland | 3,000 | -1,300 |
| 75 | The atomic nuclide with the highest mean binding energy | 2,948 | -5,158 |
| 76 | Spectroscopy, Molecular Orbitals, and Chemical Bonding | 2,948 | -5,158 |
| 77 | Gamma-Rays from the ReactionH1(n,γ)D2and the Binding Energy of the Deuteron | 2,948 | -5,158 |
| 78 | Glucose and Glucose-Containing Syrups | 2,866 | -17,767 |
| 79 | Preventing Nephropathy Induced by Contrast Medium | 2,850 | -2,250 |
| 80 | Calcium block of Na+ channels and its effect on closing rate | 2,800 | -1,450 |
| 81 | Transport and release of chemicals from plastics to the environment and to wildlife | 2,777 | -4,245 |
| 82 | Gi-Dependent Localization of β2-Adrenergic Receptor Signaling to L-Type Ca2+ Channels | 2,777 | +646 |
| 83 | UNITARY VERSUS COLLECTIVE MODELS OF THE HOUSEHOLD: IS IT TIME TO SHIFT THE BURDEN OF PROOF? | 2,775 | +200 |
| 84 | Glycerol | 2,750 | -7,900 |
| 85 | Schizophrenia | 2,705 | -1,661 |
| 86 | Temperature Management in Acute Neurologic Disorders | 2,626 | -6,930 |
| 87 | I. Ueber die Abhängigkeit der verschiedenen Vertretbarkeit des Radicalwasserstoffs in den isomeren Buttersäuren | 2,600 | -2,400 |
| 88 | Was Markovnikov’s Rule an Inspired Guess? | 2,600 | -2,400 |
| 89 | THE NATURE OF THE ACTIVE METHYL DONOR FORMED ENZYMATICALLY FROM L-METHIONINE AND ADENOSINETRIPHOSPHATE1,2 | 2,600 | -1,100 |
| 90 | Dopamine ?-Hydroxylase: Biochemistry and Molecular Biology | 2,550 | -950 |
| 91 | The Thermal Degradation of Sugars I. Thermal Polymerization of Glucose | 2,425 | -575 |
| 92 | Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) | 2,425 | -1,675 |
| 93 | Cross-examining dissociative identity disorder: Neuroimaging and etiology on trial | 2,425 | -1,675 |
| 94 | An examination of structural dissociation of the personality and the implications for cognitive behavioural therapy | 2,425 | -1,675 |
| 95 | Normal Reference Laboratory Values | 2,400 | +1,350 |
| 96 | Glossary of terms in quantities and units in Clinical Chemistry (IUPAC-IFCC Recommendations 1996) | 2,384 | -6,079 |
| 97 | Fever in the critically ill medical patient | 2,369 | -6,648 |
| 98 | The impact of malaria parasitism: from corpuscles to communities | 2,350 | -2,300 |
| 99 | Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death | 2,350 | -2,300 |
| 100 | Possible animal-body fossils in pre-Marinoan limestones from South Australia | 2,336 | -6,769 |
| 101 | Comparative Metabolic Capabilities and Inhibitory Profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17 | 2,300 | -4,050 |
| 102 | Clinical Relevance of Bacteriostatic versus Bactericidal Mechanisms of Action in the Treatment of Gram‐Positive Bacterial Infections | 2,297 | -8,346 |
| 103 | ’Atomic weight’: The name, its history, definition, and units | 2,275 | -6,025 |
| 104 | High-Performance Fibers | 2,266 | -467 |
| 105 | Acute phosphate nephropathy | 2,266 | -4,300 |
| 106 | Sodium Phosphate Tablets and Acute Phosphate Nephropathy | 2,266 | -4,300 |
| 107 | Social psychological aspects of computer-mediated communication. | 2,200 | -2,050 |
| 108 | Formate assay in body fluids: Application in methanol poisoning | 2,200 | -2,100 |
| 109 | A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea | 2,200 | -7,000 |
| 110 | New concepts in antimalarial use and mode of action in dermatology | 2,200 | -1,400 |
| 111 | Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons | 2,200 | -1,700 |
| 112 | Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill | 2,197 | -8,346 |
| 113 | A physiological model for tert-amyl methyl ether and tert-amyl alcohol: hypothesis testing of model structures | 2,192 | -2,023 |
| 114 | Formic Anhydride | 2,175 | -12,725 |
| 115 | "Ideology" from Destutt De Tracy to Marx | 2,150 | +50 |
| 116 | MusicBrainz: a semantic Web service | 2,150 | -400 |
| 117 | Prokaryotes: The unseen majority | 2,140 | -8,123 |
| 118 | High rates of microbial carbon turnover in sediments in the deepest oceanic trench on Earth | 2,133 | -8,117 |
| 119 | Geomicrobiology of High-Level Nuclear Waste-Contaminated Vadose Sediments at the Hanford Site, Washington State | 2,133 | -8,117 |
| 120 | Strategies for discovering and derisking covalent, irreversible enzyme inhibitors | 2,100 | -3,000 |
| 121 | Planck2013 results. XVI. Cosmological parameters | 2,096 | -2,648 |
| 122 | Units of Enzyme Activity. Recommendations 1978 | 2,071 | +150 |
| 123 | Peroxiredoxins are conserved markers of circadian rhythms | 2,050 | +300 |
| 124 | Of Ear Trumpets and a Resonance Plate: Early Hearing Aids and Beethoven’s Hearing Perception | 2,015 | -4,031 |
| 125 | Evaluating the Affective Component of the Cerebellar Cognitive Affective Syndrome | 2,000 | -3,200 |
| 126 | The History of the Development of the Cerebellar Examination | 2,000 | -3,200 |
| 127 | The ancient Virus World and evolution of cells | 1,985 | -4,799 |
| 128 | Here a virus, there a virus, everywhere the same virus? | 1,985 | -4,799 |
| 129 | Structural and Functional Studies of Archaeal Viruses | 1,985 | -4,799 |
| 130 | Viral metagenomics | 1,985 | -4,799 |
| 131 | Phage as agents of lateral gene transfer | 1,985 | -4,799 |
| 132 | Nucleoside conformations. 15. Flexibility of natural pyrimidine nudeosides around the glycosidic bond. | 1,950 | -1,800 |
| 133 | Design of a Novel Globular Protein Fold with Atomic-Level Accuracy | 1,912 | -5,297 |
| 134 | Structural basis of HIV-1 resistance to AZT by excision | 1,900 | +900 |
| 135 | Formaldehyde | 1,900 | -3,733 |
| 136 | How sexually dimorphic are we? Review and synthesis | 1,842 | -1,315 |
| 137 | Molecular Insights Into μ Opioid Pharmacology | 1,800 | -1,100 |
| 138 | Paracelsus to parascience: the environmental cancer distraction | 1,800 | -800 |
| 139 | Neither fat nor flesh | 1,800 | +300 |
| 140 | Adipose Tissue as an Endocrine Organ | 1,800 | +300 |
| 141 | Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: Inhibition of microglial neurotoxicity | 1,800 | -2,500 |
| 142 | Thalamus | 1,800 | -1,850 |
| 143 | The changing faces of glutathione, a cellular protagonist | 1,775 | -1,075 |
| 144 | Obesity | 1,767 | -2,792 |
| 145 | Size effect on the melting temperature of gold particles | 1,750 | -3,900 |
| 146 | Inherent tensile strength of molybdenum nanocrystals | 1,750 | -3,900 |
| 147 | Human pineal physiology and functional significance of melatonin | 1,750 | -2,000 |
| 148 | Melatonin as a chronobiotic | 1,750 | -2,000 |
| 149 | Tuberculosis | 1,730 | -1,533 |
| 150 | Cholesterol and Plants | 1,730 | -8,687 |
| 151 | Endogenous alcohol production by intestinal fermentation in sudden infant death | 1,730 | -8,687 |
| 152 | Atomic weights of the elements 2009 (IUPAC Technical Report) | 1,729 | -3,677 |
| 153 | Chlorinated Hydrocarbons | 1,725 | -675 |
| 154 | Schizophrenia | 1,721 | -1,057 |
| 155 | The National Library of Medicine. Evolution of a premier information center | 1,700 | +700 |
| 156 | Engineering trimeric fibrous proteins based on bacteriophage T4 adhesins | 1,700 | -3,433 |
| 157 | Preoperative carbohydrate treatment for enhancing recovery after elective surgery | 1,680 | +1,040 |
| 158 | Rehabilitating the Industrial Revolution | 1,678 | -2,730 |
| 159 | Human Artifice and the Science Fiction Film | 1,675 | -325 |
| 160 | Star Wars: The Pastiche of Myth and the Yearning for a Past Future | 1,675 | -325 |
| 161 | IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors | 1,655 | -1,156 |
| 162 | Primate evolution at the DNA level and a classification of hominoids | 1,650 | -1,652 |
| 163 | Solubility of Benzene in Water. | 1,650 | -2,775 |
| 164 | Surface tension measurements show that chaotropic salting-in denaturants are not just water-structure breakers. | 1,650 | -2,775 |
| 165 | A clinician’s guide to the appropriate and accurate use of antibiotics: the Council for Appropriate and Rational Antibiotic Therapy (CARAT) criteria | 1,647 | -6,260 |
| 166 | Terminology for biorelated polymers and applications (IUPAC Recommendations 2012) | 1,638 | -2,323 |
| 167 | Synthesis of the elements in stars: forty years of progress | 1,636 | -3,273 |
| 168 | miRNA: Licensed to Kill the Messenger | 1,633 | -1,400 |
| 169 | Friedrich W�hler (1800?1882), on the Bicentennial of His Birth | 1,633 | -1,400 |
| 170 | Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine | 1,628 | -1,972 |
| 171 | DNA Topoisomerases: Structure, Function, and Mechanism | 1,621 | -1,159 |
| 172 | Skin Breakdown and Blisters from Senna-Containing Laxatives in Young Children | 1,600 | -1,775 |
| 173 | Measurement of micronucleated erythrocytes and DNA damage during chronic ingestion of phenolphthalein in transgenic female mice heterozygous for thep5... | 1,600 | -1,775 |
| 174 | The isoprene rule and the biogenesis of terpenic compounds | 1,600 | -1,020 |
| 175 | Inclusion Compounds | 1,600 | -100 |
| 176 | Properties of high-temperature melts using levitation | 1,600 | 0 |
| 177 | TRANSPORT MECHANISMS FOR ORGANIC FORMS OF CARBON AND NITROGEN BETWEEN SOURCE AND SINK | 1,600 | -2,000 |
| 178 | Lawson Tait and Opposition to Germ Theory: Defining Science in Surgical Practice | 1,585 | -929 |
| 179 | Structure and spectra of tetrasulfur S4 – an ab initio MO study | 1,575 | -2,425 |
| 180 | Phosgene | 1,560 | -3,280 |
| 181 | Population Pharmacokinetics of Intravenous and Intramuscular Streptomycin in Patients with Tuberculosis | 1,550 | -6,800 |
| 182 | Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome | 1,550 | -1,058 |
| 183 | Bone Resorption by Osteoclasts | 1,550 | -100 |
| 184 | Topical anti-itch therapy | 1,542 | -500 |
| 185 | Internet security: firewalls and beyond | 1,542 | -131 |
| 186 | Defending against flooding-based distributed denial-of-service attacks: a tutorial | 1,542 | -131 |
| 187 | Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs | 1,538 | -867 |
| 188 | Density, dynamic viscosity, and derived properties of binary mixtures of methanol or ethanol with water, ethyl acetate, and methyl acetate at T=(293.1... | 1,519 | -2,738 |
| 189 | In SilicoFolding of a Three Helix Protein and Characterization of Its Free-Energy Landscape in an All-Atom Force Field | 1,508 | -5,593 |
| 190 | The Atmospheres of Uranus and Neptune | 1,500 | -1,971 |
| 191 | Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled tr... | 1,500 | -1,400 |
| 192 | Design and mechanical properties of insect cuticle | 1,500 | -3,200 |
| 193 | Microstructure, elastic properties and deformation mechanisms of horn keratin | 1,500 | -3,200 |
| 194 | The First Report on Scheme Revisited | 1,500 | 0 |
| 195 | On a New Action of the Magnet on Electric Currents | 1,500 | -550 |
| 196 | A pneumonia outbreak associated with a new coronavirus of probable bat origin | 1,500 | -616 |
| 197 | The 2019-new coronavirus epidemic: evidence for virus evolution | 1,500 | -616 |
| 198 | Why snakes probably aren’t spreading the new China virus | 1,500 | -616 |
| 199 | Structure Of Hæemoglobin: A Three-Dimensional Fourier Synthesis of Reduced Human Haemoglobin at 5.5 Å Resolution | 1,496 | -5,580 |
| 200 | A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis | 1,496 | -5,580 |